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Author: Wenping Ma Publisher: OAE Publishing Inc. ISBN: Category : Technology & Engineering Languages : en Pages : 34
Book Description
Repairing tissue defects caused by diseases and traumas presents significant challenges in the clinic. Recent advancements in biomaterials have offered promising strategies for promoting tissue regeneration. In particular, the exploration of 3D macro and microstructures of biomaterials has proven crucial in this process. The integration of macro, micro, and nanostructures facilitates the performance of biomaterials in terms of their mechanical properties, degradation rate, and distinctive impacts on cellular activities. In this review, we summarize the recent progress in biomaterials with hierarchical structures for tissue regeneration. We explore the various methods and strategies employed in designing biomaterials with hierarchical structures of different dimensions. The improvement of physicochemical properties and bioactivities by hierarchically structured biomaterials, including the regulation of mechanical properties, degradability, and the specific functions of cell behaviors, has been highlighted. Furthermore, the current applications of hierarchically structured biomaterials for tissue regeneration are discussed. Finally, we conclude by summarizing the developments of hierarchically structured biomaterials for tissue regeneration and provide future perspectives.
Author: Wenping Ma Publisher: OAE Publishing Inc. ISBN: Category : Technology & Engineering Languages : en Pages : 34
Book Description
Repairing tissue defects caused by diseases and traumas presents significant challenges in the clinic. Recent advancements in biomaterials have offered promising strategies for promoting tissue regeneration. In particular, the exploration of 3D macro and microstructures of biomaterials has proven crucial in this process. The integration of macro, micro, and nanostructures facilitates the performance of biomaterials in terms of their mechanical properties, degradation rate, and distinctive impacts on cellular activities. In this review, we summarize the recent progress in biomaterials with hierarchical structures for tissue regeneration. We explore the various methods and strategies employed in designing biomaterials with hierarchical structures of different dimensions. The improvement of physicochemical properties and bioactivities by hierarchically structured biomaterials, including the regulation of mechanical properties, degradability, and the specific functions of cell behaviors, has been highlighted. Furthermore, the current applications of hierarchically structured biomaterials for tissue regeneration are discussed. Finally, we conclude by summarizing the developments of hierarchically structured biomaterials for tissue regeneration and provide future perspectives.
Author: Qing Liu Publisher: World Scientific ISBN: 9814494852 Category : Science Languages : en Pages : 546
Book Description
This unique volume presents the recent advances in tissue regeneration. The authors are all active researchers in their respective fields with extensive experiences. The focus of the book is on the use of stem cells and nano-structured biomaterials for tissue regeneration/tissue engineering. It includes the use of stem cells, naturally derived extracellular matrix (ECM), synthetic biomimetic nano-fibers, synthetic nano-structured ceramics and synthetic nano-structured polymer/ceramic composites that can help/promote tissue regeneration. Methods on how to produce these nano-structured biomaterials are also discussed in several chapters. Future challenges and perspectives in the field of regenerative medicine (tissue regeneration) are also discussed.
Author: Primana Punnakitikashem Publisher: ISBN: Category : Biocompatible materials Languages : en Pages : 95
Book Description
Nanostructured materials have been explored in biomedical field especially in tissue engineering over a past decade. This type of material can be processed into biomaterial scaffolds; revealed many advantages to be used in human living system such as restoring, healing, replacing and improving the function of interested tissues or organs. In this work, nanostructured materials were synthesized as a nanofibrous scaffold or nanoparticles, which were characterized and tested for their biofunctions in the regeneration of blood vessels, lung and skin tissues. Firstly, biodegradable polyurethane nanofibrous scaffolds with dipyramole were electrospun to create a vascular graft, and results demonstrated that this nanofibrous scaffold matched the native artery mechanical strength, reduced the platelet deposition, improved blood compatibility, supported endothelial cell formation and inhibited the proliferation of smooth muscle cells. Next, biodegradable polylactic-glycolic acid nanoparticles were fabricated and then coated with porcine lung extracellular matrix to maximize the nanoparticle deposition on the alveolar epithelial cells. These nanoparticles also show that they were cytocompatible with alveolar type I epithelial cells and facilitated the cellular retention/uptake. Preliminary studies of electrospun nanofibrous polyurethane scaffold incorporated with nanoparticles loaded with anti-microbial peptide and/or antibiotics for wound healing application demonstrated these nanostructured materials could be used to prevent bacterial infection and suggest their potential in skin wound healing applications. Results from this research suggest that the biomaterials either in the nanofiber or nanoparticle structures could be used for regeneration of various tissue organs such as blood vessels and skins, and for protein (growth factors) or gene therapy (cDNA plasmids) delivery to facilitate lung regeneration. Hence, the nanostructured biomaterials would have high potential to be applied for tissue regeneration to manage diseased and damaged tissues/organs for human healthcare.
Author: Sang Jin Lee Publisher: Academic Press ISBN: 012802500X Category : Medical Languages : en Pages : 460
Book Description
In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body’s ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body’s own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications. Explores the body’s ability to mobilize endogenous stem cells to the site of injury Details the latest strategies developed for inducing and supporting the body’s own regenerating capacity Presents smart biomaterials in cell-based tissue engineering applications—from the cell level to applications—in the first unified volume Features chapter authors and editors who are authorities in this emerging field Prioritizes a discussion of the future direction of smart biomaterials for in situ tissue regeneration, which will affect an emerging and lucrative industry
Author: M. Elices Publisher: Elsevier ISBN: 0080541909 Category : Technology & Engineering Languages : en Pages : 379
Book Description
The ongoing process of bio-evolution has produced materials which are perfectly adapted to fulfil a specific functional role. The natural world provides us with a multitude of examples of materials with durability, strength, mechanisms of programmed self-assembly and biodegradability. The materials industry has sought to observe and appreciate the relationship between structure, properties and function of these biological materials. A multidisciplinary approach, building on recent advances at the forefront of physics, chemistry and molecular biology, has been successful in producing many synthetic structures with interesting and useful properties. Structural Biological Materials: Design and Structure-Property Relationships represents an invaluable reference in the field of biological materials science and provides an incisive view into this rapidly developing and increasingly important topic within materials science. This book focuses on the study of three sub-groups of structural biological materials: • Hard tissue engineering, focussing on cortical bone • Soft tissue engineering • Fibrous materials, particularly engineering with silk fibers. The fundamental relationship between structure and properties, and certain aspects of design and engineering, are explored in each of the sub-groups. The importance of these materials, both in their intrinsic properties and specific functions, are illustrated with relevant examples. These depict the successful integration of material properties, architecture and shape, providing a wide range of optimised designs, tailored to specific functions. Edited by Manuel Elices of the Universidad Politécnica de Madrid, Spain, this book is Volume 4 in the Pergamon Material Series.
Author: Birru Bhaskar Publisher: Springer Nature ISBN: 9811600023 Category : Medical Languages : en Pages : 587
Book Description
This book comprehensively explores the basic concepts and applications of biomaterials in tissue engineering and regenerative medicine. The book is divided into four sections; the first section deals with the basic concepts and different types of biomaterials used in tissue engineering. The second section discusses the functional requirements and types of materials that are used in developing state-of-the-art of scaffolds for tissue engineering applications. The third section presents the applications of biomaterials for hard and soft tissue engineering, as well as for specialized tissue engineering. The last section addresses the future prospects of nanobiomaterials, intelligent biomaterials, and 3D bioprinting biomaterials in tissue engineering and regenerative medicine. It also discusses various in vitro disease models for tissue bioengineering and regenerative medicine. As such, it offers a valuable resource for students, researchers, scientists, entrepreneurs, and medical/healthcare professionals.
Author: Nihal Vrana Publisher: Woodhead Publishing ISBN: 0081029071 Category : Medical Languages : en Pages : 847
Book Description
Biomaterials for Organ and Tissue Regeneration: New Technologies and Future Prospects examines the use of biomaterials in applications related to artificial tissues and organs. With a strong focus on fundamental and traditional tissue engineering strategies, the book also examines how emerging and enabling technologies are being developed and applied. Sections provide essential information on biomaterial, cell properties and cell types used in organ generation. A section on state-of-the-art in organ regeneration for clinical purposes is followed by a discussion on enabling technologies, such as bioprinting, on chip organ systems and in silico simulations. Provides a systematic overview of the field, from fundamentals, to current challenges and opportunities Encompasses the classic paradigm of tissue engineering for creation of new functional tissue Discusses enabling technologies such as bioprinting, organ-on-chip systems and in silico simulations
Author: Peter Fratzl Publisher: Springer Science & Business Media ISBN: 0387739068 Category : Technology & Engineering Languages : en Pages : 516
Book Description
Not only does this book provide a comprehensive review of current research advances in collagen structure and mechanics, it also explores this biological macromolecule’s many applications in biomaterials and tissue engineering. Readers gain an understanding of the structure and mechanical behavior of type I collagen and collagen-based tissues in vertebrates across all length scales, from the molecular (nano) to the organ (macro) level.
Author: Jason A. Burdick Publisher: Springer Science & Business Media ISBN: 3709103851 Category : Technology & Engineering Languages : en Pages : 562
Book Description
A concise overview of tissue engineering technologies and materials towards specific applications, both past and potential growth areas in this unique discipline is provided to the reader. The specific area of the biomaterial component used within the paradigm of tissue engineering is examined in detail. This is the first work to specifically covers topics of interest with regards to the biomaterial component. The book is divided into 2 sections: (i) general materials technology (e.g., fibrous tissue scaffolds) and (ii) applications in the engineering of specific tissues (e.g., materials for cartilage tissue engineering). Each chapter covers the fundamentals and reflects not only a review of the literature, but also addresses the future of the topic. The book is intended for an audience of researchers in both industry and academia that are interested in a concise overview regarding the biomaterials component of tissue engineering, a topic that is timely and only growing as a field.
Author: Wenping Ma
Author: Wenping Ma
Author: Qing Liu
Author: Primana Punnakitikashem
Author: Sang Jin Lee
Author: M. Elices
Author: Birru Bhaskar
Author: Nihal Vrana
Author: Peter Fratzl
Author: Jason A. Burdick
Author: Rui Guo