Ferromagnets-Based Multifunctional Nanoplatform for Targeted Cancer Therapy PDF Download

Author: Valentyn Novosad
Publisher:
ISBN: 9789533075136
Category :
Languages : en
Pages :

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Author: Anthony Laskovski
Publisher: BoD – Books on Demand
ISBN: 9533075139
Category : Medical
Languages : en
Pages : 578

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Book Description
Rapid technological developments in the last century have brought the field of biomedical engineering into a totally new realm. Breakthroughs in materials science, imaging, electronics and, more recently, the information age have improved our understanding of the human body. As a result, the field of biomedical engineering is thriving, with innovations that aim to improve the quality and reduce the cost of medical care. This book is the second in a series of three that will present recent trends in biomedical engineering, with a particular focus on materials science in biomedical engineering, including developments in alloys, nanomaterials and polymer technologies.

Author: Perry Yin
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 186

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Book Description
Magnetic nanoparticles (MNPs) hold tremendous potential for various biomedical applications, including cancer diagnosis and treatment, owing to their unique ability to be manipulated by magnetic fields. In particular, cancer applications of MNPs have primarily utilized MNPs as MRI contrast agents, drug delivery vehicles, and as agents for magnetic hyperthermia. Significant progress has already been made in the advancement of MNP-based therapies to the clinic; however, tumor targeting and chemoresistance remain significant challenges. Addressing these challenges, this thesis focuses on the development of novel multifunctional MNP-based combination therapies. In the first half of this thesis, novel MNP and magnetic core-shell nanoparticle (MCNP)-based combination therapies are developed to enhance the treatment of cancer by sensitizing cancer cells to subsequent therapies. To this end, MNPs are first developed for the dual purpose of delivering microRNA and inducing magnetic hyperthermia for the treatment of brain cancer. We demonstrate that the combination of lethal-7a microRNA (let-7a), which targets a number of survival pathways, can sensitize cancer cells to subsequent magnetic hyperthermia. Moreover, we demonstrate the use of MCNPs that are composed of a magnetic core and a mesoporous silica shell for the simultaneous delivery of let-7a and doxorubicin, wherein let-7a was found to sensitize breast cancer cells to subsequent doxorubicin chemotherapy. In the second half of this thesis, to overcome poor tumor targeting, a stem cell-based gene therapy is developed. Specifically, MCNPs are reported for the dual purpose of delivering and activating a heat-inducible gene vector that encodes TNF-related apoptosis-inducing ligand (TRAIL) in adipose-derived mesenchymal stem cells (AD-MSCs) for the treatment of ovarian cancer. These engineered AD-MSCs retained their innate ability to home to tumors, making them ideal cellular carriers for cancer therapy. Moreover, mild magnetic hyperthermia resulted in the selective expression of TRAIL in the engineered AD-MSCs thereby inducing significant cancer cell death. Overall, this thesis has demonstrated two multifunctional MNP-based approaches for cancer therapy: 1) combined MNP-based delivery of microRNA and magnetic hyperthermia to sensitize cancers to subsequent chemotherapy and 2) MCNP-based activation of heat-inducible genes in stem cells for targeted cancer treatment.

Author: Mohammad-Nabil Savari
Publisher: Springer
ISBN: 9789819965069
Category : Science
Languages : en
Pages : 0

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This book highlights the most efficient and latest ways to deal with cancer, focusing on IONPs. The book describes some well-designed surface modifications performed through several functional materials over the surface of IONPs, which results in the development of multifunctional IONPs-based delivery nanoplatforms by enhancing solubility, stability, and avoiding side effects on healthy cells. Several types of stimuli-responsive IONPs-based strategies are also discussed. Owing to magnetic, structural, and thermal properties, IONPs themselves can be utilized for magnetic targeting, magnetic hyperthermia, and phototherapy. Significant advancements are presented in IONPs-based immunotherapy, radiotherapy, and sonodynamic therapy for the efficient treatment of cancer. Finally, the book presents RIONs which serve as the parent platform for the development of powerful DMCAs utilized in SPECT/MRI and PET/MRI applications.

Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Author: Aimee Joy Marko
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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Author: Saji Uthaman
Publisher: Frontiers Media SA
ISBN: 2889740021
Category : Science
Languages : en
Pages : 148

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Author: Wang Zheng
Publisher: Frontiers Media SA
ISBN: 2889764621
Category : Science
Languages : en
Pages : 182

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Book Description

Author: Raghvendra Singh Yadav
Publisher: Mdpi AG
ISBN: 9783036583259
Category : Science
Languages : en
Pages : 0

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This book is a collection of review articles and research articles, which was published in the Special Issue "Multifunctional Nanomaterials: Synthesis, Properties and Applications" of the International Journal of Molecular Sciences.

Author: Mahendra Rai
Publisher: Springer Nature
ISBN: 3030297683
Category : Medical
Languages : en
Pages : 413

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Book Description
This book is specifically designed to provide information about various nanocarriers currently developed under the emerging field of nanotheranostics for a sustained, controlled, and targeted co-delivery of diagnostic and therapeutic agents. Diverse theranostic applications of nanotechnology and their limitations are also addressed. It integrates nanobiotechnology with theranostic applications. The combined term nanotheranostics has diverse application particularly in chemotherapy and other infectious diseases.Among other topics addressed are antimicrobial resistance, targeting intra-cellular pathogens, viruses and bacteria, chemotherapy, cancer therapeutics, and inflammatory disorders. This interdisciplinary volume is essential for a diverse group of readers including nanotechnologists, microbiologists, biotechnologists, bioengineering and bioprocess industry.