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Author: Andrés Aguilera Publisher: Springer Science & Business Media ISBN: 3540710213 Category : Science Languages : en Pages : 536
Book Description
This work offers a fascinating insight into a crucial genetic process. Recombination is, quite simply, one of the most important topics in contemporary biology. This book is a totally comprehensive treatment of the subject, summarizing all existing views on the topic and at the same time putting them into context. It provides in-depth and up-to-date analysis of the chapter topics, and has been written by international experts in the field.
Author: Andrés Aguilera Publisher: Springer Science & Business Media ISBN: 3540710213 Category : Science Languages : en Pages : 536
Book Description
This work offers a fascinating insight into a crucial genetic process. Recombination is, quite simply, one of the most important topics in contemporary biology. This book is a totally comprehensive treatment of the subject, summarizing all existing views on the topic and at the same time putting them into context. It provides in-depth and up-to-date analysis of the chapter topics, and has been written by international experts in the field.
Author: Alan S. Waldman Publisher: Springer Science & Business Media ISBN: 1592597610 Category : Science Languages : en Pages : 259
Book Description
Genetic recombination, in the broadest sense, can be defined as any process in which DNA sequences interact and undergo a transfer of information, producing new “recombinant” sequences that contain information from each of the original molecules. All organisms have the ability to carry out recombination, and this striking universality speaks to the essential role recombination plays in a variety of biological processes fundamentally important to the maintenance of life. Such processes include DNA repair, regulation of gene expression, disease etiology, meiotic chromosome segregation, and evolution. One important aspect of recombination is that it typically occurs only between sequences that display a high degree of sequence identity. The stringent requirement for homology helps to ensure that, under normal circumstances, a cell is protected from deleterious rearrangements since a swap of genetic information between two nearly identical sequences is not expected to dramatically alter a genome. Recombination between dissimilar sequences, which does happen on occasion, may have such harmful consequences as chromosomal translocations, deletions, or inversions. For many organisms, it is also important that recombination rates are not too high lest the genome become destabilized. Curiously, certain organisms, such as the trypanosome parasite, actually use a high rate of recombination at a particular locus in order to switch antigen expression continually and evade the host immune system effectively.
Author: K Low Publisher: Elsevier ISBN: 0323147275 Category : Science Languages : en Pages : 517
Book Description
The Recombination of Genetic Material aims to introduce the elementary properties of recombinational phenomena. Genetic recombination is a favorite research topic in biology due to its significance. In fact, a simple recombination event can have a profound effect and sometimes can mean the difference between the survival and the demise of an organism. Examples of this are provided in this book. This work also describes numerous recombination systems, mechanisms of the major types of recombination, and the macroscopic products of this biological process. Molecular analyses of recombination enzymes and substrates that have been identified or implicated are also shown. This book will be valuable as a reference material to those interested in this field of study.
Author: Lynn Margulis Publisher: Yale University Press ISBN: 9780300046199 Category : Science Languages : en Pages : 282
Book Description
A fascinating and detailed examination of the evolution--and occasional devolution--of sexuality in microorganisms and more complex forms of life. Margulis and Sagan trace sex from its inauspicious beginnings in bacteria threatened by ultraviolet radiation to its intimate relation with the origin of mitotic division of nucleated cells. The origin of meiotic sex through cannibalism followed by centriole reproductive tardiness and the connection of cell symbiosis to sex and differentiation are explored. "The authors have not only given us a new and exiting scenario for the evolution of sex, but have also provided us with critical ways in which we can test their hypotheses. . . . This is a stimulating book that is sure to invoke criticism and discussion; I strongly recommend it."--Symbiosis "The book is well organized and well written, leading the reader from one thought to another almost effortlessly. Background information is presented to aid those of us who are not experts in this field, and a glossary is appended. The book could be used at all levels of study, from interested undergraduates in general biology though postdoctoral students of genetics and evolution. I recommend this thought-provoking book to you for both your enjoyment and your enlightenment."--Richard W. Cheney, Jr., Journal of College Science Teaching "This book, undoubtedly controversial, is a thoughtful and original contribution to an important aspect of cellular biology."--John Langridge
Author: Gajanan V. Sherbet Publisher: Elsevier ISBN: 0080521908 Category : Science Languages : en Pages : 261
Book Description
Genetic recombination is a process of combining genes that leads to the generation of cell variants that possess different characteristics. This process is important to the evolution of a species and to embryonic growth and differentiation. However, this process can also lead to the development of abnormal, cancerous cells. This book reviews the role of genetic recombination in the generation of various cancers and how genetic alterations have been or could be employed to elicit clinically useful information. * Provides detailed discussion of the genetic mechanisms that result in the generation of normal and abnormal cells* Examines the role of genetic recombination in cancer including cancer invasion and metastasis* Information is presented in a manner that is useful and accessible to everyone from graduate students to established cancer researchers
Author: Bruce Alberts Publisher: Elsevier ISBN: 032314179X Category : Science Languages : en Pages : 1034
Book Description
Mechanistic Studies of DNA Replication and Genetic Recombination emerged from a symposium on DNA replication and genetic recombination held from March 16-21, 1980 in Keystone, Colorado. The event featured 30 plenary session talks, 13 workshop discussion groups, and the 210 poster sessions. The studies described in this book are paving the way for the elucidation of other basic genetic mechanisms, including ""new"" areas in molecular genetics such as those of eukaryotic gene expression and the transposition of mobile genetic elements. This book is divided into 10 parts: summaries of workshop discussion groups (Part I); studies on eukaryotic model systems for DNA replication (Part II); studies on bacterial replication origins (Part III); studies on replication origins of bacterial phages and plasmids (Part IV); studies on eukaryotic replication origins (Part V); studies on prokaryotic replication enzymology (Part VI); studies on eukaryotic replication enzymology (Part VII); studies on the fidelity of DNA replication (Part VIII); studies on DNA topoisomerases (Part IX); and studies of genetic recombination mechanisms (Part X).
Author: Harold L. K. Whitehouse Publisher: ISBN: Category : Science Languages : en Pages : 444
Book Description
A comprehensive survey of important research into genetic recombination, including consideration of bacteria and their viruses as well as fungi and other higher organisms. Discusses current theories of mechanisms of recombination and examines non-homologous recombination, which differs fundamentally from the ``normal'' mechanism in not requiring correspondence of nucleotide sequence. Includes a glossary of technical terms.
Author: Publisher: Academic Press ISBN: 0128144300 Category : Science Languages : en Pages : 610
Book Description
Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination, Volume 600, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Homologous genetic recombination remains the most enigmatic process in DNA metabolism. The molecular machines of recombination preserve the integrity of the genetic material in all organisms and generate genetic diversity in evolution. The same molecular machines that support genetic integrity by orchestrating accurate repair of the most deleterious DNA lesions, however, also promote survival of cancerous cells and emergence of radiation and chemotherapy resistance. This two-volume set offers a comprehensive set of cutting edge methods to study various aspects of homologous recombination and cellular processes that utilize the enzymatic machinery of recombination The chapters are written by the leading researches and cover a broad range of topics from the basic molecular mechanisms of recombinational proteins and enzymes to emerging cellular techniques and drug discovery efforts. Contributions by the leading experts in the field of DNA repair, recombination, replication and genome stability Documents cutting edge methods
Author: Andrés Aguilera
Author: Andrés Aguilera
Author: Bruce Alberts
Author: Alan S. Waldman
Author: K Low
Author: Raju Kucherlapati
Author: Lynn Margulis
Author: Gajanan V. Sherbet
Author: Bruce Alberts
Author: Harold L. K. Whitehouse
Author: