Favoriser les essais cliniques en oncologie pédiatrique en ayant recours aux Protocoles Maitres PDF Download

Author: Pierre-Alexis Gontier
Publisher:
ISBN:
Category :
Languages : fr
Pages : 186

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Book Description
Essais Paniers, Essais Parapluies, Essais Plateforme... Ces termes désignent des essais cliniques nés il y a une dizaine d'année : les Protocoles Maitres (ou Master Protocols en anglais). De nombreux experts voient en ces essais un moyen d'évaluer de façon plus efficiente les nouvelles thérapies en onco-pédiatrie par rapport à la méthode de référence : l'Essai Contrôlé Randomisé. L'exemple du programme AcSé ESMART, promu par l'Institut National du Cancer illustrera le propos de cette thèse.

Author: Alan D. Lopez
Publisher: World Bank Publications
ISBN: 0821362631
Category : Medical
Languages : en
Pages : 511

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Book Description
Strategic health planning, the cornerstone of initiatives designed to achieve health improvement goals around the world, requires an understanding of the comparative burden of diseases and injuries, their corresponding risk factors and the likely effects of invervention options. The Global Burden of Disease framework, originally published in 1990, has been widely adopted as the preferred method for health accounting and has become the standard to guide the setting of health research priorities. This publication sets out an updated assessment of the situation, with an analysis of trends observed since 1990 and a chapter on the sensitivity of GBD estimates to various sources of uncertainty in methods and data.

Author: Eric Topol
Publisher: Basic Books
ISBN: 0465094473
Category : Medical
Languages : en
Pages : 386

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Book Description
The essential guide by one of America's leading doctors to how digital technology enables all of us to take charge of our health A trip to the doctor is almost a guarantee of misery. You'll make an appointment months in advance. You'll probably wait for several hours until you hear "the doctor will see you now"-but only for fifteen minutes! Then you'll wait even longer for lab tests, the results of which you'll likely never see, unless they indicate further (and more invasive) tests, most of which will probably prove unnecessary (much like physicals themselves). And your bill will be astronomical. In The Patient Will See You Now, Eric Topol, one of the nation's top physicians, shows why medicine does not have to be that way. Instead, you could use your smartphone to get rapid test results from one drop of blood, monitor your vital signs both day and night, and use an artificially intelligent algorithm to receive a diagnosis without having to see a doctor, all at a small fraction of the cost imposed by our modern healthcare system. The change is powered by what Topol calls medicine's "Gutenberg moment." Much as the printing press took learning out of the hands of a priestly class, the mobile internet is doing the same for medicine, giving us unprecedented control over our healthcare. With smartphones in hand, we are no longer beholden to an impersonal and paternalistic system in which "doctor knows best." Medicine has been digitized, Topol argues; now it will be democratized. Computers will replace physicians for many diagnostic tasks, citizen science will give rise to citizen medicine, and enormous data sets will give us new means to attack conditions that have long been incurable. Massive, open, online medicine, where diagnostics are done by Facebook-like comparisons of medical profiles, will enable real-time, real-world research on massive populations. There's no doubt the path forward will be complicated: the medical establishment will resist these changes, and digitized medicine inevitably raises serious issues surrounding privacy. Nevertheless, the result-better, cheaper, and more human health care-will be worth it. Provocative and engrossing, The Patient Will See You Now is essential reading for anyone who thinks they deserve better health care. That is, for all of us.

Author: Dawn Goodwin
Publisher: Cambridge University Press
ISBN: 0521882060
Category : Medical
Languages : en
Pages : 209

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Book Description
In recent years, evidence-based medicine (EBM), clinical governance and professional accountability have become increasingly significant in shaping the organisation and delivery of healthcare. However, these notions all build upon and exemplify the idea of human-centred, individual action. In this book, Dawn Goodwin suggests that such models of practice exaggerate the extent to which practitioners are able to predict and control the circumstances and contingencies of healthcare. Drawing on ethnographic material, Goodwin explores the way that 'action' unfolds in a series of empirical cases of anaesthetic and intensive care practice. Anaesthesia configures a relationship between humans, machines and devices that transforms and redistributes capacities for action and thereby challenges the figure of a rational, intentional, acting individual. This book elucidates the ways in which various entities (machines, tools, devices and unconscious patients as well as healthcare practitioners) participate, and how actions become legitimate and accountable.

Author: Chris Chambers
Publisher: Princeton University Press
ISBN: 0691192278
Category : Psychology
Languages : en
Pages : 296

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Book Description
Why psychology is in peril as a scientific discipline—and how to save it Psychological science has made extraordinary discoveries about the human mind, but can we trust everything its practitioners are telling us? In recent years, it has become increasingly apparent that a lot of research in psychology is based on weak evidence, questionable practices, and sometimes even fraud. The Seven Deadly Sins of Psychology diagnoses the ills besetting the discipline today and proposes sensible, practical solutions to ensure that it remains a legitimate and reliable science in the years ahead. In this unflinchingly candid manifesto, Chris Chambers shows how practitioners are vulnerable to powerful biases that undercut the scientific method, how they routinely torture data until it produces outcomes that can be published in prestigious journals, and how studies are much less reliable than advertised. Left unchecked, these and other problems threaten the very future of psychology as a science—but help is here.

Author: HIpE
Publisher:
ISBN: 9780646551241
Category :
Languages : en
Pages : 16

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Author: Wangari Maathai
Publisher: Anchor
ISBN: 0307378098
Category : Political Science
Languages : en
Pages : 337

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Book Description
In this groundbreaking work, the Nobel Peace Prize-winner and founder of the Green Belt Movement offers a new perspective on the troubles facing Africa today. Too often these challenges are portrayed by the media in extreme terms connoting poverty, dependence, and desperation. Wangari Maathai, the author of Unbowed, sees things differently, and here she argues for a moral revolution among Africans themselves. Illuminating the complex and dynamic nature of the continent, Maathai offers “hardheaded hope” and “realistic options” for change and improvement. She deftly describes what Africans can and need to do for themselves, stressing all the while responsibility and accountability. Impassioned and empathetic, The Challenge for Africa is a book of immense importance.

Author: W. Richard Scott
Publisher: University of Chicago Press
ISBN: 0226743101
Category : Medical
Languages : en
Pages : 454

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Book Description
The changes in the US healthcare system since World War II are documented here, from new technologies, service-delivery arrangements, to financing mechanisms and underlying sets of organizing principles. The authors illustrate the work with five types of healthcare organizations.

Author: Christina Maslach
Publisher: John Wiley & Sons
ISBN: 0470423560
Category : Psychology
Languages : en
Pages : 200

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Book Description
Today's workforce is experiencing job burnout in epidemic proportions. Workers at all levels, both white- and blue-collar, feel stressed out, insecure, misunderstood, undervalued, and alienated at their workplace. This original and important book debunks the common myth that when workers suffer job burnout they are solely responsible for their fatigue, anger, and don't give a damn attitude. The book clearly shows where the accountability often belongs. . . .squarely on the shoulders of the organization.

Author: Laurence Kahn
Publisher: Taylor & Francis
ISBN: 1000630331
Category : Psychology
Languages : en
Pages : 157

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Book Description
What Nazism Did to Psychoanalysis explores the impact Nazism had on the evolution of psychoanalysis and tackles the enigma of the transformation of individual hate into mass psychosis and of the autocratic creation of a neo-reality. Addressing the effects of the Holocaust on the psychoanalytic world, this book does not focus on the suffering of the survivors but the analysis of the concrete mechanisms of destruction that affected language and thought, their impact on the practice of psychoanalysis and the defences that psychoanalysts tried to find against the linguistic, legal and symbolic chaos that struck the foundations of reality. Laurence Kahn discusses the struggle against the appropriation, by the Nazi language, of key terms such as demonic nature, drives, ideals and, above all, the Selbsterhaltungstrieb (the self-preservation drive), which became, with Hitler, the axis of the living space policy, the "Lebensraum". Covering key topics such as trauma, transgenerational issues, silence and secrecy and the depredation of culture, this is an essential work for psychoanalysts and anyone wishing to understand how strongly the development of psychoanalysis was affected by Nazism.