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Author: Alfredo Ferrari
Publisher:
ISBN:
Category : Particles (Nuclear physics)
Languages : en
Pages : 410

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Author: Julio E. Celis
Publisher: Elsevier
ISBN: 0121647307
Category : Science
Languages : en
Pages : 632

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Book Description
This four-volume laboratory manual contains comprehensive state-of-the-art protocols essential for research in the life sciences. Techniques are presented in a friendly step-by-step fashion, providing useful tips and potential pitfalls. The important steps and results are beautifully illustrated for further ease of use. This collection enables researchers at all stages of their careers to embark on basic biological problems using a variety of technologies and model systems. This thoroughly updated third edition contains 165 new articles in classical as well as rapidly emerging technologies. Topics covered include: Cell and Tissue Culture: Associated Techniques, Viruses, Antibodies, Immunocytochemistry (Volume 1) Organelle and Cellular Structures, Assays (Volume 2) Imaging Techniques, Electron Microscopy, Scanning Probe and Scanning Electron Microscopy, Microdissection, Tissue Arrays, Cytogenetics and In Situ Hybridization, Genomics and Transgenic Knockouts and Knock-down Methods (Volume 3) Transfer of Macromolecules, Expression Systems, Gene Expression Profiling (Volume 4) Indispensable bench companion for every life science laboratory Provides the latest information on the plethora of technologies needed to tackle complex biological problems Includes numerous illustrations, some in full color, supporting steps and results

Author: John Stephen White
Publisher: Springer Science & Business Media
ISBN: 1592591701
Category : Science
Languages : en
Pages : 1071

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Book Description
Proteins, Pep tides and Amino Acids SourceBook is the second in a series of reference books conceived to cover the explosive growth in commercially available biological reagents. The success of our first reference work, Source Book of Enzymes published in 1997, encouraged us to continue this series. Choosing proteins, peptides, and amino acids as the subject matter for the second volume was simple, given their preeminence in regulating biochemical processes and their importance to modern molecular biology. The SourceBook series was inspired by our difficulty in locating a suitable replacement for a depleted reagent in the midst of an urgent research project. To our dismay, we found the reagent supplier out of business and the product line no longer available. Other reagent catalogs on our library bookshelf offered a narrow selection and incom plete functional information. We were ultimately able to locate a satisfactory alternative only by making countless inquiries and paging through innumerable product catalogs and technical data sheets. We needed-but could not find-a single resource that cataloged available compounds, organized them in a logical and accessible format, provided critical technical information to distinguish one from another, and told us where we could buy them.

Author: G.R. Stephenson
Publisher: Springer Science & Business Media
ISBN: 9400707975
Category : Science
Languages : en
Pages : 440

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Book Description
Asymmetric synthesis is one of the most critical strategic subjects in organic chemistry, and this book describes advanced techniques and their applications to the industrial and laboratory synthesis of important chiral molecules. The international team of highly respected authors provide rigorous and concise reviews of their areas of expertise.

Author: Andreas Kling
Publisher: Springer Science & Business Media
ISBN: 3642182119
Category : Science
Languages : en
Pages : 1200

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Book Description
This book focuses on the state of the art of Monte Carlo methods in radiation physics and particle transport simulation and applications. Special attention is paid to algorithm development for modeling, and the analysis of experiments and measurements in a variety of fields.

Author: Sebastian Enck
Publisher: Logos Verlag Berlin GmbH
ISBN: 3832526129
Category : Science
Languages : en
Pages : 536

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Book Description
The architectures (three-dimensional shapes) of peptides determine their respective biological functions. Therefore, the correct alignment of functionalities in a structure by constraining the flexibility is a key process in evolution as well as in medicinal chemistry in order to increase binding affinity and selectivity. The rigidification of a peptide chain can have local effects (incorporation of the amino acid proline) or it can globally restrain flexibility (macrocyclization). Furthermore, the combination of both strategies has given rise to complex antibiotics with highly optimized modes of action. This work approaches these principles in three topics and for different purposes. The first chapter presents a novel scanning strategy which utilizes synthetic local rigidifications for the evaluation of Neuropeptide Y structure and receptor binding patterns. The fundamental process of macrocyclization is topic of the second chapter. For iminopeptides, ring-chain equilibria can be established and controlled, thereby allowing for the thermodynamic analysis of the ring closure. This leads to the identification of structural determinants that influence the inclination of a peptide chain to close the ring. In the third chapter, a sugarbased synthetic pathway leading to highly functionalized thiazole dipeptides is described. This strategy led to the synthesis of core motivs of complex thiopeptide antibiotics, as well as to diastereomers and homologs thereof.

Author: Tomislav Vladisavljevic
Publisher: Springer Nature
ISBN: 303051174X
Category : Science
Languages : en
Pages : 206

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Book Description
This thesis reports the calculation of neutrino production for the T2K experiment; the most precise a priori estimate of neutrino production that has been achieved for any accelerator-based neutrino oscillation experiment to date. The production of intense neutrino beams at accelerator facilities requires exceptional understanding of chains of particle interactions initiated within extended targets. In this thesis, the calculation of neutrino production for T2K has been improved by using measurements of particle production from a T2K replica target, taken by the NA61/SHINE experiment. This enabled the reduction of the neutrino production uncertainty to the level of 5%, which will have a significant impact on neutrino oscillation and interaction measurements by T2K in the coming years. In addition to presenting the revised flux calculation methodology in an accessible format, this thesis also reports a joint T2K measurement of muon neutrino and antineutrino disappearance, and the accompanying electron neutrino and antineutrino appearance, with the updated beam constraint.

Author: Paolo Russo
Publisher: CRC Press
ISBN: 149874155X
Category : Medical
Languages : en
Pages : 2606

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Book Description
Containing chapter contributions from over 130 experts, this unique publication is the first handbook dedicated to the physics and technology of X-ray imaging, offering extensive coverage of the field. This highly comprehensive work is edited by one of the world’s leading experts in X-ray imaging physics and technology and has been created with guidance from a Scientific Board containing respected and renowned scientists from around the world. The book's scope includes 2D and 3D X-ray imaging techniques from soft-X-ray to megavoltage energies, including computed tomography, fluoroscopy, dental imaging and small animal imaging, with several chapters dedicated to breast imaging techniques. 2D and 3D industrial imaging is incorporated, including imaging of artworks. Specific attention is dedicated to techniques of phase contrast X-ray imaging. The approach undertaken is one that illustrates the theory as well as the techniques and the devices routinely used in the various fields. Computational aspects are fully covered, including 3D reconstruction algorithms, hard/software phantoms, and computer-aided diagnosis. Theories of image quality are fully illustrated. Historical, radioprotection, radiation dosimetry, quality assurance and educational aspects are also covered. This handbook will be suitable for a very broad audience, including graduate students in medical physics and biomedical engineering; medical physics residents; radiographers; physicists and engineers in the field of imaging and non-destructive industrial testing using X-rays; and scientists interested in understanding and using X-ray imaging techniques. The handbook's editor, Dr. Paolo Russo, has over 30 years’ experience in the academic teaching of medical physics and X-ray imaging research. He has authored several book chapters in the field of X-ray imaging, is Editor-in-Chief of an international scientific journal in medical physics, and has responsibilities in the publication committees of international scientific organizations in medical physics. Features: Comprehensive coverage of the use of X-rays both in medical radiology and industrial testing The first handbook published to be dedicated to the physics and technology of X-rays Handbook edited by world authority, with contributions from experts in each field

Author: J. D. R. Thomas
Publisher: Elsevier
ISBN: 1483190757
Category : Science
Languages : en
Pages : 299

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Book Description
Ion-Selective Electrode Reviews, Volume 5 is a collection of articles that covers ion-speciation. The book aims to present the advancements of the range and capabilities of selective ion-sensors. The topics covered in the selection are neutral carrier based ion-selective electrodes; reference electrodes and liquid junction effects in ion-selective electrode potentiometry; ion transfer across water/organic phase boundaries and analytical; and carbon substrate ion-selective electrodes. The text will be of great use to chemists and chemical engineers.

Author: Gerhard F. Fueger
Publisher: Springer Science & Business Media
ISBN: 9400960301
Category : Medical
Languages : en
Pages : 498

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Book Description
G. F. FUEGER Among the many processes in Physiology few appear mo~e inviting to be studied by tracers and external imaging than the variety of the routes of migratory (blood) cells in health and disease. Much emphasis has been placed lately on the methods of labelling of the white blood cells. It is obviously quite important and necessary to refine the methods of leucocytic labelling, particularly to search for ways to label selectively a specific group of white blood cells, but there is also the need to review and keep abreast with the developing knowledge of the white blood cells themselves, especially their behaviour under pathological conditions, as seen by histology and scintigraphy, their biological properties, their immunological characteristics and the mechanisms of the control of leucocytic functions. Similarly, it appears desirable to analyze animal models of inflammation as well as to review the dosimetry and the biodistribution of labelled white blood cells in humans. This book is the result of a cooperative effort to review certain highlights of the physiology of leucocytes, labelled and unlabelled, as a corollary to the effort concerning the labelling of white blood cells. In preparing this book we aim for a better understanding and definition of the goals to be achieved by the successful labelling of the migratory cells of the body. XI CONTRIBUTORS Becker, H. Medizinische Universitaetsklinik der Uni versitaet Graz, Graz, Landeskrankenhaus, haus, Austria Bjurman, B. Department of Radiation Physics, General Hospital, Malmoe, Sweden Chiles, C.