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Author: Ajit Kumar Publisher: Springer Science & Business Media ISBN: 1468474596 Category : Science Languages : en Pages : 238
Book Description
The recent surge of interest in recombinant DNA research is understandable considering that biologists from all disciplines, using recently developed mo lecular techniques, can now study with great precision the structure and regulation of specific genes. As a discipline, molecular biology is no longer a mere subspeciality of biology or biochemistry: it is the new biology. Current approaches to the outstanding problems in virtually all the traditional disci plines in biology are now being explored using the recombinant DNA tech nology. In this atmosphere of rapid progress, the role of information exchange and swift publication becomes quite crucial. Consequently, there has been an equally rapid proliferation of symposia volumes and review articles, apart from the explosion in popular science magazines and news media, which are always ready to simplify and sensationalize the implications of recent dis coveries, often before the scientific community has had the opportunity to fully scrutinize the developments. Since many of the recent findings in this field have practical implications, quite often the symposia in molecular biology are sponsored by private industry and are of specialized interest and in any case quite expensive for students to participate in. Given that George Wash ington University is a teaching institution, our aim in sponsoring these Annual Spring Symposia is to provide, at cost, a forum for students and experts to discuss the latest developments in selected areas of great significance in biology. Additionally, since the University is located in Washington, D. C.
Author: Ajit Kumar Publisher: Springer Science & Business Media ISBN: 1468474596 Category : Science Languages : en Pages : 238
Book Description
The recent surge of interest in recombinant DNA research is understandable considering that biologists from all disciplines, using recently developed mo lecular techniques, can now study with great precision the structure and regulation of specific genes. As a discipline, molecular biology is no longer a mere subspeciality of biology or biochemistry: it is the new biology. Current approaches to the outstanding problems in virtually all the traditional disci plines in biology are now being explored using the recombinant DNA tech nology. In this atmosphere of rapid progress, the role of information exchange and swift publication becomes quite crucial. Consequently, there has been an equally rapid proliferation of symposia volumes and review articles, apart from the explosion in popular science magazines and news media, which are always ready to simplify and sensationalize the implications of recent dis coveries, often before the scientific community has had the opportunity to fully scrutinize the developments. Since many of the recent findings in this field have practical implications, quite often the symposia in molecular biology are sponsored by private industry and are of specialized interest and in any case quite expensive for students to participate in. Given that George Wash ington University is a teaching institution, our aim in sponsoring these Annual Spring Symposia is to provide, at cost, a forum for students and experts to discuss the latest developments in selected areas of great significance in biology. Additionally, since the University is located in Washington, D. C.
Author: Gerald M. Kolodny Publisher: CRC Press ISBN: 1351088831 Category : Medical Languages : en Pages : 277
Book Description
The cause of cancer and its many manifestations is at present unknown. Since many of its manifestations, including is control of cell division, appear to represent abnormal patterns of gene expression, studies of the regulation of gene expression nwill provide important insights in the understanding and treatment of cancer. This volume attempts to present some of the recent work on regulation of gene expression in eukaryotic cells.
Author: David S. Latchman Publisher: Chapman & Hall ISBN: Category : Medical Languages : en Pages : 296
Book Description
Gene Regulation provides a complete and concise picture of the processes regulating gene expression in higher organisms and man. The second edition of this well reviewed textbook has been extensively updated to reflect the scientific progress made in this area over the last four years.
Author: Gerald M. Kolodny Publisher: CRC Press ISBN: 1351088823 Category : Medical Languages : en Pages : 551
Book Description
The cause of cancer and its many manifestations is at present unknown. Since many of its manifestations, including is control of cell division, appear to represent abnormal patterns of gene expression, studies of the regulation of gene expression nwill provide important insights in the understanding and treatment of cancer. This volume attempts to present some of the recent work on regulation of gene expression in eukaryotic cells.
Author: Edgar Wingender Publisher: Wiley-Blackwell ISBN: Category : Science Languages : en Pages : 452
Book Description
A much-needed guide through the overwhelming amount of literature in the field. Comprehensive and detailed, this book combines background information with the most recentinsights. It introduces current concepts, emphasizing the transcriptional control of genetic information. Moreover, it links data on the structure of regulatory proteins with basic cellular processes. Both advanced students and experts will find answers to such intriguing questions as: - How are programs of specific gene repertoires activated and controlled? - Which genes drive and control morphogenesis? - Which genes govern tissue-specific tasks? - How do hormones control gene expression in coordinating the activities of different tissues? An abundant number of clearly presented glossary terms facilitates understanding of the biological background. Speacial feature: over 2200 (!) literature references.
Author: Richard Axel Publisher: Elsevier ISBN: 0323143504 Category : Science Languages : en Pages : 682
Book Description
Eukaryotic Gene Regulation covers the aspects and mechanisms of gene regulation of selected eukaryotes, such as yeast, Drosophila, and insect. This book is organized into eight parts, encompassing 52 chapters. The majority of the chapters are presented in an experimental manner containing an abstract, methods, results and discussion, and conclusion. This book first gives a short overview of the evolutionary role of interspersion in eukaryotic genes. It then presents considerable chapters on control of gene expression in yeast; gene mutation and isolation; structure and function; and analysis. Part III focuses on genetic and DNA sequence analysis in Drosophila. It includes discussions on allelic complementation and transvection, genetic organization, histone gene, and gene transcription. Part IV examines cell lineage; gene expression and sequences; and protein synthesis of insects, sea urchin, and mammalian cells. This is followed by discussions on structure and expression of specific eukaryotic genes from chicken, rat, rabbit, and human. Topics on the transfer of genetic information within and between cells and the structure and function of chromosome are significantly considered in Parts VI and VII. Genes evaluated in these sections include heavy chain immunoglobulin, light chain, beta-globin, and dihydrofolate reductase. Furthermore, this book describes the in vitro transcription and the factors involved; internal organization and mechanism of assembly of nucleosome; and chromatin structure. The concluding section focuses on aspects of viral genome expression including gene regulation, synthesis, processing, and alternative RNA splicing. Research biologists, geneticists, scientists, teachers, and students will greatly benefit from this book.
Author: Lucy W. Barrett Publisher: Springer Science & Business Media ISBN: 3034806795 Category : Science Languages : en Pages : 63
Book Description
There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.
Author: Burr Atkinson Publisher: Elsevier ISBN: 0323162223 Category : Science Languages : en Pages : 400
Book Description
Changes in Eukaryotic Gene Expression in Response to Environmental Stress focuses on various aspects of eukaryotic cell's response to heat stress (shock) and other stress stimuli. This book is organized into two major sections, encompassing 17 chapters that reflect the emphasis on research utilizing Drosophila, a variety of animal systems, and plants. This book first provides a brief introduction to the organization, sequences, and induction of heat shock proteins and related genes. It then describes the control of transcription during heat shock from the standpoint of molecular biology and evolutionary variations of the mechanisms in organisms with diverse metabolic needs. It goes on to discuss the issue of coordinate and noncoordinate responses of heat shock genes. It presents a model for post-transcriptional regulation on certain aspects of coordinate and noncoordinate regulations. Chapters 6-12 discuss heat shock proteins and genes and the effects of stress on gene expression of sea urchin, avian, and mammalian cells. The second part of the book focuses on the physiological role of heat shock proteins and genes in plants and fungi. It includes a discussion on experimental problems encountered during studies of the mechanisms of inhibition of photosynthesis by unfavorable environmental conditions. The changes in transcription and translation of specific mRNAs in the developing embryo during heat shock at various temperatures are described. The concluding chapters deal with heat shock response in plants, particularly the response in soybeans and maize, covering both physiological and molecular analyses. Research scientists, clinicians, and agriculturists will greatly benefit from the information presented in this book.
Author: Carsten Carlberg Publisher: Springer Nature ISBN: 3030523217 Category : Medical Languages : en Pages : 160
Book Description
This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.
Author: H.S. Ginsberg Publisher: Academic Press ISBN: 0323138659 Category : Science Languages : en Pages : 329
Book Description
Transfer and Expression of Eukaryotic Genes documents the progress in our understanding of the transfer and expression of eukaryotic genes. This book covers topics organized around three themes: gene expression and its regulation; in vivo gene transfer and development; and viral gene and oncogene systems. This text is divided into three sections encompassing 25 chapters and begins with an overview of the molecular basis of gene expression, with emphasis on transcription complexes that account for transcription control in eukaryotic genes. It then turns to experiments that assess the in vitro stimulatory effect of the SV40 72-bp repeat on specific transcription from heterologous promoter elements using a HeLa whole cell extract. The reader is methodically introduced to the regulation signals and factors of histone gene transcription; transcriptional control of beta-globin and liver-specific genes in mouse cells; and gene transfer in Drosophila and the sea urchin Strongylocentrotus purpuratus. This book also considers the splicing of messenger RNA precursors and the regulation of thymidine kinase enzyme expression, and then concludes with a chapter that describes the activation of the myc oncogene by chromosomal translocation. This book will be of interest to students and researchers in fields ranging from molecular genetics to microbiology, biochemistry, pathology, and immunology.
Author: Ajit Kumar
Author: Ajit Kumar
Author: Gerald M. Kolodny
Author: David S. Latchman
Author: Gerald M. Kolodny
Author: Edgar Wingender
Author: Richard Axel
Author: Lucy W. Barrett
Author: Burr Atkinson
Author: Carsten Carlberg
Author: H.S. Ginsberg