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Author: Michelle Yap Publisher: Frontiers Media SA ISBN: 2832545238 Category : Science Languages : en Pages : 165
Book Description
Animal venoms are complex mixtures of bioactive peptides and proteins with diverse pharmacological effects. These active molecules make up the components of venom toxins responsible for many pathological outcomes in snake envenomation. Although venom toxins can be deadly, they can potentially be lifesaving once their respective pharmacological targets and mechanistic actions are better understood. For example, the discovery of captopril from Brazilian viper, Bothrops jararaca venom which has been shown to antagonise angiotensin-converting enzyme (ACE) for the treatment of hypertension.
Author: Michelle Yap Publisher: Frontiers Media SA ISBN: 2832545238 Category : Science Languages : en Pages : 165
Book Description
Animal venoms are complex mixtures of bioactive peptides and proteins with diverse pharmacological effects. These active molecules make up the components of venom toxins responsible for many pathological outcomes in snake envenomation. Although venom toxins can be deadly, they can potentially be lifesaving once their respective pharmacological targets and mechanistic actions are better understood. For example, the discovery of captopril from Brazilian viper, Bothrops jararaca venom which has been shown to antagonise angiotensin-converting enzyme (ACE) for the treatment of hypertension.
Author: Glenn F. King Publisher: Royal Society of Chemistry ISBN: 1849737878 Category : Science Languages : en Pages : 339
Book Description
The pharmaceutical industry has become increasingly interested in biologics from animal venoms as a potential source for therapeutic agents in recent years, with a particularly emphasis on peptides. To date six drugs derived from venom peptides or proteins have been approved by the FDA, with nine further agents currently being investigated in clinical trials. In addition to these drugs in approved or advanced stages of development, many more peptides and proteins are being studied in varying stages of preclinical development. This unique book provides an up to date and comprehensive account of the potential of peptides and proteins from animal venoms as possible therapeutics. Topics covered include chemistry and structural biology of animal venoms, proteomic and transcriptomic approaches to drug discovery, bioassays, high-throughput screens and target identification, and reptile, scorpion, spider and cone snail venoms as a platform for drug development. Case studies are used to illustrate methods and successes and highlight issues surrounding administration and other important lessons that have been learnt from the development of approved therapeutics based on venoms. The first text to focus on this fascinating area and bridging an important gap, this book provides the reader with essential and current knowledge on this fast-developing area. Venoms to Drugs will find wide readership with researchers working in academia and industry working in all medicinal and pharmaceutical areas.
Author: Kurt F. Stocker Publisher: CRC Press ISBN: 9780849358463 Category : Medical Languages : en Pages : 284
Book Description
This fascinating book provides actual knowledge on evolution, anatomy habits, and classification of venomous snakes. It presents detailed, updated information on physicochemical, biochemical, and pharmacological characteristics of biomedically relevant snake venom proteins, their practical use and potential. This volume includes particular sections concerning neurotoxins and their application in neurophysiological and muscular research, snake venom proteins affecting the complement system, as well as the large field of snake venom components affecting the hemostatic and fibrinolytic system. Written in a comprehensive manner, this work communicates to the reader the importance of preventing the extinction of venomous snake species as the carriers of unique genetic information. This interesting book is a must for all who are involved with thrombosis, hemotology, toxinology, neurochemistry, as well as animal toxins within biological, medical or pharmaceutical education.
Author: World Health Organization Publisher: World Health Organization ISBN: 9241515430 Category : Business & Economics Languages : en Pages : 228
Book Description
This report is structured in five parts: national framework for traditional and complementary medicine (T&CM); product regulation; practices and practitioners; the challenges faced by countries; and finally the country profiles. Apart from the section on practices and practitioners the report is consistent with the format of the report of the first global survey in order to provide a useful comparison. The section on practices and practitioners which covers providers education and health insurance is a new section incorporated to reflect the emerging trends in T&CM and to gather new information regarding these topics at a national level. All new information received has been incorporated into individual country profiles and data graphs. The report captures the three phases of progress made by Member States; that is before and after the first WHO Traditional Medicine Strategy (1999?2005) from the first global survey to the second global survey (2005?2012) and from the second survey to the most recent timeline (2012?2018).
Author: Richard S. Larson Publisher: ISBN: 9781617799655 Category : Bioinformatics Languages : en Pages : 374
Book Description
Recent advances in drug discovery have been rapid. The second edition of Bioinformatics and Drug Discovery has been completely updated to include topics that range from new technologies in target identification, genomic analysis, cheminformatics, protein analysis, and network or pathway analysis. Each chapter provides an extended introduction that describes the theory and application of the technology. In the second part of each chapter, detailed procedures related to the use of these technologies and software have been incorporated. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Bioinformatics and Drug Discovery, Second Edition seeks to aid scientists in the further study of the rapidly expanding field of drug discovery.
Author: Katsuhiro Konno Publisher: MDPI ISBN: 3039285408 Category : Medical Languages : en Pages : 404
Book Description
Thousands of arthropod species, ranging from arachnids (spiders and scorpions) to hymenopterans (ants, bees, and wasps) and myriapods (centipedes), are venomous and use their venoms for both defense and predation. These venoms are invariably harmful to humans, and some may cause serious injuries, e.g., those from scorpions, spiders, and wasps. Arthropods’ venoms are also known as rich sources of biologically active compounds and have attracted the attention of toxin researchers for years. In this century, venom component analysis has progressed considerable due to the advances in analytical techniques, in particular, mass spectrometry and next-generation deep (DNA and RNA) sequencing. As such, proteomic and peptidomic analyses using LC–MS have enabled the full analysis of venom components, revealing a variety of novel peptide and protein toxins sequences and scaffolds, potentially useful as pharmacological research tools and for the development of highly selective peptide ligands and therapeutic leads, like chlorotoxin. Due to their specificity for numerous ion-channel subtypes, including voltage- and ligand-gated ion channels, arthropod neurotoxins have been investigated to dissect and treat neurodegenerative diseases and control epileptic syndromes. This Special Issue collects information on such progress, encouraging contributions on the chemical and biological characterization of venom components, not only peptides and proteins, but also small molecules, their mechanisms of action, and the development of venom-derived peptide leads.
Author: Michelle Yap
Author: Michelle Yap
Author: Glenn F. King
Author: Kurt F. Stocker
Author: P. Gopalakrishnakone
Author: P. Gopalakrishnakone
Author: Findlay E. Russell
Author: World Health Organization
Author: Jay Fox
Author: Richard S. Larson
Author: Katsuhiro Konno