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Author: Gianni Marone Publisher: Karger Medical Scientific ISBN: 9783805569743 Category : Chemokines Languages : en Pages : 0
Book Description
Eosinophils represent approximately 1% of peripheral blood leukocytes and play a central proinflammatory and immunoregulatory role in various immune disorders. This volume provides the reader with a comprehensive survey of the major aspects of human eosinophilic biology and immunology as well as the most clinically relevant aspects of eosinophil-related disorders. Expert contributions cover the ultrastructural and phenotypic characteristics of human eosinophils, and their fundamental biochemical features including receptors for IgE and chemokines. The production of cytokines and their role in the activation of eosinophils are reviewed. Furthermore, the classic eosinophil-related disorders such as hypereosinophilia, drug reactions, allergic disorders and some cardiovascular diseases are described. Each of the chapters is written by an investigator actively engaged in research on the topic under consideration. The well-edited and stimulating material compiled in this volume will be of interest to all those working in allergology, immunology, biochemistry and pulmonary medicine.
Author: Gianni Marone Publisher: Karger Medical Scientific ISBN: 9783805569743 Category : Chemokines Languages : en Pages : 0
Book Description
Eosinophils represent approximately 1% of peripheral blood leukocytes and play a central proinflammatory and immunoregulatory role in various immune disorders. This volume provides the reader with a comprehensive survey of the major aspects of human eosinophilic biology and immunology as well as the most clinically relevant aspects of eosinophil-related disorders. Expert contributions cover the ultrastructural and phenotypic characteristics of human eosinophils, and their fundamental biochemical features including receptors for IgE and chemokines. The production of cytokines and their role in the activation of eosinophils are reviewed. Furthermore, the classic eosinophil-related disorders such as hypereosinophilia, drug reactions, allergic disorders and some cardiovascular diseases are described. Each of the chapters is written by an investigator actively engaged in research on the topic under consideration. The well-edited and stimulating material compiled in this volume will be of interest to all those working in allergology, immunology, biochemistry and pulmonary medicine.
Author: James J. Lee Publisher: Academic Press ISBN: 012394385X Category : Health & Fitness Languages : en Pages : 679
Book Description
Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance.
Author: Alain Tressaud Publisher: Elsevier ISBN: 0080558119 Category : Medical Languages : en Pages : 821
Book Description
Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods belong to the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases having the highest mortality in the industrialized countries. The manifold facets of fluorinated biomaterials range from inorganic ceramics to perfluorinated organic molecules. Liquid perfluorocarbons are suitable for oxygen transport and as potential respiratory gas carriers, while fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel and is applied for the prophylaxis and treatment of dental caries. The various origins of human exposure to fluoride species is detailed to promote a better understanding of the effect of fluoride species on living organisms.Medicinally relevant fluorinated molecules and their interactions with native proteins are the main focus of the third part. New molecules fluorinated in strategic position are crucial for the development of pharmaceuticals with desired action and optimal pharmacological profile. Among the hundreds of marketed active drug components there are more than 150 fluorinated compounds. The chapters will illustrate how the presence of fluorine atoms alters properties of bioactive compounds at various biochemical steps, and possibly facilitate its emergence as pharmaceuticals. Finally the synthetic potential of a fluorinase, the first C-F bond forming enzyme, is summarized. - New approach of topics involving chemistry, biology and medicinal techniques - Transdisciplinar papers on fluoride products - Importance of fluoride products in health - Updated data on specific topics
Author: Garry M. Walsh Publisher: Humana ISBN: 9781493955091 Category : Medical Languages : en Pages : 0
Book Description
In Eosinophil: Methods and Protocols, experts in the field of eosinophil biology comprehensively provide detailed methodological insight into the study of this fascinating cell. This book is aimed at a diverse range of basic and clinical scientists who wish to work with eosinophils or who require an update of their knowledge or to gain the information required to study a function of the eosinophil different to their current area of enquiry. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Eosinophil: Methods and Protocols seeks to aid scientist in the discovery of new hypotheses and for further examination of this intriguing cell.
Author: Rossana C.N. Melo Publisher: Academic Press ISBN: 0128137568 Category : Medical Languages : en Pages : 520
Book Description
Eosinophil Ultrastructure: Atlas of Eosinophil Cell Biology and Pathology entirely focuses on eosinophils and their functional roles in inflammation, host defense, and normal homeostatic activities. The book explores the ultrastructure of human eosinophils, highlighting biological processes observed under normal, experimental, and pathological conditions. Created to fill a void in the eosinophil literature, the book includes an extensive array of electron microscopic images that illustrate the diversity of eosinophil morphology. While the atlas is a learning and teaching tool, it is mainly a helpful resource for researchers to identify distinguishing features and structural changes that arise during studies of human eosinophils. The book also covers the ultrastructure of mouse eosinophils under normal and activation conditions and in the context of representative diseases. - Gives guidelines to understand the human eosinophils in studies focused on structural biology, cellular immunology, innate and adaptive immunity, immune responses to pathogens, immunopathology, and inflammatory responses - Provides a core of essential knowledge to identify both immature and mature eosinophils - Comprises a representative compilation of the eosinophil ultrastructure during biological processes, such as activation and degranulation, mostly under experimental conditions - Highlights eosinophil biological processes found in vivo during human diseases, thus providing a link between basic science and clinical aspects - Helps identify distinguishing features and structural changes that arise during studies of human eosinophils after isolation from body fluids, while in cultures, or biopsies - Explains the ultrastructural organization of mature and immature mouse eosinophils, highlighting the similarities/differences between them and human eosinophils
Author: Gianni Marone Publisher: Academic Press ISBN: 0080535852 Category : Medical Languages : en Pages : 738
Book Description
Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.
Author: Gerald J. Gleich Publisher: CRC Press ISBN: 1000723577 Category : Medical Languages : en Pages : 536
Book Description
This work presents the proceedings of a conference held at Adare Manor, County Limerick, Ireland. It provides an updated, in-depth review of the biological role of eosinophils in allergic diseases, summarizing basic knowledge of these unique cationic proteins. The book features an annotated discussion of the conference's post-presentation question-and-answer session.
Author: Kenneth Murphy Publisher: Garland Science ISBN: 9780815344575 Category : Medical Languages : en Pages :
Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: Michael Hertl Publisher: Springer Science & Business Media ISBN: 3211992251 Category : Medical Languages : en Pages : 600
Book Description
Autoimmune disorders of the skin remain an enigma for many clinicians and scientists not familiar with these mostly severe and chronic diseases. The book provides an overview and the latest information on the broad spectrum of cutaneous autoimmune disorders for clinicians, scientists and practitioners in dermatology, medicine, rheumatology, ENT, pediatrics and ophthalmology. The book is unique since it presents the state-of-the-art knowledge on pathophysiology, clinical diagnosis and management of these disorders provided by the world experts in the field. The primary intention is to broaden the understanding of the pathophysiology of cutaneous autoimmune disorders and to provide a practical guide to how to identify and handle these conditions. The book is illustrated with many tables, illustrative figures and clinical color photographs. The third edition has been thoroughly updated and extended by chapters on paraneoplastic cutaneous syndromes, atopic dermatitis and autoimmunity and Skin manifestations of rheumatic diseases.
Author: Saul Suster Publisher: Elsevier Health Sciences ISBN: 0323443052 Category : Medical Languages : en Pages : 950
Book Description
Part of the highly regarded Diagnostic Pathology series, this updated volume is a visually stunning, easy-to-use reference covering all aspects of thoracic pathology. Outstanding images make this an invaluable diagnostic aid for every practicing pathologist, resident, or fellow. This second edition incorporates the most recent clinical, pathological, histological, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Unsurpassed visual coverage, with carefully annotated gross pathology, histopathology, special stains, and correlative radiologic images that provide clinically and diagnostically important information. Designed to help you identify crucial elements of each diagnosis along with associated differential diagnoses and pitfalls to more quickly resolve problems during routine sign out of cases. Time-saving reference features include bulleted text, a variety of test data tables, key facts in each chapter, annotated images, and an extensive index. Thoroughly updated content throughout, reflecting new WHO classifications of adenocarcinoma of the lung and a proliferation of molecular markers. New coverage of targeted therapies in molecular testing that determine why, when, and where these precisely classified lung cancers are found and their biologic behavior.
Author: Gianni Marone
Author: Gianni Marone
Author: James J. Lee
Author: Alain Tressaud
Author: Garry M. Walsh
Author: Rossana C.N. Melo
Author: Gianni Marone
Author: Gerald J. Gleich
Author: Kenneth Murphy
Author: Michael Hertl
Author: Saul Suster