Estrogens as Endogenous Carcinogens in the Breast and Prostate PDF Download

Author: National Cancer Institute (U.S.)
Publisher:
ISBN:
Category : Breast
Languages : en
Pages : 164

View

Book Description

Author: Ercole Cavalieri
Publisher:
ISBN: 9780199290079
Category : Breast
Languages : en
Pages : 159

View

Book Description

Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 159

View

Book Description

Author: JORDAN V. CRAIG
Publisher: Springer Science & Business Media
ISBN: 1592591523
Category : Medical
Languages : en
Pages : 422

View

Book Description
This book describes the principles underlying targeted hormonal treatments, assesses the actions of new and established agents, and illustrates the new applications of hormonal chemoprevention for breast cancer.

Author: Jonathan J. Li
Publisher: Springer Science & Business Media
ISBN: 146139208X
Category : Medical
Languages : en
Pages : 338

View

Book Description
In the past decade there has been a growing public interest and resurgence in research in the field of hormonal carcinogenesis. This is due to the widespread use of therapeutic hormonal agents worldwide and to the increasing awareness of the causal association of hormones, both endogenous and exogenously administered, and a variety of human cancers. These associations include estrogens in uterine, cervical, vaginal, liver, testicular, prostatic, and possible breast cancers; progesterone and progestational hormones in breast cancer; androgens and anabolic steroids in hepatic and prostatic cancers. Additionally, gonadotrophins playa role in the etiology of ovarian and testicular cancers and thyroid-stimulating hormones in thyroid cancers. Therefore, hormonal carcinogenesis encompasses the study of both natural and synthetic hormonal agents, including growth factors and other peptide and protein factors, which contribute substantially to the etiology of both human and animal neoplasms, benign or malignant. Hormones may be involved in all aspects of neoplastic transformation, including initiation, promotion, and progression, and the inhibition of these processes. There are a number of important issues in women's health that need to be addressed. More than 40 million U. S. women are menopausal, and these women have a life expectancy of over 30 years after the menopause. When these figures are multiplied worldwide, the numbers become staggering. After the menopause, estrogen replacement therapy (ERT) is the choice of most women in industrialized countries.

Author: W. R. Miller
Publisher: Landes Bioscience
ISBN:
Category : Breast
Languages : en
Pages : 234

View

Book Description

Author: Jonathan J. Li
Publisher: Springer Science & Business Media
ISBN: 1461220920
Category : Medical
Languages : en
Pages : 610

View

Book Description
Since our previous symposium in 1995, the pace of research in hormones and cancer has accelerated. Progress in our understanding of hormonal carcinogenic processes has been a direct result of the advances made in cell biology, endocrinology, and carcinogenesis at the molecular level. The newer fields of molecular genetics and cytogenetics already have and are expected to continue to playa major role in furthering our understanding of the cellular and molecular events in hormonal carcinogenesis. It has become increasingly clear that the risk of naturally occurring sex hormones in carcinogenic processes, both in human and in animal models, requires only minute quantities of hormones, at both the serum and tissue levels. Moreover, hormone target tissues for neoplastic transformation, perhaps with the exception of the liver, generally have relatively modest ability to metabolize sex hormones, such as the breast and prostate. Table 1 summarizes the serum, and in most cases, the tissue levels of sex hormones, both endogenously and exogenously ingested, which are associated with increased risk for endocrine-associated cancers such as breast, endometrium, and prostate, as well as the hormone levels of four experimental models that have been shown to elicit high tumor incidences. In contrast to the human, in which the hormone levels are cyclic, however, the latter require continuous hormone exposure at these relatively low levels.

Author: National Research Council
Publisher: National Academies Press
ISBN: 0309064198
Category : Science
Languages : en
Pages : 453

View

Book Description
Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.

Author: Jonathan J. Li
Publisher: Springer
ISBN: 9780387977973
Category : Medical
Languages : en
Pages : 340

View

Book Description
In the past decade there has been a growing public interest and resurgence in research in the field of hormonal carcinogenesis. This is due to the widespread use of therapeutic hormonal agents worldwide and to the increasing awareness of the causal association of hormones, both endogenous and exogenously administered, and a variety of human cancers. These associations include estrogens in uterine, cervical, vaginal, liver, testicular, prostatic, and possible breast cancers; progesterone and progestational hormones in breast cancer; androgens and anabolic steroids in hepatic and prostatic cancers. Additionally, gonadotrophins playa role in the etiology of ovarian and testicular cancers and thyroid-stimulating hormones in thyroid cancers. Therefore, hormonal carcinogenesis encompasses the study of both natural and synthetic hormonal agents, including growth factors and other peptide and protein factors, which contribute substantially to the etiology of both human and animal neoplasms, benign or malignant. Hormones may be involved in all aspects of neoplastic transformation, including initiation, promotion, and progression, and the inhibition of these processes. There are a number of important issues in women's health that need to be addressed. More than 40 million U. S. women are menopausal, and these women have a life expectancy of over 30 years after the menopause. When these figures are multiplied worldwide, the numbers become staggering. After the menopause, estrogen replacement therapy (ERT) is the choice of most women in industrialized countries.

Author: Jonathan J. Li
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 554

View

Book Description
"This volume contains the proceedings of the Second International Symposium on Hormonal Carcinogenesis, July 4 - 9, 1994, Stockholm, Sweden. In the last five years, there has been a marked resurgence of public awareness and research interest in the field of hormonal carcinogenesis. This is largely a result of the widespread use of therapeutic hormonal agents and the causal association of hormones and a variety of human cancers including: breast, prostatic, uterine, and cervical. Significant attention is devoted to the popular use of estrogen therapies in women's health care. This symposium brings together scientists from a wide variety of disciplines and presents the latest developments and research in understanding the involvement of hormones in neoplastic processes."--Publisher description (LoC).