Author: Mairéad McNamara Publisher: Karger Medical and Scientific Publishers ISBN: 1912776707 Category : Medical Languages : en Pages : 76
Book Description
Glioblastoma (also known as glioblastoma multiforme) is a malignant intrinsic tumor thought to arise from populations of stem/progenitor cells in the brain. It is the most common aggressive intrinsic brain tumor in adults, with the potential to spread rapidly within the brain. Patients with glioblastoma face a poor prognosis, with median overall survival of approximately 15 months. However, our growing understanding of the molecular biology of gliomas means that this outlook may be improving. The identification of clinically relevant subgroups defined by specific genetic mutations is challenging the traditional delineation between low- and high-grade gliomas that has been based on histological appearance and imaging. Indeed, it is becoming clear that, as a molecular entity, a glioblastoma, which by traditional classification is a grade IV glioma, may present with a lower grade initially and then become more aggressive – an important addition to the established concept. The care of a patient with a glioblastoma requires a coordinated approach delivered by a multidisciplinary team, with the aim of maintaining quality of life for as long as possible. Here, we provide a concise overview of the diagnosis and management of glioblastoma, as well as discussion of our emerging understanding of the molecular drivers that are helping us to delineate different patient subgroups. These subgroups will, hopefully, allow more targeted treatments in the future. This resource will be of interest to all those involved in caring for patients with this aggressive brain tumor, including neurologists, neurosurgeons, neuro-oncologists, radiation oncologists, palliative care specialists, specialist nurses and medical students. Contents: • Epidemiology, pathophysiology and classification • Clinical presentation • Diagnosis • Management • Treatment of associated conditions • Emerging research and treatment
Author: Lauren E. Abrey Publisher: Karger Medical and Scientific Publishers ISBN: 1905832877 Category : Medical Languages : en Pages : 146
Book Description
Despite the availability of many effective treatments, there remains a therapeutic nihilism associated with brain tumors. This highly readable second edition of 'Fast Facts: Brain Tumors' challenges this view, starting from the premise that patients with brain tumors can truly benefit from a thoughtful multidisciplinary approach. This comprehensive handbook covers all the salient features of the various brain tumors and treatment modalities in a way that will be useful to the practicing clinician. • Advances in radiology and pathology that have led to more precise and detailed diagnoses • Developments in molecular biology and imaging techniques that have improved available diagnostic modalities • New neurosurgical techniques that have enabled operations on tumors that were previously considered inoperable • Novel delivery systems that allow various treatments to reach tumors that are otherwise protected by the blood-brain barrier. This fully updated edition of 'Fast Facts: Brain Tumors' bridges the gap between primary care providers - whose role is pivotal in tumor detection and subsequent patient care - and first-level specialists such as general neurologists and neurosurgeons. Its key message is that selection of the best initial approach for an individual patient will result in the best overall outcome, both in terms of survival and quality of life. 'Fast Facts: Brain Tumors' is specifically for the primary care physician whose role is pivotal in tumor detection and subsequent patient care. Contents: • Classification and epidemiology • Diagnosis • Treatment • Brain metastases • Gliomas • Meningiomas • Neuronal tumors • Pineal region tumors • Skull base tumors • Primary central nervous system lymphoma • Brain tumor syndromes and tumor-like cysts • Geriatric neuro-oncology • Useful resources
Author: P. Dalquen Publisher: Karger Medical and Scientific Publishers ISBN: 3318071471 Category : Medical Languages : en Pages : 184
Book Description
Cytology is a universally applicable technique that can be used by both general practitioners and specialists. It enables diagnosis of lesions on surfaces such as the skin, mucous membranes or cervix by smear, and the determination of findings from internal organs by fine needle aspiration. The method is technically both simple and inexpensive and can therefore be used in all parts of the world, regardless of their level of development. This book aims to summarize the essential basics of cytology. At the same time, it provides an overview of non-neoplastic and neoplastic lesions, covering both common and rare manifestations across various body sites. The related virtual Case Collection of more than 500 cases from almost all organs provides deeper insights into the morphological spectrum of lesions and into the cytological literature. It is free to access at courses.karger.com/bundles/essentials-of-cytopathology. Table of Contents: • Preparatory methods • Cervix uteri, vagina • Ovary • Breast • Male genital tract • Urinary tract • Respiratory tract • Effusions and tumors of the serous cavities • Lymphoreticular system • Thyroid • Salivary glands • Pancreas, liver and biliary system • Gastrointestinal tract • Central and peripheral nervous system • Soft tissue tumors
Author: R.J. Buka Publisher: Karger Medical and Scientific Publishers ISBN: 3318067423 Category : Medical Languages : en Pages : 71
Book Description
Chimeric antigen receptor (CAR) T cells are genetically engineered immune cells that can seek out and destroy cancer cells. The results from their use in cancer immunotherapy have been very promising, but treatment is often associated with frequent, serious short-term toxicities. 'Fast Facts: CAR-T Therapy' explains what CAR T cells are and how they were developed, discusses the results of clinical trials and the management of toxicities, and outlines future improvements and applications. It is ideal reading for any healthcare professional wanting to know more about this exciting therapeutic field. Table of Contents: • CAR T cells • Clinical application • Practical aspects • Future directions
Author: Paul Cornes Publisher: Karger Medical and Scientific Publishers ISBN: 1912776219 Category : Medical Languages : en Pages : 130
Book Description
Biologics have revolutionized – and are revolutionizing – the treatment of many serious disorders. The evidence acquired from more than 10 years of clinical experience, with more than 50 biosimilar drugs and more than 700 million patient-days' exposure in Europe, shows that approved biosimilars can be used as safely and effectively as originator biologics. Yet concerns persist about biosimilars – particularly in curative cancer treatment, where they are relatively recent therapeutic options. 'Fast Facts: Biosimilars in Hematology and Oncology' provides a concise overview of emerging global practice in this fast-moving area together with practical information on adding biosimilars to a formulary and switching patients. Contents: • Biologics and the need for biosimilars • Why do we need biosimilars? • How is the quality of biosimilar medicines assured? • Legal issues • Switching, interchangeability and extrapolation • Safety and pharmacovigilant • Global issues • Formulary considerations: pharmacy issues • Formulary considerations: supportive care biosimilars • Formulary considerations: therapeutic anti-cancer biosimilars • Communication and awareness
Author: Alfredo Quiñones-Hinojosa Publisher: Univ of California Press ISBN: 0520949609 Category : Social Science Languages : en Pages : 328
Book Description
Today he is known as Dr. Q, an internationally renowned neurosurgeon and neuroscientist who leads cutting-edge research to cure brain cancer. But not too long ago, he was Freddy, a nineteen-year-old undocumented migrant worker toiling in the tomato fields of central California. In this gripping memoir, Alfredo Quiñones-Hinojosa tells his amazing life story—from his impoverished childhood in the tiny village of Palaco, Mexico, to his harrowing border crossing and his transformation from illegal immigrant to American citizen and gifted student at the University of California at Berkeley and at Harvard Medical School. Packed with adventure and adversity—including a few terrifying brushes with death—Becoming Dr. Q is a testament to persistence, hard work, the power of hope and imagination, and the pursuit of excellence. It’s also a story about the importance of family, of mentors, and of giving people a chance.
Author: William Blum Publisher: Karger Medical and Scientific Publishers ISBN: 1910797596 Category : Medical Languages : en Pages : 90
Book Description
This last year has seen the approval of the first targeted treatments for acute myeloid leukemia (AML) - following decades with no new developments and a poor prognosis for most patients with the disease. The new drugs reflect the remarkable progress that has been made in our understanding of the pathophysiology of AML and its underlying cytogenetic and molecular abnormalities - which differ not only between patients but also within a patient over time and with treatment. 'Fast Facts: Acute Myeloid Leukemia' provides a comprehensive yet concise foundation for understanding AML: from basic epidemiology, diagnosis, classification and the current 'standard' treatment, through to recent advances in our understanding of the cytogenetic and molecular underpinnings of the disease, such as the IDH2 mutation, and the future for tailored therapy. It will be useful to primary care providers, medical students, specialist nurses, junior doctors and allied healthcare professionals who want to develop a thorough grounding in our evolving understanding of AML and its treatment. Contents: • Epidemiology, pathophysiology and etiology • Diagnosis • Treatment • Supportive care • Prognosis and monitoring • Emerging treatments • Useful resources
Author: Miral D. Jhaveri Publisher: Elsevier Health Sciences ISBN: 0323400434 Category : Medical Languages : en Pages : 1237
Book Description
More than 300 diagnoses that are delineated, referenced, and lavishly illustrated highlight the third edition of this bestselling reference. World-renowned authority Dr. Anne G. Osborn and her expert author team of Drs. Karen L. Salzman and Miral D. Jhaveri provide carefully updated information in a concise, bulleted format, keeping you current with new disease entities and syndromes, MR imaging techniques and applications, and pathology relevant to brain imaging. Succinct text, outstanding illustrations, and up-to-date content make this title a must-have reference for neuroradiologists, general radiologists, neurologists, and neurosurgeons. Concise, bulleted text provides efficient information on more than 300 diagnoses that are clearly illustrated with 2,500 superb images Meticulously updated throughout, with new diagnoses and hundreds of new images that provide the most current information in the field. Expert guidance on CLIPPERS, second-impact syndrome in trauma, perfusion MR for tumor characterization, susceptibility-weighted imaging in stroke and brain bleeds, and molecular markers in brain tumor classification and grading. Updated coverage of brain trauma addresses newly recognized entities, techniques and imaging for rapid stroke triage, and functional imaging and dementia diagnosis.
Author: Stephen Clarke Publisher: Karger Medical and Scientific Publishers ISBN: 3318068217 Category : Medical Languages : en Pages : 128
Book Description
The treatment of cancer has been revolutionized by therapies that modulate the immune system, with benefits for quality of life and survival. Standards of care have changed to reflect developments, but the area is moving fast. Keeping abreast of new therapies and trial data can be challenging. This second edition of 'Fast Facts: Immuno-Oncology' takes you from the fundamentals of immunology through to the new concepts of immunoediting and immunotherapy and likely future directions. Whether you have worked in oncology for decades and need a refresher or you are just starting out and need a crash course, this book provides all you need to know about immuno-oncology, concisely summarized. Table of Contents: • Components of the immune system • How cancers evade the immune system • How cancer immunotherapy works • Clinical use of immune checkpoint inhibitors • The future of immuno-oncology
Author: Elke Hattingen Publisher: Springer ISBN: 3642450407 Category : Medical Languages : en Pages : 166
Book Description
This book describes the basics, the challenges and the limitations of state of the art brain tumor imaging and examines in detail its impact on diagnosis and treatment monitoring. It opens with an introduction to the clinically relevant physical principles of brain imaging. Since MR methodology plays a crucial role in brain imaging, the fundamental aspects of MR spectroscopy, MR perfusion and diffusion-weighted MR methods are described, focusing on the specific demands of brain tumor imaging. The potential and the limits of new imaging methodology are carefully addressed and compared to conventional MR imaging. In the main part of the book, the most important imaging criteria for the differential diagnosis of solid and necrotic brain tumors are delineated and illustrated in examples. A closing section is devoted to the use of MR methods for the monitoring of brain tumor therapy. The book is intended for radiologists, neurologists, neurosurgeons, oncologists and other scientists in the biomedical field with an interest in neuro-oncology.
Author: Mairéad McNamara 
Author: Lauren E. Abrey
Author: P. Dalquen
Author: R.J. Buka
Author: Paul Cornes
Author: Alfredo Quiñones-Hinojosa
Author: William Blum
Author: Miral D. Jhaveri
Author: Stephen Clarke
Author: Elke Hattingen