Author: Johng S. Rhim Publisher: Springer Nature ISBN: 3030222543 Category : Science Languages : en Pages : 246
Book Description
This book, part contributed volume, part proceedings, discusses state-of-the-art advances on human cell transformation in cell models for the study of cancer and aging. Several of the chapters are from the Human Cell Transformation: Advances in Cell Models for the Study of Cancer and Aging conference that was held in June 2018 at McGill University. The authors represent international expertise on a wide variety of topics ranging from different types of cancer (prostate, bone, breast, etc.) to tumor microenvironment, tumor progression, homogeneity, and possible therapies and treatments.
Author: Johng S. Rhim Publisher: Springer Science & Business Media ISBN: 1461402549 Category : Science Languages : en Pages : 239
Book Description
Rhim and Kremer’s state-of-the-art volume on Human Cell Transformation: Role of Stem Cells and the Microenvironment highlights the latest findings on the current state of human cell transformation model systems and provides the insight into the molecular and cellular changes involved in the conversion of normal cells to neoplastic cells. Chapters cover all recently developed novel human cell models. In addition, the rapidly growing fields of knowledge regarding not only stem cells in cancer progression, but also the role of the microenvironments in human carcinogenesis are discussed. A wealth of topics is presented including: · Derivation of epithelial, fibroblastic, and hematopoietic in vitro model systems · Oncogenes · Tumor suppressor genes · Viral transformation · In vitro model systems for viral, chemical and radiation carcinogenesis · Cell aging · The multistep nature of human carcinogenesis · The role of stem cells and the microenvironment in tumorigenesis · The genes involved in multistep carcinogenesis Unique in both scope and focus – devoted solely to human cell transformation systems – Human Cell Transformation: Role of Stem Cells and the Microenvironment provides unparalleled, in-depth coverage for cancer researchers, cell and molecular biologists, hematologists, virologists, and workers in related fields. Essential reading for everyone who needs to be kept up-to-date in this fast-paced area! Features ؠ Multistep models ؠ Breast cancer/Stem cells ؠ Prostate cancer/Stem cells ؠ Multistep / Genes
Author: Robert C. Bast, Jr. Publisher: John Wiley & Sons ISBN: 111900084X Category : Medical Languages : en Pages : 2004
Book Description
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author: Johng S. Rhim Publisher: Springer ISBN: 9781493941643 Category : Science Languages : en Pages : 224
Book Description
Rhim and Kremer’s state-of-the-art volume on Human Cell Transformation: Role of Stem Cells and the Microenvironment highlights the latest findings on the current state of human cell transformation model systems and provides the insight into the molecular and cellular changes involved in the conversion of normal cells to neoplastic cells. Chapters cover all recently developed novel human cell models. In addition, the rapidly growing fields of knowledge regarding not only stem cells in cancer progression, but also the role of the microenvironments in human carcinogenesis are discussed. A wealth of topics is presented including: · Derivation of epithelial, fibroblastic, and hematopoietic in vitro model systems · Oncogenes · Tumor suppressor genes · Viral transformation · In vitro model systems for viral, chemical and radiation carcinogenesis · Cell aging · The multistep nature of human carcinogenesis · The role of stem cells and the microenvironment in tumorigenesis · The genes involved in multistep carcinogenesis Unique in both scope and focus – devoted solely to human cell transformation systems – Human Cell Transformation: Role of Stem Cells and the Microenvironment provides unparalleled, in-depth coverage for cancer researchers, cell and molecular biologists, hematologists, virologists, and workers in related fields. Essential reading for everyone who needs to be kept up-to-date in this fast-paced area! Features ؠ Multistep models ؠ Breast cancer/Stem cells ؠ Prostate cancer/Stem cells ؠ Multistep / Genes
Author: Johng S. Rhim Publisher: Springer Science & Business Media ISBN: 1461204119 Category : Medical Languages : en Pages : 405
Book Description
The role of carcinogenic agents in the deveolopment of human cancers is now being defined using a variety of human cells as experi mental model systems. A workshop on "neoplastic transformation in human cell systems in vitro: mechanisms of carcinogenesis" was held at the Georgetown University Medical Center, Washington, DC, on April 25-26, 1991. The aims of the workshop were to present the state-of-the art in the transformation of human cells in culture, as well as to provide insight into the molecular and cellular changes involved in the conver sion of normal cells to a neoplastic state of growth. The following topics were closely related to the theme of the workshops: 1. Derivation of in vitro model systems (epithelial, fibroblastic, and hematopoietic). 2. Factors modulating cellular transformation. 3. Usefulness of defined in vitro model systems for viral, chemical, and radiation carcinogenesis. 4. Multistep nature of human cell carcinogenesis. 5. Role of activated and suppressor oncogenes in neoplastic trans formation. The workshop was organized by J. S. Rhim and A. Dritschilo (cochairmen), G. Jay, J. little, M. McCormick, R Tennant, and R R Weischelbaum. There were 32 speakers, 30 poster presentations, and about 190 participants.
Author: Rocky Cipriano Publisher: ISBN: Category : Languages : en Pages : 202
Book Description
The use of cellular transformation models has aided our understanding of tumorigenesis. The continued refinement of these cellular models is critical to expanding our understanding of the signaling pathways dysregulated in cancer and linking specific genetic alterations with the therapeutic efficiencies of new treatment options. In studies described here ablation of p73, or PTEN, or overexpression of BCL-2 resulted in a transformed phenotype which retained wild-type p53. Using this model of cellular transformation has allowed the dissection of genetic alterations that confer a sensitive or resistant phenotype to Nutlin-3, an HDM2 antagonist currently in clinical trials. Our results suggest that treating tumors harboring inactive PTEN, p73, or with elevated BCL-2 expression with Nutlin-3 could re-engage p53 activity and induce apoptosis, arguing that therapies aimed at reactivating p53 could prove efficient in tumors harboring these genetic alterations. Such studies are critical in light of findings demonstrating HDMX overexpression protects cells from Nutlin-3 toxicity. As cell culture models of human cell transformation evolve, a more detailed analysis of the pathways commonly altered during cancer development can begin to be defined. Using normal human mammary epithelial cells (HMECs) obtained from reduction mammoplasties, we established a cellular model of the basal or triple negative subtype of breast cancer. This progressive model of breast cancer initiation uncovered a novel TGF-beta mediated suppressive barrier engaged by dysregulated oncogenic signaling. Unlike fibroblasts, we report here that HMECs undergo a TGF-beta-mediated OIS in response to oncogenic RAS, which does not require p53, p16, ATM or CHK2. Finally, my studies led to the discovery and characterization of a novel oncogene, FAM83B, identified by combining a phenotypic based forward genetic screen with a HMEC transformation model. FAM83B is a previously uncharacterized protein, identified here as a driver of HMEC transformation that functions by hyperactivating the MAPK and mTOR signaling cascades. We further demonstrate that FAM83B is a member of an eight protein family which contains a conserved N-terminal DUF 1669, that is necessary and sufficient for a transformed phenotype. The results presented here have (1) linked transforming events with the therapeutic efficiency of Nutlin-3, (2) identified a novel growth arrest pathway responsible for suppressing breast cancer initiation and (3) identified a novel oncogene family which may result in the development of novel therapeutics.
Author: Kenneth Helme Chadwick Publisher: CRC Press ISBN: Category : Art Languages : en Pages : 436
Book Description
The transformation of mammalian cells in vitro provides quantitative and qualitative information on the processes by which physical and chemical agents induce malignancy. Recently, there has been considerable progress on the developmnent of new cell transformation systems and the role of oncogenes in cell transformation. An International Workshop held during April 1989 in Dublin encouraged collaborative interactions between the scientists working in this field and provided a forum for critical review of current research results. Cell Transformation and Radiation-induced Cancer is a record of the papers presented at the Workshop. It includes work which focuses on the potential of emerging human cell transformation systems and their relevance to radiation carcinogenesis, and on the role and interplay of oncogenes, retroviruses and radiation in cell transformation. Particular emphasis is placed on the influence of such variables as radiation quality, dose and dose rate, promoters and suppressors and cell types on in vitro cell transformation. Also considered are the implications of the results from cell transformation studies for radiation-induced cancer in man and for radiological protection. This book will be of interest to molecular biologists, medical physicists and cancer specialists who require a comprehensive account of the latest work on cell transformation and radiation-induced cancer.
Author: Johng S. Rhim
Author: 
Author: Johng S. Rhim
Author: Robert C. Bast, Jr.
Author: Johng S. Rhim
Author: Bruce Alberts
Author: Johng S. Rhim
Author: Rocky Cipriano
Author: J. Celis
Author: Kenneth Helme Chadwick