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Author: Schröder Publisher: Springer ISBN: 3034887612 Category : Medical Languages : en Pages : 182
Book Description
Fatty acids play an important role in the barrier function of skin and represent a major source of proinflammatory mediators such as prostaglandins, leukotrienes and other lipids in inflammatory skin disorders. This book combines the two major functions of fatty acids in skin biology. In the first part the biosynthesis of fatty acids in skin with its role in barrier function as well as the role of dietary fatty acids on skin cell function and in the treatment of inflammatory skin diseases is presented. The second part deals with skin as a source of proinflammatory eicosanoids, especially with the keratinocyte as a major cellular source. Metabolism of eicosanoids in skin, its role in psoriasis and atopic dermatitis as well as pharmacological inhibition of eicosanoid biosynthesis is reviewed. The book finishes with a chapter describing the methods used for quantification of fatty acids and derivatives in skin inflammation. Anyone interested in skin physiology would benefit from the overviews about the two sites of fatty acids' function in skin integrity and in skin inflammation.
Author: Schröder Publisher: Springer ISBN: 3034887612 Category : Medical Languages : en Pages : 182
Book Description
Fatty acids play an important role in the barrier function of skin and represent a major source of proinflammatory mediators such as prostaglandins, leukotrienes and other lipids in inflammatory skin disorders. This book combines the two major functions of fatty acids in skin biology. In the first part the biosynthesis of fatty acids in skin with its role in barrier function as well as the role of dietary fatty acids on skin cell function and in the treatment of inflammatory skin diseases is presented. The second part deals with skin as a source of proinflammatory eicosanoids, especially with the keratinocyte as a major cellular source. Metabolism of eicosanoids in skin, its role in psoriasis and atopic dermatitis as well as pharmacological inhibition of eicosanoid biosynthesis is reviewed. The book finishes with a chapter describing the methods used for quantification of fatty acids and derivatives in skin inflammation. Anyone interested in skin physiology would benefit from the overviews about the two sites of fatty acids' function in skin integrity and in skin inflammation.
Author: J. Kremer Publisher: Springer ISBN: 3034888252 Category : Medical Languages : en Pages : 162
Book Description
This volume of Progress in Inflammation Research is a unique compilation of work performed by a wide spectrum of investigators from different medical disciplines. It is fascinating that dietary alterations of fatty acid intake can result in a range of salutory changes in a great variety of medical conditions. Most of the good scien tific work which has led to these observations has been performed over just the last two decades. This is of course not a very long time in the context of the history of the human species. Recently performed analysis of fat intake from paleolithic times has indicated that our hunter-gatherer ancestors consumed as much cholesterol as modern Western man, but strikingly less saturated fatty acid and more polyunsatu rates, including n-3 fatty acids. Wild game has the terrestrial source of n-3 incorpo rated in its fat since browsing animals derive 18:3n-3 (alpha-linolenic acid) natural ly from leafy plants. There is, however, little opportunity for modern Western man to get n-3 fatty acids from the diet if one does not consume fish. Modern agribusiness provides ani mal feeds high in n-6 fatty acids, mostly derived from linoleic acid (18:2n-6) in corn feed. Therefore, grazing animals have no access to alternative fatty acids in either feed or grasses, the latter containing little or none of these potentially beneficial highly polyunsaturated fatty acids.
Author: Ronald Ross Watson Publisher: Springer Science & Business Media ISBN: 1627031677 Category : Medical Languages : en Pages : 538
Book Description
The role of Bioactive Dietary Factors and Plant Extracts in Preventive Dermatology provides current and concise scientific appraisal of the efficacy of foods, nutrients, herbs, and dietary supplements in preventing dermal damage and cancer as well as improving skin health. This important new volume reviews and presents new hypotheses and conclusions on the effects of different bioactive foods and their components derived particularly from vegetables, fruits, and herbs. Primary emphasis is on treatment and prevention of dermal damage focusing on skin cancers with significant health care costs and mortality. Bioactive Dietary Factors and Plant Extracts in Preventive Dermatology brings together expert clinicians and researchers working on the different aspects of supplementation, foods, and plant extracts and nutrition and skin health. Their expertise provides the most current knowledge in the field and will serve as the foundation for advancing future research.
Author: Thomas Ruzicka Publisher: CRC Press ISBN: 9780849360329 Category : Medical Languages : en Pages : 230
Book Description
This publication summarizes the increasing knowledge in eicosanoid research. It provides a detailed overview of this rapidly expanding field. The text contains sections on general aspects of arachidonic acid metabolism, the role of eicosanoids in skin diseases, and their biological and biochemical effects in skin. Also included is a section on inhibitors of arachidonic acid metabolism with particular reference to use in dermatology. New concepts covered are: possible physiological role of lipoxygenase products in cutaneous wound healing, restoration and maintenance of cutaneous integrity, and the recently recognized protective function of prostaglandins in skin. It is an invaluable resource for individuals involved with dermatology, pharmacology, inflammation, immunology, biochemistry, physiology, internal medicine and therapeutics.
Author: Jean Christopher Chamcheu Publisher: MDPI ISBN: 3038971928 Category : Languages : en Pages : 225
Book Description
This book is a printed edition of the Special Issue "Nutraceuticals and the Skin: Roles in Health and Disease" that was published in Nutrients
Author: T. Agner Publisher: Karger Medical and Scientific Publishers ISBN: 3318055867 Category : Medical Languages : en Pages : 172
Book Description
Although a very fragile structure, the skin barrier is probably one of the most important organs of the body. Inward/out it is responsible for body integrity and outward/in for keeping microbes, chemicals, and allergens from penetrating the skin. Since the role of barrier integrity in atopic dermatitis and the relationship to filaggrin mutations was discovered a decade ago, research focus has been on the skin barrier, and numerous new publications have become available. This book is an interdisciplinary update offering a wide range of information on the subject. It covers new basic research on skin markers, including results on filaggrin and on methods for the assessment of the barrier function. Biological variation and aspects of skin barrier function restoration are discussed as well. Further sections are dedicated to clinical implications of skin barrier integrity, factors influencing the penetration of the skin, influence of wet work, and guidance for prevention and saving the barrier. Distinguished researchers have contributed to this book, providing a comprehensive and thorough overview of the skin barrier function. Researchers in the field, dermatologists, occupational physicians, and related industry will find this publication an essential source of information.
Author: Anika Bruhs Publisher: ISBN: Category : Languages : en Pages :
Book Description
We have recently shown that topical application of sodium butyrate (SB) suppresses allergic contact dermatitis in mice. This effect was associated with the induction/activation of Treg, the activity of which is diminished in certain inflammatory dermatoses. To further study the effects of SB in chronic inflammatory skin disorders, we utilized the imiquimod (IMQ)-induced psoriasis-like skin inflammation model. Mice were treated with 5% IMQ cream (Aldarau00ae) on the shaved backs and ears for 10 days. One group of IMQ-treated mice received topically on the back skin 100 u00b5l of a 1 mM solution SB for 3 days. IMQ-treated mice developed thickening of the skin, erythema, scales as well as acanthosis, hyperkeratosis and inflammatory infiltrates. These inflammatory responses were significantly reduced upon administration of SB. On the RNA level, SB treatment leads to significant downregulation of Il17 transcription. In turn, transcription of Il10 was remarkably induced by SB. We surmise Treg to be the primary source of IL-10 which was supported by the upregulation of the mRNA of the Treg-specific transcription factor FOXP3. Together, these data support our assumption that SB might activate cutaneous Treg and thereby contribute to the downregulation of the inflammatory response. Though only topically applied, IMQ induces also systemic immunologic alterations. The number of IL-17-expressing CD45+ cells obtained from lymph nodes and spleens was remarkably enhanced in IMQ-treated mice, implying that the splenomegaly observed in IMQ treated mice may be in part due to the infiltration/expansion of IL-17+ lymphocytes. This effect was almost completely prevented by SB. In addition, significantly fewer CD45+ cells expressing FOXP3 and IL-10 were detected after IMQ administration, suggesting downregulation of Treg. Together, this implies that IMQ suppresses Treg and activates IL-17-expressing lymphocytes an effect which can be dramatically reversed by SB, explaining the beneficial effect of SB on the resolution of the IMQ-induced psoriasis-like lesions.
Author: Schröder
Author: Schröder
Author: Jens-Michael Schröder
Author: Bey Hing Goh
Author: J. Kremer
Author: Ronald Ross Watson
Author: Thomas Ruzicka
Author: Keerthi Anantha
Author: Jean Christopher Chamcheu
Author: T. Agner
Author: Anika Bruhs