Fabrication and Characterization of Nano-FET Biosensors for Studying Osteocyte Mechanotransduction PDF Download

Author: Jason Li
Publisher:
ISBN: 9780494760871
Category :
Languages : en
Pages : 182

View

Book Description
Nano-FET biosensors are an emerging nanoelectronic technology capable of real-time and label-free quantification of soluble biological molecules. This technology promises to enable novel in vitro experimental approaches for investigating complex biological systems. In this study, we first explored osteocyte mechanosensitivity under different mechanical stimuli and found that osteocytes are exquisitely sensitive to different oscillatory fluid flow conditions. We therefore aimed to characterize protein-mediated intercellular communication between mechanically-stimulated osteocytes and other bone cell populations in vitro to elucidate the underlying mechanisms of load-induced bone remodeling. To this end, we devised a novel nano-manipulation based fabrication method for manufacturing nano-FET biosensors with precisely controlled device parameters, and further investigated the effect of these parameters on sensor performance.

Author: Patricia Khashayar
Publisher: Springer
ISBN: 9783319855547
Category : Technology & Engineering
Languages : en
Pages : 197

View

Book Description
This book addresses the important clinical problem of accurately diagnosing osteoporosis, and analyzes how Bone Turnover Markers (BTMs) can improve osteoporosis detection. In her research, the author integrated microfluidic technology with electrochemical sensing to embody a reaction/detection chamber to measure serum levels of different biomarkers, creating a microfluidic proteomic platform that can easily be translated into a biomarker diagnostic. The Osteokit System, a result of the integration of electrochemical system and microfluidic chips, is a unique design that offers the potential for greater sensitivity. The implementation, feasibility, and specificity of the Osteokit platform is demonstrated in this book, which is appropriate for researchers working on bone biology and mechanics, as well as clinicians.

Author: Tuhin Subhra Santra
Publisher: MDPI
ISBN: 3036506284
Category : Science
Languages : en
Pages : 254

View

Book Description
Cells are the most fundamental building block of all living organisms. The investigation of any type of disease mechanism and its progression still remains challenging due to cellular heterogeneity characteristics and physiological state of cells in a given population. The bulk measurement of millions of cells together can provide some general information on cells, but it cannot evolve the cellular heterogeneity and molecular dynamics in a certain cell population. Compared to this bulk or the average measurement of a large number of cells together, single-cell analysis can provide detailed information on each cell, which could assist in developing an understanding of the specific biological context of cells, such as tumor progression or issues around stem cells. Single-cell omics can provide valuable information about functional mutation and a copy number of variations of cells. Information from single-cell investigations can help to produce a better understanding of intracellular interactions and environmental responses of cellular organelles, which can be beneficial for therapeutics development and diagnostics purposes. This Special Issue is inviting articles related to single-cell analysis and its advantages, limitations, and future prospects regarding health benefits.

Author: Julia Hoeng
Publisher: Academic Press
ISBN: 0128172037
Category : Technology & Engineering
Languages : en
Pages : 545

View

Book Description
Organ-on-a-Chip: Engineered Microenvironments for Safety and Efficacy Testing contains chapters from world-leading researchers in the field of organ on a chip development and applications, with perspectives from life sciences, medicine, physiology and engineering. The book contains an overview of the field, with sections covering the major organ systems and currently available technologies, platforms and methods. As readers may also be interested in creating biochips, materials and engineering best practice, these topics are also described. Users will learn about the limitations of 2D in-vitro models and the available 3D in-vitro models (what benefits they offer and some examples). Finally, the MOC section shows how the organ on a chip technology can be adapted to improve the physiology of in-vitro models. - Includes case studies of other organs on a chip that have been developed and successfully used - Provides insights into functional microphysiological organ on a chip platforms for toxicity and efficacy testing, along with opportunities for translational medicine - Presented fields (PK/PD, physiology, medicine, safety) are given a definition followed by the challenges and potential of organs on a chip

Author: Yoshiki Oshida
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110666219
Category : Technology & Engineering
Languages : en
Pages : 1046

View

Book Description
Nickel-Titanium alloys are smart materials exhibiting unique properties such as superelasticity and shape-memory effect. The material has been used as orthodontic wires in the dental field for over 20 years. This book is a comprehensive overview to the field of Ni-Ti Materials and the physical, chemical and mechanical properties of this versatile alloy. In addition, complications and challenges exhibited in applications are also discussed.

Author: Massimo Biondi
Publisher: Springer
ISBN: 3319782029
Category : Medical
Languages : en
Pages : 307

View

Book Description
This book presents an innovative approach to clinical assessment in psychiatry based on a number of psychopathological dimensions with a presumed underlying pathophysiology, that are related to fundamental phenomenological aspects and lie on a continuum from normality to pathology. It is described how the evaluation of these dimensions with a specific, validated rapid assessment instrument could easily integrate and enrich the classical diagnostic DSM-5 or ICD-10 assessment. The supplemental use of this dimensional approach can better capture the complexity underlying current categories of mental illness. The findings from a large patient sample suggest how this assessment could give a first glance at how variable and multifaceted the psychopathological components within a single diagnostic category can be, and thereby optimise diagnosis and treatment choices. Being short and easy to complete, this dimensional assessment can be done in a busy clinical setting, during an ordinary psychiatric visit, and in an acute clinical context, with limited effort by a minimally trained clinician. Therefore, it provides interesting and useful information without additional costs, and allows research work to be performed even in difficult settings.

Author: Tom Mens
Publisher: Springer Science & Business Media
ISBN: 3642453988
Category : Computers
Languages : en
Pages : 418

View

Book Description
During the last few years, software evolution research has explored new domains such as the study of socio-technical aspects and collaboration between different individuals contributing to a software system, the use of search-based techniques and meta-heuristics, the mining of unstructured software repositories, the evolution of software requirements, and the dynamic adaptation of software systems at runtime. Also more and more attention is being paid to the evolution of collections of inter-related and inter-dependent software projects, be it in the form of web systems, software product families, software ecosystems or systems of systems. With this book, the editors present insightful contributions on these and other domains currently being intensively explored, written by renowned researchers in the respective fields of software evolution. Each chapter presents the state of the art in a particular topic, as well as the current research, available tool support and remaining challenges. The book is complemented by a glossary of important terms used in the community, a reference list of nearly 1,000 papers and books and tips on additional resources that may be useful to the reader (reference books, journals, standards and major scientific events in the domain of software evolution and datasets). This book is intended for all those interested in software engineering, and more particularly, software maintenance and evolution. Researchers and software practitioners alike will find in the contributed chapters an overview of the most recent findings, covering a broad spectrum of software evolution topics. In addition, it can also serve as the basis of graduate or postgraduate courses on e.g., software evolution, requirements engineering, model-driven software development or social informatics.

Author: Henry Baltes
Publisher: John Wiley & Sons
ISBN: 3527616934
Category : Technology & Engineering
Languages : en
Pages : 612

View

Book Description
Microstructures, electronics, nanotechnology - these vast fields of research are growing together as the size gap narrows and many different materials are combined. Current research, engineering sucesses and newly commercialized products hint at the immense innovative potentials and future applications that open up once mankind controls shape and function from the atomic level right up to the visible world without any gaps. Sensor systems, microreactors, nanostructures, nanomachines, functional surfaces, integrated optics, displays, communications technology, biochips, human/machine interfaces, prosthetics, miniaturized medical and surgery equipment and many more opportunities are being explored. This new series, Advanced Micro and Nano Systems, provides cutting-edge reviews from top authors on technologies, devices and advanced systems from the micro and nano worlds.

Author: Gabriela Garcia
Publisher: Flatiron Books
ISBN: 1250776694
Category : Fiction
Languages : en
Pages : 224

View

Book Description
AN INSTANT NEW YORK TIMES BESTSELLER THE WASHINGTON POST NOTABLE BOOK OF 2021 A GOOD MORNING AMERICA BOOK CLUB PICK WINNER of the Isabel Allende Most Inspirational Fiction Award, She Reads Best of 2021 Awards • FINALIST for the 2022 Southern Book Prize • LONGLISTED for Crook’s Corner Book Prize • NOMINEE for 2021 GoodReads Choice Award in Debut Novel and Historical Fiction A sweeping, masterful debut about a daughter's fateful choice, a mother motivated by her own past, and a family legacy that begins in Cuba before either of them were born In present-day Miami, Jeanette is battling addiction. Daughter of Carmen, a Cuban immigrant, she is determined to learn more about her family history from her reticent mother and makes the snap decision to take in the daughter of a neighbor detained by ICE. Carmen, still wrestling with the trauma of displacement, must process her difficult relationship with her own mother while trying to raise a wayward Jeanette. Steadfast in her quest for understanding, Jeanette travels to Cuba to see her grandmother and reckon with secrets from the past destined to erupt. From 19th-century cigar factories to present-day detention centers, from Cuba to Mexico, Gabriela Garcia's Of Women and Salt is a kaleidoscopic portrait of betrayals—personal and political, self-inflicted and those done by others—that have shaped the lives of these extraordinary women. A haunting meditation on the choices of mothers, the legacy of the memories they carry, and the tenacity of women who choose to tell their stories despite those who wish to silence them, this is more than a diaspora story; it is a story of America’s most tangled, honest, human roots.

Author: M. M. Khrushchov
Publisher:
ISBN:
Category : Bearings (Machinery)
Languages : en
Pages :

View

Book Description