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Author: Melinda C. Mills Publisher: MIT Press ISBN: 0262357445 Category : Science Languages : en Pages : 433
Book Description
A comprehensive introduction to modern applied statistical genetic data analysis, accessible to those without a background in molecular biology or genetics. Human genetic research is now relevant beyond biology, epidemiology, and the medical sciences, with applications in such fields as psychology, psychiatry, statistics, demography, sociology, and economics. With advances in computing power, the availability of data, and new techniques, it is now possible to integrate large-scale molecular genetic information into research across a broad range of topics. This book offers the first comprehensive introduction to modern applied statistical genetic data analysis that covers theory, data preparation, and analysis of molecular genetic data, with hands-on computer exercises. It is accessible to students and researchers in any empirically oriented medical, biological, or social science discipline; a background in molecular biology or genetics is not required. The book first provides foundations for statistical genetic data analysis, including a survey of fundamental concepts, primers on statistics and human evolution, and an introduction to polygenic scores. It then covers the practicalities of working with genetic data, discussing such topics as analytical challenges and data management. Finally, the book presents applications and advanced topics, including polygenic score and gene-environment interaction applications, Mendelian Randomization and instrumental variables, and ethical issues. The software and data used in the book are freely available and can be found on the book's website.
Author: Melinda C. Mills Publisher: MIT Press ISBN: 0262357445 Category : Science Languages : en Pages : 433
Book Description
A comprehensive introduction to modern applied statistical genetic data analysis, accessible to those without a background in molecular biology or genetics. Human genetic research is now relevant beyond biology, epidemiology, and the medical sciences, with applications in such fields as psychology, psychiatry, statistics, demography, sociology, and economics. With advances in computing power, the availability of data, and new techniques, it is now possible to integrate large-scale molecular genetic information into research across a broad range of topics. This book offers the first comprehensive introduction to modern applied statistical genetic data analysis that covers theory, data preparation, and analysis of molecular genetic data, with hands-on computer exercises. It is accessible to students and researchers in any empirically oriented medical, biological, or social science discipline; a background in molecular biology or genetics is not required. The book first provides foundations for statistical genetic data analysis, including a survey of fundamental concepts, primers on statistics and human evolution, and an introduction to polygenic scores. It then covers the practicalities of working with genetic data, discussing such topics as analytical challenges and data management. Finally, the book presents applications and advanced topics, including polygenic score and gene-environment interaction applications, Mendelian Randomization and instrumental variables, and ethical issues. The software and data used in the book are freely available and can be found on the book's website.
Author: Philip Mark Meneely Publisher: Oxford University Press ISBN: 0199681260 Category : Medical Languages : en Pages : 580
Book Description
With its unique integration of genetics and molecular biology, this text probes fascinating questions that explore how our understanding of key genetic phenomena can be used to understand biological systems. Opening with a brief overview of key genetic principles, model organisms, and epigenetics, the book goes on to explore the use of gene mutations, the analysis of gene expression and activity, a discussion of the genetic structure of natural populations, and more.
Author: Kenneth Lange Publisher: Springer Science & Business Media ISBN: 0387217509 Category : Medical Languages : en Pages : 376
Book Description
Written to equip students in the mathematical siences to understand and model the epidemiological and experimental data encountered in genetics research. This second edition expands the original edition by over 100 pages and includes new material. Sprinkled throughout the chapters are many new problems.
Author: Sheldon Krimsky Publisher: Harvard University Press ISBN: 0674071093 Category : Science Languages : en Pages : 314
Book Description
Can genes determine which fifty-year-old will succumb to Alzheimer’s, which citizen will turn out on voting day, and which child will be marked for a life of crime? Yes, according to the Internet, a few scientific studies, and some in the biotechnology industry who should know better. Sheldon Krimsky and Jeremy Gruber gather a team of genetic experts to argue that treating genes as the holy grail of our physical being is a patently unscientific endeavor. Genetic Explanations urges us to replace our faith in genetic determinism with scientific knowledge about how DNA actually contributes to human development. The concept of the gene has been steadily revised since Watson and Crick discovered the structure of the DNA molecule in 1953. No longer viewed by scientists as the cell’s fixed set of master molecules, genes and DNA are seen as a dynamic script that is ad-libbed at each stage of development. Rather than an autonomous predictor of disease, the DNA we inherit interacts continuously with the environment and functions differently as we age. What our parents hand down to us is just the beginning. Emphasizing relatively new understandings of genetic plasticity and epigenetic inheritance, the authors put into a broad developmental context the role genes are known to play in disease, behavior, evolution, and cognition. Rather than dismissing genetic reductionism out of hand, Krimsky and Gruber ask why it persists despite opposing scientific evidence, how it influences attitudes about human behavior, and how it figures in the politics of research funding.
Author: Fikret Isik Publisher: Springer ISBN: 3319551779 Category : Science Languages : en Pages : 409
Book Description
This book fills the gap between textbooks of quantitative genetic theory, and software manuals that provide details on analytical methods but little context or perspective on which methods may be most appropriate for a particular application. Accordingly this book is composed of two sections. The first section (Chapters 1 to 8) covers topics of classical phenotypic data analysis for prediction of breeding values in animal and plant breeding programs. In the second section (Chapters 9 to 13) we provide the concept and overall review of available tools for using DNA markers for predictions of genetic merits in breeding populations. With advances in DNA sequencing technologies, genomic data, especially single nucleotide polymorphism (SNP) markers, have become available for animal and plant breeding programs in recent years. Analysis of DNA markers for prediction of genetic merit is a relatively new and active research area. The algorithms and software to implement these algorithms are changing rapidly. This section represents state-of-the-art knowledge on the tools and technologies available for genetic analysis of plants and animals. However, readers should be aware that the methods or statistical packages covered here may not be available or they might be out of date in a few years. Ultimately the book is intended for professional breeders interested in utilizing these tools and approaches in their breeding programs. Lastly, we anticipate the usage of this volume for advanced level graduate courses in agricultural and breeding courses.
Author: Institute of Medicine Publisher: National Academies Press ISBN: 0309047986 Category : Medical Languages : en Pages : 353
Book Description
Raising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.
Author: Raphael Falk Publisher: Cambridge University Press ISBN: 0521884187 Category : Philosophy Languages : en Pages : 331
Book Description
There is a paradox lying at the heart of the study of heredity. To understand the ways in which features are passed on down from one generation to the next, we have to dig deeper and deeper into the ultimate nature of things - from organisms, to genes, to molecules. And yet as we do this, increasingly we find we are out of focus with our subjects. What has any of this to do with the living, breathing organisms with which we started? Organisms are living. Molecules are not. How do we relate one to the other? In Genetic Analysis, one of the most important empirical scientists in the field in the twentieth century attempts, through a study of history and drawing on his own vast experience as a practitioner, to face this paradox head-on. His book offers a deep and innovative understanding of our ways of thinking about heredity.
Author: James N. Thompson, Jr Publisher: Cambridge University Press ISBN: 1139465643 Category : Science Languages : en Pages : 488
Book Description
An invaluable student-tested study aid, this primer, first published in 2007, provides guided instruction for the analysis and interpretation of genetic principles and practice in problem solving. Each section is introduced with a summary of useful hints for problem solving and an overview of the topic with key terms. A series of problems, generally progressing from simple to more complex, then allows students to test their understanding of the material. Each question and answer is accompanied by detailed explanation. This third edition includes additional problems in basic areas that often challenge students, extended coverage in molecular biology and development, an expanded glossary of terms, and updated historical landmarks. Students at all levels, from beginning biologists and premedical students to graduates seeking a review of basic genetics, will find this book a valuable aid. It will complement the formal presentation in any genetics textbook or stand alone as a self-paced review manual.
Author: R. Scott Hawley Publisher: John Wiley & Sons ISBN: 1444313088 Category : Science Languages : en Pages : 256
Book Description
Advanced Genetic Analysis brings a state-of-the-art,exciting new approach to genetic analysis. Focusing on theunderlying principles of modern genetic analysis, this bookprovides the 'how' and 'why' of the essential analytical toolsneeded. The author's vibrant, accessible style provides an easyguide to difficult genetic concepts, from mutation and genefunction to gene mapping and chromosome segregation. Throughout, abalanced range of model organisms and timely examples are used toillustrate the theoretical basics. Basic principles - Focuses students attention on the 'how' and'why' of the essential analytical tools. Vibrant, accessible style provides an easy guide throughdifficult genetic concepts and techniques. Text boxes highlight key questions and timely examples. Boxes of key information in each chapter, chapter summaries andextensive references - prompt the student to synthesise andreinforce the chapter material. Special reference section addressing a range of model organismsto help provide a particularly relevant context for students'research interests.
Author: National Research Council Publisher: National Academies Press ISBN: 0309165865 Category : Social Science Languages : en Pages : 184
Book Description
As the population of older Americans grows, it is becoming more racially and ethnically diverse. Differences in health by racial and ethnic status could be increasingly consequential for health policy and programs. Such differences are not simply a matter of education or ability to pay for health care. For instance, Asian Americans and Hispanics appear to be in better health, on a number of indicators, than White Americans, despite, on average, lower socioeconomic status. The reasons are complex, including possible roles for such factors as selective migration, risk behaviors, exposure to various stressors, patient attitudes, and geographic variation in health care. This volume, produced by a multidisciplinary panel, considers such possible explanations for racial and ethnic health differentials within an integrated framework. It provides a concise summary of available research and lays out a research agenda to address the many uncertainties in current knowledge. It recommends, for instance, looking at health differentials across the life course and deciphering the links between factors presumably producing differentials and biopsychosocial mechanisms that lead to impaired health.
Author: Melinda C. Mills
Author: Melinda C. Mills
Author: Philip Mark Meneely
Author: Kenneth Lange
Author: Sheldon Krimsky
Author: Fikret Isik
Author: Institute of Medicine
Author: Raphael Falk
Author: James N. Thompson, Jr
Author: R. Scott Hawley
Author: National Research Council