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Author: Santiago Rodríguez Publisher: Nova Science Publishers ISBN: 9781606921685 Category : Metabolic syndrome Languages : en Pages : 0
Book Description
Cardiovascular disease and mortality risk are significantly increased in people with metabolic syndrome, a cluster of interrelated metabolic disorders including obesity, insulin resistance, glucose intolerance, dyslipidemia and hypertension. A complex interplay between predisposing and protective factors ultimately determines whether an individual will develop this set of disorders or not. Genetic factors are one of the significant contributors that predispose to, or protect against, each component of the metabolic syndrome. As in other complex diseases and traits, such genetic factors are likely to be multiple and interacting, with individual polymorphisms producing only a moderate effect. The identification of genetic variants influencing the metabolic syndrome is of great importance to understanding pathogenesis, identifying groups of individuals with different relative risk, and developing or improving therapies against this cluster of metabolic disorders. This has greatly stimulated both theoretical and applied genetic research in recent years. A range of new analytical tools has been developed for the dissection of complex traits. Applied genetic analyses have identified large numbers of candidate markers and chromosomal regions (over 600 for obesity, which represents only one of the disorders of this cluster). In this chapter, the authors present a basic overview of the genetic approaches currently used for the identification of candidate genetic factors involved in the metabolic syndrome. The authors also summarise current evidence suggesting that genetic variants within elements of the endocrine system are directly involved in the risk of the metabolic syndrome. The authors focused their attention on endocrine pathways for which candidate genetic variants have been identified, and they introduced the foundations of a new hypothesis which postulates the involvement of a network of endocrine genetic setpoints as a combined contributor to the risk of the metabolic syndrome.
Author: Santiago Rodríguez Publisher: Nova Science Publishers ISBN: 9781606921685 Category : Metabolic syndrome Languages : en Pages : 0
Book Description
Cardiovascular disease and mortality risk are significantly increased in people with metabolic syndrome, a cluster of interrelated metabolic disorders including obesity, insulin resistance, glucose intolerance, dyslipidemia and hypertension. A complex interplay between predisposing and protective factors ultimately determines whether an individual will develop this set of disorders or not. Genetic factors are one of the significant contributors that predispose to, or protect against, each component of the metabolic syndrome. As in other complex diseases and traits, such genetic factors are likely to be multiple and interacting, with individual polymorphisms producing only a moderate effect. The identification of genetic variants influencing the metabolic syndrome is of great importance to understanding pathogenesis, identifying groups of individuals with different relative risk, and developing or improving therapies against this cluster of metabolic disorders. This has greatly stimulated both theoretical and applied genetic research in recent years. A range of new analytical tools has been developed for the dissection of complex traits. Applied genetic analyses have identified large numbers of candidate markers and chromosomal regions (over 600 for obesity, which represents only one of the disorders of this cluster). In this chapter, the authors present a basic overview of the genetic approaches currently used for the identification of candidate genetic factors involved in the metabolic syndrome. The authors also summarise current evidence suggesting that genetic variants within elements of the endocrine system are directly involved in the risk of the metabolic syndrome. The authors focused their attention on endocrine pathways for which candidate genetic variants have been identified, and they introduced the foundations of a new hypothesis which postulates the involvement of a network of endocrine genetic setpoints as a combined contributor to the risk of the metabolic syndrome.
Author: Jose A. Gutiérrez Fuentes Publisher: Elsevier España ISBN: 8480867809 Category : Medical Languages : en Pages : 676
Book Description
El síndrome metabólico es uno de los retos más intrigantes y fascinantes de la medicina contemporánea. Se trata de una patología en la que confluyen problemas de distintas áreas de la medicina: diferentes grados de hipertensión, acumulación de grasa, insulinoresistencia, estados protrombótico y proinflamatorio, todos juntos en la misma persona. Esta concurrencia de factores hace que la persona tenga un riesgo mucho mayor de sufrir enfermedad cardiovascular o diabetes mellitus tipo 2, que lo que la suma de los factores individuales supondría. Se trata de una "enfermedad" nueva, que ha llegado a ser un problema de salud pública muy importante en las sociedades desarrolladas y cuya rápida extensión se debe fundamentalmente a la adopción del estilo de vida occidental: fundamentalmente, muy poca actividad física e ingesta excesiva de alimentos. Esta obra trata el concepto del Síndrome metabólico en su más amplio sentido y da respuesta a la multitud de incógnitas que todavía presenta esta patología. Con un enfoque multidisciplinar y un equipo de colaboradores internacionales (España, Italia, Japón, Alemania, Estados Unidos, Reino Unido, Finlandia, Australia, etc.) de primer nivel en las distintas áreas, escrita íntegramente en inglés, revisa todos los aspectos relacionados con el Síndrome metabólico, desde el punto de vista de la fisiopatología molecular y la epidemiología genética: obesidad, insulinoresistencia, dislipidemias, hipertensión, enfermedad cardiovascular y otros nuevos como inflamación molecular, estado protrombótico, disfunción endotelial... Todos los capítulos presentan un abstract, en inglés y castellano, al inicio de cada capítulo con los puntos fundamentales que se van a desarrollar en ese capítulo. Esta obra trata el concepto del síndrome metabólico en su más amplio sentido y da respuesta a la multitud de incógnitas que todavía presenta esta patología. Se trata de una "enfermedad" nueva, que ha llegado a ser un problema de salud pública muy importante en las sociedades desarrolladas y cuya rápida extensión se debe fundamentalmente a la adopción del estilo de vida occidental. Todos los capítulos presentan un abstract, en inglés y castellano, al inicio de cada capítulo, con los puntos fundamentales que se van a desarrollar en ese capítulo.
Author: Gerald M. Reaven Publisher: Springer Science & Business Media ISBN: 1592597165 Category : Medical Languages : en Pages : 374
Book Description
Gerald Reaven, the discoverer of Syndrome X, and a panel of world-class investigators thoughtfully summarize our current understanding of how insulin resistance and its compensating hyperinsulinemia play a major role in the pathogenesis and clinical course of high blood pressure and cardiovascular disease-the so-called diseases of Western civilization. These distinguished authorities detail, for the first time, the pathophysiological consequences and the clinical syndromes, excluding Type 2 diabetes, related to insulin resistance. They also examine the genetic and lifestyle factors that contribute to the wide differences in insulin action that exist in the population at large. Timely and authoritative, Insulin Resistance: The Metabolic Syndrome X illuminates the full importance of insulin resistance as a major cause of hypertension, heart disease, and polycystic ovary syndrome.
Author: Christos S. Mantzoros Publisher: Springer Science & Business Media ISBN: 1603274537 Category : Medical Languages : en Pages : 427
Book Description
Nutrition and Metabolism: Underlying Mechanisms and Clinical Consequences brings together internationally recognized experts to comprehensively review our current understanding of how nutrition interacts with the genetic substrate as well as environmental-exogenous factors, including physical activity or the lack thereof, to result in insulin resistance and the metabolic syndrome. After presenting the scope of the problem, the first major part of the book is devoted to genetics and pathophysiology, the second part of the book presents the public health perspective of the most prevalent problems associated with nutrition and the metabolic syndrome, whereas the third major part of the book focuses on clinical assessment and management of the main disease states associated with inappropriate nutrition and the metabolic syndrome. Finally, general information useful for both clinicians and researchers alike is presented in the Appendix. Nutrition and Metabolism: Underlying Mechanisms and Clinical Consequences offers the reader an up-to-date and authoritative review of the major scientific and clinical aspects of the overlapping areas between nutrition and metabolism.
Author: Christopher D. Byrne Publisher: John Wiley & Sons ISBN: 1444347306 Category : Medical Languages : en Pages : 384
Book Description
The Metabolic Syndrome is a valuable reference text, covering all aspects of the metabolic syndrome and its constituent diseases including inflammation, oxidation and adipocytokines. This book explains the aetiology, pathogenesis and clinical treatment of all risk factors as well as the relationship with diabetes, non alcoholic fatty liver disease, polycystic ovary syndrome and coronary heart disease. The Metabolic Syndrome has been further improved from the 1st edition that was highly commended in 2006 Annual British Medical Association medical books competition. All chapters from the first edition are fully updated and this new edition contains an increase in international contributions and five new chapters on: Childhood obesity and metabolic syndrome Bariatric surgery for obesity Fitness Brain insulin resistance and appetite The nature of the insulin resistance seen in metabolic syndrome. This brand new edition of The Metabolic Syndrome will be an indispensable resource for all clinical researchers, physicians and scientists requiring detailed up-to-date information on the metabolic syndrome to further their own research or to treat and manage the syndrome and its complications. Specifically, the text will be of particular relevance to those involved and working in the fields of diabetes, endocrinology, obesity, cardiology, vascular disease and hepatology.
Author: Henning Beck-Nielsen Publisher: Springer Science & Business Media ISBN: 3709113318 Category : Medical Languages : en Pages : 236
Book Description
The metabolic syndrome is a common syndrome affecting about 20 % of the adult population in Europe, and probably the prevalence is of the same magnitude in other industrialised countries worldwide. It is mainly caused by western lifestyle resulting in abdominal obesity, but also a genetic predisposition plays a role. This syndrome, which is linked to leisure lifestyle and overeating/obesity, can develop into type 2 diabetes, cardiovascular disease and cancer. Therefore, proper treatment and prevention are heavily needed. This book discusses lifestyle intervention and treatment, specifically with pharmacological compounds, in order to formulate a strategy for treating the metabolic syndrome in the daily clinic.
Author: George A. Bray Publisher: Springer Science & Business Media ISBN: 0387321640 Category : Medical Languages : en Pages : 347
Book Description
This timely book provides an overview of topics related to obesity. These include associated health risks, childhood obesity, genetics, evaluation, treatment, behavioral strategies, and successes and failures in preventing obesity. The volume covers evaluation guidelines, different approaches to treatment, including diet, exercise, behavior, drugs, and surgery to deal with the current world-wide obesity epidemic.
Author: Roy E. Weiss Publisher: Academic Press ISBN: 0128011343 Category : Science Languages : en Pages : 462
Book Description
Genetic Diagnosis of Endocrine Disorders, Second Edition provides users with a comprehensive reference that is organized by endocrine grouping (i.e., thyroid, pancreas, parathyroid, pituitary, adrenal, and reproductive and bone), discussing the genetic and molecular basis for the diagnosis of various disorders. The book emphasizes the practical nature of diagnosing a disease, including which tests should be done for the diagnosis of diabetes mellitus in adults and children, which genes should be evaluated for subjects with congenital hypothyroidism, which genetic tests should be ordered in obese patients or for those with parathyroid carcinoma, and the rationale behind testing for multiple endocrine neoplasias. - Offers a clear presentations of pharmacogenetics and the actual assays used in detecting endocrine diseases - Teaches the essentials of the genetic basis of disease in each major endocrine organ system - Offers expert advice from genetic counselors on how to use genetic information in counseling patients - Includes new chapters on the genetics of lipid disorders and glycogen storage diseases, genetics of hypoglycemia, and whole genome/exome sequencing
Author: Juerg Hodler Publisher: Springer Nature ISBN: 3030712818 Category : Musculoskeletal system Languages : en Pages : 293
Book Description
This open access book focuses on imaging of the musculoskeletal diseases. Over the last few years, there have been considerable advances in this area, driven by clinical as well as technological developments. The authors are all internationally renowned experts in their field. They are also excellent teachers, and provide didactically outstanding chapters. The book is disease-oriented and covers all relevant imaging modalities, with particular emphasis on magnetic resonance imaging. Important aspects of pediatric imaging are also included. IDKD books are completely re-written every four years. As a result, they offer a comprehensive review of the state of the art in imaging. The book is clearly structured with learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers easily navigate through the text. As an IDKD book, it is particularly valuable for general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic knowledge, and for clinicians interested in imaging as it relates to their specialty.
Author: Barbara C. Hansen Publisher: Springer Science & Business Media ISBN: 1603271163 Category : Medical Languages : en Pages : 408
Book Description
This book covers the most important clinical and bench science aspects of metabolic syndrome. It will be of value to all of those seeking a comprehensive update on the metabolic syndrome. Furthermore, it will provide a broad basis for advancing research in the multiple intersecting disciplines encompassed by the metabolic syndrome.
Author: Santiago Rodríguez
Author: Santiago Rodríguez
Author: Jose A. Gutiérrez Fuentes
Author: Gerald M. Reaven
Author: Christos S. Mantzoros
Author: Christopher D. Byrne
Author: Henning Beck-Nielsen
Author: George A. Bray
Author: Roy E. Weiss
Author: Juerg Hodler
Author: Barbara C. Hansen