Author: Kevin Jace Miranda
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Book Description

Author: Maria Costantini
Publisher: MDPI
ISBN: 3036502548
Category : Science
Languages : en
Pages : 92

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Book Description
In recent years, marine genomics has become a rapidly growing field, helped by the large amount of information that is becoming available to the international scientific community. Taking into account the current excitement in the field of marine biotechnology, this Special Issue entitled “Genome Mining and Synthetic Biology in Marine Natural Product Discovery” aims to to assess the impact of these molecular approaches on the discovery of bioactive compounds from marine organisms. The term “genome mining” is used to identify all bioinformatic investigations aimed at detecting the biosynthetic pathways of bioactive natural products and their possible functional and chemical interactions. Several studies are now reporting on marine organisms. Oceans cover nearly 70% of the Earth’s surface and host a huge ecological, chemical, and biological diversity. The natural conditions of the sea favor, in marine organisms, the production of a large variety of novel molecules with great pharmaceutical potential. Marine organisms are unique in their structural and functional features compared to terrestrial ones. Innovation in this field is very rapid, as revealed by the funding of several Seventh Framework Programme (FP7) and Horizon 2020 projects under the topic “Blue Growth”, with the urgent goal of discovering new drugs.

Author:
Publisher:
ISBN: 9783036532998
Category : Medical
Languages : en
Pages : 244

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Book Description

Author: Taícia Pacheco Fill
Publisher: Springer Nature
ISBN: 3031417410
Category : Science
Languages : en
Pages : 256

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Book Description
​This book focuses on the importance of omics strategies and de-replication analysis to unveil new molecules from microbial sources with diverse chemical structures and biological functions. Chapters address metabolomics strategies, which will lead to a better understanding of the chemical interactions between microorganisms, plant-microorganisms, and virus-microorganisms. Authors also describe analytical tools used in microbial metabolomics and natural products discovery, in addition to describing a step-by-step protocol to identify and annotate metabolites using various databases and online platforms. The book presents the newest research, tools, and protocols for chemists, biochemists, bio-and chemical engineers, and biotechnologists, among others.

Author: Kui Hong
Publisher: MDPI
ISBN: 3039280902
Category : Science
Languages : en
Pages : 202

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Book Description
Two review papers, eight research articles, and one brief report were published in this Special Issue. They showed the rich resources that are present within the genomes of marine microorganisms and discussed the use of recently developed tools and technologies to exploit this genetic richness. Examples include the rational supply of precursors according to the relevant biosynthetic pathway and stress driven discovery together with the use of histone deacetylase inhibitors to facilitate the discovery of new bioactive molecules with potential biopharmaceutical applications. We believe that the content of this Special Issue reflects the current state-of-the-art research in this area and highlights the interesting strategies that are being employed to uncover increasing numbers of exciting novel compounds for drug discovery from marine genetic resources.

Author: Maria Costantini
Publisher:
ISBN: 9783036502557
Category :
Languages : en
Pages : 92

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Book Description
In recent years, marine genomics has become a growning rapidly field, helped by the large amount of information that is becoming available to the international scientific community. Taking into account the current excitement in the field of marine biotechnology, this Special Issue entitled “Genome Mining and Synthetic Biology in Marine Natural Product Discovery” aims to to assess the impact of these molecular approaches on the discovery of bioactive compounds from marine organisms. The term “genome mining” is used to identify all bioinformatic investigations aimed at detecting the biosynthetic pathways of bioactive natural products and their possible functional and chemical interactions. Several studies are now reporting on marine organisms. Oceans cover nearly 70% of the Earth's surface and host a huge ecological, chemical, and biological diversity. The natural conditions of the sea favor, in marine organisms, the production of a large variety of novel molecules with great pharmaceutical potential. Marine organisms are unique in their structural and functional features compared to terrestrial ones. Innovation in this field is very rapid, as revealed by the funding of several Seventh Framework Programme (FP7) and Horizon 2020 projects under the topic “Blue Growth”, with the urgent goal of discovering new drugs.

Author: Loïc Charpy
Publisher: Musee Oceanographique
ISBN:
Category : Science
Languages : en
Pages : 644

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Book Description

Author: Alan Dobson
Publisher:
ISBN: 9783039280919
Category : Biology (General)
Languages : en
Pages : 202

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Book Description
Two review papers, eight research articles, and one brief report were published in this Special Issue. They showed the rich resources that are present within the genomes of marine microorganisms and discussed the use of recently developed tools and technologies to exploit this genetic richness. Examples include the rational supply of precursors according to the relevant biosynthetic pathway and stress driven discovery together with the use of histone deacetylase inhibitors to facilitate the discovery of new bioactive molecules with potential biopharmaceutical applications. We believe that the content of this Special Issue reflects the current state-of-the-art research in this area and highlights the interesting strategies that are being employed to uncover increasing numbers of exciting novel compounds for drug discovery from marine genetic resources.

Author: Michelle Antoinette Schorn
Publisher:
ISBN:
Category :
Languages : en
Pages : 239

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Book Description
Nature has created elegant and efficient ways of assembling a wide variety of diverse chemical scaffolds. Microbes are prolific producers of these secondary metabolites, which can have profound bioactivities and be harnessed for use in medicine. Within their genomes, microbes possess the blueprints for making natural products, and recent advances in high-throughput DNA sequencing have revealed a much larger repertoire of specialized chemistry than what can be observed in the lab. This bacterial 'dark matter' has the potential to contain the instructions for making countless new chemical scaffolds and represents an untapped source for drug discovery. Connecting secondary metabolite compounds with their biosynthetic gene clusters can inform novel biosynthetic transformations, provide a renewable source of promising bioactive compounds, and inspire synthetic biology approaches to assembling new molecules. Chapter 2 of this dissertation connects two pharmaceutically relevant natural products with their corresponding biosynthetic gene clusters. The epoxyketone proteasome inhibitors epoxomicin and eponemycin are naturally produced by actinomycete bacteria, and whole genome sequencing revealed their genetic underpinnings and native resistance mechanism. This work represents the first elucidation of biosynthetic gene clusters for epoxyketone proteasome inhibitors. Chapter 3 takes a wider lens to examine an understudied group of bacteria: the rare marine actinomycetes. Whole genome sequencing of a group of rare marine actinomycetes revealed an incredible wealth of biosynthetic potential and diversity not yet represented in current sequencing databases. This study establishes rare marine actinomycetes as a group worthy of further exploration for genome mining and drug discovery. Chapter 4 investigates a more complex system with a focus on uncultivatable cyanobacterial sponge symbionts. Previous work showed that the genomes of these symbionts contained the genes necessary to produce environmentally relevant poly-brominated diphenyl ethers (PBDEs). In assembling high quality draft genomes of two symbionts of distinct sponges, their full secondary metabolite potential was revealed. Additionally, genome mining led to the identification of two novel dysinosin molecules, representing the first example of mining for gene clusters in a metagenome assembled genome leading to new chemistry.

Author: Ute Roessner
Publisher:
ISBN: 9781627035774
Category : Metabolites
Languages : en
Pages : 311

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Book Description
Classical natural product chemistry is transitioning to modern day metabolomics as a result of the advent of comprehensive analytical platforms and sensitive analytical instrumentation. Therefore, it is worthwhile to summarize recent developments with current analytical platforms and highlight how metabolomics is being integrated into this classical field to dereplicate and profile natural product extracts. Metabolomics Tools for Natural Product Discoveries: Methods and Protocols aims to unite diverse and recently developed methodologies and protocols in order to identify bioactive secondary metabolites for the purpose of drug discovery. Some topics covered in this volume include applications for the extraction of selected natural products from less common sources such as bryophytes and hard corals, various biological assays, comprehensive applications and strategies for GC-MS, LC-MS, and NMR, as well as protocols and strategies for the structure elucidation of isolated natural products. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible Metabolomics Tools for Natural Product Discoveries: Methods and Protocols seeks to serve both professionals and research students with its well-honed methodologies for natural product isolation, biomarker discovery, dereplication, biological assays, and comprehensive metabolomic platforms available for high-throughput analyses.