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Author: Daniel Johnston Publisher: ISBN: Category : Languages : en Pages : 16
Book Description
The overall goal of this research project is to investigate the cellular and membrane mechanisms associated with the heterosynaptic modulation of long-term synaptic potentiation (LTP) at mossy fiber synapses in the hippocampus. We have previously shown that norepinephrine, through beta-adrenoceptors, enhances the magnitude, duration, and probability of induction of mossy fiber LTP, while acetylcholine, through muscarinic receptors, depresses the magnitude and probability of induction of mossy fiber LTP. The goal for the second year of this research project was to test several specific hypotheses for the induction of mossy fiber LTP. Specifically, the hypotheses relate to the possible requirement of postsynaptic calcium entry through voltage-gated calcium channels during the induction LTP. Moreover, we have been investigating the properties and distribution of voltage-gated calcium channels in hippocampal neurons and the modulation of these calcium channels by noradrenergic and cholinergic agonists. In a collaborative project with Dr. David Terrian, originally at the USAFSAM in San Antonio and now at East Carolina University, the mechanisms of neurotransmitter release from a homogeneous fraction of mossy fiber synaptosomes have been investigated. Keywords: Long-term potentiation, Noreinephrine, Acetylcholine, Synaptic plasticity, Voltage clamp, Patch clamp, Calcium channels, Hippocampus, Mossy fiber. (JES).
Author: Daniel Johnston Publisher: ISBN: Category : Languages : en Pages : 16
Book Description
The overall goal of this research project is to investigate the cellular and membrane mechanisms associated with the heterosynaptic modulation of long-term synaptic potentiation (LTP) at mossy fiber synapses in the hippocampus. We have previously shown that norepinephrine, through beta-adrenoceptors, enhances the magnitude, duration, and probability of induction of mossy fiber LTP, while acetylcholine, through muscarinic receptors, depresses the magnitude and probability of induction of mossy fiber LTP. The goal for the second year of this research project was to test several specific hypotheses for the induction of mossy fiber LTP. Specifically, the hypotheses relate to the possible requirement of postsynaptic calcium entry through voltage-gated calcium channels during the induction LTP. Moreover, we have been investigating the properties and distribution of voltage-gated calcium channels in hippocampal neurons and the modulation of these calcium channels by noradrenergic and cholinergic agonists. In a collaborative project with Dr. David Terrian, originally at the USAFSAM in San Antonio and now at East Carolina University, the mechanisms of neurotransmitter release from a homogeneous fraction of mossy fiber synaptosomes have been investigated. Keywords: Long-term potentiation, Noreinephrine, Acetylcholine, Synaptic plasticity, Voltage clamp, Patch clamp, Calcium channels, Hippocampus, Mossy fiber. (JES).
Author: Per Andersen Publisher: Oxford University Press ISBN: 9780195100273 Category : Medical Languages : en Pages : 892
Book Description
The hippocampus is one of a group of remarkable structures embedded within the brain's medial temporal lobe. Long known to be important for memory, it has been a prime focus of neuroscience research for many years. The Hippocampus Book promises to facilitate developments in the field in a major way by bringing together, for the first time, contributions by leading international scientists knowledgeable about hippocampal anatomy, physiology, and function. This authoritative volume offers the most comprehensive, up-to-date account of what the hippocampus does, how it does it, and what happens when things go wrong. At the same time, it illustrates how research focusing on this single brain structure has revealed principles of wider generality for the whole brain in relation to anatomical connectivity, synaptic plasticity, cognition and behavior, and computational algorithms. Well-organized in its presentation of both theory and experimental data, this peerless work vividly illustrates the astonishing progress that has been made in unraveling the workings of the brain. The Hippocampus Book is destined to take a central place on every neuroscientist's bookshelf.
Author: Helmut L. Haas Publisher: Springer Science & Business Media ISBN: 364273202X Category : Medical Languages : en Pages : 219
Book Description
This is the second time that I have had the honor of opening an interna tional symposium dedicated to the functions of the hippocampus here in Pecs. It was a pleasure to greet the participants in the hope that their valuable contributions will make this meeting a tradition in this town. As one of the hosts of the symposium, I had the sorrowful duty to remind you of the absence of a dear colleague, Professor Graham God dard. His tragic and untimely death represents the irreparable loss of both a friend and an excellent researcher. This symposium is dedicated to his memory. If I compare the topics of the lectures of this symposium with those of the previous one, a striking difference becomes apparent. A dominating tendency of the previous symposium was to attempt to define hippocam pal function or to offer data relevant to supporting or rejecting existing theoretical positions. No such tendency is reflected in the titles of the present symposium, in which most of the contributions deal with hip pocampal phenomena at the most elementary level. Electrical, biochemi cal, biophysical, and pharmacological events at the synaptic, membrane, or intracellular level are analyzed without raising the question of what kind of integral functions these elementary phenomena are a part of.
Author: M. Baudry Publisher: MIT Press ISBN: 9780262023306 Category : Memory Languages : en Pages : 494
Book Description
Following the successful format of the first volume on long- term potentiation -- a leading candidate for the neuronal basis of learning and memory -- Volume 2 brings together the most recent data and hypotheses by top neuroscientists regarding the mechanisms of this phenomenon and of long-term depression (LTD). The book is divided into several sections covering different aspects of the field ranging from molecular mechanisms of plasticity to computational neurobiology. It revisits some of the major points covered in Volume 1, updating them in this fast-moving field. It also introduces several new issues that have arisen since then. Of the many possible new topics that could have been added, the editors have focused on retrograde messengers and the mechanisms and functions of LTP and LTD because they are the subject of much interest, research, and controversy. The section on retrograde messengers deals primarily with nitric oxide.
Author: Tim V. P. Bliss Publisher: ISBN: 9780198530305 Category : Medical Languages : en Pages : 440
Book Description
In the thirty years since its discovery by Terje Lomo and Tim Bliss, Long Term Potentiation (LTP) has become one of the most extensively studied topics in contemporary neuroscience. In LTP the strength of synapses between neurons is potentiated following brief but intense activation. LTP is thought to play a central role in learning and memory, though the exact nature of its role is less clear. In spite of years of research, there are many questions about LTP regarding its functional relevance that remain unanswered - for example, is it a model of memory formation, or is the actual neural mechanism used by the brain to store information?This volume presents a state of the art account of LTP. It begins with lively accounts, by the scientists most closely involved, of the discovery of LTP and of the experiments that established its basic properties and induction mechanisms. Later contributions contain reviews and new research that cover the range of molecular, cellular, physiological and behavioural approaches to the study of LTP. Provocative, accessible, and authoritative, this book makes it clear why LTP continues in equal measure to puzzle and beguile neuroscientists today.Advance praise for Long Term Potentiation: 'This book provides a definitive overview of the development of ideas about synaptic plasticity and about the wide range of current research in this fascinating field.' Colin Blakemore, University of OxfordReadership: Neuroscientists from postgraduate level upwards
Author: Melanie A. Woodin Publisher: Springer Science & Business Media ISBN: 1441969780 Category : Medical Languages : en Pages : 191
Book Description
This volume will explore the most recent findings on cellular mechanisms of inhibitory plasticity and its functional role in shaping neuronal circuits, their rewiring in response to experience, drug addiction and in neuropathology. Inhibitory Synaptic Plasticity will be of particular interest to neuroscientists and neurophysiologists.
Author: Daniel Johnston
Author: Daniel Johnston
Author: Marc Gabriel Weisskopf
Author: Per Andersen
Author: Helmut L. Haas
Author: Dinah Lee Misner
Author: M. Baudry
Author: Sam A. Deadwyler
Author: Tim V. P. Bliss
Author: Lorenzo A. Cingolani
Author: Melanie A. Woodin