Author: Liang MaPublisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Engineering Nanomaterials for Molecular Imaging and Targeted Therapy
Author: Liang MaNanomaterial - Based Biomedical Applications in Molecular Imaging, Diagnostics and Therapy
Author: Amitabha AcharyaPublisher: Springer Nature
ISBN: 9811542805
Category : Medical
Languages : en
Pages : 208
Book Description
This book comprehensively reviews the recent advances in nanomaterial-based molecular imaging, diagnostics, and personalized therapy. It discusses the novel biocompatible fluorescent nanomaterials, their synthesis, and modern state of art characterization, as well as the various strategies for immobilization of biomacromolecules on the nanomaterial surface and approaches for increasing their stability. In addition, the book describes the synthesis of lectin nanoconjugates using different types of biocompatible raw materials and their systematic characterization. Lastly, it presents our current understanding of the biomolecular carona, which affects nanoparticle-based targeted drug delivery, and examines the conceptual approaches to improve the in-vivo efficacy of targeted drug delivery.
Targeted Cancer Imaging
Author: Mehdi AziziPublisher: Academic Press
ISBN: 012824514X
Category : Science
Languages : en
Pages : 218
Book Description
Targeted Cancer Imaging: Design and Synthesis of Nanoplatforms based on Tumour Biology reviews and categorizes imaging and targeting approaches according to cancer type, highlighting new and safe approaches that involve membrane-coated nanoparticles, tumor cell-derived extracellular vesicles, circulating tumor cells, cell-free DNAs, and cancer stem cells, all with the goal of pointing the way to developing precise targeting and multifunctional nanotechnology-based imaging probes in the future. This book is highly multidisciplinary, bridging the knowledge gap between tumor biology, nanotechnology, and diagnostic imaging, and thus making it suitable for researchers ranging from oncology to bioengineering. Although considerable efforts have been conducted to diagnose, improve and treat cancer in the past few decades, existing therapeutic options are insufficient, as mortality and morbidity rates remain high. One of the best hopes for substantial improvement lies in early detection. Recent advances in nanotechnology are expected to increase our current understanding of tumor biology, allowing nanomaterials to be used for targeting and imaging both in vitro and in vivo experimental models. - Gives understanding of cancer biology that is appropriate for students and researchers in engineering and nanotechnology - Demonstrates cancer targeting strategies of multifunctional nanotechnology-based imaging probes - Shows how to design, synthesize and apply cancer imaging nanostructures
Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering
Author: Ashutosh TiwariPublisher: John Wiley & Sons
ISBN: 1118644743
Category : Science
Languages : en
Pages : 633
Book Description
This comprehensive volume provides the reader valuable insight into the major areas of biomedical nanomaterials, advanced nanomedicine, nanotheragnostics, and cutting-edge nanoscaffolds. The ability to control the structure of materials allows scientists to accomplish what once appeared impossible before the advent of nanotechnology. It is now possible to generate nanoscopic self-assembled and self-destructive robots for effective utilization in therapeutics, diagnostics, and biomedical implants. Nanoscopic therapeutic systems incorporate therapeutic agents, molecular targeting, and diagnostic imaging capabilities and they have emerged as the next generation of multifarious nanomedicine to improve the therapeutic outcome including chemo and translational therapy. Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering comprises fifteen chapters authored by senior scientists, and is one of the first books to cover nanotheragnostics, which is the new developmental edge of nanomedicine combining both diagnostic and therapeutic elements at the nano level. This large multidisciplinary reference work has four main parts: biomedical nanomaterials; advanced nanomedicine; nanotheragnostics; and nanoscaffolds technology. This groundbreaking volume also covers: Multifunctional polymeric nanostructures for therapy and diagnosis Metalla-assemblies acting as drug carriers Nanomaterials for management of lung disorders and drug delivery Responsive polymer-inorganic hybrid nanogels for optical sensing, imaging, and drug delivery Core/shell nanoparticles for drug delivery and diagnosis Theranostic nanoparticles for cancer imaging and therapy Magnetic nanoparticles in tissue regeneration Core-sheath fibers for regenerative medicine
Advances in Nanotheranostics II
Author: Zhifei DaiPublisher: Springer
ISBN: 9811000638
Category : Technology & Engineering
Languages : en
Pages : 386
Book Description
This book surveys recent advances in theranostics based on magnetic nanoparticles, ultrasound contrast agents, silica nanoparticles and polymeric micelles. It presents magnetic nanoparticles, which offer a robust tool for contrast enhanced MRI imaging, magnetic targeting, controlled drug delivery, molecular imaging guided gene therapy, magnetic hyperthermia, and controlling cell fate. Multifunctional ultrasound contrast agents have great potential in ultrasound molecular imaging, multimodal imaging, drug/gene delivery, and integrated diagnostics and therapeutics. Due to their diversity and multifunctionality, polymeric micelles and silica-based nanocomposites are highly capable of enhancing the efficacy of multimodal imaging and synergistic cancer therapy. This comprehensive book summarizes the main advances in multifunctional nanoprobes for targeted imaging and therapy of gastric cancer, and explores the clinical translational prospects and challenges. Although more research is needed to overcome the substantial obstacles that impede the development and availability of nanotheranostic products, such nontrivial nanoagents are expected to revolutionize medical treatments and help to realize the potential of personalized medicine to diagnose, treat, and follow-up patients with cancer. Zhifei Dai is a Professor at the Department of Biomedical Engineering, College of Engineering, Peking University, China.
Nanomaterials for Molecular Imaging
Author: Sixiang ShiPublisher:
ISBN:
Category :
Languages : en
Pages : 0
Book Description
Molecular imaging, the "visualization, characterization, and measurement of biological processes at the molecular and cellular levels in humans and other living systems", has played an important role in cancer diagnosis. With the advances in nanotechnology, nanomaterials have emerged as a promising candidate for molecular imaging, due to their unique properties. Graphene is one of the most promising nanomaterials, which is intrinsically useful for drug loading and photo therapy of cancer. However, in vivo biodistribution and tumor targeting with graphene nanomaterial is an underexplored area. In this dissertation, we designed a radiolabeled antibody conjugated reduced graphene oxide (RGO) nanoplatform for in vivo positron emission tomography (PET) and tumor vasculature targeting. Excellent tumor uptake was achieved with 64Cu-NOTA-RGO-TRC105, compared to non-targeted RGO conjugate (64Cu-NOTA-RGO). Various experiments were performed, demonstrating that the vasculature targeting is highly specific (Chapter 2). In the following study, graphene oxide (GO), another subtype of graphene nanomaterials, was conjugated with anti-angiogenesis protein vascular endothelial growth factor 121 (VEGF121) to further validate the active targeting and imaging of graphene nanomaterials. Significantly enhanced tumor accumulation (>8 %ID/g) as well as high tumor-to-muscle contrast was achieved, showing great potential for future tumor targeted imaging (Chapter 3). Although traditional chelators are generally utilized in radiolabeling and PET imaging of nanomaterials, a novel chelator-free radiolabeling approach was designed with graphene nanoparticles (Chapter 4). The chelator-free radiolabeled RGO possesses decent labeling efficiency and enhanced in vivo radiostability over NOTA-chelated RGO, making it especially suitable for nanoparticle-based radiolabeling. Bypassing the use of chemical chelator, the intrinsically radiolabeled nanoparticles are able to maintain the native pharmacokinetics, and therefore more accurately reflect the distribution in vivo. Besides graphene, layered double hydroxide (LDH) and molybdenum disulfide (MoS2) nanoparticles were also employed for chelator-free radiolabeling and examined in vivo (Chapter 5 and 6). Excellent tumor uptake and in vivo integrity were observed, further validating the potential of chelator-free labeling in molecular imaging. Taking advantaging of molecular imaging and nanotechnology, a promising multifunctional nanoplatform can be designed for in vivo cancer management. Further efforts are necessary to thoroughly understand the in vivo behavior of nanoparticles and apply them in clinic
Nanooncology
Author: Gil GonçalvesPublisher: Springer
ISBN: 3319898787
Category : Technology & Engineering
Languages : en
Pages : 457
Book Description
This book presents a systematic overview of the most relevant nanomaterials and their respective intrinsic properties that have been highly explored by the scientific community and pharmaceutical companies in several different modalities for cancer therapy and bioimaging. The chapters explore the synergistic effects provided by the different nanostructured materials and highlight the main in vitro and in vivo therapeutic achievements on cancer. This work also provides relevant discussion about the recent progresses and future challenges that nanotechnology faces on the conception of more efficient nanoformulations against primary tumors, circulating cancer cells and metastases.
Pharmaceutical Nanobiotechnology for Targeted Therapy
Author: Hamed BarabadiPublisher: Springer Nature
ISBN: 3031126580
Category : Science
Languages : en
Pages : 641
Book Description
The field of nanotechnology for targeted therapy initiated more than decade ago has grown fast and interest is increasing. Given the importance of the field for targeted drug and gene delivery systems, there are a large number of laboratory investigations today researching nanobiomaterials for diagnostic and therapeutic applications. Because of the ability of scientists to load nanoparticles with any agent, interest continues to grow and technology in this arena is rapidly evolving. These emerging nanobiomaterials-based medicines can overcome the disadvantages of traditional medicines by target-oriented and site-specific delivery of precise medicines (immunotherapeutic agents, chemotherapeutic agents, diagnostic agents, and so on). Pharmaceutical Nanobiotechnology for Targeted Therapy presents an updated overview of recent advancements in the field of pharmaceutical nanobiotechnology and nano-based drug and gene delivery systems. This comprehensive knowledge will allow researchers to discover innovative nanobiomaterials for targeted therapeutics. The chapters deal with various emerging nanobiomaterials for targeted therapeutic delivery systems and the writing is in a style that is easily disseminated and in a manner that can be readily adopted as sources for new and further studies. This book should be useful for researchers and professionals from academia and industry working in the field of nanotechnology, nanobiotechnology, as well as in the field of pharmaceutical nanotechnology. It should also be useful to those interested in a range of disciplines from material science, chemistry, molecular biology, polymer chemistry, and many more interdisciplinary areas.
Nanoplatform-Based Molecular Imaging
Author: Xiaoyuan ChenPublisher: John Wiley & Sons
ISBN: 1118110021
Category : Technology & Engineering
Languages : en
Pages : 844
Book Description
The cutting-edge guide on advancing the science of molecular imaging using nanoparticles Nanoplathform-Based Molecular Imaging provides rationale for using nanoparticle-based probes for molecular imaging, then discusses general strategies for this underutilized, yet promising, technology. It addresses general strategies of particle synthesis and surface chemistry, applications in computed tomography optical imaging, magnetic resonance imaging, ultrasound, multimodality imaging, theranostics, and finally, the clinical perspectives of nanoimaging. This comprehensive volume summarizes the opinions of those in the forefront of research and describes the latest developments by emphasizing fundamentals and initiating hands-on application.
Nanotechnology for Biomedical Imaging and Diagnostics
Author: Mikhail Y. BerezinPublisher: John Wiley & Sons
ISBN: 1118873149
Category : Technology & Engineering
Languages : en
Pages : 534
Book Description
Nanotechnology for Biomedical Imaging and Diagnostics: From Nanoparticle Design to Clinical Applications reflects upon the increasing role of nanomaterials in biological and medical imaging, presenting a thorough description of current research as well as future directions. With contributions from experts in nanotechnology and imaging from academia, industry, and healthcare, this book provides a comprehensive coverage of the field, ranging from the architectural design of nanomaterials to their broad imaging applications in medicine. Grouped into three sections, the book: Elucidates all major aspects of nanotechnology and bioimaging Provides comprehensive coverage of the field, ranging from the architectural design of nanomaterials to their broad imaging applications in medicine Written by well-recognized experts in academia, industry, and healthcare, will be an excellence source of reference With a multidisciplinary approach and a balance of research and diagnostic topics, this book will appeal to students, scientiests, and healthcare professionals alike