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Author: Dan E. Angelescu Publisher: Artech House ISBN: 159693980X Category : Technology & Engineering Languages : en Pages : 269
Book Description
The recent development of microfluidics has lead to the concept of lab-on-a-chip, where several functional blocks are combined into a single device that can perform complex manipulations and characterizations on the microscopic fluid sample. However, integration of multiple functionalities on a single device can be complicated. This a cutting-edge resource focuses on the crucial aspects of integration in microfluidic systems. It serves as a one-stop guide to designing microfluidic systems that are highly integrated and scalable. This practical book covers a wide range of critical topics, from fabrication techniques and simulation tools, to actuation and sensing functional blocks and their inter-compatibility. This unique reference outlines the benefits and drawbacks of different approaches to microfluidic integration and provides a number of clear examples of highly integrated microfluidic systems.
Author: Dan E. Angelescu Publisher: Artech House ISBN: 159693980X Category : Technology & Engineering Languages : en Pages : 269
Book Description
The recent development of microfluidics has lead to the concept of lab-on-a-chip, where several functional blocks are combined into a single device that can perform complex manipulations and characterizations on the microscopic fluid sample. However, integration of multiple functionalities on a single device can be complicated. This a cutting-edge resource focuses on the crucial aspects of integration in microfluidic systems. It serves as a one-stop guide to designing microfluidic systems that are highly integrated and scalable. This practical book covers a wide range of critical topics, from fabrication techniques and simulation tools, to actuation and sensing functional blocks and their inter-compatibility. This unique reference outlines the benefits and drawbacks of different approaches to microfluidic integration and provides a number of clear examples of highly integrated microfluidic systems.
Author: Kai Hu Publisher: Springer ISBN: 331956255X Category : Technology & Engineering Languages : en Pages : 151
Book Description
This book provides a comprehensive overview of flow-based, microfluidic VLSI. The authors describe and solve in a comprehensive and holistic manner practical challenges such as control synthesis, wash optimization, design for testability, and diagnosis of modern flow-based microfluidic biochips. They introduce practical solutions, based on rigorous optimization and formal models. The technical contributions presented in this book will not only shorten the product development cycle, but also accelerate the adoption and further development of modern flow-based microfluidic biochips, by facilitating the full exploitation of design complexities that are possible with current fabrication techniques.
Author: Paul Pop Publisher: Springer ISBN: 3319295993 Category : Technology & Engineering Languages : en Pages : 277
Book Description
This book presents the state-of-the-art techniques for the modeling, simulation, testing, compilation and physical synthesis of mVLSI biochips. The authors describe a top-down modeling and synthesis methodology for the mVLSI biochips, inspired by microelectronics VLSI methodologies. They introduce a modeling framework for the components and the biochip architecture, and a high-level microfluidic protocol language. Coverage includes a topology graph-based model for the biochip architecture, and a sequencing graph to model for biochemical application, showing how the application model can be obtained from the protocol language. The techniques described facilitate programmability and automation, enabling developers in the emerging, large biochip market.
Author: Andreas Grimmer Publisher: Springer ISBN: 3030207137 Category : Technology & Engineering Languages : en Pages : 145
Book Description
This book describes automatic methods for the design of droplet microfluidic networks. The authors discuss simulation and design methods which support the design process of droplet microfluidics in general, as well as design methods for a dedicated droplet routing mechanism, namely passive droplet routing. The methods discussed allow for simulating a microfluidic design on a high-abstraction level, which facilitates early validation of whether a design works as intended, automatically dimensioning a microfluidic design, so that constraints like flow conditions are satisfied, and automatically generating meander designs for the respective needs and fabrication settings. Dedicated methods for passive droplet routing are discussed and allow for designing application-specific architectures for a given set of experiments, as well as generating droplet sequences realizing the respective experiments. Together, these methods provide a comprehensive “toolbox" for designers working on droplet microfluidic networks in general and an integrated design flow for the passive droplet routing mechanism in particular. Provides both a comprehensive “toolbox" for designers working on droplet microfluidic networks in general and an integrated design flow for the passive droplet routing mechanism in particular; Describes for the first time CAD methods for droplet microfluidic networks, along with the first integrated design process; Includes open source implementations, in order to reach the largest possible user group within the domain of microfluidics.
Author: Sebastian Seiffert Publisher: Walter de Gruyter GmbH & Co KG ISBN: 3110487705 Category : Technology & Engineering Languages : en Pages : 295
Book Description
Microfluidics introduces the theory and practice of fluid flow on small scales. The exquisite control of such flow at low Reynolds numbers allows liquids to be processed in either a well-defined co-flow or a well-defined segmented-flow fashion. Both lays a ground for high-throughput analytics and advanced materials design. With that, this book is ideal for research scientists and Ph.D. students in the fields of chemistry, chemical engineering, biotechnology, and materials science.
Author: Usama M. Attia Publisher: ISBN: Category : Languages : en Pages :
Book Description
This thesis investigates the use of micro-injection moulding (?IM), as a high-volume process, for producing three-dimensional, integrated microfluidic devices. It started with literature reviews that covered three topics:?IM of thermoplastic microfluidics, designing for three-dimensional (3-D) microfluidics and functional integration in?IM. Research gaps were identified: Designing 3-D microfluidics within the limitations of?IM, process optimisation and the integration of functional elements. A process chain was presented to fabricate a three-dimensional microfluidic device for medical application by?IM. The thesis also investigated the effect of processing conditions on the quality of the replicated component. The design-of-experiments (DOE) approach is used to highlight the significant processing conditions that affect the part mass taking into consideration the change in part geometry. The approach was also used to evaluate the variability within the process and its effect on the replicability of the process. Part flatness was also evaluated with respect to post-filling process parameters. The thesis investigated the possibility of integrating functional elements within?IM to produce microfluidic devices with hybrid structures. The literature reviews highlighted the importance of quality control in high-volume micromoulding and in-line functional integration in microfluidics. A taxonomy of process integration was also developed based on transformation functions. The experimental results showed that?IM can be used to fabricate microfluidic devices that have true three-dimensional structures by subsequent lamination. The DOE results showed a significant effect of individual process variables on the filling quality of the produced components and their flatness. The geometry of the replicated component was shown to have effect on influential parameters. Other variables, on the other hand, were shown to have a possible effect on process variability. Optimization statistical tools were used to improve multiple quality criteria. Thermoplastic elastomers (TPE) were processed with?IM to produce hybrid structures with functional elements.
Author: Hao Yu Publisher: John Wiley & Sons ISBN: 1119218357 Category : Technology & Engineering Languages : en Pages : 290
Book Description
A thorough examination of lab-on-a-chip circuit-level operations to improve system performance A rapidly aging population demands rapid, cost-effective, flexible, personalized diagnostics. Existing systems tend to fall short in one or more capacities, making the development of alternatives a priority. CMOS Integrated Lab-on-a-Chip System for Personalized Biomedical Diagnosis provides insight toward the solution, with a comprehensive, multidisciplinary reference to the next wave of personalized medicine technology. A standard complementary metal oxide semiconductor (CMOS) fabrication technology allows mass-production of large-array, miniaturized CMOS-integrated sensors from multi-modal domains with smart on-chip processing capability. This book provides an in-depth examination of the design and mechanics considerations that make this technology a promising platform for microfluidics, micro-electro-mechanical systems, electronics, and electromagnetics. From CMOS fundamentals to end-user applications, all aspects of CMOS sensors are covered, with frequent diagrams and illustrations that clarify complex structures and processes. Detailed yet concise, and designed to help students and engineers develop smaller, cheaper, smarter lab-on-a-chip systems, this invaluable reference: Provides clarity and insight on the design of lab-on-a-chip personalized biomedical sensors and systems Features concise analyses of the integration of microfluidics and micro-electro-mechanical systems Highlights the use of compressive sensing, super-resolution, and machine learning through the use of smart SoC processing Discusses recent advances in complementary metal oxide semiconductor-integrated lab-on-a-chip systems Includes guidance on DNA sequencing and cell counting applications using dual-mode chemical/optical and energy harvesting sensors The conventional reliance on the microscope, flow cytometry, and DNA sequencing leaves diagnosticians tied to bulky, expensive equipment with a central problem of scale. Lab-on-a-chip technology eliminates these constraints while improving accuracy and flexibility, ushering in a new era of medicine. This book is an essential reference for students, researchers, and engineers working in diagnostic circuitry and microsystems.
Author: Mahadzir Ishak Publisher: BoD – Books on Demand ISBN: 9535125966 Category : Technology & Engineering Languages : en Pages : 286
Book Description
Joining and welding are two of the most important processes in manufacturing. These technologies have vastly improved and are now extensively used in numerous industries. This book covers a wide range of topics, from arc welding (GMAW and GTAW), FSW, laser and hybrid welding, and magnetic pulse welding on metal joining to the application of joining technologies for textile products. The analysis of temperature and phase transformation is also incorporated. This book also discusses the issue of dissimilar joint between metal and ceramic, as well as the technology of diffusion bonding.
Author: Wing Cheung Mak Publisher: Elsevier ISBN: 012823847X Category : Technology & Engineering Languages : en Pages : 370
Book Description
Microfluidic Biosensors provides a comprehensive overview covering the most recent emerging technologies on the design, fabrication, and integration of microfluidics with transducers. These form various integrated microfluidic biosensors with device configurations ranging from 2D to 4D levels. Coverage also includes advanced printed microfluidic biosensors, flexible microfluidics for wearable biosensors, autonomous lab-on-a-chip biosensors, CMOS-base microanalysis systems, and microfluidic devices for mobile phone biosensing. The editors and contributors of this book represent both academia and industry, come from a varied range of backgrounds, and offer a global perspective. This book discusses the design and principle of microfluidic systems and uses them for biosensing applications. The microfluidic fabrication technologies covered in this book provide an up-to-date view, allowing the community to think of new ways to overcome challenges faced in this field. The focus is on existing and emerging technologies not currently being analyzed extensively elsewhere, providing a unique perspective and much-needed content. The editors have crafted this book to be accessible to all levels of academics from graduate students, researchers, and professors working in the fields of biosensors, microfluidics design, material science, analytical chemistry, biomedical devices, and biomedical engineering. It can also be useful for industry professionals working for microfluidic device manufacturers, or in the industry of biosensors and biomedical devices. Presents an in-depth overview of microfluidic biosensors and associated emerging technologies such as printed microfluidics and novel transducers Addresses a range of microfluidic biosensors with device configurations ranging from 2D to 4D levels Includes the commercialization aspects of microfluidic biosensors that provide insights for scientists and engineers in research and development
Author: Dong Sun Publisher: Academic Press ISBN: 0323852602 Category : Technology & Engineering Languages : en Pages : 548
Book Description
Robotic Cell Manipulation introduces up-to-date research to realize this new theme of medical robotics. The book is organized in three levels: operation tools (e.g., optical tweezers, microneedles, dielectrophoresis, electromagnetic devices, and microfluidic chips), manipulation types (e.g., microinjection, transportation, rotation fusion, adhesion, separation, etc.), and potential medical applications (e.g., micro-surgery, biopsy, gene editing, cancer treatment, cell-cell interactions, etc.). The technology involves different fields such as robotics, automation, imaging, microfluidics, mechanics, materials, biology and medical sciences. The book provides systematic knowledge on the subject, covering a wide range of basic concepts, theories, methodology, experiments, case studies and potential medical applications. It will enable readers to promptly conduct a systematic review of research and become an essential reference for many new and experienced researchers entering this unique field. Introduces the applications of robot-assisted manipulation tools in various cell manipulation tasks Defines many essential concepts in association with the robotic cell manipulation field, including manipulation strategy and manipulation types Introduces basic concepts and knowledge on various manipulation devices and tasks Describes some cutting-edge cell manipulation technologies and case studies
Author: Dan E. Angelescu
Author: Dan E. Angelescu
Author: Kai Hu
Author: Paul Pop
Author: Andreas Grimmer
Author: Sebastian Seiffert
Author: Usama M. Attia
Author: Hao Yu
Author: Mahadzir Ishak
Author: Wing Cheung Mak
Author: Dong Sun