Extracellular Vesicles: from Fundamental Research to Clinical Application PDF Download

Author: Katja Goričar
Publisher:
ISBN: 9789612672157
Category :
Languages : en
Pages : 0

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Author:
Publisher: Academic Press
ISBN: 9780443294969
Category : Science
Languages : en
Pages : 0

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Book Description
Extracellular Vesicles from Basic Research to Clinical Applications, Volume 94 covers theses lipid bilayer particles containing proteins, glycoproteins, mRNA, other small RNA species, and lipids formed and released by various pathogens. Chapters in this update include Extracellular Vesicles release from protozoa parasite and animal model, EVs from parasite and biomarkers, Translational Medicine - Use of EVs as therapy, EVs and viruses and their interaction with cells, EVs and Toxoplasma gondii, EVs and Fungi, Biogenesis of EVs in parasites, Extracellular vesicles, EVs and Leishmania, EVs in neuropsychiatry, EVs and Bacteria. Other sections cover EVs and sleep deprivation, EVs and cancer, Extracellular vesicles and methods to isolation, purification, and characterization.

Author: Qian Wang
Publisher: Springer Nature
ISBN: 9819983657
Category :
Languages : en
Pages : 586

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Author: Matías Sáenz-Cuesta
Publisher: Frontiers Media SA
ISBN: 2889196453
Category : Medicine (General)
Languages : en
Pages : 68

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Book Description
During the last years, the research on extracellular vesicles (EVs) has raised giving new insights into pathophysiology of several diseases. EVs are membrane-bound particles secreted by almost all cell types. Depending on their biogenesis and size they include exosomes, microparticles / microvesicles and apoptotic bodies. Characteristically, EVs carry markers from the source cell membrane and contain genetic material, lipids and proteins inside. They are known to play a role in cell-to-cell communication and to produce genotypic and phenotypic modifications in the target cell including: antigen presentation, apoptosis induction, cellular activation, inhibition or differentiation. In particular, increasing concentrations of EVs have been found in many diseases such as cancer, autoimmune and cardiovascular diseases, among others. Most of the studies in EVs are focused on the characterization of EVs compounds, identifying mechanism of action, their potential use as biomarkers, and few of them investigate a therapeutic usage. However, there are some issues to be achieved on the path to their clinical application. This research topic offers a common place to discuss current and novel clinical applications of EVs pointing on future directions. We encouraged the submission of original articles, reviews, hypothesis, controversies, future perspectives and personal viewpoints on the following topics of interest, but not limited to: • Contribution of EVs to better understand the pathology of immunological diseases. • Standardization of isolation and quantification protocols in the daily clinical practice. • Possible applications of EVs as clinical biomarkers (diagnostic, prognostic and evolution marker). • Therapeutic role of EVs being vehicles of specific cargo: current clinical trials? • Novel immunological functions of EVs.

Author: Anand Krishnan
Publisher: Elsevier
ISBN: 9780443238918
Category : Technology & Engineering
Languages : en
Pages : 0

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Book Description
Extracellular Vesicles for Therapeutic and Diagnostic Applications provides an introduction to exosomes and extracellular vesicles, including their unique properties and characterization, before detailing the most-utilized isolation, purification, and surface engineering techniques for their preparation as therapeutic and diagnostic agents. This book reviews recent developments in interdisciplinary research on exosome structure, properties, and engineering approaches as well as their use in diagnosis and treatment of a variety of illnesses such as cancer, tuberculosis, Alzheimer's disease, ophthalmic diseases, and others. Extracellular Vesicles for Therapeutic and Diagnostic Applications is an important reference for those interested in the development and application of exosomes and extracellular vesicles as biomaterials for us in the diagnosis and treatment of disease.

Author: Zhenhua Li
Publisher: John Wiley & Sons
ISBN: 3527842144
Category : Science
Languages : en
Pages : 213

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Book Description
Biomedical Applications of Extracellular Vesicles Unique resource focusing on biomedical applications and clinical translation of extracellular vesicles in science and medicine Focusing on key points to better understand extracellular vesicles (EVs) and their development, Biomedical Applications of Extracellular Vesicles describes in detail the biogenesis of EVs, the mechanism of intercellular communication, and the treatment of various diseases of EVs and the EV-based drug delivery platforms. An application-oriented resource, the work presents rapidly newer biomedical and clinical applications of natural and engineered EVs such as drug delivery, diagnosis, prognosis monitoring, immunotherapy, and more. The first part of this book provides a basic background on EVs. Next, the book introduces the excellent therapeutic effects of EVs themselves and the underlying mechanisms, followed by how EVs from different sources were used to construct drug delivery platforms. The latest research on EVs from leading groups around the world is presented. Sample topics covered in Biomedical Applications of Extracellular Vesicles include: Biogenesis of various EVs Pros and cons of the different instrumental and methodological developments for analytical strategies applied to EVs EVs in treatment of major diseases, such as cancer, cardiovascular and respiratory diseases Current methods of engineering EVs, and a comparison of the advantages and disadvantages of each method Biomaterials, such as hydrogels, scaffolds, and microneedles, that have been developed to further enhance the therapeutic efficacy of EVs Key challenges, such as quality control, scalability, and biosafety, that limit the clinical and industrial translation of EVs Explaining in detail how extracellular vesicles are produced and engineered, along with potential applications and commercial developments of EVs in science and industry, Biomedical Applications of Extracellular Vesicles is an essential resource on the subject for chemists, cell biologists, and molecular physicists.

Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Book Description

Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

View

Book Description
During the last years, the research on extracellular vesicles (EVs) has raised giving new insights into pathophysiology of several diseases. EVs are membrane-bound particles secreted by almost all cell types. Depending on their biogenesis and size they include exosomes, microparticles / microvesicles and apoptotic bodies. Characteristically, EVs carry markers from the source cell membrane and contain genetic material, lipids and proteins inside. They are known to play a role in cell-to-cell communication and to produce genotypic and phenotypic modifications in the target cell including: antigen presentation, apoptosis induction, cellular activation, inhibition or differentiation. In particular, increasing concentrations of EVs have been found in many diseases such as cancer, autoimmune and cardiovascular diseases, among others. Most of the studies in EVs are focused on the characterization of EVs compounds, identifying mechanism of action, their potential use as biomarkers, and few of them investigate a therapeutic usage. However, there are some issues to be achieved on the path to their clinical application. This research topic offers a common place to discuss current and novel clinical applications of EVs pointing on future directions. We encouraged the submission of original articles, reviews, hypothesis, controversies, future perspectives and personal viewpoints on the following topics of interest, but not limited to: • Contribution of EVs to better understand the pathology of immunological diseases. • Standardization of isolation and quantification protocols in the daily clinical practice. • Possible applications of EVs as clinical biomarkers (diagnostic, prognostic and evolution marker). • Therapeutic role of EVs being vehicles of specific cargo: current clinical trials? • Novel immunological functions of EVs.

Author: Junjie Xiao
Publisher: Springer
ISBN: 9811043973
Category : Science
Languages : en
Pages : 300

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Book Description
The book provides and intensive overview on exosomes in cardiovascular diseases, its potential as biomarkers, as well as pathological and therapeutic effects. It firstly describes the general aspects of exosomes including the definition, formation and secretion of exosomes and highlight their roles as biomarkers and pathological and therapeutic effects in cardiovascular diseases as well. Secondly, basic aspects of exosomes including the purification methods of exosomes, exosomes content, and functional roles of the cardiovascular exosomes are summarized. Thirdly, exosomes as biomarkers of cardiovascular diseases are overviewed including their roles in diagnosis, prognosis and reaction to therapy. Fourthly, pathological effects of exosomes and therapeutic effects of exosomes are highlighted. Finally, future prospects of exosomes in cardiovascular research would be provided. This is an essential reference for researchers working in cell biology and regeneration, as well as clinicians such as cardiologist.

Author: Lawrence R. Edelstein
Publisher: Academic Press
ISBN: 0128160543
Category : Science
Languages : en
Pages : 550

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Book Description
Exosomes: A Clinical Compendium is a comprehensive and authoritative account of exosomes in the context of biomarkers, diagnostics, and therapeutics across a wide spectrum of medical disciplines, as well as their role in cell-cell communication. It is intended to serve as a reference source for clinicians, physicians, and research scientists who wish to gain insight into the most recent advances in this rapidly growing field. The exosome revolution may well be the greatest advance in physiology and medicine since antibiotics. The discovery of their epigenetic role in intercellular signaling in virtually all tissues is a major breakthrough in our understanding of how cells function. - Provides readers with a broad and timely overview of exosomes in health and disease, closing with a thought-provoking chapter on transgenerational inheritance, Darwin and Lamarck. - Summarizes the most recent laboratory and clinical findings on exosomes across numerous medical disciplines, thereby offering readers a broad-ranging and solid foundation for prospective investigative efforts - Twenty-one chapters authored by a global team of peer-acknowledged experts, each representing a key medical disciplineProvides readers with a broad and timely overview of exosomes in health and disease, closing