Enhanced Electric Pulse Technology for the Ablation of Pancreatic Cancer PDF Download

Author: Siqi Guo
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages :

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Book Description
Electric pulse based technology has been developed and studied as a non-thermal ablation method for local control of pancreatic cancer. Irreversible electroporation (IRE) has shown a significant survival benefit for local advanced pancreatic cancer in clinical trials. However, incomplete ablation with local recurrence and major complications limit the potential of this new technology. We have developed an integrated moderate heating electric pulse delivery system which consists of controllable tumor heating, multi-parameter monitoring and electric pulse delivery. The impedance of tumor is greatly decreased after moderate heating at 42°C for 1-2 min, which does not cause any cell death. Moderate heating significantly enlarges the ablation zone of tumor treated with IRE. In contrast to IRE alone, moderate heating assisted IRE results in a high rate of complete tumor regression and a significant longer median survival. Another electric pulse technology, nanosecond electric pulses, has been assessed for the treatment of pancreatic cancer as well. Nanosecond electric pulse treatment achieves more survival benefit in animals with partial tumor ablation than those treated with IRE and leads to a vaccine-like protective effect in animals with complete local ablation. More studies are needed to demonstrate the advantages and translational feasibility of the enhanced electric pulse technologies.

Author: Martijn R. Meijerink
Publisher: Springer
ISBN: 3319551132
Category : Medical
Languages : en
Pages : 281

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Book Description
This book provides a comprehensive overview of the clinical use of irreversible electroporation (IRE) – better known by its commercial name, NanoKnife – which is one of the most exciting new needle-guided cancer treatments. The coverage includes the history of IRE, general technique, preclinical research, applications in clinical practice and early clinical results, and future perspectives. Contraindications, treatment planning, potential complications, follow-up imaging, and other practical aspects are fully discussed, with highlighting of useful tips and tricks. Through the delivery of short but highly intense electrical pulses, IRE results in tumor cell membrane permeabilization, causing cells to go into apoptosis. The minimally invasive nature of IRE, combined with the prospect of completely eradicating tumors while preserving delicate structures in the ablation zone, makes IRE the object of worldwide clinical research. This book will be of value for practitioners and trainees in interventional and diagnostic radiology, surgery, medical oncology, HPB and gastroenterology, urology, and radiation oncology.

Author: Boris Rubinsky
Publisher: Springer Science & Business Media
ISBN: 364205420X
Category : Technology & Engineering
Languages : en
Pages : 320

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Book Description
Non-thermal irreversible electroporation is a new minimally invasive surgical p- cedure with unique molecular selectivity attributes – in fact it may be considered the first clinical molecular surgery procedure. Non-thermal irreversible electro- ration is a molecular selective mode of cell ablation that employs brief electrical fields to produce nanoscale defects in the cell membrane, which can lead to cell death, without an effect on any of the other tissue molecules. The electrical fields can be produced through contact by insertion of electrode needles around the undesirable tissue and non-invasively by electromagnetic induction. This new - dition to the medical armamentarium requires the active involvement and is of interest to clinical physicians, medical researchers, mechanical engineers, che- cal engineers, electrical engineers, instrumentation designers, medical companies and many other fields and disciplines that were never exposed in their training to irreversible electroporation or to a similar concept. This edited book is designed to be a comprehensive introduction to the field of irreversible electroporation to those that were not exposed or trained in the field before and can also serve as a reference manual. Irreversible electroporation is broad and interdisciplinary. Therefore, we have made an attempt to cover every one of the various aspects of the field from an introductory basic level to state of the art.

Author: Luis Rodrigo
Publisher: BoD – Books on Demand
ISBN: 1789236401
Category : Medical
Languages : en
Pages : 226

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Book Description
Pancreatic cancer is a growing source of cancer-related death and has poor survival rates, which have not improved in the last few decades. Its high-mortality rate is attributed to pancreatic cancer biology, difficulty in early diagnosis, and lack of standardized international guidelines in assessing the pancreatic masses. This book aims to provide an update in the current state of play in pancreatic cancer diagnosis and to evaluate the benefits and limitations of the available diagnostic technology and therapy. The main modalities for diagnosis are imaging with HCT, MRI, USE, and PET. Some chapters review the improvements in the techniques used. Timely and accurate diagnosis of pancreatic cancer can lead to improve in the current poor outcome of this disease.

Author: Hidenori Akiyama
Publisher: Springer
ISBN: 4431560955
Category : Technology & Engineering
Languages : en
Pages : 491

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Book Description
This book focuses on bioelectrics, a new multidisciplinary field encompassing engineering and biology with applications to the medical, environmental, food, energy, and biotechnological fields. At present, 15 universities and institutes in Japan, the USA and the EU comprise the International Consortium of Bioelectrics, intended to advance this novel and important research field. This book will serve as an introductory resource for young scientists and also as a textbook for use by both undergraduate and graduate students – the world’s first such work solely devoted to bioelectrics.

Author: Yujin Hoshida
Publisher: Springer
ISBN: 3030215407
Category : Medical
Languages : en
Pages : 366

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Book Description
This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.

Author: Andrei G. Pakhomov
Publisher: CRC Press
ISBN: 1439819076
Category : Medical
Languages : en
Pages : 542

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Book Description
A reflection of the intense study of the effects of electromagnetic fields on living tissues that has taken place during the last decades, Advanced Electroporation Techniques in Biology and Medicine summarizes most recent experimental findings and theories related to permeabilization of biomembranes by pulsed electric fields. Edited by experts and

Author: Andrea Natale
Publisher: John Wiley & Sons
ISBN: 1119963842
Category : Medical
Languages : en
Pages : 381

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Book Description
This concise text presents best practices for all aspects of atrial fibrillation ablation as outlined in the new version of the VeniceChart International Consensus document, which is presented in conjunction with the biannual Venice Arrhythmias conference. In addition to discussing the latest in a-fib ablation research, this 2011 update covers all the key areas of therapy and patient management, including: • Techniques and technologies • Procedural endpoints • Patient management pre-, peri- and post-ablation • Prevention and treatment of complications • Definition of success and long-term results With contributions from the world’s recognized thought leaders in this field, this book is a highly valuable source of information not only for specialists in electrophysiology, but also for general cardiologists, fellows in cardiology and others interested in this dynamic and increasingly important topic.

Author: Evangelos Kalaitzakis
Publisher: Springer Nature
ISBN: 3030289648
Category : Medical
Languages : en
Pages : 277

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Book Description
This book provides an up-to-date review of therapeutic EUS with an equal focus on technical descriptions with ample endoscopic images/video clips by world experts and the scientific evidence behind the described techniques. The book provides an overview of the field in a structured manner, starting with general topics on equipment and service development and extending to the fields of EUS-guided drainage, anti-tumor therapies, and other specific EUS-guided interventional treatments. Therapeutic Endoscopic Ultrasound is a key resource for endoscopists, gastroenterologists, surgeons, and GI oncologists.

Author: Eric van Sonnenberg
Publisher: Springer Science & Business Media
ISBN: 0387286748
Category : Medical
Languages : en
Pages : 554

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Book Description
There is an enormous sense of excitement in the communities of cancer research and cancer care as we move into the middle third of the ?rst decade of the 21st century. For the ?rst time,there is a true sense of c- ?dence that the tools provided by the human genome project will enable cancer researchers to crack the code of genomic abnormalities that allow tumor cells to live within the body and provide highly speci?c, virtually non-toxic therapies for the eradication,or at least ?rm control of human cancers. There is also good reason to hope that these same lines of inquiry will yield better tests for screening, early detection, and prev- tion of progression beyond curability. While these developments provide a legitimate basis for much op- mism, many patients will continue to develop cancers and suffer from their debilitating effects, even as research moves ahead. For these in- viduals, it is imperative that the cancer ?eld make the best possible use of the tools available to provide present day cancer patients with the best chances for cure, effective palliation, or, at the very least, relief from symptoms caused by acute intercurrent complications of cancer. A modality that has emerged as a very useful approach to at least some of these goals is tumor ablation by the use of physical or physiochemical approaches.