Author: [Anonymus AC01808815]Publisher:
ISBN: 9789283212676
Category :
Languages : en
Pages : 424
Book Description
Human immunodeficiency viruses and human T-cell lymphotropic viruses : this publication represents the views and expert opinions of an IARC working group on the evaluation of carcinogenic risks to humans, which met in Lyon, 11-18 June 1996
Author: [Anonymus AC01808815]Publisher:
ISBN: 9789283212676
Category :
Languages : en
Pages : 424
Book Description
Human immunodeficiency viruses and human T-cell lymphotropic viruses
Author: Working Group On The Ev IarcPublisher: World Health Organization
ISBN: 9789283212676
Category :
Languages : en
Pages : 424
Book Description
Includes index.
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
Author: IARC Working Group on the Evaluation of Carcinogenic Risks to HumansPublisher:
ISBN:
Category : Carcinogenesis
Languages : en
Pages : 454
Book Description
Human Immunodeficiency Viruses and Human T-cell Lymphotropic Viruses
Author: IARC Working Group on the Evaluation of Carcinogenic Risks to HumansPublisher: World Health Organization
ISBN:
Category : Medical
Languages : en
Pages : 452
Book Description
Evaluates the carcinogenic risk to humans posed by infections with human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2) and human T-cell lymphotropic viruses types I and II (HTLV-I and HTLV-II). Although emphasis is placed on carcinogenicity assessment, the monographs also provide richly detailed descriptions of the viruses' genetic and structural features, methods of detection, routes of transmission, geographical distribution of infection, clinical manifestations of non-neoplastic disorders, and currently available methods of treatment and prevention. For HIV infection, the evaluation of studies of cancer in humans considers abundant evidence, from case reports and epidemiological studies, pointing to greatly increased incidences of Kaposi's sarcoma and non-Hodgkin's lymphoma in persons infected with HIV-1. Data suggesting an association between HIV infection and cervical, anal, and several other cancers are also carefully assessed. Other data considered include findings from animal studies and investigations of the mechanisms by which immune dysfunction may contribute to the genesis of cancer. On the basis of this evaluation, the monograph concludes that infection with HIV-1 is carcinogenic to humans. Infection with HIV-2 was classified as possibly carcinogenic to humans. The second monograph provides a similarly detailed evaluation of human T-cell lymphotropic viruses, which are the only known human oncornavirinae. Concerning studies of cancer in humans, particular attention is given to evidence of an association between HTLV-I and adult T-cell leukemia/lymphoma, which occurs almost exclusively in areas where this infection is endemic. In addition, several case-control studies have found an association between HTLV-I seroprevalence and tumors of the vagina, cervix and liver, but confounding effects and bias could not be excluded. The evaluation also considered findings from animal carcinogenicity studies and from investigations of the molecular mechanisms of leukemogenesis. On the basis of this evaluation, the monograph concludes that HTLV-I is carcinogenic to humans. HTLV-II could not be classified as to its carcinogenicity to humans.
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
Author: International Agency for Research on CancerPublisher:
ISBN: 9789283212676
Category : AIDS (Disease)
Languages : en
Pages : 424
Book Description
The Stationery Office Agency Catalogue
Author: Stationery Office (Great Britain)Publisher:
ISBN:
Category : International agencies
Languages : en
Pages : 364
Book Description
Outdoor Air Pollution
Author: IARC Working Group on the Evaluation of Carcinogenic Risks to HumansPublisher: IARC Monographs on the Evaluat
ISBN: 9789283201472
Category : Medical
Languages : en
Pages : 0
Book Description
"This publication represents the views and expert opinions of an IARC Working Group on the Evaluation of Carcinogenic Risk to Humans, which met in Lyon, 8-15 October 2013."
Peroxisome Proliferation and Its Role in Carcinogenesis
Author: Publisher: World Health Organization
ISBN:
Category : Carcinogenesis
Languages : en
Pages : 104
Book Description
A state-of-the-art consensus report on what is known about peroxisome proliferation, the mechanisms involved, and their relevance to carcinogenesis. Peroxisomes are single, membrane-limited, cytoplasmic organelles that are found in cells of animals, plants, fungi, and protozoa. Peroxisome proliferators include certain hypolipidaemic drugs, phthalate ester plasticizers, industrial solvents, herbicides, food flavours, leukotriene D4 antagonists, and hormones. Numerous studies in rats and mice have demonstrated the hepatocarcinogenic effects of peroxisome proliferators, and these compounds have been unequivocally established as carcinogens. Since humans are exposed to peroxisome proliferators to a significant extent, assessment of the adverse biological effects of this group of compounds, and particularly their potential carcinogenicity, has become an important issue. The report has two parts. The first records the consensus reached by a group of eleven experts, including several of the leading investigators in this field. Questions addressed include the mechanisms by which peroxisome proliferators exert their carcinogenic effects in rodents, the relevance of animal studies to the evaluation of carcinogenic risk in humans, and the potential use of peroxisome proliferation as a biological marker for liver cancer. The report concludes that compounds inducing peroxisome proliferation in rats and mice have little, if any, effect on human liver. The report also issues advice on the interpretation of peroxisome proliferation, demonstrated in animal studies, when evaluating the carcinogenic risk to humans. The second part consists of three background papers presented by members of the working group.
Molecular Epidemiology
Author: Paul A. SchultePublisher: Academic Press
ISBN: 0323138578
Category : Medical
Languages : en
Pages : 609
Book Description
This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.
Toxicological Profile for Polycyclic Aromatic Hydrocarbons
Author: Publisher:
ISBN:
Category : Polycyclic aromatic hydrocarbons
Languages : en
Pages : 500
Book Description