Helicobacter Pioneers PDF Download

Author: Barry Marshall
Publisher: Wiley-Blackwell
ISBN: 9780867930351
Category : Medical
Languages : en
Pages : 244

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Book Description
Blackwell is proud to announce Professor Barry Marshall, along with Dr. Robin Warren, have been awarded the Nobel Prize in physiology or medicine. Providing background and the human touch of a discovery process taking almost a century, Helicobacter Pioneers is a collection of accounts from pioneering researchers of Helicobacter pylori, of who had firsthand knowledge of the pioneer. A remarkable work with original accounts that will never date, this book will inspire readers interested in gastroenterology, microbiology, or any facet of medical or scientific history.

Author: Hidekazu Suzuki
Publisher: Springer
ISBN: 4431557059
Category : Medical
Languages : en
Pages : 265

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Book Description
This book provides a detailed review of the most recent pathogenetic, diagnostic and therapeutic approaches in connection with Helicobacter pylori, along with priority areas in research and trends in clinical practice to address this significant pathogen acknowledged as the causative agent in a wide range of diseases, including gastric adenocarcinoma, MALT lymphoma and immune thrombocytopenic purpura (ITP). Medical authorities worldwide now recommend a “test and treat” strategy for this bacterial infection. Eradication therapy approaches range from general mass eradication therapy to tailor-made therapy for antibiotic-resistant refractory infection. In regions with high prevalence of H. pylori infection, the infection itself would be considered a major parameter to predict the risk of gastric adenocarcinoma development. The main interest has shifted recently to the risk stratification strategy for gastric cancer development and to the wide-ranging application of its serological prevention program. This book will benefit all gastroenterologists, hematologists, dermatologists, primary care doctors, epidemiologists, physicians who related with community hygiene, as well as basic scientists, particularly microbiologists, bacteriologists, pathologists, molecular biologists, biochemists, immunologists and oncologists.

Author: Bruna Maria Roesler
Publisher: BoD – Books on Demand
ISBN: 183881146X
Category : Science
Languages : en
Pages : 136

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Book Description
Helicobacter pylori is an universally distributed bacterium which affects more than half of the world population. H. pylori infection causes persistent inflammation with different clinical outcomes in humans, including chronic gastritis, peptic ulcer disease and gastric cancer. The infection has also been associated with several extradigestive disorders. In this book there is a comprehensive overview of contributors on H. pylori infection in diverse areas, including virulence factors of H. pylori and their importance for the clinical outcome of the diseases, discussions about the principal therapeutic regimens of bacterium eradication, also considering the antimicrobial resistance. H. pylori is clearly a very interesting bacteria and great studies and discussions about all its aspects are welcome to the medical and scientific communities.

Author: Shawna L. Fleming
Publisher: Infobase Publishing
ISBN: 1438101449
Category : Medical
Languages : en
Pages : 142

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Book Description
Describes the symptoms and effects of helicobacter pylori infections--the leading cause of stomach ulcers--the role of the bacteria in harboring other diseases, how they affect digestion, and treatment options.

Author: T. Ulf Westblom
Publisher: Springer Science & Business Media
ISBN: 3642600131
Category : Medical
Languages : en
Pages : 320

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Book Description
I am delighted to be able to write the foreword for this new book on Helicobacter pylori by three pioneers in the field, Vlf West blom, Steven Czinn and John Nedrud. Because of their long experience in both basic and clinical aspects of H. pylori, the editors have been able to produce a volume which is authoritative and up to date in the science of H. pylori, while still being concise and interesting for the practicing physician or H. pylori novice. To achieve this, they have collected a very distinguished group of authors from within the Vnited States and around the world. The chapters are sequenced in approximately the same order as developments in H. pylori science over the past 15 years. The first chapter on the discovery of H. pylori is by Cliodna McNulty, who was the first person to culture the organism in Europe. The epidemiology is then described followed by the main clinical as sociations, which are gastritis and dyspepsia, peptic ulcers, can cers and lymphoma. This naturally leads to discussion of the laboratory aspects of H. pylori, especially the microbiology, in cluding essential information on antibiotic resistance patterns. Next, virulence and pathogenicity of H. pylori are explained as defined in studies using animal models, then by discussion of the metabolism of the organism. Finally, the interaction of the bac terium with the host immune systems is dealt with, including the implications of these findings as they relate to the development of future vaccines.

Author: Theodore H. Tulchinsky
Publisher: Academic Press
ISBN: 0128045868
Category : Technology & Engineering
Languages : en
Pages : 605

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Book Description
Case Studies in Public Health contains selected case studies of some of the most important and influential moments in medicine and epidemiology. The cases chosen for this collection represent a wide array of public health issues that go into the makeup of what can be termed the New Public Health (NPH), which includes traditional public health, such as sanitation, hygiene and infectious disease control, but widens its perspective to include the organization, financing and quality of health care services in a much broader sense. Each case study is presented in a systematic fashion to facilitate learning, with the case, background, current relevance, economic issues, ethical issues, conclusions, recommendation and references discussed for each case. The book is a valuable resource for advanced students and researchers with specialized knowledge who need further information on the general background and history of public health and important scientific discoveries within the field. It is an ideal resource for students in public health, epidemiology, medicine, anthropology, and sociology, and for those interested in how to apply lessons from the past to present and future research. - Explores the history of public health through important scientific events and flashpoints - Presents case studies in a clear, direct style that is easy to follow - Uses a systematic approach to help learn lessons from the past and apply them to the present

Author: R.H. Hunt
Publisher: Springer Science & Business Media
ISBN: 9780792387909
Category : Medical
Languages : en
Pages : 574

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Book Description
The fifth meeting in the successful series Helicobacter pylori: Basic Mechanisms to Clinical Cure took place in Maui, Hawaii, November 2002. The meeting focused on all current aspects of H. pylori research. Internationally acclaimed basic and clinical researchers explored, in depth, the novel information across the spectrum of H. pylori infection, the characteristics of the organism, the inflammatory and tissue modifying consequences, the overall impact of this infection on a global scale, and new therapeutic possibilities. H. pylori infection, both in man and in the laboratory animal, has become a standard model to investigate fundamental problems in biology, such as microbial-host interactions, intracellular signalling, modulation of inflammation, mucosal atrophic metaplasia, and microbial resistance, to name just a few. The issues addressed in this book are grouped according to their leading theme. Topics include: the new Helicobacters, strain differences of H. pylori and their consequence on microbial-host interactions and the effects of H. pylori infection on the gastric mucosa. The role of H. pylori is explained in relation to: gastric carcinogenesis; gastroesophageal reflux disease; dyspepsia and long-term acid suppression. Eradication therapies are reviewed with respect to their global consequences and problems. The last two sections are devoted to a global update on therapeutic indications and finally on priorities for further research. These proceedings accurately reflect the state-of-the-art presentations delivered by world experts. This latest volume will further enrich this top-class series on H. pylori infection.

Author: Anders ØVerby
Publisher:
ISBN: 9784991166211
Category :
Languages : en
Pages : 194

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Book Description
The significance of the gram-negative, microaerophilic, spiral bacterium Helicobacter pylori (Hp) in the formation of gastric and duodenal diseases now widely recognized, and it is no longer necessary to explain it. J Robin Warren and Barry Marshall were awarded the Nobel Prize in Physiology or Medicine in 2005 for establishing the importance of this bacterium, which is significantly involved in gastric and duodenal ulcers. Dr. Marshall even appeared in a TV commercial that is broadcast in Japan, discussing a Meiji Dairies yogurt containing one of the lactobacilli (i.e. LG20) targeting the reduction of Hp. The Hp-based eradication of chronic gastritis has begun to be covered by the national health insurance system through the efforts of the Helicobacter Society of Japan, and approx. 1 million people receive eradication treatment each year in Japan. Gastric cancer caused by Hp may eventually become a rare disease even in Japan and east Asian countries, where gastric cancer remains a common cause of death. However, in daily medical care, many physicians have encountered patients in whom chronic gastritis is revealed by gastroscopy, but Hp is not detected even after various tests. I have the impression that this type of case is gradually increasing now that Hp eradication has become commonplace. A polymerase chain reaction (PCR) test revealed that these cases contained a significant proportion of non-Helicobacter pylori Helicobacter species (NHPH), which are the subject of this book. NHPH is included in the same genus as Hp, but has some characteristics that differ from those of Hp. Especially in terms of diagnosis, the diagnostic method that applies urease, which is widely used for Hp, often does not give a positive result for NHPH, thus overlooking these bacteria. In addition, NHPH are found not only in the mucous layer of the stomach but also in the gastric glands, especially in the intracellular canaliculus and cytoplasm of the acid-secreting parietal cells. Dogs, cats, pigs, and other non-human species are the main natural hosts of NHPH, presenting a zoonotic infection pattern. It is thus expected that the ratio of NHPH infections will increase, now that the number of people who are Hp-positive continue to decreases due to the above-mentioned eradication, and the natural hosts of NHPH bacteria can be expected to transmit to these bacteria. In 2010, with a grant from the Helicobacter Society of Japan, our research group began to investigate cases all over Japan by the PCR method, and we observed that a high percentage of individuals with mucosa-asssociated lymphoid tissue (MALT) lymphoma who were negative for Hp, nodular gastritis, and chronic gastritis were positive for NHPH. These data were reported to Helicobacter (Journal) in 2020. In recent years, as with Hp, the culturing of bacteria from biopsy tissues of dogs, cats, and humans -which was not possible in the past- has been succeeded and the whole genome analyses of NHPH have become possible. The precise infection status of each NHPH and its pathogenic factors are expected to be revealed in the near future. In this book, we summarize or group' research history first as dialogue, and we then clarify the present challenges. The history of the research of NHPH in connection with Hp, its biology and the relation to diseases are then discussed.

Author: Martin J. Blaser, MD
Publisher: Henry Holt and Company
ISBN: 0805098119
Category : Science
Languages : en
Pages : 289

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Book Description
“In Missing Microbes, Martin Blaser sounds [an] alarm. He patiently and thoroughly builds a compelling case that the threat of antibiotic overuse goes far beyond resistant infections.”—Nature Renowned microbiologist Dr. Martin J. Blaser invites us into the wilds of the human microbiome, where for hundreds of thousands of years bacterial and human cells have existed in a peaceful symbiosis that is responsible for the equilibrium and health of our bodies. Now this invisible Eden is under assault from our overreliance on medical advances including antibiotics and caesarian sections, threatening the extinction of our irreplaceable microbes and leading to severe health consequences. Taking us into the lab to recount his groundbreaking studies, Blaser not only provides elegant support for his theory, he guides us to what we can do to avoid even more catastrophic health problems in the future. “Missing Microbes is science writing at its very best—crisply argued and beautifully written, with stunning insights about the human microbiome and workable solutions to an urgent global crisis.”—David M. Oshinsky, author of the Pulitzer Prize-winning Polio: An American Story

Author: Gilbert Thompson
Publisher: World Scientific
ISBN: 1848168276
Category : Medical
Languages : en
Pages : 373

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Book Description
This book brings together in one volume fifteen Nobel Prize-winning discoveries that have had the greatest impact upon medical science and the practice of medicine during the 20th century and up to the present time. Its overall aim is to enlighten, entertain and stimulate. This is especially so for those who are involved in or contemplating a career in medical research. Anyone interested in the particulars of a specific award or Laureate can obtain detailed information on the topic by accessing the Nobel Foundation''s website. In contrast, this book aims to provide a less formal and more personal view of the science and scientists involved, by having prominent academics write a chapter each about a Nobel Prize-winning discovery in their own areas of interest and expertise.