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Author: Rongqiao He Publisher: Springer ISBN: 9402411771 Category : Medical Languages : en Pages : 326
Book Description
This book introduces important, new knowledge regarding formaldehyde, especially endogenous formaldehyde, revealing its many key roles in the human body. It reviews the relationship between endogenous formaldehyde and cognition as well as age-related cognitive impairment, by discussing different aspects such as formaldehyde metabolism, its function in the brain, links with epigenetics and neurophysiology, and epidemiological and clinical investigations. The author also provides suggestions on how to prevent cognitive impairment resulting from excess endogenous formaldehyde. This book appeals to all readers who are interested in cognitive science and toxicology.
Author: Rongqiao He Publisher: Springer ISBN: 9402411771 Category : Medical Languages : en Pages : 326
Book Description
This book introduces important, new knowledge regarding formaldehyde, especially endogenous formaldehyde, revealing its many key roles in the human body. It reviews the relationship between endogenous formaldehyde and cognition as well as age-related cognitive impairment, by discussing different aspects such as formaldehyde metabolism, its function in the brain, links with epigenetics and neurophysiology, and epidemiological and clinical investigations. The author also provides suggestions on how to prevent cognitive impairment resulting from excess endogenous formaldehyde. This book appeals to all readers who are interested in cognitive science and toxicology.
Author: KNEZEVIC Publisher: Springer Science & Business Media ISBN: 1468468057 Category : Science Languages : en Pages : 508
Book Description
It was Oscar Wilde who defined the tragedy of old age by saying that " . . . as soon as you are old enough to know better, you don't know anything at all. " As improvements in the quality of health care bring about longer life, our attention has turned from the prolonging of life to the maintenance of involvement in life. In developed nations, a full 100% increase in the ranks of the elderly has appeared and with the benefits of this prolongation have come new and greater needs of the elderly cohort. Our interest is in those processes that may lead to dementia among the elderly, for in dementia we see a thief that robs victims of their memories and their place in life. This text was conceived and developed from an international con ference on neurodevelopment, aging, and cognition; the purpose of this few days a group of experts in these conference was to bring together for a fields from around the world to generate a dialog on common themes and unresolved problems. Our hope was that by keeping the meeting small and informal, we could break through barriers of terminology unique to the areas of developmental neurobiology, neuroscience, cognitive sci ence, and clinical medicine, and have a meaningful discussion on pro cesses that affect the biological integrity and cognitive performance of the aging nervous system.
Author: Publisher: Elsevier ISBN: 0080538495 Category : Medical Languages : en Pages : 273
Book Description
Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences.Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas.The last decade has seen tremendous advances in our understanding of the pathobiology of Alzheimer's disease. These will lead to the first generation of drugs aimed at prevention rather than cure. This book covers some of the most important and exciting of these advances, with chapters written by many of the leading researchers in the field.With genetic studies as a backbone to this volume many chapters are devoted to the function and regulation of amyloid b-protein precursor (APP) and apolipoprotein E (ApoE). Other chapters describe cell biological approaches helping to piece together the link between the genetic alterations and the phenotype we call Alzheimer's disease.Although APP and its proteolytic cleavage product, amyloid b-protein, do not answer all the questions, detailed research into this system has undoubtedly increased our knowledge of the pathobiology of AD and has lead to the identification of other risk factors. Understanding the role of ApoE in the pathology of Alzheimer's disease promises to open a whole new field in AD research.* * Reviews the current knowledge of the pathogenesis of Alzheimer's Disease from a clinical perspective to a genetic and cell biological perspective* A comprehensive description of the role of amyloid B-protein precursor in Alzheimer's disease.* Up-to-date research data* Clear illustrations complement the text
Author: Karyn M. Frick Publisher: Oxford University Press, USA ISBN: 0190645903 Category : Psychology Languages : en Pages : 525
Book Description
"A book about the influence of estrogens on memory would have been unthinkable as recently as 30 years ago. Although a few small studies in the late 1970's reported a beneficial effect of estrogens on memory in human women (Hackman and Galbraith, 1976; Fedor-Freybergh, 1977), examination of the role of estrogens in memory did not truly capture more widespread attention until the pioneering work of Barbara Sherwin and colleagues in 1988 and beyond. In her initial paper, Sherwin showed that bilateral removal of the ovaries (aka surgical menopause) led to impaired short-term and long-term memory, whereas treatment of surgically menopausal women with estradiol alone, testosterone alone, or estradiol plus testosterone prevented this decline (Sherwin, 1988). As a search for the terms "estrogen" and "memory" in PubMed illustrates, well over 2000 papers have been published on the subject of estrogens and memory in the ensuing decades. The vast majority of these studies have focused on the hippocampus, a bilateral medial temporal lobe structure essential for the formation of episodic memories, particularly those with spatial, contextual, relational, temporal, and recognition components (Olton et al., 1979; Morris et al., 1982; Kim and Fanselow, 1992; Squire, 1992; Cohen and Stackman, 2015; Tonegawa et al., 2015; Eichenbaum, 2017). Although various forms of learning and memory are mediated by numerous brain regions, including the prefrontal cortex, medial temporal lobe cortices, amygdala, striatum, and cerebellum, the hippocampus has received the lion's share of attention due to its central importance for episodic memory formation. Hippocampal damage produces profound retrograde amnesia for facts and events, as well as anterograde amnesia for new information and impairments in spatial navigation (Winocur, 1990; Anagnostaras et al., 2001; Clark et al., 2002; Gilboa et al., 2006). Hippocampal dysfunction in middle-aged and aged subjects is a primary contributor to age-related memory decline (Golumb et al., 1996; Grady et al., 2003; Apostolova et al., 2010; Burke and Barnes, 2010; Small et al., 2011; Yassa et al., 2011), and has also been implicated in the cognitive impairments observed in diseases such as schizophrenia and depression (Small et al., 2011; Nakahara et al., 2018; Santos et al., 2018; Ott et al., 2019). Moreover, the hippocampi of patients with Alzheimer's disease are substantially atrophied and burdened with copious amounts of amyloid plaques and neurofibrillary tangles, the hallmark pathologies of this insidious disease (Hyman et al., 1984; Walsh and Selkoe, 2004; Selkoe and Hardy, 2016). As such, understanding how estrogens influence hippocampal functioning may provide important insights not only about the fundamental neurobiology of memory processes, but also into the etiology of neuropsychiatric and neurodegenerative diseases"--
Author: Laird S. Cermak Publisher: Springer Science & Business Media ISBN: 1489911960 Category : Medical Languages : en Pages : 430
Book Description
Researchers who were influenced by Dr. Nelson Butters contribute articles to this volume to honor him and his thirty-year career. Their contributions reflect how Dr. Butters impacted their current work and offer an historical account of research theory and paradigmatic shifts within the field of cognitive neuropsychology. Researchers, clinicians, and students working in the neurosciences will appreciate this volume.
Author: Brian Burrell Publisher: ISBN: 9780767906777 Category : Anatomical museums Languages : en Pages : 0
Book Description
What makes one man a genius and another a criminal? Is there a physical explanation for these differences? For hundreds of years, scientists have been fascinated by this question. In Postcards from the Brain Museum, Brian Burrell relates the story of the first scientific attempts to locate the sources of both genius and depravity in the physical anatomy of the human brain. It describes the men who studied and collected special brains, the men who gave them up, and the sometimes cruel fate of the brains themselves. The fascination with elite brains was an aspect of the scientific mania for measurement that gripped the Western world in the mid-nineteenth century, along with a passionate interest in the biological basis of genius or exceptional talent. Many leading intellectuals and artists willed their brains to science, and the brains of notorious criminals were also collected by eager anatomists ghoulishly waiting in the execution chamber with a bag full of sharp metal tools. Focusing on the posthumous sagas of brains belonging to Byron, Whitman, Lenin, Einstein, the mathematician Carl Friedrich Gauss, and many others, Burrell describes how the brains of famous men were first collected--by means both fair and foul--and then weighed, measured, dissected, and compared; exhaustive studies analyzed their fissural complexity and cell or neuron size. In various cities in Europe, Russia, and the United States, brain collections were painstakingly assembled and studied. A veritable who's who of literary, artistic, musical, scientific, and political achievement waited in Formalin-filled jars for their secrets to be unlocked. The men who built the brain collections werecolorful and eccentric figures like Rudolph Wagner, whose study of the brain of Carl Friedrich Gauss led to one of the great scientific debates of the nineteenth century. In America, the Fowler brothers brought phrenology to the United States and made a convert of Walt Whitman, whose brain was donated to science and disappeared under mysterious circumstances. Eventually, this project was abandoned, and with the discovery of new technologies the study of the brain has moved on to a higher plane. But the collections themselves still exist, and today, in Paris, London, Stockholm, Philadelphia, Moscow, and even Tokyo, the brains of nineteenth century geniuses sit idle, gathering dust in their jars. Brian Burrell has visited these collections and looked into the original intentions and purposes of their creators. In the process, he unearths a forgotten byway in the history of science--a tale of colorful eccentrics bent on laying bare the secrets of the human mind.
Author: Institute of Medicine Publisher: National Academies Press ISBN: 0309166608 Category : Social Science Languages : en Pages : 336
Book Description
Children's health has clearly improved over the past several decades. Significant and positive gains have been made in lowering rates of infant mortality and morbidity from infectious diseases and accidental causes, improved access to health care, and reduction in the effects of environmental contaminants such as lead. Yet major questions still remain about how to assess the status of children's health, what factors should be monitored, and the appropriate measurement tools that should be used. Children's Health, the Nation's Wealth: Assessing and Improving Child Health provides a detailed examination of the information about children's health that is needed to help policy makers and program providers at the federal, state, and local levels. In order to improve children's health-and, thus, the health of future generations-it is critical to have data that can be used to assess both current conditions and possible future threats to children's health. This compelling book describes what is known about the health of children and what is needed to expand the knowledge. By strategically improving the health of children, we ensure healthier future generations to come.
Author: Publisher: World Health Organization ISBN: Category : House & Home Languages : en Pages : 488
Book Description
This book presents WHO guidelines for the protection of public health from risks due to a number of chemicals commonly present in indoor air. The substances considered in this review, i.e. benzene, carbon monoxide, formaldehyde, naphthalene, nitrogen dioxide, polycyclic aromatic hydrocarbons (especially benzo[a]pyrene), radon, trichloroethylene and tetrachloroethylene, have indoor sources, are known in respect of their hazardousness to health and are often found indoors in concentrations of health concern. The guidelines are targeted at public health professionals involved in preventing health risks of environmental exposures, as well as specialists and authorities involved in the design and use of buildings, indoor materials and products. They provide a scientific basis for legally enforceable standards.
Author: Ivica Kostović Publisher: Birkhauser ISBN: Category : Medical Languages : en Pages : 432
Book Description
It was Oscar Wilde who defined the tragedy of old age by saying that " . . . as soon as you are old enough to know better, you don't know anything at all. " As improvements in the quality of health care bring about longer life, our attention has turned from the prolonging of life to the maintenance of involvement in life. In developed nations, a full 100% increase in the ranks of the elderly has appeared and with the benefits of this prolongation have come new and greater needs of the elderly cohort. Our interest is in those processes that may lead to dementia among the elderly, for in dementia we see a thief that robs victims of their memories and their place in life. This text was conceived and developed from an international con ference on neurodevelopment, aging, and cognition; the purpose of this few days a group of experts in these conference was to bring together for a fields from around the world to generate a dialog on common themes and unresolved problems. Our hope was that by keeping the meeting small and informal, we could break through barriers of terminology unique to the areas of developmental neurobiology, neuroscience, cognitive sci ence, and clinical medicine, and have a meaningful discussion on pro cesses that affect the biological integrity and cognitive performance of the aging nervous system.
Author: Rongqiao He
Author: Rongqiao He
Author: KNEZEVIC
Author: 
Author: Karyn M. Frick
Author: Laird S. Cermak
Author: Brian Burrell
Author: Institute of Medicine
Author: Bruce S. McEwen
Author: 
Author: Ivica Kostović