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Author: Alexander Vologodskii Publisher: Cambridge University Press ISBN: 1107034930 Category : Science Languages : en Pages : 279
Book Description
This book surveys the last sixty years of research in the rapidly advancing field of DNA biophysics, addressing key questions and facilitating further research.
Author: Alexander Vologodskii Publisher: Cambridge University Press ISBN: 1107034930 Category : Science Languages : en Pages : 279
Book Description
This book surveys the last sixty years of research in the rapidly advancing field of DNA biophysics, addressing key questions and facilitating further research.
Author: Thomas Jue Publisher: Springer Nature ISBN: 3030550435 Category : Technology & Engineering Languages : en Pages : 279
Book Description
This is the first book in the series to focus on dynamic hyperpolarized nuclear magnetic resonance, a burgeoning topic in biophysics. The volume follows the format and style of the Handbook of Modern Biophysics series and expands on topics already discussed in previous volumes. It builds a theoretical and experimental framework for students and researchers who wish to investigate the biophysics and biomedical application of dynamic hyperpolarized NMR. All contributors are internationally recognized experts, lead the dynamic hyperpolarized NMR field, and have first-hand knowledge of the chapter material. The book covers the following topics: Hyperpolarization by dissolution Dynamic Nuclear Polarization Design considerations for implementing a hyperpolarizer Chemical Shift Imaging with Dynamic Hyperpolarized NMR Signal Sampling Strategies in Dynamic Hyperpolarized NMR Kinetic Modeling of Enzymatic Reactions in Analyzing Hyperpolarized NMR Data Using Hyperpolarized NMR to Understand Biochemistry from Cells to Humans Innovating Metabolic Biomarkers for Hyperpolarized NMR New Insights into Metabolic Regulation from Hyperpolarized 13C MRS/MRI Studies Novel Views on Heart Function from Dynamic Hyperpolarized NMR Insights on Lactate Metabolism in Skeletal Muscle based on 13C Dynamic Nuclear Polarization Studies About the Editors Dirk Mayer is Professor of Diagnostic Radiology and Nuclear Medicine at the University of Maryland and is the Director of Metabolic Imaging. He is a recognized expert on dynamic nuclear polarization (DNP) MRI-based imaging techniques and has optimized acquisition and reconstruction techniques, has constructed kinetic modeling for quantitative analysis, and has developing new probes. Thomas Jue is Professor of Biochemistry and Molecular Medicine at the University of California Davis. He is an internationally recognized expert in developing and applying magnetic resonance techniques to study animal as well as human physiology in vivo. He served as a Chair of the Biophysics Graduate Group Program at UC Davis, where he started to redesign a graduate curriculum that balances physical science/mathematics formalism and biomedical perspective in order to promote interest at the interface of physical science, engineering, mathematics, biology, and medicine. The Handbook of Modern Biophysics represents an aspect of that effort.
Author: Irina R. Fomina Publisher: John Wiley & Sons ISBN: 1119510376 Category : Science Languages : en Pages : 607
Book Description
Written and edited by some of the most well-respected authors in the area of the adaptation of plants and animals to climate change, this groundbreaking new work is an extremely important scientific contribution to the study of global warming. Global climate change is one of the most serious and pressing issues facing our planet. Rather than a "silver bullet" or a single study that solves it, the study of global climate change is like a beach, with each contribution a grain of sand, gathered together as a whole to create a big picture, moving the science forward. This new groundbreaking study focuses on the adaptation and tolerance of plants and animal life to the harsh conditions brought on by climate change or global warming. Using the papers collected here, scientists can better understand global climate change, its causes, results, and, ultimately, the future of life on our planet. The first section lays out a methodology and conceptual direction of the work as a whole, covering the modeling, approaches, and the impacts studied throughout the book. The second section focuses on certain hypotheses laid out by the authors regarding how plants and animal life can adapt and survive in extreme environments. The third section compiles a series of ecological experiments and their conclusions, and a final section is dedicated to previous scientific breakthroughs in this field and the scientists who made them. Whether for the scientist in the field, the student, or as a reference, this groundbreaking new work is a must-have. Focusing on a small part of the global climate change "beach," this "grain of sand" is an extremely important contribution to the scientific literature and a step forward in understanding the problems and potentialities of the issue.
Author: Matthew S. Wiseman Publisher: University of Toronto Press ISBN: 148751963X Category : History Languages : en Pages : 276
Book Description
Between 1945 and 1970, Canada’s Department of National Defence sponsored scientific research into the myriad challenges of military operations in cold regions. To understand and overcome the impediments of the country’s cold climate, scientists studied cold-weather acclimatization, hypothermia, frostbite, and psychological morale for soldiers assigned to active duty in northern Canada. Frontier Science investigates the history of military science in northern Canada during this period of the Cold War, highlighting the consequences of government-funded research for humans and nature alike. The book reveals how under the guise of “environmental protection” research, the Canadian military sprayed pesticides to clear bushed areas, used radioactive substances to investigate vector-borne diseases, pursued race-based theories of cold tolerance, and enabled wide-ranging tests of newly developed weapons and equipment. In arguing that military research in northern Canada was a product of the Cold War, Matthew S. Wiseman tackles questions of government power, scientific authority, and medical and environmental research ethics. Based on a long and deep pursuit of declassified records, archival sources, and oral testimony, Frontier Science is a fascinating new history of military approaches to the human-nature relationship.
Author: Giovanni Nigita Publisher: Frontiers Media SA ISBN: 2889457419 Category : Languages : en Pages : 127
Book Description
Following the formulation of the central dogma of molecular biology and the later discovery of classes of non-coding RNAs, the primary focus of Genetics was essentially on variation of DNA aiming at elucidating biological pathways perturbed in diseases. Recently, extensive attention has shifted towards the study of posttranscriptional RNA modifications occurring in both protein-coding as well as non-coding RNAs, revealing a novel and finer layer of complexity in gene regulation. This, in turn, has led to the birth of the novel field of ‘Epitranscriptomics’. The recent increase of applications of high-throughput sequencing technology (HTS) has allowed the unprecedented opportunity to identify on a transcriptome-wide scale, millions of RNA modifications in human genes, counting today more than 140 distinct types such as: methylation (e.g. m6A, m1A, m5C, hm5C, 2’OMe) methylation (e.g. m6A, m1A, m5C, hm5C, 2’OMe), pseudourylation (?), deamination (e.g. A-to-I RNA editing). The scope of this Research Topic was to collect both reviews and research articles addressing the wet lab approaches and bioinformatics methodologies necessary to aid in the identification of novel RNA modifications and characterization of their biological functions. Among the articles embracing the aim of the Research Topic, we have collected four original research and methods articles, five reviews, and a technology article.
Author: Igor A. Kaltashov Publisher: John Wiley & Sons ISBN: 1118232119 Category : Science Languages : en Pages : 312
Book Description
The definitive guide to mass spectrometry techniques in biology and biophysics The use of mass spectrometry (MS) to study the architecture and dynamics of proteins is increasingly common within the biophysical community, and Mass Spectrometry in Structural Biology and Biophysics: Architecture, Dynamics, and Interaction of Biomolecules, Second Edition provides readers with detailed, systematic coverage of the current state of the art. Offering an unrivalled overview of modern MS-based armamentarium that can be used to solve the most challenging problems in biophysics, structural biology, and biopharmaceuticals, the book is a practical guide to understanding the role of MS techniques in biophysical research. Designed to meet the needs of both academic and industrial researchers, it makes mass spectrometry accessible to professionals in a range of fields, including biopharmaceuticals. This new edition has been significantly expanded and updated to include the most recent experimental methodologies and techniques, MS applications in biophysics and structural biology, methods for studying higher order structure and dynamics of proteins, an examination of other biopolymers and synthetic polymers, such as nucleic acids and oligosaccharides, and much more. Featuring high-quality illustrations that illuminate the concepts described in the text, as well as extensive references that enable the reader to pursue further study, Mass Spectrometry in Structural Biology and Biophysics is an indispensable resource for researchers and graduate students working in biophysics, structural biology, protein chemistry, and related fields.
Author: Alexander Vologodskii
Author: Alexander Vologodskii
Author: Thomas Jue
Author: National Library of Medicine (U.S.)
Author: Irina R. Fomina
Author: Matthew S. Wiseman
Author: Giovanni Nigita
Author: 
Author: National Library of Medicine (U.S.)
Author: Igor A. Kaltashov
Author: