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Author: Jacob Evans Publisher: States Academic Press ISBN: 9781639892495 Category : Medical Languages : en Pages : 246
Book Description
The sensory receptors which belong to the vestibular and auditory systems of vertebrates are termed as hair cells. They are present within the ears. These cells are able to detect movement around them through mechanotransduction. In mammals, hair cells are located in the cochlea of the inner ear. These cells can be categorized into two types, the inner and outer hair cells. They are functionally and anatomically different from each other. The inner hair cells are responsible for converting the sound vibrations in the fluids of the cochlea into electrical signals which are then conveyed to the brain. They are unable to regenerate. Therefore, any injury or damage to them is permanent and can lead to a decrease in hearing sensitivity. This book covers in detail some existent theories and innovative concepts revolving around the regeneration, repair and death of hair cells. Its aim is to present researches that have transformed this discipline and aided its advancement. This book will help the readers in keeping pace with the rapid changes in this field.
Author: Jacob Evans Publisher: States Academic Press ISBN: 9781639892495 Category : Medical Languages : en Pages : 246
Book Description
The sensory receptors which belong to the vestibular and auditory systems of vertebrates are termed as hair cells. They are present within the ears. These cells are able to detect movement around them through mechanotransduction. In mammals, hair cells are located in the cochlea of the inner ear. These cells can be categorized into two types, the inner and outer hair cells. They are functionally and anatomically different from each other. The inner hair cells are responsible for converting the sound vibrations in the fluids of the cochlea into electrical signals which are then conveyed to the brain. They are unable to regenerate. Therefore, any injury or damage to them is permanent and can lead to a decrease in hearing sensitivity. This book covers in detail some existent theories and innovative concepts revolving around the regeneration, repair and death of hair cells. Its aim is to present researches that have transformed this discipline and aided its advancement. This book will help the readers in keeping pace with the rapid changes in this field.
Author: Richard J. Salvi Publisher: Springer Science & Business Media ISBN: 0387733647 Category : Science Languages : en Pages : 323
Book Description
Not male pattern baldness, but the loss of sensory hair, is a very serious topic. Sensory hair cells convert sound and motion into our sense of hearing, movement, and head position. In mammals, the loss of hair cells is irreversible. Or is it? Hair cells in other vertebrates are capable of regenerating and recovering partial or complete function. This book provides a comprehensive survey of the regeneration of sensory hair cells.
Author: Mark E. Warchol Publisher: Springer Nature ISBN: 3031206614 Category : Medical Languages : en Pages : 242
Book Description
This volume provides a detailed update on progress in the field of hair cell regeneration. This topic is of considerable interest to academicians, clinicians, and commercial entities, including students of auditory and vestibular neuroscience, audiologists, otologists, and industry, all of whom may have interest in hair cell regeneration as a potential future therapy for hearing and balance dysfunction. In 2008, Springer published a SHAR volume on this subject (Hair Cell Regeneration, Repair, and Protection, Editors Richard Salvi and Richard Fay). Since that time, there has been considerable advancement in this field.This book provides a historical perspective on the field, but the emphasis is on more "prospective" views of the various facets of regeneration research, in the hope that the volume will stimulate new projects and approaches, focusing on the limitations of current knowledge and describing promising strategies for future work. The book will include the following key features of hair cell regeneration: • Cellular and molecular control hair cell regeneration in non-mammalian species (in particular zebrafish and chickens) • Our current understanding of the capacity for hair cell replacement in mammals (rodents and humans). • Signals controlling pro-regenerative behaviors in supporting cells, the hair cell progenitors. • New techniques that have been applied to study the genetic and epigenetic regulation of hair cell regeneration in mammals and non-mammals. • Contributions of stem cells toward building new tools to explore how hair cell regeneration is controlled and toward developing cells and tissue for therapeutic transplantation. • Studies that have applied gene and drug therapy to promote regeneration in mammals.
Author: Richard J. Salvi Publisher: Springer ISBN: 9780387520032 Category : Science Languages : en Pages : 0
Book Description
Not male pattern baldness, but the loss of sensory hair, is a very serious topic. Sensory hair cells convert sound and motion into our sense of hearing, movement, and head position. In mammals, the loss of hair cells is irreversible. Or is it? Hair cells in other vertebrates are capable of regenerating and recovering partial or complete function. This book provides a comprehensive survey of the regeneration of sensory hair cells.
Author: Anthony Atala Publisher: Academic Press ISBN: 0123814235 Category : Science Languages : en Pages : 1203
Book Description
Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs
Author: Kursad Turksen Publisher: Springer Science & Business Media ISBN: 1597450375 Category : Science Languages : en Pages : 504
Book Description
Now in two volumes, this completely updated and expanded edition of Embryonic Stem Cells: Methods and Protocols provides a diverse collection of readily reproducible cellular and molecular protocols for the manipulation of nonhuman embryonic stem cells. Volume one, Embryonic Stem Cell Protocols: Isolation and Characterization, Second Edition, provides a diverse collection of readily reproducible cellular and molecular protocols for the isolation, maintenance, and characterization of embryonic stem cells. The second volume, Embryonic Stem Cell Protocols: Differentiation Models, Second Edition, covers state-of-the-art methods for deriving many types of differentiating cells from ES cells. Together, the two volumes illuminate for both novices and experts our current understanding of the biology of embryonic stem cells and their utility in normal tissue homeostasis and regenerative medicine applications.
Author: Robert Vink Publisher: University of Adelaide Press ISBN: 0987073052 Category : Medical Languages : en Pages : 354
Book Description
The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Author: Gregory R. Bock Publisher: John Wiley & Sons ISBN: 0470514132 Category : Science Languages : en Pages : 352
Book Description
An international group of leading investigators discuss recent progress of sensory structures in lower and higher vertebrates. Experts in two relevant fields--the cell cycle and mitogenic growth factors--present insightful contributions in the search for precursors and/or stem cells in each sense organ plus the signals which regulate those precursors' differentiation both in normal development and regeneration.
Author: Institute of Medicine Publisher: National Academies Press ISBN: 0309170427 Category : Science Languages : en Pages : 112
Book Description
Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.
Author: Jacob Evans
Author: Jacob Evans
Author: Richard J. Salvi
Author: Mark E. Warchol
Author: Richard J. Salvi
Author: 
Author: Anthony Atala
Author: Kursad Turksen
Author: Robert Vink
Author: Gregory R. Bock
Author: Institute of Medicine