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Author: Srinivasan Sukumar Publisher: ISBN: Category : Diagnostic imaging Languages : en Pages : 0
Book Description
"The purpose of this research was to investigate the potential of a laser-based optical polarimetric imaging system, operating under light backscattering geometry, for tumor detection utilizing an optical tumor phantom. Image plays a key role in tumor detection studies. The polarization state of the scattered light from a tumor-like structure and the discrimination of randomly polarized light from weakly polarized light can provide meaningful information regarding the nature of the tumor itself. This information can be both physiological and structural. In this research study, experiments were performed at two optical wavelengths, one visible and one near-infrared wavelength. The weakly scattered light from the tumor tissue like phantom had the necessary information relevant to the structure of the tumor. A Rotating Retarder Polarimeter was used to analyze this weakly scattered light from the phantom. The images obtained from the Rotating Retarder Polarimeter were then processed by means of a data reduction algorithm, based on Polarimetric Measurement matrix method to calculate the Degree of Linear Polarization (DOLP) image. Then, the DOLP images obtained from the two different wavelength lasers were subtracted to enhance the information present in the image. The Signal-to-Background ratio, a measure of contrast, was calculated to determine the quality of the image. Results from the experiments and the contrast analysis procedures showed that, the subtracted DOLP images provides better contrast in terms of higher numerical value compared to the single DOLP image. Overall, this optical imaging system combined with data reduction algorithm and image processing technique served as an effective imaging methodology in optical tumor phantom study."--Page iii-iv.
Author: Srinivasan Sukumar Publisher: ISBN: Category : Diagnostic imaging Languages : en Pages : 0
Book Description
"The purpose of this research was to investigate the potential of a laser-based optical polarimetric imaging system, operating under light backscattering geometry, for tumor detection utilizing an optical tumor phantom. Image plays a key role in tumor detection studies. The polarization state of the scattered light from a tumor-like structure and the discrimination of randomly polarized light from weakly polarized light can provide meaningful information regarding the nature of the tumor itself. This information can be both physiological and structural. In this research study, experiments were performed at two optical wavelengths, one visible and one near-infrared wavelength. The weakly scattered light from the tumor tissue like phantom had the necessary information relevant to the structure of the tumor. A Rotating Retarder Polarimeter was used to analyze this weakly scattered light from the phantom. The images obtained from the Rotating Retarder Polarimeter were then processed by means of a data reduction algorithm, based on Polarimetric Measurement matrix method to calculate the Degree of Linear Polarization (DOLP) image. Then, the DOLP images obtained from the two different wavelength lasers were subtracted to enhance the information present in the image. The Signal-to-Background ratio, a measure of contrast, was calculated to determine the quality of the image. Results from the experiments and the contrast analysis procedures showed that, the subtracted DOLP images provides better contrast in terms of higher numerical value compared to the single DOLP image. Overall, this optical imaging system combined with data reduction algorithm and image processing technique served as an effective imaging methodology in optical tumor phantom study."--Page iii-iv.
Author: Suman Shrestha Publisher: ISBN: Category : Electrical engineering Languages : en Pages : 131
Book Description
In the year 2012, there were approximately 226,160 cases of lung cancer and 160,340 deaths out of it as per the National Cancer Institute. There are mainly two types of lung cancer, small cell lung cancer and non-small cell lung cancer, of which 87% are diagnosed as non-small cell. A physical algorithm and a systematic study relating the morphological, chemical and metabolic properties of lung cancer to the physical and optical parameters of the polarimetric detection process are missing. Therefore, one of the purposes of the study is to explore the polarimetric phenomenology of near infrared light interaction with healthy and lung cancer monoline cells by using efficient polarimetric backscattering detection techniques. Preliminary results indicate that enhanced discrimination between healthy and different types of lung cancer cells can be achieved based on their backscattered intensities, Mueller matrix, diattenuation and depolarization properties. Also, various optical parameters like linear depolarization ratio and degree of linear polarization play an important role in discriminating healthy and different lung cancer cells. Specifically, the sizes of the nuclei of the cancer cells and the nucleus-to-cytoplasmic ratios appear to have potential impact on the detected polarimetric signatures leading to enhanced discrimination of lung cancer cells. The second work in this thesis has been done with the support of the Air Force Research Laboratory (AFRL). Polarimetric signals have always played an important role in the identification, discrimination and analysis of a material's optical properties. This work presents a novel remote sensing approach based on polarimetric fractal detection principles. Backscattered polarimetric signals contribution from different materials used in space applications have already been detected using a laboratory LADAR testbed and this thesis presents implememtation of the LADAR testbed and analysis techniques of these backscattered signals based on fractal analysis. Fractal dimension has been chosen as a measure for the discrimination purposes of these materials. The outcome of this thesis indicates that polarimetric fractal principles may enhance the capabilities of the LADAR for characterization and discrimination of different materials.
Author: Valery V. Tuchin Publisher: Springer Science & Business Media ISBN: 3540453210 Category : Science Languages : en Pages : 281
Book Description
Optical Polarization in Biomedical Applications introduces key developments in optical polarization methods for quantitative studies of tissues, while presenting the theory of polarization transfer in a random medium as a basis for the quantitative description of polarized light interaction with tissues. This theory uses the modified transfer equation for Stokes parameters and predicts the polarization structure of multiple scattered optical fields. The backscattering polarization matrices (Jones matrix and Mueller matrix) important for noninvasive medical diagnostic are introduced. The text also describes a number of diagnostic techniques such as CW polarization imaging and spectroscopy, polarization microscopy and cytometry. As a new tool for medical diagnosis, optical coherent polarization tomography is analyzed. The monograph also covers a range of biomedical applications, among them cataract and glaucoma diagnostics, glucose sensing, and the detection of bacteria.
Author: Wolfgang Drexler Publisher: Springer Science & Business Media ISBN: 3540775501 Category : Medical Languages : en Pages : 1346
Book Description
Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is emerging as a powerful imaging technique that enables non-invasive, in vivo, high resolution, cross-sectional imaging in biological tissue. This book introduces OCT technology and applications not only from an optical and technological viewpoint, but also from biomedical and clinical perspectives. The chapters are written by leading research groups, in a style comprehensible to a broad audience.
Author: Wolfgang Sigmund Publisher: CRC Press ISBN: 1000654494 Category : Science Languages : en Pages : 357
Book Description
Despite the widespread growth and acceptance of particulate technology, challenges in the design, operation, and manufacturing of these systems still exists. These critical issues must be resolved so that particle technology may continue to serve as a foundation for new nano and biotechnologies. Particulate Systems in Nano- and Biotechnologies pres
Author: Valery Tuchin Publisher: ISBN: 9781628415162 Category : Diagnostic imaging Languages : en Pages : 988
Book Description
This third edition of the biomedical optics classic Tissue Optics covers the continued intensive growth in tissue optics—in particular, the field of tissue diagnostics and imaging—that has occurred since 2007. As in the first two editions, Part I describes fundamentals and basic research, and Part II presents instrumentation and medical applications. However, for the reader’s convenience, this third edition has been reorganized into 14 chapters instead of 9. The chapters covering optical coherence tomography, digital holography and interferometry, controlling optical properties of tissues, nonlinear spectroscopy, and imaging have all been substantially updated. The book is intended for researchers, teachers, and graduate and undergraduate students specializing in the physics of living systems, biomedical optics and biophotonics, laser biophysics, and applications of lasers in biomedicine. It can also be used as a textbook for courses in medical physics, medical engineering, and medical biology.
Author: James G. Fujimoto Publisher: Oxford University Press ISBN: 0199722293 Category : Science Languages : en Pages : 435
Book Description
Biomedical optical imaging is a rapidly emerging research area with widespread fundamental research and clinical applications. This book gives an overview of biomedical optical imaging with contributions from leading international research groups who have pioneered many of these techniques and applications. A unique research field spanning the microscopic to the macroscopic, biomedical optical imaging allows both structural and functional imaging. Techniques such as confocal and multiphoton microscopy provide cellular level resolution imaging in biological systems. The integration of this technology with exogenous chromophores can selectively enhance contrast for molecular targets as well as supply functional information on processes such as nerve transduction. Novel techniques integrate microscopy with state-of-the-art optics technology, and these include spectral imaging, two photon fluorescence correlation, nonlinear nanoscopy; optical coherence tomography techniques allow functional, dynamic, nanoscale, and cross-sectional visualization. Moving to the macroscopic scale, spectroscopic assessment and imaging methods such as fluorescence and light scattering can provide diagnostics of tissue pathology including neoplastic changes. Techniques using light diffusion and photon migration are a means to explore processes which occur deep inside biological tissues and organs. The integration of these techniques with exogenous probes enables molecular specific sensitivity.
Author: Fabian Kiessling Publisher: Springer ISBN: 3319422022 Category : Medical Languages : en Pages : 871
Book Description
This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.
Author: Srinivasan Sukumar
Author: Srinivasan Sukumar
Author: Suman Shrestha
Author: Valery V. Tuchin
Author: Wolfgang Drexler
Author: Wolfgang Sigmund
Author: Valery Tuchin
Author: James G. Fujimoto
Author: Fabian Kiessling
Author: 
Author: Alexander A. Oraevsky