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Author: Manjie Zhang Publisher: Frontiers Media SA ISBN: 2832552196 Category : Science Languages : en Pages : 154
Book Description
Early diagnosis of cancer is still a major challenge in cancer therapy. In recent years, the development of multifunctional nanomaterials has provided a new diagnosis and treatment platform to combat cancer. Polymer-inorganic nanomaterials with novel structures such as bowl-shaped/Janus/core-shell have drawn much attention owing to their diversity in composition or asymmetry in structure. More importantly, imparting unique optical, electrical, and magnetic properties to these nanocomposites can further extend their function repertoire. However, to fulfill this vision, fundamental understandings regarding strategies of precise synthesis, mechanisms of structure formation, in vivo synergistic effects in bioapplications, and biosafety of these materials are needed. Besides, nanomaterials with novel structures are well positioned for imaging-guided cancer theranostic. On one hand, nanomaterials themselves are suitable for imaging because of their intrinsic properties such as fluorescent or magnetic properties. On the other hand, nanomaterials can serve as functional platforms that integrate various therapeutic modalities including photothermal therapy, chemodynamic/ion-interference therapy, photodynamic therapy, and cuproptosis to efficiently kill cancer cells. This Research Topic aims at collecting works about synthesis, and biomedical applications of polymer/mesoporous inorganic nanomaterials, especially in the aspect of novel synthetic approaches for fabricating nanomaterials with unique structures. Additionally, we hope that in-depth research articles on this topic can provide insights into the mechanism of nanomaterials acting in cancer diagnosis and therapy. These include the mechanisms of customized drug load/release and synergistic effects in theranostics of these materials. Meanwhile, elucidations of key proteins’ roles in cancer development are also anticipated. Lastly, we hope that this topic can brew new ideas for the adaption of nanomaterials as platforms that allow for multimodal therapeutic modalities. The current Research Topic centers on the design, precise synthesis, and biomedical applications of nanomaterials. It aims to cover novel and promising research trends in nanomaterials with different morphology for cancer theranostics. Manuscripts from the following aspects, but not limited to, are welcomed: • Tailoring of asymmetrically structured (bowl-shaped, Janus, Yin Yang-like) polymer-inorganic nanomaterials; • Inorganic functional nanocrystals and functionalized mesoporous nanomaterials; • Design and synthesis of functional biomaterials, including lipids, polymers, and 2D materials • Non-viral DNA/mRNA delivery or drug/molecular inhibitor delivery; • Synthesizing biomaterials with novel nanostructures such as bowl-shaped, core-shell, spherical, Janus, and quantum dots; • Conquering drug resistance issues, tumor metastasis, and recurrence, as well as designing combination nanomedicines; • Dissecting the role of menin in prostate cancer and breast cancer: crosstalk between menin and AR signaling; • Multi-stimulus-responsive drug release and biological molecules.
Author: Manjie Zhang Publisher: Frontiers Media SA ISBN: 2832552196 Category : Science Languages : en Pages : 154
Book Description
Early diagnosis of cancer is still a major challenge in cancer therapy. In recent years, the development of multifunctional nanomaterials has provided a new diagnosis and treatment platform to combat cancer. Polymer-inorganic nanomaterials with novel structures such as bowl-shaped/Janus/core-shell have drawn much attention owing to their diversity in composition or asymmetry in structure. More importantly, imparting unique optical, electrical, and magnetic properties to these nanocomposites can further extend their function repertoire. However, to fulfill this vision, fundamental understandings regarding strategies of precise synthesis, mechanisms of structure formation, in vivo synergistic effects in bioapplications, and biosafety of these materials are needed. Besides, nanomaterials with novel structures are well positioned for imaging-guided cancer theranostic. On one hand, nanomaterials themselves are suitable for imaging because of their intrinsic properties such as fluorescent or magnetic properties. On the other hand, nanomaterials can serve as functional platforms that integrate various therapeutic modalities including photothermal therapy, chemodynamic/ion-interference therapy, photodynamic therapy, and cuproptosis to efficiently kill cancer cells. This Research Topic aims at collecting works about synthesis, and biomedical applications of polymer/mesoporous inorganic nanomaterials, especially in the aspect of novel synthetic approaches for fabricating nanomaterials with unique structures. Additionally, we hope that in-depth research articles on this topic can provide insights into the mechanism of nanomaterials acting in cancer diagnosis and therapy. These include the mechanisms of customized drug load/release and synergistic effects in theranostics of these materials. Meanwhile, elucidations of key proteins’ roles in cancer development are also anticipated. Lastly, we hope that this topic can brew new ideas for the adaption of nanomaterials as platforms that allow for multimodal therapeutic modalities. The current Research Topic centers on the design, precise synthesis, and biomedical applications of nanomaterials. It aims to cover novel and promising research trends in nanomaterials with different morphology for cancer theranostics. Manuscripts from the following aspects, but not limited to, are welcomed: • Tailoring of asymmetrically structured (bowl-shaped, Janus, Yin Yang-like) polymer-inorganic nanomaterials; • Inorganic functional nanocrystals and functionalized mesoporous nanomaterials; • Design and synthesis of functional biomaterials, including lipids, polymers, and 2D materials • Non-viral DNA/mRNA delivery or drug/molecular inhibitor delivery; • Synthesizing biomaterials with novel nanostructures such as bowl-shaped, core-shell, spherical, Janus, and quantum dots; • Conquering drug resistance issues, tumor metastasis, and recurrence, as well as designing combination nanomedicines; • Dissecting the role of menin in prostate cancer and breast cancer: crosstalk between menin and AR signaling; • Multi-stimulus-responsive drug release and biological molecules.
Author: Tamilselvan Mohan Publisher: John Wiley & Sons ISBN: 3527827668 Category : Technology & Engineering Languages : en Pages : 718
Book Description
A succinct handbook explaining interdisciplinary processing, methods, and applications of bio-based materials This book merges the two most important trends in biomaterials: functionalization and renewable chemistry. It covers a variety of biopolymers and various approaches for the transformation of these biopolymers into functional units. Sample topics covered by the two well-qualified authors include: Fundamental knowledge of biopolymers–natural ones, such as cellulose and other polysaccharides, and synthetic ones, such as polyethylene The origin, classifications, chemical nature, and isolation methods of specific biopolymers The different classical and modern approaches for the transformation of biopolymers into different shapes, ranging from thin films (model surfaces), to nanoparticles, to nanofibers, all the way to 3D scaffolds The morphology, structure, shape, thermal, electrical, and surface properties of biomaterials This all-inclusive reference guide, which covers fundamentals, methods, and applications alike, is a key resource for both students and practicing scientists involved in programs of study or disciplines that intersect with the field of biomaterials.
Author: Anuj Kumar Publisher: CRC Press ISBN: 1000912086 Category : Medical Languages : en Pages : 325
Book Description
Discusses design chemistry, modification, and processing of biomaterials Describes the efficacy of biomaterials at various scales for biological response and drug delivery Demonstrates technological advances from conventional to additive manufacturing Covers future of biofabrication and customized medical devices
Author: Helena S. Azevedo Publisher: Woodhead Publishing ISBN: 0081020120 Category : Technology & Engineering Languages : en Pages : 614
Book Description
Self-assembling biomaterials: molecular design, characterization and application in biology and medicine provides a comprehensive coverage on an emerging area of biomaterials science, spanning from conceptual designs to advanced characterization tools and applications of self-assembling biomaterials, and compiling the recent developments in the field. Molecular self-assembly, the autonomous organization of molecules, is ubiquitous in living organisms and intrinsic to biological structures and function. Not surprisingly, the exciting field of engineering artificial self-assembling biomaterials often finds inspiration in Biology. More important, materials that self-assemble speak the language of life and can be designed to seamlessly integrate with the biological environment, offering unique engineering opportunities in bionanotechnology. The book is divided in five parts, comprising design of molecular building blocks for self-assembly; exclusive features of self-assembling biomaterials; specific methods and techniques to predict, investigate and characterize self-assembly and formed assemblies; different approaches for controlling self-assembly across multiple length scales and the nano/micro/macroscopic properties of biomaterials; diverse range of applications in biomedicine, including drug delivery, theranostics, cell culture and tissue regeneration. Written by researchers working in self-assembling biomaterials, it addresses a specific need within the Biomaterials scientific community. Explores both theoretical and practical aspects of self-assembly in biomaterials Includes a dedicated section on characterization techniques, specific for self-assembling biomaterials Examines the use of dynamic self-assembling biomaterials
Author: Preetkanwal Singh Bains Publisher: Springer Nature ISBN: 9811399778 Category : Technology & Engineering Languages : en Pages : 256
Book Description
This book focuses on the recent advances in the field of orthopaedic biomaterials, with a particular emphasis on their design and fabrication. Biomimetic materials, having similar properties and functions to that of the natural tissue, are becoming a popular choice for making customized orthopaedic implants and bone scaffolds. The acceptability of these materials in the human body depends on the right balance between their mechanical and biological properties. This book provides a comprehensive overview of the state-of-the-art research in this rapidly evolving field. The chapters cover different aspects of multi-functional biomaterials design, and cutting-edge methods for the synthesis and processing of these materials. Advanced manufacturing techniques, like additive manufacturing, used for developing new biomimetic materials are highlighted in the book. This book is a valuable reference for students and researchers interested in biomaterials for orthopaedic applications.
Author: Anuj Kumar Publisher: CRC Press ISBN: 1000912094 Category : Technology & Engineering Languages : en Pages : 374
Book Description
With the emergence of additive manufacturing, mass customization of biomaterials for complex tissue regeneration and targeted drug delivery applications is possible. This book emphasizes the fundamental concepts of biomaterials science, their structure–property relationships and processing methods, and biological responses in biomedical engineering. It focuses on recent advancements in biomedical applications, such as tissue engineering, wound healing, drug delivery, cancer treatments, bioimaging, and theranostics. This book: Discusses design chemistry, modification, and processing of biomaterials Describes the efficacy of biomaterials at various scales for biological response and drug delivery Demonstrates technological advances from conventional to additive manufacturing Covers future of biofabrication and customized medical devices This volume serves as a go-to reference on functional biomaterials and is ideal for multi-disciplinary communities such as students and research professionals in materials science, biomedical engineering, healthcare, and medical fields.
Author: Hiromitsu Urakami Publisher: ISBN: 9781124209562 Category : Languages : en Pages : 325
Book Description
This dissertation describes the syntheses of functional polymeric biomaterials from natural monomeric building blocks for application specific to vectors for gene delivery. Chapter 1 of this dissertation introduces and discusses the various chemical and biological challenges of synthetic polymeric vectors for gene delivery. In particular, Chapter 1 examines various barriers at the cellular level for efficient gene transfer. In addition, chemical strategies to overcome such biological barriers are also discussed. Finally, a variety of synthetic vectors with various design and chemical diversities are presented. In particular, incorporation of an environmentally responsive bond into synthetic vectors is introduced as one of the main design characteristics necessary for overcoming multiple biological challenges. Overall, the introductory chapter attempts to illustrate the sensitive balances and complexities observed in the field of gene delivery. Chapter 2 of this dissertation describes the influence of structural modifications on saccharide-peptide hybrid copolymer (SPHC) as a synthetic vector for plasmid DNA and short interfering RNA delivery. SPHCs with various cationic charge densities, buffering capabilities, and cross-linking densities were prepared and consequences of these modifications on SPHCs are discussed. Chapter 3 of this dissertation describes the surfactant-free synthesis of bioreducible and biocompatible cationic nanogels intended for siRNA delivery. Nanogels were prepared by cross-linking the linear polymeric precursors in combination with polar and non-polar organic solvents without the addition of surfactants. The presence of amine side chains off the polymer backbone were determined to be crucial for efficient siRNA complexation. Our results (size, stability, environment responsiveness, and toxicity profile) clearly reveal the potential of this nanogel to be applied as a nano-colloidal drug carrier. Chapter 4 describes an efficient living ring-opening polymerization (ROP) of a permethoxylated-caprolactone [(OMe)CL] catalyzed by yttrium(III) isopropoxide for development of degradable protein-resistant polymers [P(OMe)CL]. The lactone monomer was efficiently prepared from a reduced sugar, D-dulcitol. A series of block copolymers consisting of permethoxylated lactone and [varepsilon]-caprolactone [P(OMe)CL-b-PCL] were synthesized and characterized. Finally, surface plasmon resonance (SPR) sensorgrams demonstrated that both P(OMe)CL and the P(OMe)CL-b-PCL block copolymers exhibit excellent resistance to protein adsorption.
Author: Weibo Cai Publisher: CRC Press ISBN: 1498720943 Category : Medical Languages : en Pages : 451
Book Description
Over the last decade, an unprecedented expansion in the field of nanomedicine has resulted in the development of new nanomaterials for diagnosis and therapy of various diseases such as cancer. This book covers the design, synthesis and applications of various functionally-hybridized nanomaterials for biomedical applications. It includes strategies for design and synthesis of hybrid nanomaterials, surface engineering of various nanoparticle-based hybrid nanosystems for cancer imaging and therapy, toxicity aspects of nanomaterials and the challenges in translation research of hybrid nanomaterials.
Author: Thakur Raghu Raj Singh Publisher: CRC Press ISBN: 1351648276 Category : Medical Languages : en Pages : 289
Book Description
Hydrogels are crosslinked, macromolecular polymeric materials arranged in a three-dimensional network, which can absorb and retain large amounts of water. Hydrogels are commonly used in clinical practice and experimental medicine for a wide range of applications, including drug delivery, tissue engineering and regenerative medicine, diagnostics, cellular immobilization, separation of biomolecules or cells, and barrier materials to regulate biological adhesions. This book elucidates the underlying concepts and emerging applications of hydrogels and will provide key case studies and critical analysis of the existing research.
Author: Manjie Zhang
Author: Manjie Zhang
Author: Tamilselvan Mohan
Author: Anuj Kumar
Author: Helena S. Azevedo
Author: Preetkanwal Singh Bains
Author: Anuj Kumar
Author: Hiromitsu Urakami
Author: Weibo Cai
Author: Thakur Raghu Raj Singh
Author: Emmanuel Stratakis