Horizontal gene transfer mediated bacterial antibiotic resistance, vol II PDF Download

Author: Dongchang Sun
Publisher: Frontiers Media SA
ISBN: 2832529534
Category : Science
Languages : en
Pages : 149

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Author: Dongchang Sun
Publisher: Frontiers Media SA
ISBN: 2889638804
Category :
Languages : en
Pages : 223

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Book Description
Throughout history, human life has been seriously threatened by bacterial infectious diseases. After the discovery of antibiotics, humanity thought it had won the fight against infectious bacteria. However, considering the rapid evolution of bacterial multidrug resistance and exhausted pipeline of antibiotics for fighting bacterial infectious diseases, we are approaching the ‘post-antibiotic’ era. Unlike eukaryote, bacteria are proficient in exchanging their genetic materials with others by means of horizontal gene transfer (HGT). As a vehicle for antibiotic resistance gene (ARG), plasmid is self-replicable and transferable in a wide range of host bacteria. Moreover, ways of HGT-mediated ARGs spreading are highly diverse among different species, implicating complex evolution routes for the development of multidrug resistance in bacteria. In recent years, multidrug resistance plasmids have been widely found in bacteria not only from clinical patients, but also from animals, birds and plants, as well as from natural environmental settings including soil and water – heralding that the ‘post-antibiotic’ era is much closer than we previously thought. The global crisis of multidrug resistance calls for a closer collaboration among people of different professions in different regions, countries and continents, which will help us recognize the current situation and eventually find effective and long-lasting solutions for fighting against infectious bacteria.

Author: Odo Diekmann
Publisher: Princeton University Press
ISBN: 1400845629
Category : Science
Languages : en
Pages : 517

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Book Description
Mathematical modeling is critical to our understanding of how infectious diseases spread at the individual and population levels. This book gives readers the necessary skills to correctly formulate and analyze mathematical models in infectious disease epidemiology, and is the first treatment of the subject to integrate deterministic and stochastic models and methods. Mathematical Tools for Understanding Infectious Disease Dynamics fully explains how to translate biological assumptions into mathematics to construct useful and consistent models, and how to use the biological interpretation and mathematical reasoning to analyze these models. It shows how to relate models to data through statistical inference, and how to gain important insights into infectious disease dynamics by translating mathematical results back to biology. This comprehensive and accessible book also features numerous detailed exercises throughout; full elaborations to all exercises are provided. Covers the latest research in mathematical modeling of infectious disease epidemiology Integrates deterministic and stochastic approaches Teaches skills in model construction, analysis, inference, and interpretation Features numerous exercises and their detailed elaborations Motivated by real-world applications throughout

Author: Jun Lin
Publisher: Frontiers Media SA
ISBN: 2889195260
Category : Antibiotics
Languages : en
Pages : 226

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Book Description
Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.

Author: Maria Boekels Gogarten
Publisher: Humana Press
ISBN: 9781603278522
Category : Science
Languages : en
Pages : 0

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Book Description
Horizontal gene transfer (HGT) events encompass processes as varied as the exchange of genetic material between microbes coexisting in the same environment, between symbiotic bacteria and their eukaryotic hosts, and the evolution of organelles by symbiosis, in which whole genomes are acquired. In Horizontal Gene Transfer: Genomes in Flux, expert researchers contribute an overview of HGT concepts as well as specific case histories that highlight the most current progress to inspire future work. Divided into three sections, the volume begins with an overview of terminology, concepts and the implications of HGT on current evolutionary thought and philosophy, and continues with methods involving computer and bioinformatics analyses of genomic data as well as molecular biology techniques for identifying, quantifying, and differentiating instances of HGT. A section of case studies follows, which provides detailed accounts of how HGT has shaped evolution across the diversity of organisms and organismal lineages. As a volume of the highly successful Methods in Molecular BiologyTM series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Cutting-edge and thoroughly detailed, Horizontal Gene Transfer: Genomes in Flux examines how HGT has contributed to genome evolution and how understanding HGT impacts our ability to accurately reconstruct and comprehend the web-like evolutionary history in order to aid scientists in furthering their own research.

Author: Satoru Suzuki
Publisher: Frontiers Media SA
ISBN: 2889451313
Category :
Languages : en
Pages : 109

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Rivers, lakes and the ocean receive antibiotic resistance genes from human environments. The aquatic environments are a huge reservoir and exchange stage of antibiotic resistance genes.

Author: Abigail A. Salyers
Publisher: Springer
ISBN: 9783540602057
Category : Medical
Languages : en
Pages : 0

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Book Description
This book is about the gene transfer between bacteria in the mammalian intestine. Bacterial gene transfer is not only an exciting area of basic research, but also has important implications for human health, food safety and release of genetically engineered microbes. This book surveys what is known about mechanisms of gene exchange, describes the conditions and types of bacteria found in various parts of the intestinal tract and assesses the likelihood of gene transfer in this context. It also discusses the practical impact of gene transfer and provides a critical assessment of human practices that may encourage gene transfer, such as feeding antibiotics to livestock animals, selling antibiotics over the counter, and using antibiotic resistance genes to construct bacteria intended for release into the environment.

Author: Hervé Tettelin
Publisher: Springer Nature
ISBN: 3030382818
Category : Science
Languages : en
Pages : 311

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Book Description
This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.

Author: David R. Harper
Publisher: Springer Nature
ISBN: 3319419862
Category : Medical
Languages : en
Pages : 1376

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This first major reference work dedicated to the mannifold industrial and medical applications of bacteriophages provides both theoretical and practical insights into the emerging field of bacteriophage biotechnology. The book introduces to bacteriophage biology, ecology and history and reviews the latest technologies and tools in bacteriophage detection, strain optimization and nanotechnology. Usage of bacteriophages in food safety, agriculture, and different therapeutic areas is discussed in detail. This book serves as essential guide for researchers in applied microbiology, biotechnology and medicine coming from both academia and industry.

Author: Terry McGenity
Publisher: Springer
ISBN: 9783540775881
Category : Science
Languages : en
Pages : 4699

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This handbook provides a comprehensive overview of microbial interactions with the major forms of hydrocarbons, oils, and lipids in or entering the biosphere. It is the definitive resource on the physiological mechanisms and adaptive strategies characteristic of the microbial lifestyle that plays out at hydrophobic material: aqueous liquid interfaces.