Human Umbilical Cord Blood in Emerging Disease PDF Download

Author: Dr. Biplabendu Talukdar
Publisher: Archers & Elevators Publishing House
ISBN: 8119653971
Category : Antiques & Collectibles
Languages : en
Pages : 215

View

Book Description
At the very beginning, I wish to express my sincere gratitude to my respected principal investigator Prof Dr. Niranjan Bhattacharya, former professor and HOD, Department of Regenerative Medicine and Translational Science, STM, Kolkata and co-investigator Prof. Dr Rita Ghosh, professor department of Biochemistry and Biophysics, university of Kalyani. I have received his and her valuable guidance at every moment in my long journey. Without the continuous support it would have been very difficult to complete the work. I also express my sincere thanks to the respected Professor Dr. Sanjukta Bhattacharya, Professor (retired), Jadavpur University, for her continuous support during my research work and assistance in developing tools of research.

Author: Suzanne Kadereit
Publisher: World Scientific
ISBN: 9812833293
Category : Science
Languages : en
Pages : 372

View

Book Description
Umbilical cord blood, previously discarded after birth, has emerged over recent years as an alternative source of hematopoietic stem cells for hematological reconstitution, mainly for leukemia patients, as well as for some hematological deficiencies and bone marrow failures. In recent years, it has become increasingly clear that cord blood, as well as the surrounding tissue of the umbilical cord, contain additional stem cells which have been shown to be of great potential for regenerative medicine. Importantly, cord blood is abundant, it can be banked and shipped with ease, and thus has an indisputable potential for future medicines and regenerative therapies. Driven by a massive interest for regenerative medicine and alternative yet ethically acceptable stem cell sources, the scientific literature on umbilical cord and cord blood stem cells has increased tremendously. This book provides a consolidated, up-to-date overview of basic research on hematopoietic and mesenchymal stem cells contained within umbilical cord tissue, as well as other more recently described stem and precursor cells of not yet fully elucidated potential. It also takes an in-depth look at basic and translational research efforts with stem cells from the umbilical cord in academic institutions and biotech companies. Suitable for use as a primer and reference book by medical fellows and researchers entering the research fields of stem cell biology and regenerative medicine, it can also be used by students (undergraduate and graduate) as a starting point for read-up on the literature on stem cells and their potential and applications, or as a teaching tool in graduate schools for biologists, particularly for students wanting to enter the emerging field of stem cell biology.

Author: Catherine Stavropoulos-Giokas
Publisher: Elsevier
ISBN: 0124078362
Category : Medical
Languages : en
Pages : 399

View

Book Description
Cord Blood Stem Cells and Regenerative Medicine discusses the current applications for cord blood stem cells and techniques for banking cord blood. Cord blood, blood from the umbilical cord and placenta of an infant, represents an alternate source of stem cells that can be used to treat a myriad of disorders. Cord blood stem cells are being used more frequently and studied more seriously, as evidenced by the explosion of scientific literature on the topic. Currently, clinical and pre-clinical trials are being done in the field, treating conditions as severe as heart failure. Coupled with regenerative medicine, cord blood stem cells potentially carry the future of research and medicine in treating tissue damage, genetic disorders, and degenerative diseases. Read about new applications for cord blood stem cells and new techniques for banking cord blood — the future of regenerative medicine therapy. - Comprehensive coverage of the medical application of cord blood stem cells - Practical guide for usage of allogeneic and autologous cord blood in regenerative medicine - Covers new applications of cord blood stem cells, particularly transplantation and HIV - Introduces new technologies for cord blood stem cells and regenerative medicine

Author: European Group on Ethics in Science and New Technologies to the European Commission
Publisher:
ISBN:
Category : Banques de sang de cordon ombilical
Languages : de
Pages : 192

View

Book Description

Author: David Steenblock
Publisher: ReadHowYouWant
ISBN: 9781459611894
Category : Health & Fitness
Languages : en
Pages : 308

View

Book Description
We are standing at the threshold of a new and exciting medical era-an era of regeneration, rejuvenation, and renewal in which stems cells will set the stage for healing and in some cases, the restoration of injured, diseased, and debilitated tissues and organ. While stem cell therapy is still in its infancy, the field is rich with promise. The debate over the use of embryonic stem cells and the questionable effectiveness of adult stem cells have led many scientists and clinicians to concentrate their energies on umbilical-cord-derived stem cells from healthy newborn babies. While these cells are technically classifed as "adult stem cells," they appear to have greater restorative and regenerative potential than stem cells derived from adult tissues due to their young age. Human umbilical-cord stem cells (hUCSCs) have demonstrated great efficacy in promoting the healing of many conditions. In the last decade or so, pure cord-blood stem cells have been used by physcians to treat a mulitude of intractable diseases such as progressive multiple sclerosis, amyotrophic lateral sclerosis, certain degenerative eye disorders, stroke, diabetes, and various forms of heart disease. While certainly no cure all, umbilical-cord stem cell therapy appears to be amassing a respectable track record in terms of both safety and clinical utility. In "Umblical Cord Stem Cell Therapy: The Gift of Healing from Health Newborns", Drs. steenblock and Payne share some of the science that underlies stem cell therapy and put a human face on this field with accounts of people who have benefited from hUCSC treatments. And, in providing this information, they encourage readers to take that bold first step into this vast and wondrous medical frontier.

Author: Lisandra Vanostrand
Publisher: Nova Science Publishers
ISBN: 9781626180727
Category : Medical
Languages : en
Pages : 0

View

Book Description
In this book, the authors discuss cord blood banks and banking, the ethical issues involved and the risks and benefits. Topics include the virological risks and benefits of cord blood banking; mesenchymal stem cells and their role in regenerative medicine applications; osteogenic potential of human umbilical cord-derived mesenchymal stromal cells; public versus private cord blood banking; CCR5 deficient cord blood as a means of treatment for HIV-1 infection; and the therapeutic use of umbilical cord blood.

Author: Phuc Van Pham
Publisher: Springer
ISBN: 303019857X
Category : Science
Languages : en
Pages : 225

View

Book Description
This new series, based on a bi-annual conference and its topics, represents a major contribution to the emerging science of cancer research and regenerative medicine. Each volume brings together some of the most pre-eminent scientists working on cancer biology, cancer treatment, cancer diagnosis, cancer prevention and regenerative medicine to share information on currently ongoing work which will help shape future therapies. These volumes are invaluable resources not only for already active researchers or clinicians but also for those entering these fields, plus those in industry. Tissue Engineering and Regenerative Medicine is a proceedings volume which reflects papers presented at the 3rd bi-annual Innovations in Regenerative Medicine and Cancer Research conference; taken with its companion volume Stem Cells: Biology and Engineering it provides a complete overview of the papers from that meeting of international experts.

Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309095867
Category : Medical
Languages : en
Pages : 335

View

Book Description
With the potential for self-renewal and differentiation, the possibilities for stem cells are enormous. One specific type of stem cell, the hematopoietic progenitor cell (HPC), which is derived from umbilical cord blood (as well as adult bone marrow and mobilized peripheral blood), holds particular promise. To make the most of these HPCs, the Institute of Medicine was asked to consider the optimal structure for a national cord blood program and to address pertinent issues related to maximizing the potential of stem cell technology. Cord Blood: Establishing a National Hematopoietic Stem Cell Bank Program examines: The role of cord blood in stem cell transplantation The current status of blood banks already in existence The optimal structure for the cord blood program The current use and utility of cord blood for stem cell transplants The best way to advance the use of cord blood units and make them available for research Expert advice from leaders in the fields of economics, public health, medicine, and biostatistics combine to make this very timely and topical book useful to a number of stakeholders.

Author: Axel R. Zander
Publisher: Springer Science & Business Media
ISBN: 3642611222
Category : Science
Languages : en
Pages : 534

View

Book Description
The 11 th meeting in "Modern Trends in Human Leukemia" took place from June 19 to 21, 1994 in Wilsede in the middle of the Liineburger Heide, South of Hamburg. Interwoven with the Leukemia program was the Nato-sponsored Symposium of the ASI-Series "Gene Technology in Analysis of Malignant and Inherited Human Diseases Related to Development" . The Wilsede meeting was continued on a ship of the Neva leading through lake Ladoga and lake Onega. The topics of both meetings included discussion on recent progress isolation and development of hematopoietic stem cells, genes crucial for development and diseases, methods of gene transfer, application of gene transfer; oncogenes and anti-oncogenes as targets for gene therapy; receptors and their ligands in normal development and diseases, immunology and immunotherapy, radiation biology, clinical leukemias and bone marrow transplantation. The Nato workshop concentrated not only on analysis of cell systems useful for somatic gene therapy, but also on actual themes directly related to correction of human diseases. The latter aspects emphasized themes related to biotechnology, the first part was by nature more general. We also included a few contributions that discussed perspectives for the future of gene therapy and possible relationships to evolution.

Author: Donna Darlington
Publisher:
ISBN:
Category :
Languages : en
Pages :

View

Book Description
Treated mice were studied using standard behavioral tests to determine the effects of infusion on the multiple cognitive domains affected by AD, followed by biochemical and histological analyses that included A&beta load and amyloid precursor protein (APP) processing. Specifically, PSAPP mice and their wild-type (WT) littermates were treated monthly with a peripheral HUCBC infusion over a period of 6 and 10 months, followed by cognitive and motor evaluation. Additionally, based on reports that tumor cells can originate from stem cells present in HUCB, we further examined whether monocytes purified from HUCBCs would have a similar significant effect on the reduction of AD-like pathology in PSAPP mice. HUCB cells homed into tissues including the brain. The principal finding was significant reduction in A&beta levels and &beta&ndashamyloid plaques following low-dose infusions of both HUCBC&ndash derived mononuclear cells as well as HUCBC-derived monocytes, with the monocytes providing a stronger effect. Results further demonstrated that HUCBC and HUCBC&ndash derived monocyte infusion could improve memory function and locomotor ability in treated PSAPP mice. A possible reason for behavioral improvements in these animals may be the significant reduction in both A&beta levels and plaque load. This study also identified significant reduction in microglial activation and astrocytosis, both of which can contribute to AD pathology. In conclusion, our data suggest that it might be the HUCBC&ndashderived monocytic population rather than stem cells that are responsible for the reduction in AD pathology.