Evaluation of Cone Beam Computed Tomography Enhancement Using a Liver Specific Contrast Agent For Stereotactic Body Radiation Therapy Guidance PDF Download

Author: John Lincoln
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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Book Description
This study evaluated contrast enhancement provided by Gadoxetate Disodium, a liver specific contrast agent. Image quality from cone-beam computed tomography was benchmarked against helical fan-beam computed tomography for comparison in cylindrical and ellipsoidal geometries. Concentrations were diluted to 0.0125 - 0.1 mmol/kg corresponding to expected physiological concentrations in the liver. CBCT imaging parameters tube voltage, tube current, and filtration were investigated on board a TrueBeam STx linear accelerator. All parameters were optimized according to the contrast-noise ratio, following the Rose criterion. Acceptable combinations of contrast dose, tube voltage, tube exposure-time product, and filtration gave CNR greater than three. This was found in a range of expected concentrations from 0.025 to 0.1 mmol/kg for a tube voltage of 100 kV, half-fan bowtie filtration, and exposures between 2025 and 5085 mAs. This research provides optimized pre-clinical dosing information and imaging parameters to use Gadoxetate Disodium in a clinical trial with CBCT.

Author: International Atomic Energy Agency
Publisher:
ISBN: 9789201032188
Category : Technology & Engineering
Languages : en
Pages : 39

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Book Description
This publication provides guidelines, and highlights the milestones to be achieved by radiotherapy departments in the safe and effective introduction of image guided radiotherapy. Recent advances in external beam radiotherapy include the technology to image the patient in the treatment position, in the treatment room at the time of treatment. Since this technology and associated image techniques, termed image guided radiotherapy, are perceived as the cutting-edge of development in the field of radiotherapy, this publication addresses the concerns of personnel in radiotherapy departments as to the preparatory conditions and resources involved in implementation. Information is also presented on the current status of the evidence supporting the use of image guided radiotherapy in terms of patient outcomes.

Author: X. Allen Li
Publisher: CRC Press
ISBN: 1439816352
Category : Medical
Languages : en
Pages : 404

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Book Description
Modern medical imaging and radiation therapy technologies are so complex and computer driven that it is difficult for physicians and technologists to know exactly what is happening at the point-of-care. Medical physicists responsible for filling this gap in knowledge must stay abreast of the latest advances at the intersection of medical imaging an

Author: Dwight E. Heron, MD, MBA, FACRO, FACR
Publisher: Springer Publishing Company
ISBN: 0826168574
Category : Medical
Languages : en
Pages : 600

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Book Description
Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy (SBRT) is a comprehensive guide for the practicing physician and medical physicist in the management of complex intracranial and extracranial disease. It is a state-of-the-science book presenting the scientific principles, clinical background and procedures, treatment planning, and treatment delivery of SRS and SBRT for the treatment of tumors throughout the body. This unique textbook is enhanced with supplemental video tutorials inclusive to the resource. Beginning with an overview of SRS and SBRT, Part I contains insightful coverage on topics such as the evolving radiobiological principles that govern treatment, imaging, the treatment planning process, technologies and equipment used, as well as focused chapters on quality assurance, quality management, and patient safety. Part II contains the clinical application of SRS and SBRT for tumors throughout the body including those in the brain, head and neck, lung, pancreas, adrenal glands, liver, prostate, cervix, spine, and in oligometastatic disease. Each clinical chapter includes an introduction to the disease site, followed by a thorough review of all indications and exclusion criteria, in addition to the important considerations for patient selection, treatment planning and delivery, and outcome evaluation. These chapters conclude with a detailed and site-specific dose constraints table for critical structures and their suggested dose limits. International experts on the science and clinical applications of these treatments have joined together to assemble this must-have book for clinicians, physicists, and other radiation therapy practitioners. It provides a team-based approach to SRS and SBRT coupled with case-based video tutorials in disease management, making this a unique companion for the busy radiosurgical team. Key Features: Highlights the principles of radiobiology and radiation physics underlying SRS and SBRT Presents and discusses the expected patient outcomes for each indicated disease site and condition including a detailed analysis of Quality of Life (QOL) and Survival Includes information about technologies used for the treatment of SRS and SBRT Richly illustrated with over 110 color images of the equipment, process flow diagrams and procedures, treatment planning techniques and dose distributions 7 high-quality videos reviewing anatomy, staging, treatment simulation and planning, contouring, and management pearls Dose constraint tables at the end of each clinical chapter listing critical structures and their appropriate dose limits Includes access to the fully-searchable downloadable eBook

Author: Jeremy David Page Hoisak
Publisher: CRC Press
ISBN: 0429951809
Category : Medical
Languages : en
Pages : 515

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Book Description
Surface Guided Radiation Therapy provides a comprehensive overview of optical surface image guidance systems for radiation therapy. It serves as an introductory teaching resource for students and trainees, and a valuable reference for medical physicists, physicians, radiation therapists, and administrators who wish to incorporate surface guided radiation therapy (SGRT) into their clinical practice. This is the first book dedicated to the principles and practice of SGRT, featuring: Chapters authored by an internationally represented list of physicists, radiation oncologists and therapists, edited by pioneers and experts in SGRT Covering the evolution of localization systems and their role in quality and safety, current SGRT systems, practical guides to commissioning and quality assurance, clinical applications by anatomic site, and emerging topics including skin mark-less setups. Several dedicated chapters on SGRT for intracranial radiosurgery and breast, covering technical aspects, risk assessment and outcomes. Jeremy Hoisak, PhD, DABR is an Assistant Professor in the Department of Radiation Medicine and Applied Sciences at the University of California, San Diego. Dr. Hoisak’s clinical expertise includes radiosurgery and respiratory motion management. Adam Paxton, PhD, DABR is an Assistant Professor in the Department of Radiation Oncology at the University of Utah. Dr. Paxton’s clinical expertise includes patient safety, motion management, radiosurgery, and proton therapy. Benjamin Waghorn, PhD, DABR is the Director of Clinical Physics at Vision RT. Dr. Waghorn’s research interests include intensity modulated radiation therapy, motion management, and surface image guidance systems. Todd Pawlicki, PhD, DABR, FAAPM, FASTRO, is Professor and Vice-Chair for Medical Physics in the Department of Radiation Medicine and Applied Sciences at the University of California, San Diego. Dr. Pawlicki has published extensively on quality and safety in radiation therapy. He has served on the Board of Directors for the American Society for Radiology Oncology (ASTRO) and the American Association of Physicists in Medicine (AAPM).

Author: James D. Cox
Publisher: CRC Press
ISBN: 0849387825
Category : Medical
Languages : en
Pages : 210

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Book Description
Lung cancer is the leading cause of cancer death in the United States, but IGRT (image guided radiation therapy) offers the possibility of more aggressive and enhanced treatments. The only available source on the subject that emphasizes new imaging techniques, and provides step-by-step treatment guidelines for lung cancer, this source helps clinici

Author: Simon S. Lo
Publisher: Springer Science & Business Media
ISBN: 364225604X
Category : Medical
Languages : en
Pages : 433

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Book Description
Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.

Author: George Starkschall
Publisher: CRC Press
ISBN: 1439825823
Category : Science
Languages : en
Pages : 332

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Book Description
Reflecting the increased importance of the collaborations between radiation oncology and informatics professionals, Informatics in Radiation Oncology discusses the benefits of applying informatics principles to the processes within radiotherapy. It explores how treatment and imaging information is represented, stored, and retrieved as well as how this information relates to other patient data. The book deepens your knowledge of current and emerging information technology and informatics principles applied to radiation oncology so that all the data gathered—from laboratory results to medical images—can be fully exploited to make treatments more effective and processes more efficient. After introducing the basics of informatics and its connection to radiation oncology, the book examines the process of healthcare delivery in radiation oncology, the challenges of managing images in radiotherapy, and the burgeoning field of radiogenomics. It then presents teaching, clinical trials, and research tools and describes open access clinical imaging archives in radiotherapy, techniques for maximizing information from multimodality imaging, and the roles of images in treatment planning. It also looks at how informatics can improve treatment planning, the safety and efficiency of delivery systems, image-guided patient positioning, and patient assessment. The book concludes with discussions on how outcomes modeling evaluates the effectiveness of treatments, how quality control informatics improves the reliability of processes, and how to perform quality assurance on the informatics tools. With contributions from a host of top international experts in radiation oncology, medical physics, and informatics, this book leads the way in moving the field forward. It encourages you to find new ways of applying informatics to radiation oncology and help your patients in their fight against cancer.

Author: Jason P. Sheehan
Publisher: CRC Press
ISBN: 1000514374
Category : Science
Languages : en
Pages : 837

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Book Description
In this third edition of Intracranial Stereotactic Radiosurgery, Drs. Sheehan and Lunsford provide an updated assessment of the practice of stereotactic radiosurgery. Topics include benign and malignant tumors, cerebrovascular abnormalities, and functional disorders. Several new topics are now included and focus on immunotherapy, hypofractionation, and repeat radiosurgery. Each chapter contains key figures and tables to illustrate the critical concepts of the work. Contributors to the book represent many of the most prestigious stereotactic radiosurgery centers across the world. This book is comprised of 36 chapters and represents a comprehensive update to prior editions. It is intended to be a readable, credible, and accessible reference on stereotactic radiosurgery. Editors Jason Sheehan, MD, PhD, FACS, FAANS, is the Vice Chair and Harrison Distinguished Professor of Neurological Surgery at the University of Virginia (UVA). He also serves as the Neurosciences Service Line Director at UVA. Dr. Sheehan is the current chair of the American Association of Neurological Surgeons (AANS) and Congress of Neurological Surgeons (CNS) Section on Tumors. He serves as the Editor-In-Chief of the Journal of Neuro-Oncology. L. Dade Lunsford, MD, serves as the Lars Leksell Professor and Distinguished Professor at the Department of Neurological Surgery at the University of Pittsburgh. He is also director of the Center for Image-Guided Neurosurgery at the University of Pittsburgh Medical Center and an internationally recognized authority on stereotactic surgery, radiosurgery, and minimally invasive surgery. He has authored or coauthored more than 1,000 scientific reports and 16 books.

Author: Arjun Sahgal
Publisher: CRC Press
ISBN: 1498722857
Category : Medical
Languages : en
Pages : 368

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Book Description
The recent development of hypofractionated stereotactic radiation therapy (SRT), which calls for one to five fractions of high-dose radiation to be administered using special equipment, has resulted in the need for education on practice guidelines. Image-Guided Hypofractionated Stereotactic Radiosurgery: A Practical Approach to Guide Treatment of B