Author: Brian Edwin ChenPublisher:
ISBN:
Category : Cerebral cortex
Languages : en
Pages : 280
Book Description
Experience-dependent Synaptic Plasticity in the Adult Barrel Cortex
Author: Brian Edwin ChenPublisher:
ISBN:
Category : Cerebral cortex
Languages : en
Pages : 280
Book Description
The Role of Pre-and Post Synaptic Activity in Experience Dependent Synaptic Plasticity in Barrel Cortex
Author: Helen Louise WallacePublisher:
ISBN:
Category :
Languages : en
Pages : 530
Book Description
Comprehensive Developmental Neuroscience: Neural Circuit Development and Function in the Heathy and Diseased Brain
Author: D.E. ShulzPublisher: Elsevier Inc. Chapters
ISBN: 0128063181
Category : Medical
Languages : en
Pages : 74
Book Description
Experience-dependent Plasticity in the Mouse Barrel Cortex
Author: Nathalie Johnston-WengerPublisher:
ISBN:
Category :
Languages : en
Pages : 141
Book Description
The Neuroscience of Adolescence
Author: Adriana GalvánPublisher: Cambridge University Press
ISBN: 1107089921
Category : Medical
Languages : en
Pages : 341
Book Description
Written by an award-winning developmental neuroscientist, this is a comprehensive and cutting-edge account of the latest research on the adolescent brain.
Computational Model of Experience-dependent Plasticity in Adult Rat Barrel Cortex
Author: Lubica BeňuškováPublisher:
ISBN:
Category : Adaptation (Physiology)
Languages : en
Pages : 70
Book Description
Comprehensive Developmental Neuroscience: Cellular Migration and Formation of Neuronal Connections
Author: R. EavriPublisher: Elsevier Inc. Chapters
ISBN: 0128062908
Category : Medical
Languages : en
Pages : 27
Book Description
Homeostatic Synaptic Plasticity: From Synaptic Circuit Assembly to Neurological Disorders
Author: Lorenzo A. CingolaniPublisher: Frontiers Media SA
ISBN: 2889669882
Category : Science
Languages : en
Pages : 174
Book Description
Experience-dependent Dendrite Remodeling of GABAergic Interneurons in the Adult Visual Cortex
Author: Jerry L. ChenPublisher:
ISBN:
Category :
Languages : en
Pages : 97
Book Description
An ever increasing amount of evidence is demonstrating that structural plasticity is a diverse and ongoing feature that contributes to plasticity in the adult brain. It was previously shown that dendritic arbors of inhibitory interneurons in superficial layer 2/3 can remodel in the adult cortex. Here, we investigated the role of these structural rearrangements during experience-dependent adult plasticity. Using in vivo two photon imaging, we monitored intemeuron dendritic branch tip remodeling in response to changes in visual experience in the adult mouse visual cortex. We find that branch tip dynamics are induced by novel experiences in a stimulus-specific manner. Visual deprivation produces rearrangements that are circuit-specific and are different for branch tips extending into LI or L2/3. The weakening of dendritic input onto these cells functions to reduce levels of inhibition in local cortical circuits. This reduced inhibitory tone provides more salience to remaining instructive input, allowing more structural and functional adaptations to occur. In order to better understand how synaptic plasticity accompanies these dendritic arbor rearrangements as well as other forms of structural plasticity, we developed a method to simultaneously monitor structural and synaptic dynamics in the mammalian brain using in vivo two-photon microscopy. Structural and synaptic components can be labeled in cortical neurons of mice in a cell type and laminar specific manner through co-injection of independent lentiviral vectors at a late embryonic or early postnatal age. We demonstrate that excitatory and inhibitory post-synaptic densities can be visualized by tagging fluorescent proteins to PSD95 and Gephyrin, respectively. Finally, we show that the fluorescent proteins, Teal and Venus, can be simultaneously excited and spectrally resolved through linear unmixing so that individual structural and synaptic components can be identified and followed over time. Through this approach, the relationship between synaptic and structural plasticity can be studied in the living brain.
Plasticity of Adult Barrel Cortex
Author: Malgorzata KossutPublisher: F P Graham Company
ISBN:
Category : Medical
Languages : en
Pages : 286
Book Description