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Author: Carolina M. Maier Publisher: Springer Science & Business Media ISBN: 1592596533 Category : Medical Languages : en Pages : 242
Book Description
A comprehensive review of the scientific and clinical studies that have led to the resurgence of interest in hypothermia as a neuroprotective strategy in the treatment of stroke and traumatic brain injury. Topics of special importance include intraoperative and intensive care management of hypothermia-treated patients, a critical look at the potential for combining hypothermia with pharmacotherapy, and an update on the latest technological advances that have made hypothermic treatment possible in today's clinical setting.
Author: Carolina M. Maier Publisher: Springer Science & Business Media ISBN: 1592596533 Category : Medical Languages : en Pages : 242
Book Description
A comprehensive review of the scientific and clinical studies that have led to the resurgence of interest in hypothermia as a neuroprotective strategy in the treatment of stroke and traumatic brain injury. Topics of special importance include intraoperative and intensive care management of hypothermia-treated patients, a critical look at the potential for combining hypothermia with pharmacotherapy, and an update on the latest technological advances that have made hypothermic treatment possible in today's clinical setting.
Author: Samuel Tisherman Publisher: Springer Science & Business Media ISBN: 038725403X Category : Medical Languages : en Pages : 264
Book Description
Therapeutic Hypothermia will provide a review of the subject, in particular, resuscitative hypothermia and include known mechanisms of action and results from both mechanistic and outcome laboratory studies and clinical trials. Cooling methods and potential side effects of hypothermia will be addressed as well as recommendations for future laboratory and clinical research. This volume will be of interest to both the researcher interested in therapeutic hypothermia as well as the clinician interested in the potential use of therapeutic hypothermia in their patient population.
Author: N. Hayashi Publisher: Springer Science & Business Media ISBN: 4431668829 Category : Medical Languages : en Pages : 253
Book Description
Rapid progress in technology and its application to diagnosis and monitoring of brain tissue temperature and metabolism have resulted in advances in the therapy for critically brain-injured patients and breakthroughs in understanding the pathophysiology of brain damage. The latest concept of brain hypothermia therapy clarifies targets such as brain thermal pooling, masking brain hypoxia associated with catecholamine surge, the metabolic shift from glucose to lipids, and selective radical damage of dopamine in the central nervous system. This volume explains the mechanism of brain injury and how brain hypothermia treatment differs from other hypothermia therapy in four major sections: Brain Injury Mechanism, Pathophysiology of Hypothermia, Basic Research of Hypothermia Treatment, and Clinical Studies of Brain Hypothermia. The book is a valuable source for practitioners and researchers in neurosurgery and neurology and in critical care and emergency medicine.
Author: N. Hayashi Publisher: Springer Science & Business Media ISBN: 4431539611 Category : Medical Languages : en Pages : 352
Book Description
The International Brain Hypothermia Symposium 2004, held in Tokyo, was a forum for many of the world’s leading researchers and clinicians to present and discuss developments on the cutting edge of this most promising of neurological therapies. With a view to sharing this knowledge and encouraging the spread of new techniques, the editors have compiled these proceedings covering the latest technology and methods. Topics include brain thermo-pooling, hemoglobin-dysfunction-associated neuronal hypoxia, intensive care management of brain hypothermia for severely brain-injured patients, new findings not yet recorded in animal models, and control of hypothermia-associated immune crises. Also included are advanced clinical results from trauma, stroke, and cardiac arrest patients. The result is a volume that will be a valuable resource for professionals in the fields of emergency treatment, critical medicine, and neurosurgery.
Author: Farid Sadaka Publisher: BoD – Books on Demand ISBN: 953510960X Category : Medical Languages : en Pages : 163
Book Description
This book describes the evidence behind the application of Therapeutic Hypothermia on patients with injury to the brain and spinal cord, that includes ischemia reperfusion after cardiac arrest or asphyxiation, traumatic brain injury, acute ischemic stroke, hemorrhagic stroke, refractory intracranial hypertension, cerebral edema in acute liver failure, subarachnoid hemorrhage, as well as spinal cord injury. This book discusses the mechanisms by which therapeutic hypothermia can mitigate the pathophysiologies responsible for secondary brain injury, and provides information to help guide this treatment with regard to timing, depth, duration, and management of side-effects. The book also discusses the methods and technologies used to induce and maintain therapeutic hypothermia. It also describes how hypothermia can influence the ability to prognosticate these injured patients and provides grounds for future directions in the application of and research with therapeutic hypothermia.
Author: Justin B. Lundbye Publisher: Springer Science & Business Media ISBN: 1447129512 Category : Medical Languages : en Pages : 134
Book Description
Therapeutic hypothermia has emerged as a very important treatment option for patients with cardiac arrest as it provides significant protection from developing neurologic injury once the patient has been successfully resuscitated. Studies have demonstrated over 15% absolute risk reduction in death and neurologic injury using this therapy. Although hospitals and medical centers have become familiar with this important intervention it still remains greatly under utilized due to an experience and lack of resources to safely and effectively deploy such a program. The objective of this book is to educate and familiarize both providers and institutions as to how to develop and deploy and provide therapeutic hypothermia to their patients. The current knowledge for this is provided by speakers and national experts and also by literature review. There are several courses being provided on this as well throughout the US. These are good venues for people to come and see and get hands on experience, but there still needs to be a concrete book with references on how to go about getting this program started.
Author: Michael Pinsky Publisher: Springer Science & Business Media ISBN: 3642560369 Category : Medical Languages : en Pages : 316
Book Description
Cerebral Blood Flow: Quantifying Consciousness Although the heart may be the source of energy needed to generate blood flow,and other organs absolutely essential for normal living,the brain is the reason we are alive. The collected book chapters are aimed at addressing this most fundamental organ and its blood flow. These papers reflect detailed descriptions of similar topics presented over a two-day period as part of the 5th International Symposium on Applied Physiology of the Peripheral Circulation held in Pittsburgh, Pennsylvania, in June 2000. The symposium and this volume were organized into four distinct groupings that follow in a logical fashion. The initial papers focus on the basic unique physiology and pathophysiology of the cerebral circulation, including a historical reviewof the means to measure cerebral blood flow and its implications of the past 30 years. Dr. Walter D. Obrist was one of the original investigators to use radiolabeled markers to assess cerebral blood flow. His equations and initial studies form an impressive introduction to where we are now. As with much of the body's special organs, the brain too has many circulatory features unique to itself.These include the unique blood-brain barrier function ofthe endothelium, local neural regulation control, and intracranial pressure effects. These special issues,plus genetic factors that may predispose individuals to developing cere bral aneurysm, make up the initial section of the monograph.
Author: Ian Sutcliffe Publisher: ISBN: Category : Languages : en Pages : 0
Book Description
Hypothermia has long been known to be neuroprotective following brain injury, yet the correlates of this neuroprotection are poorly understood. We postulated that moderate hypothermia would attenuate leukocyte rolling and adhesion following IL-1beta or cerebral ischemia induced inflammation. Laser Doppler was used to demonstrate successful induction of global cerebral ischemia in C57/B16 mice. ISEL, NeuN, and GFAP staining of brain sections were used to demonstrate temporal and spatial injury in this murine model of 10-minutes global cerebral ischemia. Four hours hypothermia (32°C) induced immediately following normothermic (37°C) cerebral ischemia provided protection against cell death and astrocytosis for up to 7 days post-ischemia. An open cranial window and intravital microscopy were used to visualize leukocyte rolling and adhesion in pial venules at 4-h following injection of IL-1beta, and 0 to 4-h following global cerebral ischemia. Increases in leukocyte rolling and adhesion were observed in IL-1beta injected mice. Four hours of hypothermia begun immediately following injection of IL-1beta reduced both rolling and adhesion. Similarly, increases in leukocyte rolling and adhesion were observed at 0-h and 2-h following cerebral ischemia in normothermic mice, and 2-h of post-ischemic hypothermia reduced both rolling and adhesion. In contrast, MPO and neutrophil immunohistochemistry showed that no significant infiltration of neutrophils into the brain following global cerebral ischemia. Molecular mechanisms of hypothermic effects were investigated in vitro. We showed that neither IL-1beta nor hypothermia altered the expression of CD18, or chemotaxis in human neutrophils. Together, these findings suggest that one mechanism by which hypothermia may provide neuroprotection is by reduction of leukocyte-endothelial interactions in the cerebromicrovasculature.
Author: Carolina M. Maier
Author: Carolina M. Maier
Author: Carolina M. Maier
Author: Samuel Tisherman
Author: N. Hayashi
Author: N. Hayashi
Author: Farid Sadaka
Author: Justin B. Lundbye
Author: Michael Pinsky
Author: Kym Campbell
Author: Ian Sutcliffe