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Author: Daniel Hollander Publisher: Springer Science & Business Media ISBN: 1468456970 Category : Medical Languages : en Pages : 228
Book Description
Gastric secretions contain hydrogen ions at a concentration that is more than one million times higher than their intracellular concentration. This phenomenal gradient as well as the demonstrated ability of gastric juice to digest tissues has motivated clinicians and investigators alike to emphasize acid secretion and acid ablation in studying the pathogenesis and therapy of peptic ulcer disease. Conse quently, over the past 150 years, we have made considerable progress in under standing the mechanisms and regulation of acid secretion by the stomach. Not surprisingly, therapy for both peptic disease and mucosal injury has also been predominantly directed at either neutralizing acid or suppressing its production. During the past 10 years, attention has been focused on factors other than acid in the genesis and therapy of ulcer disease. Work done worldwide demon strated that acid hypersecretion is not a common event in peptic ulcer disease. Therefore, we began realizing that factors other than acid secretion may be important in the genesis of ulcer disease or in gastroduodenal mucosal damage. In addition, new physiological information has established that the gas troduodenal mucosa is normally protected by a complex series of events includ ing mucus and bicarbonate secretion, cell renewal, surface mucosal restitution, and preservation of the microvasculature and mucosal proliferative zone.
Author: Daniel Hollander Publisher: Springer Science & Business Media ISBN: 1468456970 Category : Medical Languages : en Pages : 228
Book Description
Gastric secretions contain hydrogen ions at a concentration that is more than one million times higher than their intracellular concentration. This phenomenal gradient as well as the demonstrated ability of gastric juice to digest tissues has motivated clinicians and investigators alike to emphasize acid secretion and acid ablation in studying the pathogenesis and therapy of peptic ulcer disease. Conse quently, over the past 150 years, we have made considerable progress in under standing the mechanisms and regulation of acid secretion by the stomach. Not surprisingly, therapy for both peptic disease and mucosal injury has also been predominantly directed at either neutralizing acid or suppressing its production. During the past 10 years, attention has been focused on factors other than acid in the genesis and therapy of ulcer disease. Work done worldwide demon strated that acid hypersecretion is not a common event in peptic ulcer disease. Therefore, we began realizing that factors other than acid secretion may be important in the genesis of ulcer disease or in gastroduodenal mucosal damage. In addition, new physiological information has established that the gas troduodenal mucosa is normally protected by a complex series of events includ ing mucus and bicarbonate secretion, cell renewal, surface mucosal restitution, and preservation of the microvasculature and mucosal proliferative zone.
Author: Ludmila P. Filaretova Publisher: Karger Medical and Scientific Publishers ISBN: 3318021830 Category : Medical Languages : en Pages : 259
Book Description
Up-to-date reviews on the mechanisms of gastrointestinal injury and protection In recent years, there have been significant advances both in understanding the mechanisms involved in gastrointestinal mucosal injury and protection, as well as in the development of successful strategies for prevention and treatment of gastrointestinal injury. Nevertheless, many people worldwide still suffer from gastrointestinal damage. This book contains contributions by an international panel of researchers in the form of up-to-date reviews on the mechanisms of gastrointestinal injury and protection. These are complemented by papers discussing how these new findings about cell/tissue injury and cytoprotection/organoprotection can be applied to the prevention and treatment of tissue damage in the gastrointestinal tract. Moreover, the publication includes a special chapter on Andre Robert, who has discovered the phenomenon of gastric cytoprotection. This publication will be of great interest for both basic and clinical researchers in gastroenterology and pharmacology, reviewing the advances made so far and pointing towards future developments.
Author: Chi-Hin Cho Publisher: Karger Medical and Scientific Publishers ISBN: 3805573820 Category : Medical Languages : en Pages : 260
Book Description
Over the last decade, considerable progress has been made in understanding cellular and molecular mechanisms involved in gastrointestinal mucosal injury and repair. These findings provide the basis to identify the etiology and pathogenesis of various gut mucosal injury-related diseases and to develop new therapeutic approaches. The publication at hand is divided into three sections: Epithelial restitution, mucosal repair and ulcer healing, and experimental therapeutics. The first part highlights the early rapid mucosal restitution, focussing on the roles of extracellular matrix, cytoskeleton, cytokines, Ca2+ signaling, polyamines, and the protein kinase C/DAG pathways. The next section deals with aspects of chronic mucosal healing, concentrating on the roles of primary response gene expression, angiogenesis and angiogenic growth factors, platelets, and the mechanisms of cell renewal after injury in special circumstances. The last part explores new therapeutic approaches, stressing potential clinical applications of nitric oxide-releasing agents, polysaccharides, nitric oxide synthase modulators, growth factors, prostaglandins, and cyclooxygenase inhibitors. Covering the current state-of-the-art findings relevant to gut mucosal injury and repair as well as providing the underlying conceptual basis and knowledge regarding experimental therapeutics for gastrointestinal mucosal injury-related diseases, this publication will be a timely guide for investigators working in the field.
Author: Timothy S. Gaginella Publisher: CRC Press ISBN: 9780849383045 Category : Medical Languages : en Pages : 468
Book Description
Gastroenterology has advanced through the development and application of increasingly sophisticated methods to measure changes in gastrointestinal function. Handbook of Methods in Gastrointestinal Pharmacology brings together details on commonly employed approaches in investigative gastroenterology. The book provides comprehensive coverage of methods and techniques used to investigate the mechanism of action of drugs on the GI tract. An integral part of each chapter is the discussion of development of techniques based upon physiologic mechanisms and principles in pharmacology. In vivo and in situ techniques involving whole animals, isolated tissue methodology, the use of single cell systems, and molecular biology approaches are covered. Illustrations provide a clear understanding of methodologies discussed. Emphasis is placed on advantages and disadvantages of each technique in answering specific research questions. Chapters are written by experts experienced in the techniques they discuss; many pioneered one or more widely used methods. The wide variety of topics included make the Handbook of Methods in Gastrointestinal Pharmacology useful to established investigators, research fellows, and graduate students. Additionally, reviewers of grants and manuscripts can use it to clarify questions that arise regarding appropriate use of a technique in a particular setting.
Author: Tetsuro Urushidani Publisher: Springer Science & Business Media ISBN: 1461509718 Category : Science Languages : en Pages : 368
Book Description
This volume represents the proceedings of the 9th International Proton Transport Conference, "Mechanisms and Consequences of Proton Transport" held in Leura, Australia, August 19 -21, 200 I. This conference has been held since 1971 every 3 to 4 years with few exceptions in association with the Congress of the International Union of Physiological Sciences. The first meeting was held in Frankfurt, Germany, at the Max-Planck'Institute. Countries hosting the conference have been Germany (twice), Sweden (twice), India, Canada, USA, Great Britain, and now Australia. Over the past 30 years participants at these Proton Transport Conferences have been principal contributors to the major discoveries in the physiology, biochemistry and pharmacology of gastric acid secretion. These include development of the H2-receptor blockers, defining the signaling pathways for the regulation of acid secretion, identifying the gastric proton pump, discovery and development of proton pump inhibitory drugs, and elucidating the physiology and biochemistry of Helicobacter pylori.
Author: Timothy S. Gaginella Publisher: Springer Science & Business Media ISBN: 9401153906 Category : Medical Languages : en Pages : 381
Book Description
The Gastrointestinal Section of the International Union of Pharmacology (IUPHAR) was established in 1994 in Montreal, Canada. The establishment of the GI Section recognizes the international progress of gastrointestinal pharmacology, including basic and human studies. The Gastrointestinal Section of IUPHAR organized the first symposium, Biochemical Pharmacology as an Approach to Gastrointestinal Diseases: from Basic Science to Clinical Perspectives, on 10-12 October, 1995, in Pécs, Hungary. The main topics were: Gastrointestinal secretory and excretory fuctions Gastrointestinal motility Biochemical-pharmacological mechanisms in neural and hormonal actions involved in GI functions Main normal and pathological biochemical mechanisms in GI functions GI mucosal injury and protection Molecular mechanisms of premalignant and malignant diseases in GI tract Use of isolated cells and cell cultures in bioochemical-pharmacological studies to approach GI diseases. The presented papers are published in this book.
Author: Mahendra Rai Publisher: CRC Press ISBN: 1439853622 Category : Health & Fitness Languages : en Pages : 511
Book Description
Presenting recent discoveries on ethnomedicinal plants around the world, this book focuses on evaluating the progress to date as well as the future potential of drug development in ethnomedicine. Eight reviews examine therapeutic applications including the spasmolitic effects of various plants, the anti-inflammatory activity of plants from Brazil a
Author: Victor R. Preedy Publisher: CRC Press ISBN: 1351369296 Category : Medical Languages : en Pages : 802
Book Description
This book covers all aspects of gastrointestinal tract problems caused by alcohol misuse. Opening chapters discuss epidemiology and the metabolism of alcohol and the liver's role in that process. Alcohol and acetaldehyde dehydrogenases, free radicals, and endocrine changes are discussed in detail. Recent advances in the pathophysiology of alcohol-induced disorders are summarized and many chapters detail techniques such as permeability and protein synthesis. Effects on specific organs, including the salivary glands, stomach, pancreas, and small intestine, are also discussed. All contributors and both editors are internationally recognized experts in their fields.
Author: Daniel Hollander
Author: Daniel Hollander
Author: Ludmila P. Filaretova
Author: Sandor Szabo
Author: Chi-Hin Cho
Author: Timothy S. Gaginella
Author: Rodolfo Cheli
Author: Tetsuro Urushidani
Author: Timothy S. Gaginella
Author: Mahendra Rai
Author: Victor R. Preedy