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Author: Rudolf Jaenisch Publisher: Springer ISBN: 9783319868011 Category : Medical Languages : en Pages : 0
Book Description
This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.
Author: Rudolf Jaenisch Publisher: Springer ISBN: 9783319868011 Category : Medical Languages : en Pages : 0
Book Description
This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.
Author: Rudolf Jaenisch Publisher: Springer ISBN: 331960192X Category : Medical Languages : en Pages : 123
Book Description
This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.
Author: James Giordano Publisher: CRC Press ISBN: 1439825866 Category : Science Languages : en Pages : 357
Book Description
New technologies that allow us to investigate mechanisms and functions of the brain have shown considerable promise in treating brain disease and injury. These emerging technologies also provide a means to assess and manipulate human consciousness, cognitions, emotions, and behaviors, bringing with them the potential to transform society. Neurotechnology: Premises, Potential, and Problems explores the technical, moral, legal, and sociopolitical issues that arise in and from today’s applications of neuroscience and technology and discusses their implications for the future. Some of the issues raised in this thought-provoking volume include: Neurotechnology in education: an enablement, a treatment, or an enhancement? The potential and limitations of neuroimaging technology in determining patient prognoses Tissue implantation technology as a way of engendering personalized medicine Neuroprostheses: restoration of functions of the disabled vs. enhancement to transhuman capabilities Deep brain stimulation and its use in restoring, preserving, or changing patients’ personal identity The benefit and risk of cognitive performance tools Cyborg technology and its potential to change our vision of humanity Methodologies for reducing the risk of neurotechnology’s impact on ethical, legal, and social issues With contributions from an international group of experts working on the cutting edge of neurotechnology, this volume lays the groundwork to appreciate the ethical, legal, and social aspects of the science in ways that keep pace with this rapidly progressing field.
Author: Luis María Vaschetto Publisher: CRC Press ISBN: 1000540839 Category : Mathematics Languages : en Pages : 315
Book Description
The CRISPR-Cas9 genome-editing system is creating a revolution in the science world. In the laboratory, CRISPR-Cas9 can efficiently be used to target specific genes, correct mutations and regulate gene expression of a wide array of cells and organisms, including human cells. CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases is a unique reading material for college students, academicians, and other health professionals interested in learning about the broad range of applications of CRISPR/Cas9 genetic scissors. Some topics included in this book are: the role of the CRISPR/Cas9 system in neuroscience, gene therapy, epigenome editing, genome mapping, cancer, virus infection control strategies, regulatory challenges and bioethical considerations.
Author: Joel Paris Publisher: Oxford University Press ISBN: 0190601019 Category : Psychology Languages : en Pages : 217
Book Description
Psychiatry, once proud of its biopsychosocial model, has now adopted a neuroscience-based approach that strongly favors psychopharmacological treatments and downplays the role of psychotherapies (or social interventions). This kind of practice can be sufficient for the psychoses, but it is neither evidence-based nor beneficial for patients with common mental disorders such as depression, anxiety, substance use, and personality disorders. Current practice derives from a theoretical model in which psychiatry is viewed primarily as an application of neuroscience, with little reference to the vast literature on psychology, social sciences, and psychotherapy. This work reviews research bearing on these issues, and it shows why existing data support a different set of conclusions from those held by many experts and most practitioners
Author: Alfred A. Bertelsen Publisher: ISBN: 9781536164268 Category : Biotechnology Languages : en Pages : 0
Book Description
This compilation focuses on the CRISPR/Cas9 system, a genome editing tool that has been hailed as the most profound molecular biology discovery in the past decade. By employing the natural process of bacterial immunity towards bacteriophages, the tool allows researchers to precisely excise and edit parts of the genetic sequence to modify them.The authors summarize the molecular pathogenesis of hepatocellular carcinoma, available treatments/drugs and their limitations, the landscape of CRISPR targeting hepatocellular carcinoma, limitations and potential targets in future.The closing review summarises the use of CRISPR/Cas9 gene editing in ophthalmology and focuses on the advancement of gene editing in the cornea. The majority of corneal dystrophies are the result an autosomal dominant inheritance pattern within the TGFBI gene, which presents an ideal model suited for a CRISPR/Cas9 knock out methodology.
Author: Matt Carter Publisher: Academic Press ISBN: 0323915612 Category : Medical Languages : en Pages : 416
Book Description
Modern neuroscience research is inherently multidisciplinary, with a wide variety of cutting edge new techniques to explore multiple levels of investigation. This Third Edition of Guide to Research Techniques in Neuroscience provides a comprehensive overview of classical and cutting edge methods including their utility, limitations, and how data are presented in the literature. This book can be used as an introduction to neuroscience techniques for anyone new to the field or as a reference for any neuroscientist while reading papers or attending talks. Nearly 200 updated full-color illustrations to clearly convey the theory and practice of neuroscience methods Expands on techniques from previous editions and covers many new techniques including in vivo calcium imaging, fiber photometry, RNA-Seq, brain spheroids, CRISPR-Cas9 genome editing, and more Clear, straightforward explanations of each technique for anyone new to the field A broad scope of methods, from noninvasive brain imaging in human subjects, to electrophysiology in animal models, to recombinant DNA technology in test tubes, to transfection of neurons in cell culture Detailed recommendations on where to find protocols and other resources for specific techniques "Walk-through" boxes that guide readers through experiments step-by-step
Author: Wim E. Crusio Publisher: Elsevier ISBN: 9780080536866 Category : Psychology Languages : en Pages : 962
Book Description
The book gives a broad overview of recombinant DNA techniques for the behavioral neuroscientist, with illustrative examples of applications. Species covered include rodents (mainly mice), Drosophila melanogaster, Caenorhabditis elegans and Danio rerio. Experimental techniques required to characterize the behavioral phenotypes of mutant animals is provided. Several aspects of novel molecular-genetic techniques are overviewed and possible research strategies are explained. The sections of the book start with general descriptions of techniques followed by illustrative examples. It is divided into six sections. Section 1, bioinformatics and genomics research. Section 2, top-down strategies, where the researcher starts with the phenotype and then analyzes the associated genes; bottom-up strategies, where the physiological chain leading to a phenotype is analyzed starting from the gene product. Section 3, transgenic approaches in rodents including overexpressing foreign genes and gene-targeting; systemic manipulation approaches directly targeting the central nervous system and methods used with invertebrates. Section 4, methods used to evaluate relevant behavioral phenotypes, including learning and aggression. Section 5, examples on molecular brain research in man. Section 6, ethical aspects of research in this field.
Author: Simon G Sprecher Publisher: Humana ISBN: 9781627036542 Category : Medical Languages : en Pages : 0
Book Description
Providing widely used techniques in genetic model systems and many complementing animal models, Brain Development: Methods and Protocols focuses its expert contributions on two key technical aspects of developmental neurobiology: detection of gene expression and functional characterization of developmental control genes. Covering animal models such as the fruit fly, zebra fish, chicken, and mouse, this detailed book views in situ hybridization, reporter gene expression, and immunohistochemical staining methods, as well as RNA interference, Morpholino, or transgenic techniques through the prism of these models. Written in the highly successful Methods in Molecular Biology series format, chapter include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and cutting-edge, Brain Development: Methods and Protocols aims to provide precise technical protocols but also allows for comparing a wide range of protocols in different tissues and species.
Author: Larry Squire Publisher: Academic Press ISBN: 0080561020 Category : Psychology Languages : en Pages : 1277
Book Description
Fundamental Neuroscience, Third Edition introduces graduate and upper-level undergraduate students to the full range of contemporary neuroscience. Addressing instructor and student feedback on the previous edition, all of the chapters are rewritten to make this book more concise and student-friendly than ever before. Each chapter is once again heavily illustrated and provides clinical boxes describing experiments, disorders, and methodological approaches and concepts.Capturing the promise and excitement of this fast-moving field, Fundamental Neuroscience, 3rd Edition is the text that students will be able to reference throughout their neuroscience careers! 30% new material including new chapters on Dendritic Development and Spine Morphogenesis, Chemical Senses, Cerebellum, Eye Movements, Circadian Timing, Sleep and Dreaming, and Consciousness Additional text boxes describing key experiments, disorders, methods, and concepts Multiple model system coverage beyond rats, mice, and monkeys Extensively expanded index for easier referencing
Author: Rudolf Jaenisch
Author: Rudolf Jaenisch
Author: Rudolf Jaenisch
Author: James Giordano
Author: Luis María Vaschetto
Author: Joel Paris
Author: Alfred A. Bertelsen
Author: Matt Carter
Author: Wim E. Crusio
Author: Simon G Sprecher
Author: Larry Squire