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Author: M. Palkovič Publisher: Elsevier ISBN: 1483153835 Category : Medical Languages : en Pages : 557
Book Description
Hormones, Lipoproteins and Atherosclerosis, Volume 35, emerged from the international symposium on ""Hormones, Lipoproteins and Atherosclerosis"" held in Bratislava, Czechoslovakia. The symposium was devoted to the problems of hormonal effects on lipoprotein metabolism and atherosclerosis, and was also concerned with problems of composition, structure, synthesis, and degradation of liporoteins, as well as with genetical and clinical aspects. The participants of the symposium have contributed to this volume not only by presenting new data but also new ideas and stimulating new trends in the research and therapy of metabolic derangements of lipoproteins and the resulting pathological conditions. The 51 contributions are organized into five parts. Part I includes papers on the metabolism of lipoproteins. Part II presents studies on hormones and lipoproteins. Part III is devoted to atherosclerosis and lipoproteins. Part IV takes up the clinical aspects of hyperlipoproteinemias. Part V on methods contains two studies—the first on the isolation of human plasma high density lipoproteins; the second on the separation of subfractions of the serum triacylglycerols.
Author: M. Palkovič Publisher: Elsevier ISBN: 1483153835 Category : Medical Languages : en Pages : 557
Book Description
Hormones, Lipoproteins and Atherosclerosis, Volume 35, emerged from the international symposium on ""Hormones, Lipoproteins and Atherosclerosis"" held in Bratislava, Czechoslovakia. The symposium was devoted to the problems of hormonal effects on lipoprotein metabolism and atherosclerosis, and was also concerned with problems of composition, structure, synthesis, and degradation of liporoteins, as well as with genetical and clinical aspects. The participants of the symposium have contributed to this volume not only by presenting new data but also new ideas and stimulating new trends in the research and therapy of metabolic derangements of lipoproteins and the resulting pathological conditions. The 51 contributions are organized into five parts. Part I includes papers on the metabolism of lipoproteins. Part II presents studies on hormones and lipoproteins. Part III is devoted to atherosclerosis and lipoproteins. Part IV takes up the clinical aspects of hyperlipoproteinemias. Part V on methods contains two studies—the first on the isolation of human plasma high density lipoproteins; the second on the separation of subfractions of the serum triacylglycerols.
Author: R.W. Stout Publisher: Springer Science & Business Media ISBN: 9401162646 Category : Medical Languages : en Pages : 203
Book Description
As the acute infectious diseases recede in importance, and as the number of people surviving into middle and old age increases, the chronic 'degenerative' diseases assume greater importance as causes of death and disability. Of these diseases, atherosclerosis is by far the most prevalent and its consequences the most devastating. The search for the cause of atherosclerosis is consuming large amounts of resources of both money and research talent. As yet, the cause remains unknown. Much of the research effort into atherosclerosis has been concerned with lipid metabolism. This is based on the knowledge that abnormalities of certain lipids and lipoproteins predispose to cardiovascular disease. Often the research has not been directly related to atherosclerosis and it is only recently that widespread attention has been paid to the artery. The development of methods of growing vascular endothelial and smooth muscle cells in culture has made possible detailed studies of the biology of the arterial wall. There are a number of reasons why investigations of lipid metabolism alone will not identify the cause of atherosclerosis. First, only a minority of patients with cardiovascular disease have abnormal circulating lipids and lipoproteins. Second, there are three major predisposing factors for atherosclerosis which cannot be entirely explained by abnormal lipid metabolism - age, sex, and diabetes mellitus. Third, it is now clear that lipid is only one component of the atheromatous plaque, and incorporation of lipid may be a late feature of the development of the lesion.
Author: Gregory Pincus Publisher: Academic Press ISBN: 1483270645 Category : Health & Fitness Languages : en Pages : 501
Book Description
Hormones and Atherosclerosis covers the proceedings of the conference held in Brighton, Utah on March 11-14, 1958. The book focuses on the role of hormones in atherosclerosis, as well as cholesterol metabolism and biosynthesis, lipogenesis, and lipid transport. The selection first discusses the biosynthesis of cholesterol and aspects of the biosynthesis of cholesterol from mevalonic acid. Discussions focus on components of liver homogenates and coenzymes required for squalene and sterol synthesis from mevalonic acid and preservation of enzymes and microsomes. The text also ponders on the formation and metabolism of bile acids under different conditions and thyroid function, thyroxine analogs, and cholesterol metabolism in rats and rabbits. The book elaborates on the comparison of the participations of fibroblasts and reticuloendothelial cells in the synthesis and metabolism of cortisol and cholesterol and control of aortal lipid metabolism and lipid movement by hormones and vitamins. The manuscript also examines the influence of estrogens on lipids and atherosclerosis in experimental animals and the effect of adrenals, pituitary, liver, and mucopolysaccharides on blood lipids. The selection is a dependable reference for readers interested in the relationship of hormones and atherosclerosis.
Author: Armin Steinmetz Publisher: Springer Science & Business Media ISBN: 3642848559 Category : Science Languages : en Pages : 311
Book Description
An intimate relation between hormones and lipoprotein metabolism has been known for a long time especially from hormone-deficiency or -overproduction syndromes. The mechanisms through which hormones influence lipid metabolism have become a field of major interest in sci ence. The more we learn about cellular hormonal actions the better we understand regulatory processes and phenomena occuring in patients. The present book summarizes data discussed at an International Meet ing at Marburg, Germany, on "Hormones in Lipoprotein Metabolism". It was an attempt to pull together knowledge in basic science from the mode of action of hormones all the way to clinical appearance of hor monal disorders involving lipoprotein metabolism. Thus data on molec ular biology, on hormonal regulation of apolipoprotein synthesis, on lipoprotein receptors and enzyme induction are discussed together with the large field of oral contraceptive use, postmenopausal estrogen sub stitution, lipid disorders in diabetes mellitus, in thyroid dysfunction, in adrenal insufficiency and in glucocorticoid application. We are aware of the fact that such an overview cannot be complete but should serve as a collection of data and ideas for those interested in hormonal regulation of lipid metabolism. We thank all authors for taking an extra effort in writing up their presentations and thus making this edition possible. We also thank Bristol-Myers-Squibb for generous support of the meeting and of the final publication. Marburg, Germany ARMIN STEINMETZ JURGEN SCHNEIDER HANS KAFFARNIK Contents Molecular Biology Chairmen: D. J. Rader, A.
Author: Claude L. Malmendier Publisher: Springer Science & Business Media ISBN: 146841268X Category : Science Languages : en Pages : 248
Book Description
Atherosclerosis which accounts in Western Europe for more than 40 % of deaths, is a generalized disease that develops slowly and is symptomless until lesions have become sufficiently severe to cause myocardial or cerebral infarction. Research on specific and precocious markers of atherosclerosis and the development of non invasive techniques for their early detection represent major challenges in biomedical field. We hope that this volume of edited papers, a consequence of the third international colloquium on atherosclerosis, conducted at the University of Brussels, Belgium through the support of the "Fondation de Recherche sur l' AtherosclE,rose" will contribute to this goal. Among the topics discussed the major ones were the mechanism of action of lipolytic enzymes, the deficiency or dysregulation of cellular receptors, the genetic deficiencies of apolipoproteins, and the panoply of external factors as diet, physical exercise, drugs, which mOdify the lipoprotein metabolism. Special interest was also devoted to potent techniques as kinetic analysis of metabolic tracers and use of monoclonal antibodies. Their contribution to the detection and treatment of atherosclerosis will be obviously essential in the future.
Author: Angelo Scanu Publisher: Elsevier ISBN: 0323159443 Category : Science Languages : en Pages : 240
Book Description
Lipoprotein(a) presents the proceedings of the International Symposium, held in Chicago, Illinois, on December 2–3, 1988. It discusses the different aspects of the research on lipoprotein(a), commonly referred to as Lp(a). It covers a wide range of topics, including comparative biology, metabolism, structure, epidemiology, and treatment. Comprised of 15 chapters, the book starts with an overview of the role of Lp(a) in atherosclerotic cardiovascular disease (ASCVD), followed by a discussion on recent findings and developments. It then considers the relationship between elevated plasma Lp(a) and the inherited risk factor for the development of coronary heart disease. The reader is also introduced to the various components of Lp(a), which include neutral lipids, polar lipids, apoprotein(a), and apoprotein B. Other chapters discuss the specific functions of apolipoproteins in plasma lipid metabolism, which determine the fate of the various lipoprotein particles in plasma. This book will be of benefit to cardiologists and medical practitioners.
Author: Gerhard Kostner Publisher: BoD – Books on Demand ISBN: 9535121782 Category : Science Languages : en Pages : 166
Book Description
In mammalian blood plasma there exist some 6 major lipoprotein classes. Under physiological conditions lipoproteins are certainly beneficial as they transport nutrients and steroids to numerous organs for further metabolism. On the other hand, under pathophysiological conditions most lipoprotein classes promote atherogenesis except of HDL that are considered to be anti-atherogenic. Lipoprotein research is a wide field comprising basic science, analytical methods and clinical investigations. Thus this issue does not raise the claim to give a comprehensive picture of the current knowledge, but rather focuses on specific questions related to animal models in lipoprotein research as well as features of the most atherogenic lipoprotein, Lp(a).