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Author: Guangshun Wang Publisher: MDPI ISBN: 3038424625 Category : Medical Languages : en Pages : 291
Book Description
This book is a printed edition of the Special Issue "Identification and Characterization of Antimicrobial Peptides with Therapeutic Potential" that was published in Pharmaceuticals
Author: Guangshun Wang Publisher: MDPI ISBN: 3038424625 Category : Medical Languages : en Pages : 291
Book Description
This book is a printed edition of the Special Issue "Identification and Characterization of Antimicrobial Peptides with Therapeutic Potential" that was published in Pharmaceuticals
Author: Guangshun Wang (Ed.) Publisher: ISBN: 9783038424635 Category : Languages : en Pages :
Book Description
Annotation Antimicrobial peptides are key defense molecules adopted by all life forms to prevent infection. They also have other beneficial effects such as boosting immune response, anticancer, and wound healing. The antiviral effects of antimicrobial peptides have laid the foundations for developing new agents to combat seasonal Flu, HIV-1, RSV, Zika, and Ebola. This eBook is constructed to systematically deal with antimicrobial peptides from a variety of natural sources, including fungi, plants, and animals (insects, fish, amphibians, birds, and reptiles). It covers peptide discovery, antimicrobial activity, 3D structure, mechanisms of action and potential applications. Naturally Occurring Antimicrobial Peptides, an eBook published by the journal Pharmaceuticals, provides a helpful introduction to newcomers and refreshes the minds of veterans.
Author: K. Ajesh Publisher: Academic Press ISBN: 0323903207 Category : Science Languages : en Pages : 347
Book Description
Antimicrobial Peptides: Challenges and Future Perspectives covers the latest developments about antimicrobial peptides in the scenario of drug resistance. The book is divided into 16 chapters arranged in sequence and preceded by chapters on historical developments and their role as regulatory molecules in innate defense mechanism. Emphasis is given to purification techniques and characterization suitable for interdisciplinary research. Chapters provide an inventory of various antimicrobial peptides, from a diverse array of organisms such as bacteria, fungi, insects, amphibians, plants and mammals. A section on marine ecosystem broadens readers understanding on marine based antimicrobial peptides. Additional sections provide an informative overview on peptides with antiviral properties and those targeting multi-drug resistant bacteria. Recent reports and mechanism on resistance against antimicrobial peptides are also provided, along with key insights into the challenges and future perspectives of peptide drug development. - Emphasizes antimicrobial peptides targeting various human viruses and multidrug resistant bacteria - Written by internationally recognized experts who provide readers with a wide and useful perspective - Provides in-depth resources for undertaking a research work in antimicrobial peptides with the inclusion of chapters on purification techniques and structural details - Addresses the possibility and availability of peptide antibiotics in the global drug market - Serves as a complete resource from the discovery to drug development of peptide antibiotics
Author: Katsumi Matsuzaki Publisher: Springer ISBN: 9811335885 Category : Medical Languages : en Pages : 304
Book Description
This book presents an overview of antimicrobial peptides (AMPs), their mechanisms of antimicrobial action, other activities, and various problems that must still be overcome regarding their clinical application. Divided into four major parts, the book begins with a general overview of AMPs (Part I), and subsequently discusses the various mechanisms of antimicrobial action and methods for researching them (Part 2). It then addresses a range of activities other than antimicrobial action, such as cell penetration, antisepsis, anticancer, and immunomodulatory activities (Part 3), and explores the prospects of clinical application from various standpoints such as the selective toxicity, design, and discovery of AMPs (Part 4). A huge number of AMPs have been discovered in plants, insects, and vertebrates including humans, and constitute host defense systems against invading pathogenic microorganisms. Consequently, many attempts have been made to utilize AMPs as antibiotics. AMPs could help to solve the urgent problem of drug-resistant bacteria, and are also promising with regard to sepsis and cancer therapy. Gathering a wealth of information, this book will be a bible for all those seeking to develop antibiotics, anti-sepsis, or anticancer agents based on AMPs.
Author: Gordon Tiddy Publisher: Royal Society of Chemistry ISBN: 1849733783 Category : Science Languages : en Pages : 283
Book Description
NanoFormulation covers advances in research, development and applications of innovative formulation technologies where nanomaterials play an essential role.
Author: Dhiren Satish Dunraj Publisher: ISBN: Category : Anti-infective agents Languages : en Pages : 256
Book Description
Pseudomonas aeruginosa is a commonly occurring opportunistic pathogen with the capacity to form biofilms. Pathogenic bacteria such as Pseudomonas aeruginosa have been known to develop bacterial resistance. Therefore new compounds are required to address this problem; antimicrobial peptides have been identified as a potential solution. The bioactive peptide lactoferricin has known activity against Pseudomonas aeruginosa but suffers from a number of drawbacks including metabolic instability and possible development of resistance. To address these issues, this thesis describes four strategies of peptide-design; namely incorporation of non-protein amino acids, truncation with novel C-terminal modifications, tetrabranching and conjugation to porphyrin. It was a necessity that the synthesized compounds incorporating these modifications were able to exhibit sufficient antimicrobial activity. Porphyrin-peptide conjugates were synthesized for their potentially novel antibacterial mechanism of action via intrinsic haem-uptake pathways. Both solid and solution phase synthetic strategies were explored for the porphyrin-peptide conjugates, with the solid phase strategy giving superior results. All successful analogues, were biologically evaluated by agar diffusion and MIC assays. The results of this have demonstrated that the incorporation of the non-protein amino acid, 3-aminobenzoic acid, resulted in loss of antibacterial activity of the original sequence; rendering any potential improvements on metabolic stability futile. Conversely, all other structural modifications demonstrated promising MIC values against Pseudomonas aeruginosa verifying these compounds as potent antimicrobials. Those showing promising antimicrobial activity render themselves as future candidates for evaluation of their enhanced therapeutic potential including analysis of metabolic stability. A potentially novel finding was the observation of antimicrobial activity of porphyrin-peptide conjugates in the absence of applied light. Porphyrin compounds which have shown antibacterial activity in the literature act exclusively through photodynamic mechanisms which have a requirement of an applied source of irradiation. The porphyrin-peptides in this study show retention of antimicrobial activity which is either due solely to antimicrobial peptide sequence by itself or possibly due to a mechanism related to the manipulation of haem-uptake pathways. At present, no explicit declaration of such mechanisms of action can be made. The promising antibacterial activity displayed by the series of novel compounds proposes further evaluation with potential to address the universal issue of bacterial resistance development.
Author: David A. Phoenix Publisher: John Wiley & Sons ISBN: 9783527332632 Category : Science Languages : en Pages : 0
Book Description
In this text, the small team of expert authors presents the field in a comprehensive and accessible manner that is well suited for students and junior researchers. The result is a highly readable and systematically structured introduction to antimicrobial peptides, their structure, biological function and mode of action. The authors point the way towards a rational design of this potentially highly effective new class of clinical antibiotics on the brink of industrial application. They do this by discussing their design principles, target membranes and structure-activity relationships. The final part of the book describes recent successes in the application of peptides as anticancer agents.
Author: Ved Srivastava Publisher: Royal Society of Chemistry ISBN: 1788014332 Category : Science Languages : en Pages : 572
Book Description
Peptide therapy has become a key strategy in innovative drug development, however, one of the potential barriers for the development of novel peptide drugs in the clinic is their deficiencies in clearly defined chemistry, manufacturing and controls (CMC) strategy from clinical development to commercialization. CMC can often become a rate-limiting step due to lack of knowledge and lack of a formal policy or guidelines on CMC for peptide-based drugs. Regulators use a risk-based approach, reviewing applications on a case-by-case basis. Peptide Therapeutics: Strategy and Tactics for Chemistry, Manufacturing, and Controls covers efficient manufacturing of peptide drug substances, a review of the process for submitting applications to the regulatory authority for drug approval, a holistic approach for quality attributes and quality control from a regulatory perspective, emerging analytical tools for the characterisation of impurities, and the assessment of stability. This book is an essential reference work for students and researchers, in both academia and industry, with an interest in learning about CMC, and facilitating development and manufacture of peptide-based drugs.
Author: Anton Ficai Publisher: Elsevier ISBN: 0323461514 Category : Science Languages : en Pages : 724
Book Description
Nanostructures for Antimicrobial Therapy discusses the pros and cons of the use of nanostructured materials in the prevention and eradication of infections, highlighting the efficient microbicidal effect of nanoparticles against antibiotic-resistant pathogens and biofilms. Conventional antibiotics are becoming ineffective towards microorganisms due to their widespread and often inappropriate use. As a result, the development of antibiotic resistance in microorganisms is increasingly being reported. New approaches are needed to confront the rising issues related to infectious diseases. The merging of biomaterials, such as chitosan, carrageenan, gelatin, poly (lactic-co-glycolic acid) with nanotechnology provides a promising platform for antimicrobial therapy as it provides a controlled way to target cells and induce the desired response without the adverse effects common to many traditional treatments. Nanoparticles represent one of the most promising therapeutic treatments to the problem caused by infectious micro-organisms resistant to traditional therapies. This volume discusses this promise in detail, and also discusses what challenges the greater use of nanoparticles might pose to medical professionals. The unique physiochemical properties of nanoparticles, combined with their growth inhibitory capacity against microbes has led to the upsurge in the research on nanoparticles as antimicrobials. The importance of bactericidal nanobiomaterials study will likely increase as development of resistant strains of bacteria against most potent antibiotics continues. - Shows how nanoantibiotics can be used to more effectively treat disease - Discusses the advantages and issues of a variety of different nanoantibiotics, enabling medics to select which best meets their needs - Provides a cogent summary of recent developments in this field, allowing readers to quickly familiarize themselves with this topic area
Author: Guangshun Wang
Author: Guangshun Wang
Author: Guangshun Wang (Ed.)
Author: Wan Siti Nur Atirah Wan Mohd. Azemin
Author: K. Ajesh
Author: Katsumi Matsuzaki
Author: Gordon Tiddy
Author: Dhiren Satish Dunraj
Author: David A. Phoenix
Author: Ved Srivastava
Author: Anton Ficai