Author: Sonja PaunovicPublisher:
ISBN:
Category :
Languages : en
Pages : 112
Book Description
Functional Analysis of the Sex-determining Gene Transformer in Musca Domestica and Drosophila Melanogaster
Author: Sonja PaunovicMolekular Analysis of the Sex-determining Gene Transformer-2 [transformer] of Drosophila Melanogaster
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Author: Hubert AmreinMolecular Analysis of the Sex-determining Gene Transformer-2 of Drosophila Melanogaster
Author: Hubert AmreinMolecular Analysis of the Sex-determination Gene Transformer-2 of Drosophila Melanogaster
Author: Hubert AmreinMolecolar Analysis of the Sex-determining Gene Transformer-2 of Drosphila Melanogaster
Author: Structure, Expression and Function of the Drosophila Sex-determining Gene Transformer
Author: Irmgard Irminger-FingerPublisher:
ISBN:
Category :
Languages : en
Pages : 72
Book Description
Molecular Analysis of Virilizer, a Gene Required for the Expression and Function of the Sex-determining Gene Sex-lethal in Drosophila Melanogaster
Author: Markus NiessenFunction and Interaction of Sex Determination Genes in the Hemimetabolous Insect Oncopeltus Fasciatus
Author: Mara LasloPublisher:
ISBN: 9781303058110
Category : Drosophila melanogaster
Languages : en
Pages : 51
Book Description
The regulation and evolution of sex is a fundamental question in developmental biology. Sex determination mechanisms have only been studied in holometabolous insects, or insects with complete metamorphosis. In addition to being closely related to several human and agricultural pests, O. fasciatus is a member of the most closely related clade to these extensively studied holometabolous insects. Determining the genetic basis of sex in an outgroup such as O. fasciatus will shed light on how sex evolves. Candidate genes were chosen from the sex determination pathway of D. melanogaster. Transcript levels of transformer-2A, transformer-2B, intersex, and fruitless were examined at each developmental stage using quantitative PCR; a full list of significant pairwise comparisons is available in Supplementary Tables 1 and 2. Functional analyses of candidate genes virilizer, female-2-d, transformer-2, male-specific lethal-2, male-specific lethal-3, intersex , and fruitless were done using RNA interference methods. Results indicate that these sex determination genes play different roles in O. fasciatus compared to the established D. melanogaster model---most genes do not appear to have a role in sex determination. Additionally, although the genes fruitless and intersex are conserved, the phenotypes produced by the knockdown are non sex-specific. Interaction data suggests that fruitless promotes intersex expression---a novel interaction at the most downstream point of the sex determination pathway. These data support the theory that although upstream sex-determining genes vary widely across insect groups, downstream genes remain conserved.
Genetic Control of Malaria and Dengue
Author: Zach N. AdelmanPublisher: Academic Press
ISBN: 0128004053
Category : Medical
Languages : en
Pages : 487
Book Description
Genetic Control of Malaria and Dengue focuses on the knowledge, technology, regulation and ethics of using genetically modified mosquitoes to interrupt the transmission of important vector-borne diseases including Malaria. It contains coverage of the current state of knowledge of vector-borne diseases and how they are currently controlled; vaccine, drug and insecticide development; various strategies for altering the genome of mosquitoes in beneficial ways; and the regulatory, ethical and social environment concerning these strategies. For more than five decades, the prospect of using genetically-modified mosquitoes to control vector-borne disease transmission has been a purely hypothetical scenario. We simply did not have the technology or basic knowledge to be able to do it. With the explosion of field trials and potential interventions in development, Genetic Control of Malaria and Dengue provides a comprehensive overview of research in genetics, microbiology, virology, and ecology involved in the development and implementation of genetic modification programs for virus and disease control. This book is meant to provide a practical guide to researchers, regulators and the general public about how this technology actually works, how it can be improved, and what is still unknown. Includes coverage of vectorial capacity, critical to understanding vector-borne disease transmission Provides a summary of the concepts of both population suppression and population replacement Contains pivotal coverage of ethical and ecological ramifications of genetics-based control strategies
Regulation of Alternative Splicing
Author: Philippe JeanteurPublisher: Springer Science & Business Media
ISBN: 3662097281
Category : Science
Languages : en
Pages : 254
Book Description
The discovery in 1977 that genes are split into exons and introns has done away with the one gene - one protein dogma. Indeed, the removal of introns from the primary RNA transcript is not necessarily straightforward since there may be optional pathways leading to different messenger RNAs and consequently to different proteins. Examples of such an alternative splicing mechanism cover all fields of biology. Moreover, there are plenty of occurrences where deviant splicing can have pathological effects. Despite the high number of specific cases of alternative splicing, it was not until recently that the generality and extent of this phenomenon was fully appreciated. A superficial reading of the preliminary sequence of the human genome published in 2001 led to the surprising, and even deceiving to many scientists, low number of genes (around 32,000) which contrasted with the much higher figure around 150,000 which was previously envisioned. Attempts to make a global assessment of the use of alternative splicing are recent and rely essentially on the comparison of genomic mRNA and EST sequences as reviewed by Thanaraj and Stamm in the first chapter of this volume. Most recent estimates suggest that 40-60% of human genes might be alternatively spliced, as opposed to about 22% for C. elegans.