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Author: Sandra Knowles Weller Publisher: Caister Academic Press Limited ISBN: 9781904455769 Category : Science Languages : en Pages : 0
Book Description
Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.
Author: Sandra Knowles Weller Publisher: Caister Academic Press Limited ISBN: 9781904455769 Category : Science Languages : en Pages : 0
Book Description
Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.
Author: Rachel Sarah O'Toole Publisher: University of Pittsburgh Pre ISBN: 0822977966 Category : History Languages : en Pages : 274
Book Description
Bound Lives chronicles the lived experience of race relations in northern coastal Peru during the colonial era. Rachel Sarah O'Toole examines how Andeans and Africans negotiated and employed casta, and in doing so, constructed these racial categories. Royal and viceregal authorities separated "Indians" from "blacks" by defining each to specific labor demands. Casta categories did the work of race, yet, not all casta categories did the same type of work since Andeans, Africans, and their descendants were bound by their locations within colonialism and slavery. The secular colonial legal system clearly favored indigenous populations. Andeans were afforded greater protections as "threatened" native vassals. Despite this, in the 1640s during the rise of sugar production, Andeans were driven from their assigned colonial towns and communal property by a land privatization program. Andeans did not disappear, however; they worked as artisans, muleteers, and laborers for hire. By the late seventeenth and early eighteenth centuries, Andeans employed their legal status as Indians to defend their prerogatives to political representation that included the policing of Africans. As rural slaves, Africans often found themselves outside the bounds of secular law and subject to the judgments of local slaveholding authorities. Africans therefore developed a rhetoric of valuation within the market and claimed new kinships to protect themselves in disputes with their captors and in slave-trading negotiations. Africans countered slaveholders' claims on their time, overt supervision of their labor, and control of their rest moments by invoking customary practices. Bound Lives offers an entirely new perspective on racial identities in colonial Peru. It highlights the tenuous interactions of colonial authorities, indigenous communities, and enslaved populations and shows how the interplay between colonial law and daily practice shaped the nature of colonialism and slavery.
Author: David Ward Publisher: Fairleigh Dickinson Univ Press ISBN: 9780838636763 Category : History Languages : en Pages : 260
Book Description
This book is an in-depth analysis of three of the most crucial years in twentieth-century Italian history, the years 1943-46. After more than two decades of a Fascist regime and a disastrous war experience during which Italy changed sides, these years saw the laying of the political and cultural foundations for what has since become known as Italy's First Republic. Drawing on texts from the literature, film, journalism, and political debate of the period, Antifascisms offers a thorough survey of the personalities and positions that informed the decisions taken in this crucial phase of modern Italian history.
Author: Ptolemy Publisher: Princeton University Press ISBN: 0691002606 Category : Science Languages : en Pages : 712
Book Description
Ptolemy's Almagest is one of the most influential scientific works in history. A masterpiece of technical exposition, it was the basic textbook of astronomy for more than a thousand years, and still is the main source for our knowledge of ancient astronomy. This translation, based on the standard Greek text of Heiberg, makes the work accessible to English readers in an intelligible and reliable form. It contains numerous corrections derived from medieval Arabic translations and extensive footnotes that take account of the great progress in understanding the work made in this century, due to the discovery of Babylonian records and other researches. It is designed to stand by itself as an interpretation of the original, but it will also be useful as an aid to reading the Greek text.
Author: Publisher: Chronicle Books ISBN: 1452181896 Category : Humor Languages : en Pages : 114
Book Description
Featuring 30 types of breasts, The Boob Book is an illustrated celebration of womanhood and the boobs that come with it. Scattered throughout are boob miscellany: a boob personality flow chart, boob facts, boob self-care tips, a roundup of bras, types of nipples, a boob doodle, and illustrated ways we show off the goods. This joyful book features breasts of all colors and sizes—from "The Handful" to "The Mom-To-Be" to "The Small but Mighty"—showing women that every boob type is weird, beautiful, and natural. • An illustrated love letter to a girl's breast friend • Filled with fun and interactive boob-related miscellany, like a boob personality test (are you a "Chillaxer" or a "Handful"?), boob facts, and breast self-care tips • Light, celebratory, and a little cheeky—but ultimately sincere Let's hear it for our bosom buddies. Our mammary mamas. Our breasts-in-arms. From small and mighty to large and in charge to long, short, hairy, bumpy, or any boobs in between, this book uplifts them all. • A perfect book for women of all generations—from friends to mothers and daughters—or anyone who wants to send some extra support and love to their ladies • Ideal for anyone who needs a boob-size boost • Great for those who enjoyed Feminist Activity Book by Gemma Correll, Celebrating You: (And the Beautiful Person You Are) by M. H. Clark, and Gross Anatomy: Dispatches from the Front (and Back) by Mara Altman
Author: John Dryden Publisher: Createspace Independent Publishing Platform ISBN: 9781724490773 Category : Languages : en Pages : 94
Book Description
Absalom and Achitophel by John Dryden Absalom and Achitophel is "generally acknowledged as finest political satire in the English language."It is also described as an allegory regarding contemporary political events, and a mock heroic narrative. On the title page, Dryden himself describes it simply as "a poem." We are delighted to publish this classic book as part of our extensive Classic Library collection. Many of the books in our collection have been out of print for decades, and therefore have not been accessible to the general public. The aim of our publishing program is to facilitate rapid access to this vast reservoir of literature, and our view is that this is a significant literary work, which deserves to be brought back into print after many decades. The contents of the vast majority of titles in the Classic Library have been scanned from the original works. To ensure a high quality product, each title has been meticulously hand curated by our staff. Our philosophy has been guided by a desire to provide the reader with a book that is as close as possible to ownership of the original work. We hope that you will enjoy this wonderful classic work, and that for you it becomes an enriching experience.
Author: Daniel Bussier Shumway Publisher: Alpha Edition ISBN: 9789356784512 Category : Languages : en Pages : 0
Book Description
The Nibelungenlied, has been regarded as significant work throughout human history, and in order to ensure that this work is never lost, we have taken steps to ensure its preservation by republishing this book in a contemporary format for both current and future generations. This entire book has been retyped, redesigned, and reformatted. Since these books are not made from scanned copies, the text is readable and clear.
Author: Sandra Knowles Weller
Author: Sandra Knowles Weller
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Author: Rachel Sarah O'Toole
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Author: David Ward
Author: Ptolemy
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Author: John Dryden
Author: Daniel Bussier Shumway