Author: John W. KenningtonPublisher:
ISBN:
Category : Beta lactam antibiotics
Languages : en
Pages : 180
Book Description
I. Approaches to the Synthesis of Nogalamycin and Related Substances
Author: John W. KenningtonPublisher:
ISBN:
Category : Beta lactam antibiotics
Languages : en
Pages : 180
Book Description
American Doctoral Dissertations
Author: Publisher:
ISBN:
Category : Dissertation abstracts
Languages : en
Pages : 796
Book Description
DNA and Aspects of Molecular Biology
Author: Eric T. KoolPublisher: Pergamon
ISBN: 9780080431659
Category : DNA.
Languages : en
Pages : 0
Book Description
This volume is intended to cover the chemistry of one of the most widely studied and important natural products, DNA. Discussed in detail are physicochemical properties of the molecule itself as well as small-molecule natural products that are known to interact with it. Also included are methods to synthesize and manipulate DNA and modified analogues. Twenty chapters are devoted to this overall topic. thermodynamics and kinetics of double helix formation; the next two describe triple- and tetra- helical structures formed by DNA; and the last two focus on methods for probing DNA structure (specifically, NMR methods and chemical probing methods, respectively). analogues. The first of these addresses nonenzymatic methods for synthesizing DNA, and the next chapter, methods for attachment of reporter groups to it. Modifications of DNA structure are discussed in chapters eight to eleven; the first of these addresses nucleoside analogues useful as biochemical probes, while others discuss alterations to the DNA backbone, bases, and topology, respectively. The extensive chemistry of DNA damage is reviewed in the last chapter (chapter 12). Included in this group are a large number of natural and non-natural products, which fall into the classes of intercalators (chapter 13), minor groove binders (chapter 14), DNA-binding peptides (chapter 15), and DNA-damaging natural products (chapter 16). The last two chapters focus more specifically on two broad classes of medicinally important agents which interact with DNA; specifically, the enediyne natural products (chapter 17), and topoisomerase inhibitors (chapter 18). are being used in many chemically-oriented laboratories. The first (chapter 19) covers selection of novel ligands and catalysts from sequence-randomized libraries of DNA. The second (chapter 20) covers other useful molecular biology methods such as cloning and the polymerase chain reaction.
Research Awards Index
Author: Recent Progress in the Chemical Synthesis of Antibiotics and Related Microbial Products
Author: Gabor LukacsPublisher:
ISBN:
Category : Medical
Languages : en
Pages : 990
Book Description
Dissertation Abstracts International
Author: Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 972
Book Description
Cumulated Index Medicus
Author: Index to Theses Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards
Author: Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 372
Book Description
Natural Product Biosynthesis
Author: Christopher T. WalshPublisher: Royal Society of Chemistry
ISBN: 1788010760
Category : Science
Languages : en
Pages : 787
Book Description
This textbook describes the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era.
Medicinal Chemistry of Anticancer Drugs
Author: Carmen AvendañoPublisher: Elsevier
ISBN: 0444626670
Category : Science
Languages : en
Pages : 767
Book Description
Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. - Presents information in a clear and concise way using a large number of figures - Historical background provides insights on how the process of drug discovery in the anticancer field has evolved - Extensive references to primary literature