Fabrication and Biological Evaluation of the Coating Co-doped Strontium and Zinc Nanoparticles on Porous Pure Titanium Surface by Hydrothermal Method PDF Download
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Author: fuming he Publisher: ISBN: Category : Languages : en Pages :
Book Description
BackgroundFor dental implants, early infection and peri-implantitis after implant restoration are major reasons for implant failure1. Plaque biofilm formation is the initiator for implant-related infection2. Therefore, itu2019s urgent to develop a new antibacterial implant materials or treatment methods. It is found that nanostructured titanium surface can resist bacterial adherence and promote bactericidal capability3. Zinc (Zn) not only exhibits excellent antibacterial behavior with broad spectrum and limits drug-resistance bacteria induction, but also is active in osteogenesis4. Strontium (Sr) has various effects of improving immunologic reaction, promoting osteogenesis and inhibiting osteoclastic differentiation4. AimIn this study, Sr- and Zn- incorporated micro/nano-structured titanium surface with nanorods (MNT-Sr/Zn) was fabricated by a two-step hydrothermal process, aiming to improve osseointegration and reduce implant failure caused by implant-related infection and broaden new ideas for the future research on the antibacterial properties of biological materials.Materials & MethodsThe Mod Ti surfaces were used as a control. The characterization of different surfaces was detected by a field emission scanning electron microscope (FE-SEM) equipped with energy dispersive spectra (EDS) detector. Meanwhile, Staphylococcus aureus (S. aureus) was selected to evaluate antibacterial properties through Live/Dead Staining and watching the adhesive bacterial morphology under FE-SEM. Whatu2019s more, rat bone marrow-derived mesenchymal stem cells (rBMSCs) were cultured on the surfaces to detect their early osteogenic properties, like the alkaline phosphatase(ALP) activity and the expressions of osteogenesis related genes.Results The results confirmed that nanorod-like particles with a diameter of about 30-50 nm of MNT-Sr/Zn. In the EDS spectra, the elements of Zn and Sr were evenly distributed, and approximately 1.49 u00b1 0.16 wt% and 21.69 u00b1 2.74 wt% respectively. More importantly, Zn-containing nanorod-like particles and the morphology could work together, slightly decreasing adhesion of S. aureus but increasing the proportion of dead cells, thus inhibiting subsequent biofilm formation, compared with the controlled group. In addition to this, MNT-Sr/Zn could enhance the osteogenic differentiation via the upregulation of the transcription of osteogenic related genes in vitro. ConclusionsThis research provides a new surface modification method on titanium substrate for multi-functional implant material development. Due to the co-doping of Sr and Zn in the coating, biomechanical stability, antibacterial capability and early osteogenic inductive effect are enhanced, which has the potential to be applied in dental implantation in the future.References[1] Hickok, N. J. , Shapiro, I. M. , Chen, A. F. (2018). The impact of incorporating antimicrobials into implant surfaces. Journal of Dental Research, 002203451773176.[2] Chouirfa, H., Bouloussa, H., Migonney, V., Falentin-Daudre, C (2019). Review of titanium surface modification techniques and coatings for antibacterial applications. Acta biomaterialia 83:37-54[3] Jaggessar, A., Shahali, H., Mathew, A., Yarlagadda, P. K. D. V. (2017). Bio-mimicking nano- and micro-structured surface fabrication for antibacterial properties in medical implants. Journal of Nanobiotechnology, 15(1), 64.[4] Edward Ou2019Neill, Awale, G., Daneshmandi, L., Umerah, O., & Lo, W. H. (2018). The roles of ions on bone regeneration. Drug Discovery Today.
Author: fuming he Publisher: ISBN: Category : Languages : en Pages :
Book Description
BackgroundFor dental implants, early infection and peri-implantitis after implant restoration are major reasons for implant failure1. Plaque biofilm formation is the initiator for implant-related infection2. Therefore, itu2019s urgent to develop a new antibacterial implant materials or treatment methods. It is found that nanostructured titanium surface can resist bacterial adherence and promote bactericidal capability3. Zinc (Zn) not only exhibits excellent antibacterial behavior with broad spectrum and limits drug-resistance bacteria induction, but also is active in osteogenesis4. Strontium (Sr) has various effects of improving immunologic reaction, promoting osteogenesis and inhibiting osteoclastic differentiation4. AimIn this study, Sr- and Zn- incorporated micro/nano-structured titanium surface with nanorods (MNT-Sr/Zn) was fabricated by a two-step hydrothermal process, aiming to improve osseointegration and reduce implant failure caused by implant-related infection and broaden new ideas for the future research on the antibacterial properties of biological materials.Materials & MethodsThe Mod Ti surfaces were used as a control. The characterization of different surfaces was detected by a field emission scanning electron microscope (FE-SEM) equipped with energy dispersive spectra (EDS) detector. Meanwhile, Staphylococcus aureus (S. aureus) was selected to evaluate antibacterial properties through Live/Dead Staining and watching the adhesive bacterial morphology under FE-SEM. Whatu2019s more, rat bone marrow-derived mesenchymal stem cells (rBMSCs) were cultured on the surfaces to detect their early osteogenic properties, like the alkaline phosphatase(ALP) activity and the expressions of osteogenesis related genes.Results The results confirmed that nanorod-like particles with a diameter of about 30-50 nm of MNT-Sr/Zn. In the EDS spectra, the elements of Zn and Sr were evenly distributed, and approximately 1.49 u00b1 0.16 wt% and 21.69 u00b1 2.74 wt% respectively. More importantly, Zn-containing nanorod-like particles and the morphology could work together, slightly decreasing adhesion of S. aureus but increasing the proportion of dead cells, thus inhibiting subsequent biofilm formation, compared with the controlled group. In addition to this, MNT-Sr/Zn could enhance the osteogenic differentiation via the upregulation of the transcription of osteogenic related genes in vitro. ConclusionsThis research provides a new surface modification method on titanium substrate for multi-functional implant material development. Due to the co-doping of Sr and Zn in the coating, biomechanical stability, antibacterial capability and early osteogenic inductive effect are enhanced, which has the potential to be applied in dental implantation in the future.References[1] Hickok, N. J. , Shapiro, I. M. , Chen, A. F. (2018). The impact of incorporating antimicrobials into implant surfaces. Journal of Dental Research, 002203451773176.[2] Chouirfa, H., Bouloussa, H., Migonney, V., Falentin-Daudre, C (2019). Review of titanium surface modification techniques and coatings for antibacterial applications. Acta biomaterialia 83:37-54[3] Jaggessar, A., Shahali, H., Mathew, A., Yarlagadda, P. K. D. V. (2017). Bio-mimicking nano- and micro-structured surface fabrication for antibacterial properties in medical implants. Journal of Nanobiotechnology, 15(1), 64.[4] Edward Ou2019Neill, Awale, G., Daneshmandi, L., Umerah, O., & Lo, W. H. (2018). The roles of ions on bone regeneration. Drug Discovery Today.
Author: Marta Mohedano Publisher: MDPI ISBN: 3036505520 Category : Science Languages : en Pages : 172
Book Description
Plasma electrolytic oxidation (PEO), also known as micro-arc oxidation (MAO), functionalizes surfaces, improving the mechanical, thermal, and corrosion performance of metallic substrates, along with other tailored properties (e.g., biocompatibility, catalysis, antibacterial response, self-lubrication, etc.). The extensive field of applications of this technique ranges from structural components, in particular, in the transport sector, to more advanced fields, such as bioengineering. The present Special Issue covers the latest advances in PEO‐coated light alloys for structural (Al, Mg) and biomedical applications (Ti, Mg), with 10 research papers and 1 review from leading research groups around the world.
Author: Sergey V. Dorozhkin Publisher: CRC Press ISBN: 9814364177 Category : Science Languages : en Pages : 863
Book Description
Due to a great chemical similarity with the biological calcified tissues, many calcium orthophosphates possess remarkable biocompatibility and bioactivity. Materials scientists use this property extensively to construct artificial bone grafts that are either entirely made of or only surface-coated with the biologically relevant calcium orthophospha
Author: Seung H Ko Publisher: Royal Society of Chemistry ISBN: 1849737509 Category : Science Languages : en Pages : 323
Book Description
Surface area has a directly relationship with the efficiency of energy devices. Hierarchical nanostructuring has the potential to greatly increase surface area, and their electrical properties are favourable, not only to energy generation and storage, but also energy-consuming electronic circuits. This book provides systematic coverage of how nanostructured materials can be applied to energy devices, with an emphasis on the process of generation to storage and consumption. The fundamentals (including properties, characterisation and synthesis) are clearly presented across the first chapters of the book, providing readers new to the field with a clear overview of this expanding topic. The detailed discussion of applications will be an inspiration to those already well-versed in the field. The editors have more than a decade of experience in working on all aspects of energy generation and storage - in academia, national laboratories and industry. The book presents a balanced view from all sectors and is presented in a format accessible by postgraduate students and professional researchers alike.
Author: Kenneth Gonsalves Publisher: John Wiley & Sons ISBN: 0470185821 Category : Science Languages : en Pages : 543
Book Description
Learn to Use Nanoscale Materials to Design Novel Biomedical Devices and Applications Discover how to take full advantage of nanoscale materials in the design and fabrication of leading-edge biomedical devices. The authors introduce you to a variety of possible clinical applications such as drug delivery, diagnostics, and cancer therapy. In addition, the authors explore the interface between micron and nanoscale materials for the development of applications such as tissue engineering. Finally, they examine the mechanisms of cell interactions with material surfaces through the use of nanotechnology-based material processing and characterization methods. The text's three sections highlight its interdisciplinary approach: * Part One: Nanostructure Fabrication * Part Two: Bio-Nano Interfaces * Part Three: Clinical Applications of Nanostructures Among the key topics covered are nanotechnology in tissue regeneration; biomolecular engineering; receptor-ligand interactions; cell-biomaterial interactions; nanomaterials in diagnostics, drug delivery, and cancer therapy; and nano- and micron-level engineering and fabrication. Throughout the text, clear examples guide you through the chemistry and the processing involved in designing and developing nanoscale materials for biomedical devices. Each chapter begins with an introduction and ends with a conclusion highlighting the key points. In addition, references at the end of the chapter help you expand your research on any individual topic. In summary, this book helps biomedical researchers and engineers understand the physical phenomena that occur at the nanoscale in order to design novel cell-based constructs for a wide range of applications.
Author: Iulian Vasile Antoniac Publisher: Springer ISBN: 9783319124599 Category : Technology & Engineering Languages : en Pages : 0
Book Description
This handbook describes several current trends in the development of bioceramics and biocomposites for clinical use in the repair, remodelling, and regeneration of bone tissue. Comprehensive coverage of these materials allows fundamental aspects of the science and engineering to be seen in close relation to the clinical performance of dental and orthopaedic implants. Bioceramics and biocomposites appear to be the most dynamic area of materials development for both tissue engineering and implantable medical devices. Almost all medical specialties will continue to benefit from these developments, but especially dentistry and orthopaedics. In this Handbook, leading researchers describe the use of bionanomaterials to create new functionalities when interfaced with biological molecules or structures. Also described are technologies for bioceramics and biocomposites processing in order to fabricate medical devices for clinical use. Another important section of the book is dedicated to tissue regeneration with development of new matrices. A targeted or personalized treatment device reduces drug consumption and treatment expenses, resulting in benefits to the patient and cost reductions for public health systems. This authoritative reference on the state-of-the-art in the development and use of bioceramics and biocomposites can also serve as the basis of instructional course lectures for audiences ranging from advanced undergraduate students to post-graduates in materials science and engineering and biomedical engineering.
Author: Mohamed Gebril Publisher: ISBN: Category : Languages : en Pages :
Book Description
Surface modification is a well-known approach to enhance the osseointegration of titanium dental implants. In this study, a novel hydrothermal method for coating titanium surfaces with bioactive glass was developed. Our method included sol-gel synthesis of bioactive glass, followed by hydrothermal coating of titanium under different NaOH concentrations. The surface properties of coated substrates were evaluated by scanning electron microscopy, X-ray diffraction, energy dispersive X-ray spectroscopy, and surface profilometry. By varying the alkalinity of the hydrothermal process, different surface topographies, crystalline phases and chemistries could be obtained. Soaking the hydrothermally coated titanium substrates in simulated body fluid resulted in hydroxyapatite deposition, demonstrating bioactivity. All titanium surfaces were biocompatible and the topography of the coated titanium surfaces played a major role in determining the attachment of MC3T3-E1 osteoblastic cells. Our studies suggest that this novel coating method has the potential to improve the osseointegration of dental implants.
Author: Roger Narayan Publisher: Woodhead Publishing ISBN: 0081007256 Category : Technology & Engineering Languages : en Pages : 578
Book Description
Nanobiomaterials: Nanostructured materials for biomedical applications covers an extensive range of topics related to the processing, characterization, modeling, and biomedical applications of nanostructured ceramics, polymers, metals, composites, self-assembled materials, and macromolecules. Novel approaches for bottom-up and top-down processing of nanostructured biomaterials are highlighted. In addition, innovative techniques for characterizing the in vitro behavior and in vivo behavior of nanostructured biomaterials are considered. Applications of nanostructured biomaterials in dentistry, drug delivery, medical diagnostics, surgery and tissue engineering are examined. Provides a concise description of the materials and technologies used in the development of nanostructured biomaterials Provides industrial researchers with an up-to-date and handy reference on current topics in the field of nanostructured biomaterials Includes an integrated approach that is used to discuss both the biological and engineering aspects of nanostructured biomaterials
Author: fuming he
Author: fuming he
Author: Marta Mohedano
Author: Sergey V. Dorozhkin
Author: Seung H Ko
Author: Kenneth Gonsalves
Author: JiaPing Li
Author: 龔冠臣
Author: Iulian Vasile Antoniac
Author: Mohamed Gebril
Author: Roger Narayan