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Author: Publisher: Karger Medical and Scientific Publishers ISBN: 3805578849 Category : Medical Languages : en Pages : 97
Book Description
Practical and concise, this guide addresses clinical and experimental hematologists, technicians and teachers interested in human hematopoietic stem cells. Offering a unique collection of photographs taken at steady reproducible culture conditions by a hematologist with extensive clinical and experimental experience, it fills a gap in the current hematology literature.
Author: D. Metcalf Publisher: Springer Science & Business Media ISBN: 364281140X Category : Medical Languages : en Pages : 397
Book Description
The cloning of hemopoietic cells in semisolid medium began some 12 years ago, and when colonies of T = and B = lymphocytes were grown by several groups last year, the last major subclasses of hemopoietic cells had been successfully cultured in vitro. The time seemed appropriate to write a short general account of this exciting new area of hematology, emphasizing particularly the potential value of these new techniques for direct studies on patients with leukemia and allied diseases. I had hoped to refer to, or at least record, every paper published in this field, but the literature proved to be larger than I had realized, and furthermore, some areas were so active that chapters had to be rewritten over a period of less than a year. I regret that ·what follows is an incomplete account and no doubt, by the time this book becomes available, the material will be even more out of date. However, I have described the basic techniques in some detail and have tried, where possible, to explain how and why the techniques can fail. It is already possible to see patterns, perhaps even principles, emerging from this work which may well be applicable to other cell populations. These have been emphasized in the text in an attempt to make this review as creative as possible.
Author: Publisher: Karger Medical and Scientific Publishers ISBN: 3805578849 Category : Medical Languages : en Pages : 97
Book Description
Practical and concise, this guide addresses clinical and experimental hematologists, technicians and teachers interested in human hematopoietic stem cells. Offering a unique collection of photographs taken at steady reproducible culture conditions by a hematologist with extensive clinical and experimental experience, it fills a gap in the current hematology literature.
Author: Donald Metcalf Publisher: Harvard University Press ISBN: 9780674581579 Category : Blood cells Languages : en Pages : 182
Book Description
This book presents a masterful overview of the mechanics of blood cell formation and the factors that control blood cell growth. Cells circulating in the blood perform functions essential for the survival of organisms, yet blood cells and associated blood-cell-forming (hemopoietic) tissues have certain features that make them quite different from other vital organs in the body. These features include the short life span of mature blood cells, the multiplicity of blood cell types, and the wide dispersion of hemopoietic tissue in the body. The regulation of hemopoiesis in response to emergencies such as blood loss or infections is an exceedingly complex process. However, our knowledge of hemopoietic growth factors, known generally as colony-stimulating factors or CSFs, has made exciting advances in recent years. This book provides a leading authority's review of the purification and cloning of CSFs and their actions in regulating white blood cell production in the body. Donald Metcalf also examines the role of CSFs in controlling resistance to infections and in the initiation and suppression of myeloid leukemia. Metcalf's involvement at the center of this research from its inception to the present day enables him to give a historical view as well as a lucid summary of recent research. In addition, he addresses the broader question of the relation between growth control and cancer development. This excellent synopsis should be of particular interest to hematologists, virologists, general clinicians, and medical students.
Author: Mehdi Tavassoli Publisher: Springer Science & Business Media ISBN: 1461244943 Category : Medical Languages : en Pages : 469
Book Description
In 1868, Ernst Neumann recognized that blood cells re quire continuous replenishment during postnata1life. Before him, the assumption was that cells of the blood, like nerves once formed in the embryo, remain in the body throughout life. Neumann also recognized that this process occurred within the bone marrow, because this tissue provided a fa vorable environment for proliferation and differentiation of blood cell precursors. Vera Danchakoff, the Russian embryologist working in the US, in 1916 made an analogy to the soil and the seed. Bone marrow forms the soil, providing a favorable environment for the growth of seed, the hemopoietic stem cell, and other progenitor cells. Imagine in the remote past a heap of similar tree seeds. These seeds develop in our moderate climate into a tall and many branched tree. Suppose the wind bears a part of the seeds away and brings them to a land possessing different environmental conditions, we will say the arc tic lands. There the seeds may develop but they may pro duce trees no higher than our moss.
Author: L. J. Cole Publisher: ISBN: Category : Hematopoietic system Languages : en Pages : 24
Book Description
THE CAPACITY OF INTRAVENOUSLY INJECTED CELLS FROM PERITONEAL FLUID, PERIPHERAL BLOOD, LYMPH NODES, THYMUS AND BONE MARROW OF MICE TO RESTORE HEMATOPOIESIS IN LETHALLY X-irradiated (880 rad) isogenic recipients, was investigated. Thirtyday survival, and visible colony formation in the spleen were employed as he criteria. Administration of 6 million or 11 million peritoneal cells, and 6,400,000 or 15 million peripheral leukocytes afforded protection against mortality, and elicited colonies in the spleen; comparable effects were observe after injection of 110,000 marrow cells. The injection of 34 million adult lymph node cells or of 9 million thymus cells from newborn mice had no effect on mortality, nor did they elicit spleen colony formation. A corelation appears to exist between the capacity of isogenic cells to restore hemopoiesis in lethally irradiated mice and their ability to elicit visible colony formation in the spleen. The evidence suggests that normal peritoneal cell populations and peripheral blood leukocytes contain hemopoietic stem-cell elements, with a frequency 30 to 50 times lower than among bone marrow cells. No evidence was adduced to support the concept that normal lymphoid tissue lymphocytes give rise to hemopoietic cell lines. (Author).
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Author: D. Metcalf
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Author: Donald Metcalf
Author: E. A. Luriya
Author: Donald Metcalf
Author: Donald Metcalf
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Author: Mehdi Tavassoli
Author: L. J. Cole
Author: John Lamar Curry