Evaluation de la prévalence des interactions médicamenteuses pharmacocinétiques avec les anticancéreux oraux en pratique courante PDF Download

Author: Thibaut Barsagol
Publisher:
ISBN:
Category :
Languages : fr
Pages : 0

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Book Description
L'utilisation des thérapies ciblées orales anticancéreuses en pratique courante n'a cessé de croître. Avec ces thérapies, les interactions médicamenteuses sont fréquentes et peuvent avoir un impact sur le succès du traitement. Au regard du faible nombre d'études, nous avons réalisé une analyse rétrospective des interactions médicamenteuses d'ordre pharmacocinétique sur les cytochromes et le transporteur P-gp, au sein d'une cohorte de 753 patients traités par anticancéreux oraux. Il a été relevé une forte prévalence (53%) d'interactions médicamenteuses. Ces interactions étaient majoritairement inhibitrices induisant un risque de surdosage des co-médications et des anticancéreux. Le risque d'apparition d'interaction était associé au nombre d'anticancéreux des protocoles, à la polymédication, à la prescription d'inhibiteurs de kinases et de médicaments du système cardiovasculaire.

Author: World Health Organization
Publisher:
ISBN: 9789241548120
Category : Medical
Languages : en
Pages : 166

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These guidelines have been developed to support countries to relieve pain in their paediatric populations. These guidelines address persisting pain in children caused by conditions such as cancer, HIV/AIDS, sickle-cell disease, burns, trauma, and phantom limb pain. Recommendations -- developed following a careful and transparent appraisal of available evidence -- are presented for the pharmacological treatment of mild, moderate and severe pain. The guidelines include chapters on the various systems used to classify pain and on the evaluation of pain, which reviews the available tools for routine pain measurement in children. Provision of sustainable pain relief within health care systems is covered in a separate chapter. Since morphine and other opioid analgesics -- required for the relief of moderate-to-severe pain in children -- are listed under the 1961 UN Single Convention on Narcotic Drugs, the new guidelines include an annex explaining the Convention's requirements for the handling and procurement of opioid analgesics for the relief of pain.

Author: Alan D. Lopez
Publisher: World Bank Publications
ISBN: 0821362631
Category : Medical
Languages : en
Pages : 511

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Book Description
Strategic health planning, the cornerstone of initiatives designed to achieve health improvement goals around the world, requires an understanding of the comparative burden of diseases and injuries, their corresponding risk factors and the likely effects of invervention options. The Global Burden of Disease framework, originally published in 1990, has been widely adopted as the preferred method for health accounting and has become the standard to guide the setting of health research priorities. This publication sets out an updated assessment of the situation, with an analysis of trends observed since 1990 and a chapter on the sensitivity of GBD estimates to various sources of uncertainty in methods and data.

Author: Marc E. de Broe
Publisher: Springer Science & Business Media
ISBN: 1402025866
Category : Medical
Languages : en
Pages : 719

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Book Description
To you the reader, the joy of discovery begins, for We continue in our goal of providing a text which us the job is done. In this edition, we have corrected is useful, not only to the clinician, but of equal interest past deficiencies, added new topics, expanded infor- to the investigator. The selection of content has been mation regarding the pediatric age group, provided directed at topics of current interest rather than those up to date (March 2003) references, while remaining of historic contribution. We have stressed the cont- true to our concept of a multi-national author book. bution of cell biology and pathophysiology, were it We continue to believe that scientific information is an exists, believing it provides both a better understa- international commodity whose interpretation and ap- ing of toxic injury when known, and a rational dir- plication are strongly influenced by both the cultural tion for therapy and prevention. and ethnic background of the observer. The oppor- nity to share in the rich diversity of the international We are encouraged by the accumulation of rec- scientific community remains a fundamental goal of nized risk factors, which allow pre-treatment strati- this endeavor. To participate as equals leads to mu- cation of our patients’ relative risk and allow us to - tual respect and peer appreciation. The sharing of in- cus our preventative techniques on the individuals tellectual resources fostered by this effort should and most likely to gain the greatest benefit.

Author: Francis Rouessac
Publisher: John Wiley & Sons
ISBN: 1118681878
Category : Science
Languages : en
Pages : 494

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Book Description
Completely revised and updated, Chemical Analysis: Second Edition is an essential introduction to a wide range of analytical techniques and instruments. Assuming little in the way of prior knowledge, this text carefully guides the reader through the more widely used and important techniques, whilst avoiding excessive technical detail. Provides a thorough introduction to a wide range of the most important and widely used instrumental techniques Maintains a careful balance between depth and breadth of coverage Includes examples, problems and their solutions Includes coverage of latest developments including supercritical fluid chromatography and capillary electrophoresis

Author:
Publisher:
ISBN:
Category : Drugs
Languages : en
Pages : 1110

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Author: Giuseppe Anastasi
Publisher:
ISBN: 9788870517897
Category :
Languages : en
Pages : 0

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Author: Michael Lee Cain
Publisher: Sunderland, Mass. : Sinauer Associates
ISBN: 9780393940558
Category : Science
Languages : en
Pages : 800

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Book Description
Thoroughly revised and updated, Discover Biology, Second Edition, presents the essential concepts of modern biology in a text designed specifically for nonmajors. The authors emphasize a level of detail appropriate for nonmajors, freeing instructors to focus on the scientific issues-HIV, global climate change, DNA fingerprinting, genetic engineering, cancer-that students read about in the paper, vote on in elections, and face in their daily lives. With two new chapters, refined pedagogy and art programs, and a powerful ancillary package, Discover Biology, Second Edition, is the best choice for the nonmajors introductory course.

Author: Mark S. Meskin
Publisher: CRC Press
ISBN: 1420031694
Category : Medical
Languages : en
Pages : 221

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Book Description
Are soy isoflavones neuroprotective? Just how different is one species of Echinacea from another? Which phytochemicals will be effective as therapeutic agents in vivo? Supported by solid scientific research, Phytochemicals in Nutrition and Health helps provide answers to these and other probing questions concerning the mechanisms of action associat

Author: Joanne Willey
Publisher: McGraw-Hill Science/Engineering/Math
ISBN: 9780077350130
Category : Science
Languages : en
Pages : 1070

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Book Description
The author team of Prescott’s Microbiology continues the tradition of past editions by providing a balanced, comprehensive introduction to all major areas of microbiology. Because of this balance, Microbiology is appropriate for microbiology majors and mixed majors courses. The new authors have focused on readability, artwork, and the integration of several key themes (including evolution, ecology and diversity) throughout the text, making an already superior text even better. Users who purchase Connect Plus receive access to the full online ebook version of the textbook.