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Author: Gabriel Rabinovich Publisher: Wiley-Blackwell ISBN: 9781573318396 Category : Science Languages : en Pages : 0
Book Description
Carbohydrates are ubiquitous, essential molecules, as important as nucleic acids and proteins yet less well understood. Mounting data demonstrate that microbial and mammalian glycans and their protein-binding partners (lectins) play central roles in all innate and adaptive immune responses. Indeed, programmed remodeling of host glycans can modulate infection, autoimmunity, and cancer, while microbial glycoconjugates can serve as canonical innate receptor agonists that induce B cell and T cell activation. Glycobiology of the Immune Response explores the integration of state-of-the-art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
Author: Gabriel Rabinovich Publisher: Wiley-Blackwell ISBN: 9781573318396 Category : Science Languages : en Pages : 0
Book Description
Carbohydrates are ubiquitous, essential molecules, as important as nucleic acids and proteins yet less well understood. Mounting data demonstrate that microbial and mammalian glycans and their protein-binding partners (lectins) play central roles in all innate and adaptive immune responses. Indeed, programmed remodeling of host glycans can modulate infection, autoimmunity, and cancer, while microbial glycoconjugates can serve as canonical innate receptor agonists that induce B cell and T cell activation. Glycobiology of the Immune Response explores the integration of state-of-the-art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
Author: Marija Pezer Publisher: Springer Nature ISBN: 3030769127 Category : Medical Languages : en Pages : 588
Book Description
This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy. Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present in the human body, the book also discusses other classes of human immunoglobulins, as well as immunoglobulins produced in other species and production systems. Further, it reviews the glycoanalytical methods applied to antibodies and addresses a range of less commonly explored topics, such as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengineering (such as monoclonal antibody production), to those still in the research stages (such as exploration of antibody glycosylation as a clinical or biological age biomarker), and the potential use of antibody glycosylation in the optimization of vaccine production and immunization protocols. Summarizing the current knowledge on the broad topic of antibody glycosylation and its therapeutic and biomarker potential, this book will appeal to a wide biomedical readership in academia and industry alike. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author: Ajit Varki Publisher: CSHL Press ISBN: 9780879696818 Category : Medical Languages : en Pages : 694
Book Description
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Author: Jasmeen S. Merzaban Publisher: Frontiers Media SA ISBN: 2889636968 Category : Languages : en Pages : 205
Book Description
Glycans represent a major constituency of post-translational modifications that occur on most, if not all, proteins. Whether on mammalian or invertebrate cell surfaces, they exist as sugar chain moieties designed from the exquisite and coordinated activity of cell-specific glycosylation. Some of the more common glycan structures are linked to cell surface polypeptides via an asparagine (N)-linked residue or a serine/threonine (O)-linked residue, along with a notable contingent found linked to ceramides in the lipid bilayer known as glycosphingolipids. These glycans can associate with complementary glycan-binding proteins (GBP) or lectins to mediate and translate this carbohydrate recognition to cell function. In immunity, there is increasing evidence that precise immune cell glycans are recognized by corresponding GBPs in a cell-intrinsic or -extrinsic manner. Unique carbohydrate recognition domains within GBPs are comprised of precisely spaced amino acid functional groups that allow for selective engagement of a particular glycan target. This structure-function relationship is present in immune signaling pathways, whereby glycans and GBPs on the surface of immune cells (and non-immune cells) help control processes such as immune cell activation, recognition of pathogens, suppression and tissue-specific migration. The diversity of glycan structures and glycosylation among individual immune cell subsets is controlled by the expression of genes involved in glycan biosynthesis including glycosyltransferases, glycosidases, glycan-precursor biosynthetic enzymes and nucleotide-sugar transporters. These genes represent more than 3% of the human genome, and cell-specific expression of these genes dictates a cell’s glycan repertoire, ultimately influencing its molecular interactions with GBPs. Altogether, these emerging lines of investigation highlight the regulatory capacity of glycans in immune health and disease, which in turn, pave the way for novel diagnostic, prognostic, and therapeutic strategies.
Author: Elizabeth Yuriev Publisher: Frontiers Media SA ISBN: 2889196380 Category : Immunologic diseases. Allergy Languages : en Pages : 104
Book Description
Interest in understanding the biological role of carbohydrates has increased significantly over the last 20 years. The use of structural techniques to understand carbohydrate-protein recognition is still a relatively young area, but one that is of emerging importance. The high flexibility of carbohydrates significantly complicates the determination of high quality structures of their complexes with proteins. Specialized techniques are often required to understand the complexity of carbohydrate recognition by proteins. In this Research Topic, we will focus on structural and computational approaches to understanding carbohydrate recognition by proteins involved in immunity and infection. Particular areas of focus include cancer immunotherapeutics, carbohydrate-lectin interactions, glycosylation and glycosyltransferases.
Author: Hans-Joachim Gabius Publisher: John Wiley & Sons ISBN: 3527644946 Category : Science Languages : en Pages : 560
Book Description
A reader friendly overview of the structure and functional relevance of natural glycosylation and its cognate proteins (lectins), this book is also one of the few books to cover their role in health and disease. Edited by one of the pioneering experts in the field and written by a team of renowned researchers this resource is a perfect introduction for all students in life and medical sciences, biochemistry, chemistry and pharmacy. Website: WWW.WILEY-VCH.DE/HOME/THESUGARCODE
Author: Gabriel Rabinovich
Author: Gabriel Rabinovich
Author: Marija Pezer
Author: Azita Alavi
Author: Ajit Varki
Author: Matthew S. Macauley
Author: Jasmeen S. Merzaban
Author: Elizabeth Yuriev
Author: Hans-Joachim Gabius
Author: Els J. M. Van Damme
Author: John Isaacs