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Author: Ariela Benigni Publisher: Karger Medical and Scientific Publishers ISBN: 3805585055 Category : Medical Languages : en Pages : 177
Book Description
Initially conceived as a strategy to remedy inherited genetic disorders, gene therapy has been successfully applied in the last decade to ameliorate the renal function compromised by progressive renal diseases and to prevent kidney allograft rejection in experimental animals. In the present book, world-renowned experts are presenting new insights into viral and non-viral systems used to effect gene delivery, one chapter being dedicated to the new field of RNA interference (RNAi). This latter method may be successfully used in renal ischemia-reperfusion injury, trauma and transplantation. In the near future, gene therapy might also prove to be a new strategy to target molecules involved in tissue damage and inflammation processes that underlie ARF. So far, gene transfer has been successfully applied in experimental glomerulonephritis and interstitial fibrosis, and studies in larger animals are keenly awaited. Also covered are issues related to transplantation, which is the therapy of choice in many end-stage organ failures. Transfer of genes whose protein products have immunomodulatory properties have proven beneficial in treating acute and chronic graft rejection, one of the problems not satisfactorily solved by current anti-rejection drugs. Gene therapy thus may become a reality in clinical transplantation once its efficacy in larger animals has been demonstrated. Last but not least, a possible benefit of targeted gene therapy in renal cancer or HIV-associated nephropathy is explored. Covering a wide spectrum of topics, this publication provides a valuable overview of current developments and issues.
Author: Ariela Benigni Publisher: Karger Medical and Scientific Publishers ISBN: 3805585055 Category : Medical Languages : en Pages : 177
Book Description
Initially conceived as a strategy to remedy inherited genetic disorders, gene therapy has been successfully applied in the last decade to ameliorate the renal function compromised by progressive renal diseases and to prevent kidney allograft rejection in experimental animals. In the present book, world-renowned experts are presenting new insights into viral and non-viral systems used to effect gene delivery, one chapter being dedicated to the new field of RNA interference (RNAi). This latter method may be successfully used in renal ischemia-reperfusion injury, trauma and transplantation. In the near future, gene therapy might also prove to be a new strategy to target molecules involved in tissue damage and inflammation processes that underlie ARF. So far, gene transfer has been successfully applied in experimental glomerulonephritis and interstitial fibrosis, and studies in larger animals are keenly awaited. Also covered are issues related to transplantation, which is the therapy of choice in many end-stage organ failures. Transfer of genes whose protein products have immunomodulatory properties have proven beneficial in treating acute and chronic graft rejection, one of the problems not satisfactorily solved by current anti-rejection drugs. Gene therapy thus may become a reality in clinical transplantation once its efficacy in larger animals has been demonstrated. Last but not least, a possible benefit of targeted gene therapy in renal cancer or HIV-associated nephropathy is explored. Covering a wide spectrum of topics, this publication provides a valuable overview of current developments and issues.
Author: Giuseppe Remuzzi Publisher: Springer Science & Business Media ISBN: 9401010056 Category : Medical Languages : en Pages : 385
Book Description
This title provides a comprehensive and state-of-the-art summary of current and future immunosuppressive strategies in transplantation, with emphasis on the basic science mechanisms and clinical applicability of these strategies. The uniqueness of this book is the inclusion of up-to-date information on the basic mechanisms of actions of the immunosuppressive drugs as well as a summary of the clinical trials data and the potential use of these drugs in clinical organ transplantation. In addition to describing the various immunosuppressive strategies, the book has three special features, including immunosuppression in xenotransplantation, gene therapy approaches, and transplantation tolerance. A group of outstanding investigators have been assembled to write the chapters. The book is intended for the transplant professional and the specialist who wants to stay abreast of the current status of immunosuppression in organ transplantation. The book is also useful for basic scientists who work in the field of transplantation immunology.
Author: Eli A. Friedman Publisher: World Scientific ISBN: 9814280038 Category : Medical Languages : en Pages : 202
Book Description
Introduction and options in therapy / Eli A. Friedman -- ch. 1. Peritoneal dialysis : past and current practices / Mary C. Mallappallil -- ch. 2. Hemodialysis / Yalemzewd Woredekal -- ch. 3. Kidney transplantation / Fasika Tedla -- ch. 4. Home hemodialysis : present and future therapies / Barbara G. Delano -- ch. 5. Hemofiltration / Halim S. Ghali -- ch. 6. Self-care in-center hemodialysis / Susan H. Bray -- ch. 7. Opting for death rather than dialysis in chronic renal failure / Anthony J. Joseph -- ch. 8. Ethical concerns in marketing kidneys / Amy L. Friedman -- ch. 9. The wearable artificial kidney : a new paradigm in the treatment of ESRD / Victor Gura -- ch. 10. Xenotransplantation / Moro O. Salifu, Syed Shah and Subodh Saggi -- ch. 11. Can the bowel serve as a kidney? / Eli A. Friedman
Author: Frances Flinter Publisher: ISBN: Category : Medical Languages : en Pages : 600
Book Description
Renal genetic disorders may become apparent at any time in life and recognition of specific renal disorders is important in allowing accurate genetic counselling. Active counselling requires knowledge about the natural history of the disorder, an understanding of the genetic component and mode of inheritance, risk of the disorder in other family members, information about patient attitudes towards family planning and the possibility of pre-natal diagnosis. The Genetics of Renal Disease covers these issues in detail. The book provides a comprehensive account of both the hereditary nephropathies and more generalised disorders which may affect the renal tract. It includes comprehensive guidelines from an international group of authors on renal function and development, choromosomal disorders, dysmorphic syndromes, inherited predisposition to kidney cancer and gene therapy for renal cancer. Specific chapters deal with individual renal tract disorders such as an extensive discussion of Alport's disease, cystic renal diseases, the Bardet-Biedl and Alstrom syndromes. Each section gives a brief description of the clinical and pathological features of a particular disorder, followed by a review of the genetics of the disorder including incidence, inheritance of familial occurrence, genetic linkage and gene assignment, and prenatal diagnosis and carrier detection. Original studies are extensively quoted and are referenced at the end of each section. There are a great many dysmorphic syndromes which involve the urinary tract. These are incorporated within the book. Aimed primarily at clinical and medical geneticists, this book will also appeal to researchers into genetic kidney disease and genetic counsellors as well as nephrologists with an interest in this area.
Author: Geraldo Bezerra da Silva Junior Publisher: Springer Nature ISBN: 3031115708 Category : Medical Languages : en Pages : 538
Book Description
Our world is facing unprecedented technological development, which affects all the sectors of society. The 4th industrial revolution has brought numerous advances that are currently integrated in our daily life, including artificial intelligence (A.I.), internet of things (IoT), genetic engineering, 3D-printing and robotics. The health care sector is one of the most impacted by these technologies of the so-called digital era. From the simple advent of medical records to robotic surgery, health care has significantly changed from the XX to XXI century and is constantly changing, incorporating novel technologies. Nephrology is itself an innovative branch of medicine, created as a discipline in the 1960s, with breakthrough inventions, such as the dialysis machine, which made it possible to prolong life of those who suffer from chronic kidney disease; kidney transplant, with point-of-care immunosuppression that favours maintenance of kidney allografts for long years; kidney biopsy, which made it possible to discover the mysteries of glomerulonephritis and nephropathology. Novel technologies, such as A.I., IoT, robotics, stem cells, 3D-printing, mHealth, eHealth and several others are starting to be applied in nephrology, with promising results. It is possible that a great part of these technologies will become routinely available in clinical practice, and the burden of kidney diseases will significantly decrease once prevention, prediction, detection, monitoring and treatment of kidney diseases are more precise, with patients taking part in the process and becoming more and more connected. This book gathers essential information on the technologies that have been applied in nephrology and that can be applied in the future, with real possibilities of improving the care of kidney diseases. At first glance, this work is directed to the entire nephrology community and all the healthcare professionals that deal with kidney diseases. Researchers from different fields, not directly linked to nephrology, may also be interested in the book since many of the topics presented are related to other areas and serve as examples of their uses in medicine, such as artificial intelligence, robotics, and big data. Finally, the content provides an important resource to medical students, discussing technologies that will certainly be integrated in their professional practice.
Author: P. Cochat Publisher: Springer Science & Business Media ISBN: 9780792364207 Category : Medical Languages : en Pages : 264
Book Description
This text, the proceedings of the 32nd International Conference on Transplantation and Clinical Immunology, held in Lyon, France, on May 25-26, 2000, addresses novel issues in terms of changing indications for transplantation in the management of organ failure, whether humans will remain the only source for organ procurement, prospects for engineering in organ replacement, and whether transplantation will remain the most appropriate approach to organ failure. Some promising treatments are approached, such as enzymic and biochemical replacement, gene therapy, tolerance induction, stem cell transplantation, and xenotransplantation.
Author: Birru Bhaskar Publisher: Springer Nature ISBN: 9811600023 Category : Medical Languages : en Pages : 587
Book Description
This book comprehensively explores the basic concepts and applications of biomaterials in tissue engineering and regenerative medicine. The book is divided into four sections; the first section deals with the basic concepts and different types of biomaterials used in tissue engineering. The second section discusses the functional requirements and types of materials that are used in developing state-of-the-art of scaffolds for tissue engineering applications. The third section presents the applications of biomaterials for hard and soft tissue engineering, as well as for specialized tissue engineering. The last section addresses the future prospects of nanobiomaterials, intelligent biomaterials, and 3D bioprinting biomaterials in tissue engineering and regenerative medicine. It also discusses various in vitro disease models for tissue bioengineering and regenerative medicine. As such, it offers a valuable resource for students, researchers, scientists, entrepreneurs, and medical/healthcare professionals.
Author: Peter J. Morris Publisher: W.B. Saunders Company ISBN: Category : Medical Languages : en Pages : 614
Book Description
This fifth edition of KIDNEY TRANSPLANTATION remains the most comprehensive and definitive text on all aspects of renal transplantation as well as the psychological and ethical issues involved. Almost every chapter has been revised or rewritten by new authors, to incorporate the most essential and up-to-date information.
Author: Ariela Benigni
Author: Ariela Benigni
Author: Giuseppe Remuzzi
Author: Eli A. Friedman
Author: Frances Flinter
Author: Maria Sandovici
Author: Geraldo Bezerra da Silva Junior
Author: P. Cochat
Author: Birru Bhaskar
Author: Martin Erlichman
Author: Peter J. Morris