Author: Lena SamuelssonPublisher:
ISBN:
Category : Adipose tissues
Languages : en
Pages : 86
Book Description
Gene Regulation During Adipocyte Differentiation
Author: Lena SamuelssonPublisher:
ISBN:
Category : Adipose tissues
Languages : en
Pages : 86
Book Description
Regulation of Adipocyte Fatty Acid Binding Protein (a-FABP) Gene Expression During the Early Events of Adipocyte Differentiation
Author: Philippe ThuillierPublisher:
ISBN:
Category : Cell differentiation
Languages : en
Pages : 380
Book Description
TCDD-mediated Inhibition of Adipocyte Differentiation
Author: Paul Robert HanlonLipid Signaling and Metabolism
Author: James M. NtambiPublisher: Academic Press
ISBN: 0128194057
Category : Science
Languages : en
Pages : 566
Book Description
Lipid Signaling and Metabolism provides foundational knowledge and methods to examine lipid metabolism and bioactive lipid signaling mediators that regulate a broad spectrum of biological processes and disease states. Here, world-renowned investigators offer a basic examination of general lipid, metabolism, intracellular lipid storage and utilization that is followed by an in-depth discussion of lipid signaling and metabolism across disease areas, including obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders. Throughout, authors demonstrate how expanding our understanding of lipid mediators in metabolism and signaling enables opportunities for novel therapeutics. Emphasis is placed on bioactive lipid metabolism and research that has been impacted by new technologies and their new potential to transform precision medicine. Provides a clear, up-to-date understanding of lipid signaling and metabolism and the impact of recent technologies critical to advancing new studies Empowers researchers to examine bioactive lipid signaling and metabolism, supporting translation to clinical care and precision medicine Discusses the role of lipid signaling and metabolism in obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders, among others
Adipose Tissue in Health and Disease
Author: Todd LeffPublisher: John Wiley & Sons
ISBN: 9783527629534
Category : Science
Languages : en
Pages : 530
Book Description
This timely and most comprehensive reference available on the topic covers all the different aspects vital in the fight against the global obesity epidemic. Following a look at adipose tissue development and morphology, the authors go on to examine its metabolic and endocrine functions and its role in disease. The final section deals with comparative and evolutionary aspects of the tissue. The result is an essential resource for cell and molecular biologists, physiologists, biochemists, pharmacologists, and those working in the pharmaceutical industry.
The Control of Apolipoprotein C-I Gene Expression During Adipocyte Differentiation
Author: Publisher:
ISBN: 9780542723919
Category : Apolipoproteins
Languages : en
Pages :
Book Description
Serial analysis of gene expression (SAGE) was used to generate global gene expression profiles of 3T3-L1 preadipocytes and adipocytes. Our primary interest was in late gene expression, specifically genes that encode secreted proteins, so that we may detect novel adipocyte genes that are related to energy balance and obesity. SAGE detected the expression of apolipoprotein C-1 (apoC-I) mRNA in 3T3-L1 adipocytes, but not preadipocytes. ApoC-1, the product of the Apoc1 gene, is a 6.6 kDa protein which is found in plasma associated with chylomicrons, very low-density lipoproteins (VLDLS), and high-density lipoproteins (HDLs). The function of apoC-I and the regulation of its production is not well understood, though studies have suggested that it may interfere with triglyceride-rich lipoprotein clearance, free fatty acid transport into peripheral tissues, and cholesterol ester transfer protein (CETP) activity (Jong, et al., 1999). To elucidate the SAGE findings, the expression of apoC-I was determined by quantitative PCR and ELISA. Apoc1 mRNA expression was shown to increase during late-phase adipocyte differentiation and positively correlate with lipid accumulation, suggesting that it may be regulated by cellular triglyceride or cholesterol content. (Abstract shortened by UMI.).
Handbook of Nutrition, Diet, and Epigenetics
Author: Vinood B. PatelPublisher: Springer
ISBN: 9783319555294
Category : Medical
Languages : en
Pages : 0
Book Description
This multivolume reference work addresses the fact that the well being of humankind is predicated not only on individuals receiving adequate nutrition but also on their genetic makeup. The work includes more than 100 chapters organized in the following major sections: Introduction and Overview; Epigenetics of Organs and Diseases in Relation to Diet and Nutrition; Detailed Processes in Epigenetics of Diet and Nutrition; Modulating Epigenetics with Diet and Nutrition; and Practical Techniques. While it is well known that genes may encode proteins responsible for structural and dynamic components, there is an increasing body of evidence to suggest that nutrition itself may alter the way in which genes are expressed via the process of epigenetics. This is where chemically imposed alteration in the DNA sequence occurs or where the functional expression of DNA is modulated. This may include changes in DNA methylation, non-coding RNA, chromatin, histone acetylation or methylation, and genomic imprinting. Knowledge regarding the number of dietary components that impact on epigenetic processes is increasing almost daily. Marshalling all the information on the complex relationships between diet, nutrition, and epigenetic processes is somewhat difficult due to the wide myriad of material. It is for this reason that the present work has been compiled.
The Roles of ENC-1 and Pref-1 During Adipocyte Differentiation
Author: Ling ZhaoAdipocyte Biology and Hormone Signaling
Author: James M. NtambiPublisher:
ISBN:
Category : Medical
Languages : en
Pages : 256
Book Description
This text emphasizes the molecular regulation of lipid biogenesis in the context of adipocyte metabolism, differentiation, gene expression, hormone and growth signaling. Many disciplines such as genetics, cell biology and biochemistry are merging to provide a more detailed understanding of the dyamnic role that the fat cell plays in metabolism, disease and signaling.
Adipogenesis
Author: Yunfeng LinPublisher: Nova Science Publishers
ISBN: 9781628087505
Category : Adipose tissues
Languages : en
Pages : 0
Book Description
Adipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. Adipogenesis has been one of the most intensively studied models of cellular differentiation. The exact mechanisms of adipogenesis remain unclear, since it involves abundant gene, growth factors, cytokines and environmental factors. This book provides an in-depth overview of current knowledge about the subject of adipogenesis in the human body, including what is known about molecular mechanisms (eg: cytokine- and growth-factor-related). Transcriptional regulators control the expression of target genes by the interaction with cofactors, coactivators, chromatin remodelling complexes and also with general transcriptional machinery. Current data suggests that adipogenesis is regulated by complex signalling pathway interactions involving multiple transcription factors. Many signaling pathways follow an inverse relationship between osteogenic and adipogenic differentiation. To provide better insight into the basic mechanisms of MSC fate determination, it is crucial to understand the various signalling pathways and cytokine interactions that co-ordinate this process. Further elucidation of this dichotomy may both improve understanding of human disease and speed the realisation of MSC mediated tissue engineering. There are a number of gaps in current knowledge of how adipogenesis actually occurs, and the authors are hopeful that the publication of this book will help researchers in this field to decide where to focus their future efforts. Contributions are therefore sought from anyone who is undertaking research in this area. The book will also provide an overview for surgeons and clinicians who wish to be kept abreast of developments in this fascinating subject.