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Author: Dr Adel Tundey Publisher: Independently Published ISBN: Category : Languages : en Pages : 30
Book Description
Diabetes mellitus is a chronic endocrine disorder of carbohydrate, fat and protein metabolism characterized by an increase in both fasting and postprandial glucose level and it has been reported to be the major cause of mortality worldwide. There is an alarming projection of 471 million people with the disease by the year 2035. Diabetes is grouped into two forms; type 1, insulin dependent diabetes mellitus and type 2, non- insulin dependent diabetes mellitus. Type 2 is the major form accounting about 90% of cases worldwide. In type 2 diabetes mellitus (DM2), postprandial hyperglycemia is important in the development of the disease; Current treatment for Type 2 diabetes remains inadequate so prevention is preferable. The major strategy for the management of Type 2 diabetes is to decrease postprandial hyperglycemia. The α-glucosidase inhibitors, such as acarbose, have been used in the clinic to control blood glucose increase, especially postprandial, in DM2.Herbal medicine is predominantly available for the treatment of diabetes and the main advantages of the use of herbal drugs are effectiveness, safety, and acceptability. The mechanism of action of these medicinal plant of its products involve retarding the absorption of glucose by inhibiting the carbohydrate hydrolyzing enzymes, such as pancreatic amylase and α-glucosidase and through the inhibition of these enzymes, medicinal plants can effectively control the postprandial rise in blood glucose. Several medicinal plants have a high potential in inhibiting α-amylase enzyme activity.Annona muricata (A. muricata) is a tropical plant species belonging to family Annonaceae and known for its many ethnomedicinal uses. All parts of Annona are used in natural medicine in the tropics. It is considered to be a good source of natural antioxidants for various diseases. Traditionally, the leaves are used for headaches, insomnia, cystitis, liver problems, and diabetes, antitumor, anti-inflammatory. The health benefits of this plant have been attributed to their unique phytochemical composition.There is, however, a paucity of information that demonstrates the comparative α-amylase and α-glucosidase inhibitory properties of different extracts and fractions, of the various parts of the plant (fruit-pulp, leaf, stem-bark and root-bark) with relation to its anti-diabetic activity. Hence, the present study was carried out to investigate the comparative α-amylase and α-glucosidase inhibitory potentials of methanolic, ethyl acetate and dichloromethane extracts of the fruit-pulp, leaf, stem-bark and root-bark of Annona muricata and also to determine the possible modes and mechanisms of inhibition of these enzymes by these extracts. The justification for this research is the severe gastrointestinal side effects such as abdominal pain, flatulence and diarrhea that have been reported in the patients after the use of conventional drugs, so that the identification of natural interventions through the use of plants like Annona muricata, becomes beneficial due to their very minimal or absence of negative side effects.
Author: Dr Adel Tundey Publisher: Independently Published ISBN: Category : Languages : en Pages : 30
Book Description
Diabetes mellitus is a chronic endocrine disorder of carbohydrate, fat and protein metabolism characterized by an increase in both fasting and postprandial glucose level and it has been reported to be the major cause of mortality worldwide. There is an alarming projection of 471 million people with the disease by the year 2035. Diabetes is grouped into two forms; type 1, insulin dependent diabetes mellitus and type 2, non- insulin dependent diabetes mellitus. Type 2 is the major form accounting about 90% of cases worldwide. In type 2 diabetes mellitus (DM2), postprandial hyperglycemia is important in the development of the disease; Current treatment for Type 2 diabetes remains inadequate so prevention is preferable. The major strategy for the management of Type 2 diabetes is to decrease postprandial hyperglycemia. The α-glucosidase inhibitors, such as acarbose, have been used in the clinic to control blood glucose increase, especially postprandial, in DM2.Herbal medicine is predominantly available for the treatment of diabetes and the main advantages of the use of herbal drugs are effectiveness, safety, and acceptability. The mechanism of action of these medicinal plant of its products involve retarding the absorption of glucose by inhibiting the carbohydrate hydrolyzing enzymes, such as pancreatic amylase and α-glucosidase and through the inhibition of these enzymes, medicinal plants can effectively control the postprandial rise in blood glucose. Several medicinal plants have a high potential in inhibiting α-amylase enzyme activity.Annona muricata (A. muricata) is a tropical plant species belonging to family Annonaceae and known for its many ethnomedicinal uses. All parts of Annona are used in natural medicine in the tropics. It is considered to be a good source of natural antioxidants for various diseases. Traditionally, the leaves are used for headaches, insomnia, cystitis, liver problems, and diabetes, antitumor, anti-inflammatory. The health benefits of this plant have been attributed to their unique phytochemical composition.There is, however, a paucity of information that demonstrates the comparative α-amylase and α-glucosidase inhibitory properties of different extracts and fractions, of the various parts of the plant (fruit-pulp, leaf, stem-bark and root-bark) with relation to its anti-diabetic activity. Hence, the present study was carried out to investigate the comparative α-amylase and α-glucosidase inhibitory potentials of methanolic, ethyl acetate and dichloromethane extracts of the fruit-pulp, leaf, stem-bark and root-bark of Annona muricata and also to determine the possible modes and mechanisms of inhibition of these enzymes by these extracts. The justification for this research is the severe gastrointestinal side effects such as abdominal pain, flatulence and diarrhea that have been reported in the patients after the use of conventional drugs, so that the identification of natural interventions through the use of plants like Annona muricata, becomes beneficial due to their very minimal or absence of negative side effects.
Author: Dr Angie Bairot Publisher: ISBN: Category : Languages : en Pages : 48
Book Description
Manage and Cure Diabetes Naturally Using Graviola (Soursop): Home Made Solution without Side EffectAre you looking for an home made therapy and natural method to manage or cure Diabetes? Look no further! Graviola, otherwise known as Soursop or Brazilian Paw Paw is a tested, trusted natural herbal and traditional therapy that has been used for years to treat numerous ailment. Graviola is packed with: Vitamins Antioxidant Potassium Fiber Anti-carcinogenic Zinc and many more nutrients beneficial to healthy living The nutrients enriched in Soursop helps reduce blood sugar thereby making management of Diabetes easier. Join the leagues of those who have had there health condition improved using Graviola by buying a copy of Using Graviola for Diabetes. Just click the Buy Now button on your right hand.
Author: Dr Adel Tundey Publisher: Independently Published ISBN: Category : Languages : en Pages : 26
Book Description
Hypertension is a major risk factor for the development of cardiovascular disease, and medications aimed at reducing blood pressure levels have been shown to reduce the morbidity and mortality. However, many of these medications produce undesirable side effects. As a result, there is much inter-est in the use of alternative medicine in the treatment of hypertension and in the search for plants with hypoten-sive activity and less adverse side effects, reported that a decoction made from the fruits, leaves, and twigs of Annona muri-cata Linn (Annonaceae) is drunk to treat high blood pressure, and there have been reports that the plant extract has antihypertensive properties .A. muricata is found widely in the West Indies, South and Central America, tropical West Africa, and Asia. In the West Indies, various parts of the plant, including the leaves, bark and roots have been used to treat disease conditions such as diabetes and arthritis. Other reported medicinal uses of A. muricata include its anticancer, antibacterial and antifungal actions, as well as, its antinociceptive and anti-inflammatory effects.Phytochemical screening of the leaves of A. muricata has shown it to consist of alkaloids such as reticuline, coreximine, coclarine and anomurine, annomuricin E, annomuricin C, muricato-cin C, gigantetronenin and muricapentocin with anti-oxidant and antitumor properties, as well as, essential oils such as β-caryophyllene, δ-cadinene, epi-α-cadinol and α-cadinol.Although there are reports that the A. muricata plant may have antihypertensive properties, the mechanism of action has not been investigated and remains unknown. e present study therefore sought to investigate the pos-sible mechanisms of action of the hypotensive effect of the aqueous leaf extract of A. muricata in normotensive Sprague-Dawley rats.
Author: Victor R Preedy Publisher: Academic Press ISBN: 0123849381 Category : Technology & Engineering Languages : en Pages : 1612
Book Description
While there have been many claims of the benefits of teas through the years, and while there is nearly universal agreement that drinking tea can benefit health, there is still a concern over whether the lab-generated results are representative of real-life benefit, what the risk of toxicity might be, and what the effective-level thresholds are for various purposes. Clearly there are still questions about the efficacy and use of tea for health benefit. This book presents a comprehensive look at the compounds in black, green, and white teas, their reported benefits (or toxicity risks) and also explores them on a health-condition specific level, providing researchers and academics with a single-volume resource to help in identifying potential treatment uses. No other book on the market considers all the varieties of teas in one volume, or takes the disease-focused approach that will assist in directing further research and studies. Interdisciplinary presentation of material assists in identifying potential cross-over benefits and similarities between tea sources and diseases Assists in identifying therapeutic benefits for new product development Includes coverage and comparison of the most important types of tea – green, black and white
Author: Dr Adel Tundey Publisher: Independently Published ISBN: Category : Languages : en Pages : 32
Book Description
Cancer is the second leading cause of mortality worldwide. Over 10 million new patients are diagnosed with cancer annually with over 6 million associated deaths, representing roughly 12% of worldwide mortality. The occurrence of new cancer cases is expected to grow by about 70% over the next two decades and estimated to reach over 15 million new cases diagnosed annually by the end of year 2020. This rapid increase is due to both an aging and growing population, along with carcinogens, infections, genetic mutations, hormones, immune conditions, and the adoption of behavioral and dietary risk factors, such as smoking, unhealthy diet, physical inactivity, and environmental pollutants. The risk factors may act singly or in concert to cause mutation of normal cells. Many of these mutations alter the expression or activity of key gene products, causing unregulated cell division leading to cancer. Currently, the main cancer treatment modalities are surgery, radiation-based therapy, chemotherapy, gene therapy, and/or hormonal therapy, either singly or in combination. The most commonly used chemotherapy drugs are antimetabolites, DNA-interacting agents, antitubulin agents, hormones, and molecular targeting agents, all of which work to destroy cancerous cells or limit their proliferation. However, most cytotoxic drugs act on both cancerous and healthy cells and therefore elicit side effects such as hair loss, bone marrow suppression, drug resistance, gastrointestinal lesions, neurologic dysfunction, and cardiac toxicity. Consequently, development of new anticancer agents with higher efficacy, selectivity, and little or no side effects is an urgent goal.Natural products, especially phytochemicals, have been used to help mankind sustain health since the dawn of medicine. Phytotherapy (also called herbalism or herbal medicine) has provided remedies for ailments, including cancer, to the present day. Dietary phytochemicals have many built-in advantages over synthetic compounds due to their proven safety, low cost, and oral bioavailability. However, it is only recently that researchers have begun to elucidate the mode of action of plant-derived agents at the molecular, cellular, and tissue level. Many natural products have now been extensively researched, and numerous compounds have exhibited anticancer and other beneficial actions in modern controlled studies. Most anticancerous natural products interfere with the initiation, development, and progression of cancer by modulating various mechanisms including cellular proliferation, differentiation, apoptosis, angiogenesis, and metastasis.Extracts from Annona muricata (also known as graviola) are among a myriad of botanical products which have shown promising medicinal value. Studies have linked A. muricata-derived compounds to a variety of anticancer effects including cytotoxicity, induction of apoptosis, necrosis, and inhibition of proliferation on a variety of cancer cell lines, including breast, prostate, colorectal, lung, leukemia, renal, pancreatic, hepatic, oral, melanoma, cervical, and ovarian cancers. Moreover, all aerial parts of this plant, including the bark, fruit, leaves, root, and seeds, are used as natural medicines in the tropics. However, there is a need for more rigorous studies to establish safe and effective care regimes. This review summarizes the recent advances in the application and mechanisms of A. muricata extracts against several cancers both in vitro and in vivo.
Author: Appian Subramoniam Publisher: CRC Press ISBN: 1482249901 Category : Health & Fitness Languages : en Pages : 591
Book Description
The incidence and severity of diabetes mellitus is increasing worldwide, presenting a significant burden to society both in economic terms and overall well-being. Fortunately, time-tested anti-diabetes mellitus plant foods exist that are safe and could be effective in addressing this condition when consumed judiciously with a concomitant change in lifestyle. Plants with Anti-Diabetes Mellitus Properties presents an exhaustive compilation of the anti-diabetes mellitus activities of more than 1000 plants occurring worldwide. The author provides a brief botanical description, distribution, pharmacological properties, and phytochemicals, where appropriate. A list of traditional medicinal plants used to treat diabetes, but not tested for anti-diabetic activity, is also given. This unique reference highlights anti-diabetes mellitus plant foods along with a list of the edible parts of plants with anti-diabetes mellitus properties. Anti-diabetes mellitus nutraceuticals are described with guidelines for the development of food supplements and formulations of diets appropriate for diabetic patients. This is a valuable source of information for researchers, students, doctors, diabetic patients, and other individuals wanting to learn more about plant-based treatments for diabetes mellitus.
Author: Laucy Kenneth Publisher: ISBN: 9781539511793 Category : Languages : en Pages :
Book Description
If you want to expand your mind with knowledge of a fruit you probably never knew existed, continue onward to see what soursop is and what it has to offer Online Buyer Review: "I have learned so much about the fruit "Soursup," from this book. The author has done a great job explaining all of the health benefits from this fruit, which I had no idea about prior to reading this book. There is a list inside of this book which contains all of the natural substances inside the fruit, soursop and they are all very beneficial to our bodies. This book is great and I am so happy I had the chance to read it. I have learned so much from this book and you can to!"
Author: Kenny Ausubel Publisher: Simon and Schuster ISBN: 1594775850 Category : Health & Fitness Languages : en Pages : 480
Book Description
A powerful and substantiated expose of the medical politics that prevents promising alternative cancer therapies from being implemented in the United States. • Focuses on Harry Hoxsey, the subject of the author's award-winning documentary, who claimed to cure cancer using herbal remedies. • Presents scientific evidence supporting Hoxsey's cancer-fighting claims. • Published to coincide with the anticipated 2000 public release of the government-sponsored report finding "noteworthy cases of survival" among Hoxsey patients. Harry Hoxsey claimed to cure cancer using herbal remedies, and thousands of patients swore that he healed them. His Texas clinic became the world's largest privately owned cancer center with branches in seventeen states, and the value of its therapeutic treatments was upheld by two federal courts. Even his arch-nemesis, the AMA, admitted his treatment was effective against some forms of cancer. But the medical establishment refused an investigation, branding Hoxsey the worst cancer quack of the century and forcing his clinic to Tijuana, Mexico, where it continues to claim very high success rates. Modern laboratory tests have confirmed the anticancer properties of Hoxsey's herbs, and a federal govenment-sponsored report is now calling for a major reconsideration of the Hoxsey therapy. When Healing Becomes a Crime exposes the overall failure of the War on Cancer, while revealing how yesterday's "unorthodox" treatments are emerging as tomorrow's medicine. It probes other promising unconventional cancer treatments that have also been condemned without investigation, delving deeply into the corrosive medical politics and powerful economic forces behind this suppression. As alternative medicine finally regains its rightful place in mainstream practice, this compelling book will not only forever change the way you see medicine, but could also save your life.
Author: Ina Vandebroek Publisher: Springer Nature ISBN: 3030489272 Category : Science Languages : en Pages : 257
Book Description
This book highlights the results from over a year of ethnobotanical research in a rural and an urban community in Jamaica, where we interviewed more than 100 people who use medicinal plants for healthcare. The goal of this research was to better understand patterns of medicinal plant knowledge, and to find out which plants are used in consensus by local people for a variety of illnesses. For this book, we selected 25 popular medicinal plant species mentioned during fieldwork. Through individual interviews, we were able to rank plants according to their frequency of mention, and categorized the medicinal uses for each species as “major” (mentioned by more than 20% of people in a community) or “minor” (mentioned by more than 5%, but less than 20% of people). Botanical identification of plant specimens collected in the wild allowed for cross-linking of common and scientific plant names. To supplement field research, we undertook a comprehensive search and review of the ethnobotanical and biomedical literature. Our book summarizes all this information in detail under specific sub-headings.
Author: Dr Adel Tundey
Author: Dr Adel Tundey
Author: Dr Angie Bairot
Author: Dr Adel Tundey
Author: Victor R Preedy
Author: Dr Adel Tundey
Author: Appian Subramoniam
Author: Laucy Kenneth
Author: Margarita Restrepo
Author: Kenny Ausubel
Author: Ina Vandebroek