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Publisher: Springer Nature
ISBN: 9811663769
Category :
Languages : en
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Author: Naoki Nakashima
Publisher: Springer Nature
ISBN: 9811916225
Category : Medical
Languages : en
Pages : 135

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Book Description
This book analyzes the development of medical big data projects in Japan.Japan is experiencing unprecedented population aging, and labor productivity has decreased accordingly. Big data analysis of the Japanese medical real-world database (RWD) has the potential to tackle this issue.To allow readers to gain an understanding of Japanese medical big data analysis, the book discusses the original Japanese system that generates medical RWDs in the hospital medical records system, the nationwide standardized health checkup system, and the public medical insurance system in Japan.After introducing four major big data projects in the healthcare–medical field in Japan, the book explains the importance of creating information standards to maintain data quality and to analyze medical big data. It enables readers to analyze which standards are installed in which RWDs, how the standards are maintained, and which issues are prevalent in Japan.This book also describes the ethical processes involved in big data projects involving medical RWDs in Japan.

Author: National Research Council
Publisher: National Academies Press
ISBN: 0309255716
Category : Medical
Languages : en
Pages : 424

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Book Description
In the late 1980s, the National Cancer Institute initiated an investigation of cancer risks in populations near 52 commercial nuclear power plants and 10 Department of Energy nuclear facilities (including research and nuclear weapons production facilities and one reprocessing plant) in the United States. The results of the NCI investigation were used a primary resource for communicating with the public about the cancer risks near the nuclear facilities. However, this study is now over 20 years old. The U.S. Nuclear Regulatory Commission requested that the National Academy of Sciences provide an updated assessment of cancer risks in populations near USNRC-licensed nuclear facilities that utilize or process uranium for the production of electricity. Analysis of Cancer Risks in Populations near Nuclear Facilities: Phase 1 focuses on identifying scientifically sound approaches for carrying out an assessment of cancer risks associated with living near a nuclear facility, judgments about the strengths and weaknesses of various statistical power, ability to assess potential confounding factors, possible biases, and required effort. The results from this Phase 1 study will be used to inform the design of cancer risk assessment, which will be carried out in Phase 2. This report is beneficial for the general public, communities near nuclear facilities, stakeholders, healthcare providers, policy makers, state and local officials, community leaders, and the media.

Author: Jodhbir Mehta
Publisher: Frontiers Media SA
ISBN: 2889743144
Category : Medical
Languages : en
Pages : 142

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Author: R. Brian Haynes
Publisher: Lippincott Williams & Wilkins
ISBN: 1451178794
Category : Medical
Languages : en
Pages : 516

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The Third Edition of this popular text focuses on clinical-practice research methods. It is written by clinicians with experience in generating and answering researchable questions about real-world clinical practice and health care—the prevention, treatment, diagnosis, prognosis, and causes of diseases, the measurement of quality of life, and the effects of innovations in health services. The book has a problem-oriented and protocol-based approach and is written at an introductory level, emphasizing key principles and their applications. A bound-in CD-ROM contains the full text of the book to help the reader locate needed information.

Author: Wei Zhang
Publisher: CRC Press
ISBN: 1000567990
Category : Mathematics
Languages : en
Pages : 318

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Book Description
Advanced Statistics in Regulatory Critical Clinical Initiatives is focused on the critical clinical initiatives introduced by the 21st Century Cure Act passed by the United States Congress in December 2016. The book covers everything from the outline of the initiatives to analysis on the effect on biopharmaceutical research and development. Advanced Statistics in Regulatory Critical Clinical Initiatives provides innovative ways to resolve common challenges in statistical research of rare diseases such small sample sizes and provides guidance for combined use of data. With analysis from regulatory and scientific perspectives this book is an ideal companion for researchers in biostatistics, pharmaceutical development, and policy makers in related fields. Key Features: Provides better understanding of innovative design and analysis of each critical clinical initiatives which may be used in regulatory review/approval of drug development. Makes recommendations to evaluate submissions accurately and reliably. Proposes innovative study designs and statistical methods for oncology and/or rare disease drug development. Provides insight regarding current regulatory guidance on drug development such as gene therapy and rare diseases.

Author: Fu-Sheng Tsai
Publisher: Frontiers Media SA
ISBN: 2832519237
Category : Medical
Languages : en
Pages : 271

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Author: Demissie Alemayehu, PhD
Publisher: CRC Press
ISBN: 1351252674
Category : Mathematics
Languages : en
Pages : 274

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Book Description
With ever-rising healthcare costs, evidence generation through Health Economics and Outcomes Research (HEOR) plays an increasingly important role in decision-making about the allocation of resources. Accordingly, it is now customary for health technology assessment and reimbursement agencies to request for HEOR evidence, in addition to data from clinical trials, to inform decisions about patient access to new treatment options. While there is a great deal of literature on HEOR, there is a need for a volume that presents a coherent and unified review of the major issues that arise in application, especially from a statistical perspective. Statistical Topics in Health Economics and Outcomes Research fulfils that need by presenting an overview of the key analytical issues and best practice. Special attention is paid to key assumptions and other salient features of statistical methods customarily used in the area, and appropriate and relatively comprehensive references are made to emerging trends. The content of the book is purposefully designed to be accessible to readers with basic quantitative backgrounds, while providing an in-depth coverage of relatively complex statistical issues. The book will make a very useful reference for researchers in the pharmaceutical industry, academia, and research institutions involved with HEOR studies. The targeted readers may include statisticians, data scientists, epidemiologists, outcomes researchers, health economists, and healthcare policy and decision-makers.

Author: Richard Van Praagh
Publisher: Elsevier Health Sciences
ISBN: 0323775535
Category : Medical
Languages : en
Pages : 1112

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Book Description
Authored by the originator of the standard nomenclature for this spectrum of disorders, Congenital Heart Disease: A Clinical, Pathological, Embryological, and Segmental Analysis discusses the history, anatomic features, and physiologic consequences of CHD—in one authoritative resource. The Van Praagh approach to the segmental classification of CHD, developed and implemented by Dr. Richard Van Praagh in the 1960s at Boston Children's Hospital, remains widely used today, facilitating communication among radiologists, cardiologists, surgeons, and pediatricians who are involved in the diagnosis, characterization, and management of this disease. This unique atlas offers complete coverage of the ubiquitous Van Praagh "language of CHD, including the signs, symptoms, and clinical manifestations of malpositioned, malformed, or absent cardiovascular chambers, vessels, and valves using traditional as well as state-of-the-art technology. - Based upon the systematic, widely accepted Van Praagh system of three-part notation used to succinctly describe the visceroatrial situs, the orientation of the ventricular loop, and the position and relation of the great vessels. - Demonstrates how the Van Praagh approach facilitates interpreting and reporting findings through cardiac imaging with CT, MR, and ultrasonography, including fetal cardiac imaging. - Presents the pathologic anatomy that pediatric and adult cardiologists, radiologists, and echocardiographers need to understand in order to make accurate diagnoses in complex congenital heart disease; as well as the pathologic anatomy that interventionists, pediatric cardiac surgeons, and adult congenital heart surgeons need to know in order to manage their patients successfully. - Features more than 550 high-quality images to help you visualize and recognize malformations. - Shares the knowledge and expertise of a world-renowned authority on congenital heart disease—a master teacher and the originator of the Van Praagh segmental classification system. - Explores the synergy between the various disciplines who manage patient care, including surgeons, radiologists, cardiologists, pathologists, and pediatricians. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Author: Eric N. Prystowsky
Publisher: Elsevier Health Sciences
ISBN: 0443183139
Category : Medical
Languages : en
Pages : 233

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Book Description
In this issue, guest editors bring their considerable expertise to this important topic.Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.