Author: Jason Brant CarmelPublisher:
ISBN:
Category :
Languages : en
Pages : 332
Book Description
Gene Expression and Spinal Cord Injury
Author: Jason Brant CarmelInjury Responses in the Spinal Cord
Author: Catriona Helen HayThe Neuroscience of Spinal Cord Injury-
Author: Rajkumar RajendramPublisher: Academic Press
ISBN: 0323995764
Category : Medical
Languages : en
Pages : 1186
Book Description
Diagnosis and Treatment of Spinal Cord Injury will enhance readers’ understanding of the complexities of the diagnosis and management of spinal cord injuries. Featuring chapters on drug delivery, exercise, and rehabilitation, this volume discusses in detail the impact of the clinical features, diagnosis, management, and long-term prognosis of spinal cord injuries on the lives of those affected. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand spinal cord injuries. Spinal injury affects about 10 million people annually worldwide, impacting on the family unit and causing lifelong disabilities, with varied symptoms including paresthesia, spasticity, loss of motor control, and often severe pain. Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury will enhance readers’ understanding of the biological and psychological effects of spinal cord injury. Featuring chapters on gene expression, metabolic effects, and behavior, this volume discusses in detail the impact of spinal cord injury to better understand the underlying pathways and processes. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries. Diagnosis and Treatment of Spinal Cord Injury: Covers both the diagnosis and treatment of spinal cord injury Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding Features chapters on epidemiology and pain Includes MRI usage, biomarkers, and stem cell and gene therapy for management of spinal cord injury Discusses pain reduction, drug delivery, and rehabilitation Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury: Summarizes the neuroscience of spinal cord injury, including cellular and molecular biology Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding Features chapters on signaling and hormonal events Includes plasticity and gene expression Examines health and stress behaviors after spinal cord injury
Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury
Author: Rajkumar RajendramPublisher: Academic Press
ISBN: 0128224282
Category : Medical
Languages : en
Pages : 558
Book Description
Spinal injury affects about 10 million people annually worldwide, impacting on the family unit and causing lifelong disabilities, with varied symptoms including paresthesia, spasticity, loss of motor control, and often severe pain. Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury will enhance readers’ understanding of the biological and psychological effects of spinal cord injury. Featuring chapters on gene expression, metabolic effects, and behavior, this volume discusses in detail the impact of spinal cord injury to better understand the underlying pathways and processes. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries. Summarizes the neuroscience of spinal cord injury, including cellular and molecular biology Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding Features chapters on signaling and hormonal events Includes plasticity and gene expression Examines health and stress behaviors after spinal cord injury
Gene Expression Analysis of Neurotrophins, Trk Receptors, and Associated Regulatory Molecules After Contusive Spinal Cord Injury
Author: Matthew Tyler HouglandPublisher:
ISBN:
Category : Nerves
Languages : en
Pages : 111
Book Description
Traumatic spinal cord injury (SCI) results in changes to the anatomical, neurochemical, and physiological properties of cells in the central and peripheral nervous system. Neurotrophins, acting by binding to their cognate Trk receptors on target cell membranes, contribute to modulation of anatomical, neurochemical, and physiological properties of neurons in sensorimotor circuits in both the intact and injured spinal cord. Neurotrophin signaling is associated with many post-SCI changes including maladaptive plasticity leading to pain and autonomic dysreflexia, but also therapeutic approaches such as training-induced locomotor improvement. Here we characterize expression of mRNA for neurotrophins and Trk receptors in lumbar dorsal root ganglia (DRG) and spinal cord after two different severities of mid-thoracic injury and at 6 and 12 weeks post-SCI. There was complex regulation that differed with tissue, injury severity, and survival time, including reversals of regulation between 6 and 12 weeks, and the data suggest that natural regulation of neurotrophins in the spinal cord may continue for months after birth. Our assessments determined that a coordination of gene expression emerged at the 12 week post-SCI time point and bioinformatic analyses address possible mechanisms. Additionally, we sought to determine if the regulatory patterns we observed were perhaps due to an inflammatory molecule that mediated the coordinated expression pattern that we observed at 12 weeks post injury, and identified the chemokine CCL2 as a potential candidate gene.
Neurobiology of Spinal Cord Injury
Author: Robert G. KalbPublisher: Springer Science & Business Media
ISBN: 1592592007
Category : Medical
Languages : en
Pages : 293
Book Description
Distinguished researchers review the latest scientific understanding of spinal cord injury (SCI), focusing on the mechanisms causing paralysis after spinal cord trauma, the molecular determinants of neural regeneration, and methods for improving damaged function. The authors examine the role of intracellular Ca2+ in neuronal death, the possibility of spinal learning, growth-promoting molecules for regenerating neurons, and the biochemistry and cell biology of microtubules. Among the treatment possibilities discussed are cell transplantation strategies beyond the use of fetal spinal cord tissue, remyelination in spinal cord demyelination models, high steroid therapy immediately after SCI, and the mixed use of anti- and proinflammatories. Comprehensive and highly promising, Neurobiology of Spinal Cord Injury summarizes and integrates the great progress that has been made in understanding and combating the paralysis that follows spinal cord injury.
Bone Morphogenetic Proteins (Bmps) Mediate Cellular Response and Regulate Neural Stem Cell Differentiation After Acute Spinal Cord Injury in the Adult Mice
Author: Qi XiaoPublisher:
ISBN: 9781374702202
Category :
Languages : en
Pages :
Book Description
This dissertation, "Bone Morphogenetic Proteins (BMPS) Mediate Cellular Response and Regulate Neural Stem Cell Differentiation After Acute Spinal Cord Injury in the Adult Mice" by Qi, Xiao, 肖琦, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. DOI: 10.5353/th_b4129044 Subjects: Bone morphogenetic proteins Gene expression Stem cells Spinal cord - Wounds and injuries Mice
Regeneration-associated Gene Expression in Hamster Rubrospinal Motoneurons Following Partial Spinal Cord Injury
Author: Paul David StorerTherapeutic Strategies to Spinal Cord Injury
Author: Pavla JendelovaPublisher: MDPI
ISBN: 3038974064
Category : Electronic books
Languages : en
Pages : 239
Book Description
This book is a printed edition of the Special Issue "Therapeutic Strategies to Spinal Cord Injury" that was published in IJMS
Model Organisms in Spinal Cord Regeneration
Author: Catherina G. BeckerPublisher: John Wiley & Sons
ISBN: 3527610359
Category : Medical
Languages : en
Pages : 423
Book Description
This handbook provides a comprehensive overview for students, clinicians and researchers planning to enter the field of neural regeneration, combining the latest knowledge with an understanding of all important model organisms in one handy volume. By covering the strengths and weaknesses as well as possible applications of different models it saves researchers both time and resources in their choice of the appropriate model organism. An equally valuable introduction for the novice planning to enter the field.