Cytotoxic T-Lymphocytes in Human Viral and Malaria Infections PDF Download

Author: Michael B.A. Oldstone
Publisher: Springer Science & Business Media
ISBN: 3642785301
Category : Medical
Languages : en
Pages : 215

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Book Description
Cytotoxic T lymphocytes (CTL) control several viral infections in animals based on deletion and reconstitution experiments with CTL clones and use of CD8 genetically deficient (knock-out) mice. In this volume, data for the role that CTL play in human infectious diseases is presented. As such, this represents the first volume in which such information from several different viral and protozoan infections is brought together.

Author: Volker ter Meulen
Publisher: Springer Science & Business Media
ISBN: 3642786219
Category : Medical
Languages : en
Pages : 204

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Book Description
Measles, also called the greatest killer of children in history, still annually affects about 50 million individuals and causes close to a million deaths primarily in developing countries. Before the advent of measles vaccine some 30 years ago, these figures were roughly three times higher. Attenuated measles virus (MV) strains, all quite closely related to the original Edmonston isolate, have a very good record as a safe and highly efficacious vaccine and have brought down the measles toll in industrialized countries to almost negligible levels. However, recent outbreaks in the USA and Europe have again brought the measles problem to public attention. Sadly enough, these outbreaks were more instrumental in inducing activities to drastically reduce and hopefully finally eradicate measles than were the ten thousand times higher number of victims in developing countries. To reach this goal, as detailed in this volume, apparently it is not enough to of the existing vaccine as was the rigorously enforce use case with smallpox eradication: the intricacies of measles disease phenomena, in particular the generalized immune suppression which favors secondary infections, require more basic knowledge of the virus-host interactions and probably the development of new vaccines for special applications such as first immunizations of very young infants in developing countries.

Author: Marc H. V. Van Regenmortel
Publisher: CRC Press
ISBN: 9780849392252
Category : Medical
Languages : en
Pages : 444

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Book Description
Volume 3 of Structure of Antigens presents analytical methods used to elucidate the structure of antigens. As in the first two volumes, this reference focuses on the structure and analysis of antibody binding sites. It brings together the structural basis of major types of antigens, including lysozyme, cytochrome c, muscle proteins, cereal and milk proteins, carbohydrate antigens, and more. Major groups of antigens associated with particular biological systems, such as the cytoskeleton, muscle proteins, and viral antigens, are discussed. This reference analyzes the molecular basis of antibody specificity and the structure of T cell epitopes.

Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1860

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Author: Cold Spring Harbor Laboratory
Publisher: CSHL Press
ISBN: 9780879695163
Category : Medical
Languages : en
Pages : 396

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Book Description
Over its lifespan so far, this annual series has traced the state of the art of vaccination from empiricism to molecular design. In this work, the investigation of immunogens at a structural level is especially prominent, as is further exploration of DNA immunization.

Author:
Publisher:
ISBN:
Category : Chemistry
Languages : en
Pages : 2540

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Author: William P. Taylor
Publisher: Elsevier
ISBN: 0080455891
Category : Nature
Languages : en
Pages : 390

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Book Description
Rinderpest and Peste des Petits Ruminants tells the story of how, by the year 2010, scientists are set to globally eradicate one of the great historic plagues that has ravaged human livestock for centuries. Descriptions of the disease in Europe date back to the 4th century and it was regularly re-introduced following wars and other civil unrest until late in the 19th century. It was introduced with devastating effect into Africa towards the end of the 19th century and is now widespread across sub-Saharan Africa, the Middle East and Southern Asia. Its causative agent, rinderpest virus, a morbillivirus very closely related to human measles virus, decimates the cattle population along with those of other susceptible domestic ruminants and many wildlife species wherever it is present. - The history of Rinderpest including the history of vaccines and vaccination - Details other Morbillaviruses - Epidemiology and transmission of Rinderpest

Author: Adrian Bot
Publisher: Springer Science & Business Media
ISBN: 1475731639
Category : Medical
Languages : en
Pages : 185

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Book Description
Wolf's discovery demonstrating that a reporter gene is expressed in myocytes subsequent to injection of naked DNA, was exploited by immunologists and vaccinologists to develop a new generation of vaccines. This observation galvanized the research and in a short lapse of time, an oceanic volume of knowledge has been accumulated. The research carried out in a variety of animal models showed the efficacy of genetic immunization against viruses, bacteria, and some parasites by the ability to induce a strong priming effect resulting from long-lasting persistence of plasmid as episomes. Furthermore, it was demonstrated that newborn or infant immune unresponsiveness to classical vaccines can be corrected by genetic immunization. The applications of genetic immunization for prophylaxis of infections was extended to immunotherapy, namely, cancerous, auto immune, and allergic diseases. Immunologists have provided pertinent information on the cellular basis of the immune responses elicited by genetic immunization, and molecular biologists have established the molecular basis of intrinsic adjuvant properties of plasmids.

Author: Hiroshi Kiyono
Publisher: Elsevier
ISBN: 0080537057
Category : Medical
Languages : en
Pages : 501

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Book Description
This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. - Provides the latest views on mucosal vaccines - Applies basic principles to the development of new vaccines - Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases - Unique and user-friendly organization

Author: Andras Falus
Publisher: Springer Science & Business Media
ISBN: 0387792082
Category : Medical
Languages : en
Pages : 284

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Book Description
Innate immunity is one the most evolutionally conserved systems, designed to protect the organism from viruses and bacterial infections, stress and many other types of attacks from the outside world. During the past decade, the capacity of molecular biology and information technology to produce and analyse data have grown exponentially, rapidly reforming many aspects of immunology research in the post-genomics era. As a result, scientific understanding of signalling networks governing the innate immunity response in human tissues and other organisms has evolved beyond recognition, compared to even just a decade ago. Many strategies have been designed over the years to identify novel proteins, which have a crucial role in innate immunity responses by regulating particular signalling pathways. These projects had many advantages, including the definition of novel drug targets, as exemplified by the recent success of anti-TNF therapy, as well as leading to a better, system-wide understanding of the molecular control of innate immunity. In the past few years, a new concept, Immunomics, has been adopted to define an emerging, multidisciplinary field of research (Schonbach, 2003). Although rapid progress has been made to identify the proteins playing pivotal roles in the innate immunity–related signalling pathways (for example, TIR signalling pathways), the catalogue of proteins with a key regulatory function identified and studied is far from completed. Novel proteins need to be char- terised to gain a more comprehensive picture of how signalling networks are regulated.